{"id":"https://openalex.org/W7204179071","doi":"https://doi.org/10.1080/14737159.2026.2719602","title":"LINC00673 upregulation and rs9914618 polymorphism: associations with risk and prognosis of lung squamous cell carcinoma","display_name":"LINC00673 upregulation and rs9914618 polymorphism: associations with risk and prognosis of lung squamous cell carcinoma","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204179071","doi":"https://doi.org/10.1080/14737159.2026.2719602","pmid":"https://pubmed.ncbi.nlm.nih.gov/42642337"},"language":"en","primary_location":{"id":"doi:10.1080/14737159.2026.2719602","doi":"https://doi.org/10.1080/14737159.2026.2719602","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14737159.2026.2719602","pdf_url":null,"source":{"id":"https://openalex.org/S124386304","display_name":"Expert Review of Molecular Diagnostics","issn_l":"1473-7159","issn":["1473-7159","1744-8352"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Molecular Diagnostics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.6084/m9.figshare.33335020","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5144407763","display_name":"Xingshu Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xingshu Zhang","raw_affiliation_strings":["First Affiliated Hospital of Guizhou University of Traditional Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Guizhou University of Traditional Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148043738","display_name":"Fen Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128628","display_name":"Peking University Shenzhen Hospital","ror":"https://ror.org/03kkjyb15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fen Wang","raw_affiliation_strings":["Peking University Shenzhen Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University Shenzhen Hospital","institution_ids":["https://openalex.org/I4210128628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148072960","display_name":"Licai Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Licai Zhang","raw_affiliation_strings":["Zigong Fourth People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zigong Fourth People\u2019s Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148059901","display_name":"Liquan Qiu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liquan Qiu","raw_affiliation_strings":["Zigong Fourth People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zigong Fourth People\u2019s Hospital","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023921072","display_name":"Jijun Xue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jijun Xue","raw_affiliation_strings":["Sun Yat-Sen University Cancer Center Gansu Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-Sen University Cancer Center Gansu Hospital","institution_ids":["https://openalex.org/I4210146711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5023921072"],"corresponding_institution_ids":["https://openalex.org/I4210146711"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.65491688,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"10","first_page":"863","last_page":"872"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/linc00673","display_name":"LINC00673","score":1.0},{"id":"https://openalex.org/keywords/lung-squamous-cell-carcinoma","display_name":"lung squamous cell carcinoma","score":0.9279999732971191},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.7509999871253967},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.6800000071525574},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8059999942779541},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.8769999742507935},{"id":"https://openalex.org/keywords/gene-upregulation","display_name":"gene upregulation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.770799994468689},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7107999920845032},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.49070000648498535},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47049999237060547},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.47049999237060547},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4625000059604645},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4408000111579895},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42910000681877136},{"id":"https://openalex.org/C2779327097","wikidata":"https://www.wikidata.org/wiki/Q5749020","display_name":"Squamous-cell carcinoma of the lung","level":3,"score":0.3977999985218048},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.34769999980926514},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3222000002861023},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.29989999532699585},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.26989999413490295},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.263700008392334},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.2572999894618988},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.2565999925136566}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1080/14737159.2026.2719602","doi":"https://doi.org/10.1080/14737159.2026.2719602","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14737159.2026.2719602","pdf_url":null,"source":{"id":"https://openalex.org/S124386304","display_name":"Expert Review of Molecular Diagnostics","issn_l":"1473-7159","issn":["1473-7159","1744-8352"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Molecular Diagnostics","raw_type":"journal-article"},{"id":"pmid:42642337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42642337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of molecular diagnostics","raw_type":"Journal Article"},{"id":"doi:10.6084/m9.figshare.33335020","doi":"https://doi.org/10.6084/m9.figshare.33335020","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.33335020","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.33335020.v1","doi":"https://doi.org/10.6084/m9.figshare.33335020.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.33335020.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.33335020.v2","doi":"https://doi.org/10.6084/m9.figshare.33335020.v2","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.33335020.v2","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.6084/m9.figshare.33335020","doi":"https://doi.org/10.6084/m9.figshare.33335020","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.33335020","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G4590051215","display_name":null,"funder_award_id":"2025-3-086","funder_id":"https://openalex.org/F4320324678","funder_display_name":"Lanzhou Science and Technology Bureau"}],"funders":[{"id":"https://openalex.org/F4320324678","display_name":"Lanzhou Science and Technology Bureau","ror":"https://ror.org/030q46522"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W2903238853","https://openalex.org/W2954754264","https://openalex.org/W2972529129","https://openalex.org/W2986549885","https://openalex.org/W3146333778","https://openalex.org/W3179646315","https://openalex.org/W3195156548","https://openalex.org/W3208983446","https://openalex.org/W4210504015","https://openalex.org/W4210998676","https://openalex.org/W4211023763","https://openalex.org/W4229447827","https://openalex.org/W4232542801","https://openalex.org/W4283738813","https://openalex.org/W4292466760","https://openalex.org/W4306404102","https://openalex.org/W4307362411","https://openalex.org/W4308616034","https://openalex.org/W4312095046","https://openalex.org/W4316341727","https://openalex.org/W4385064056","https://openalex.org/W4389397880","https://openalex.org/W4399855521","https://openalex.org/W4403458118","https://openalex.org/W4404201935","https://openalex.org/W4404844812","https://openalex.org/W4413274074"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,50,91,133,144],"specific":[2],"effect":[3],"of":[4,104,115],"the":[5,88,105],"LINC00673":[6,44,76,101,145],"rs9914618":[7,51,95,134,146],"single":[8],"nucleotide":[9],"polymorphism":[10,135,147],"(SNP)":[11],"on":[12],"lung":[13],"squamous":[14],"cell":[15],"carcinoma":[16],"(LUSC)":[17],"remains":[18],"unclear.":[19],"This":[20],"study":[21],"aims":[22],"to":[23,87],"evaluate":[24],"its":[25],"association":[26],"with":[27,71,99,118,160],"LUSC":[28,38,82],"susceptibility":[29],"and":[30,40,84,128,163],"prognosis.":[31],"MATERIALS":[32],"AND":[33],"METHODS:":[34],"We":[35],"recruited":[36],"305":[37],"patients":[39],"336":[41],"healthy":[42],"controls.":[43],"expression":[45,77],"was":[46,53,60,78,96,136],"measured":[47],"by":[48,62],"qRT-PCR.":[49],"genotype":[52,110],"determined":[54],"using":[55],"TaqMan":[56],"assays.":[57],"Disease-free":[58],"survival":[59,131],"estimated":[61],"Kaplan-Meier":[63],"analysis.":[64],"Multivariate":[65],"Cox":[66],"regression":[67],"yielded":[68],"hazard":[69],"ratios":[70],"95%":[72],"confidence":[73],"intervals.":[74],"RESULTS:":[75],"significantly":[79],"upregulated":[80],"in":[81],"tissues":[83],"serum":[85],"relative":[86],"control":[89],"group.":[90],"A":[92,106],"allele":[93,107],"at":[94],"positively":[97],"associated":[98],"increased":[100],"transcription.":[102],"Carriers":[103],"or":[108,120],"AA":[109,121],"had":[111],"a":[112,151],"higher":[113],"risk":[114,164],"LUSC.":[116],"Patients":[117],"GA":[119],"genotypes":[122],"showed":[123],"more":[124],"severe":[125],"clinicopathological":[126],"features":[127],"lower":[129],"five\u2011year":[130],"rates.":[132],"validated":[137],"as":[138,150],"an":[139],"independent":[140],"prognostic":[141,153],"factor.":[142],"CONCLUSION:":[143],"may":[148],"serve":[149],"potential":[152],"factor":[154],"for":[155],"LUSC,":[156],"showing":[157],"significant":[158],"associations":[159],"patient":[161],"outcomes":[162],"stratification.":[165]},"counts_by_year":[],"updated_date":"2026-10-03T13:16:28.481748","created_date":"2026-08-26T00:00:00"}