{"id":"https://openalex.org/W7204177993","doi":"https://doi.org/10.3390/microorganisms14091889","title":"Ehrlichia chaffeensis DapE Is Essential for Intracellular Growth and Represents a Promising Therapeutic Target","display_name":"Ehrlichia chaffeensis DapE Is Essential for Intracellular Growth and Represents a Promising Therapeutic Target","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204177993","doi":"https://doi.org/10.3390/microorganisms14091889","pmid":"https://pubmed.ncbi.nlm.nih.gov/42795471"},"language":"en","primary_location":{"id":"doi:10.3390/microorganisms14091889","doi":"https://doi.org/10.3390/microorganisms14091889","is_oa":true,"landing_page_url":"https://doi.org/10.3390/microorganisms14091889","pdf_url":null,"source":{"id":"https://openalex.org/S4210222090","display_name":"Microorganisms","issn_l":"2076-2607","issn":["2076-2607"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microorganisms","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/microorganisms14091889","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Mengyao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengyao Wang","raw_affiliation_strings":["Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038837593","display_name":"Yuhong Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhong Zhou","raw_affiliation_strings":["Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144076642","display_name":"Mengxiao Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengxiao Li","raw_affiliation_strings":["Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101308094","display_name":"Shanhua Qin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanhua Qin","raw_affiliation_strings":["Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144032973","display_name":"Ziyue Qi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyue Qi","raw_affiliation_strings":["Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088456662","display_name":"Meifang Li","orcid":"https://orcid.org/0000-0002-9138-3080","observed_orcids":["https://orcid.org/0000-0002-9138-3080"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meifang Li","raw_affiliation_strings":["Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057370042","display_name":"Nan Yang","orcid":"https://orcid.org/0009-0005-1075-9277","observed_orcids":["https://orcid.org/0009-0005-1075-9277"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Yang","raw_affiliation_strings":["Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China"],"raw_orcid":"https://orcid.org/0009-0005-1075-9277","affiliations":[{"raw_affiliation_string":"Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082758021","display_name":"Yi Zhou","orcid":"https://orcid.org/0000-0002-9919-3898","observed_orcids":["https://orcid.org/0000-0002-9919-3898","https://orcid.org/0000-0002-8432-8075"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Zhou","raw_affiliation_strings":["Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084802829","display_name":"Xiaoya Wei","orcid":"https://orcid.org/0000-0001-5681-0764","observed_orcids":["https://orcid.org/0000-0001-5681-0764"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoya Wei","raw_affiliation_strings":["Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China"],"raw_orcid":"https://orcid.org/0000-0001-5681-0764","affiliations":[{"raw_affiliation_string":"Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148060193","display_name":"Yujie Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujie Zhang","raw_affiliation_strings":["Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101317535","display_name":"Zhonghui Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhonghui Yang","raw_affiliation_strings":["Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5144007621","display_name":"Zhihui Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhihui Cheng","raw_affiliation_strings":["Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300071, China","institution_ids":["https://openalex.org/I205237279"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5144007621"],"corresponding_institution_ids":["https://openalex.org/I205237279"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.66947244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"9","first_page":"1889","last_page":"1889"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ehrlichia-chaffeensis","display_name":"Ehrlichia chaffeensis","score":1.0},{"id":"https://openalex.org/keywords/dape","display_name":"DapE","score":0.890999972820282},{"id":"https://openalex.org/keywords/lysine-biosynthesis","display_name":"lysine biosynthesis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/human-monocytic-ehrlichiosis","display_name":"human monocytic ehrlichiosis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/intracellular-bacterial-growth","display_name":"intracellular bacterial growth","score":0.8370000123977661},{"id":"https://openalex.org/keywords/disulfiram","display_name":"disulfiram","score":0.902999997138977},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.578000009059906},{"id":"https://openalex.org/keywords/il-8-expression","display_name":"IL-8 expression","score":0.9160000085830688},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.7860000133514404},{"id":"https://openalex.org/keywords/antibiotic-development","display_name":"antibiotic development","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C2909063110","wikidata":"https://www.wikidata.org/wiki/Q5348629","display_name":"Ehrlichia chaffeensis","level":4,"score":0.8910999894142151},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6973999738693237},{"id":"https://openalex.org/C153726182","wikidata":"https://www.wikidata.org/wiki/Q3720909","display_name":"Intracellular parasite","level":3,"score":0.5759999752044678},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5728999972343445},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.41769999265670776},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.3668000102043152},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.33889999985694885},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.3366999924182892},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.322299987077713},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31529998779296875},{"id":"https://openalex.org/C2777179404","wikidata":"https://www.wikidata.org/wiki/Q422442","display_name":"Doxycycline","level":3,"score":0.3125},{"id":"https://openalex.org/C115867849","wikidata":"https://www.wikidata.org/wiki/Q753175","display_name":"Protein-fragment complementation assay","level":5,"score":0.3037000000476837},{"id":"https://openalex.org/C40479148","wikidata":"https://www.wikidata.org/wiki/Q844460","display_name":"Syncytium","level":3,"score":0.30059999227523804},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.29919999837875366},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.2937999963760376},{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.29010000824928284},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2653000056743622},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.2551000118255615},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.2524000108242035},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.2500999867916107}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/microorganisms14091889","doi":"https://doi.org/10.3390/microorganisms14091889","is_oa":true,"landing_page_url":"https://doi.org/10.3390/microorganisms14091889","pdf_url":null,"source":{"id":"https://openalex.org/S4210222090","display_name":"Microorganisms","issn_l":"2076-2607","issn":["2076-2607"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microorganisms","raw_type":"journal-article"},{"id":"pmid:42795471","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42795471","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microorganisms","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13609616","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13609616/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13609616/pdf/microorganisms-14-01889.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microorganisms","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:eb5cca111c1449a58701a988d51e5c89","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/eb5cca111c1449a58701a988d51e5c89","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microorganisms, Vol 14, Iss 9, p 1889 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/microorganisms14091889","doi":"https://doi.org/10.3390/microorganisms14091889","is_oa":true,"landing_page_url":"https://doi.org/10.3390/microorganisms14091889","pdf_url":null,"source":{"id":"https://openalex.org/S4210222090","display_name":"Microorganisms","issn_l":"2076-2607","issn":["2076-2607"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microorganisms","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1380187141","display_name":null,"funder_award_id":"22JCYBJC00790","funder_id":"https://openalex.org/F4320326190","funder_display_name":"Tianjin Science and Technology Committee"},{"id":"https://openalex.org/G2352947791","display_name":null,"funder_award_id":"63241535","funder_id":"https://openalex.org/F4320323021","funder_display_name":"Nankai University"},{"id":"https://openalex.org/G4155310597","display_name":null,"funder_award_id":"63241534","funder_id":"https://openalex.org/F4320323021","funder_display_name":"Nankai University"},{"id":"https://openalex.org/G7549553805","display_name":null,"funder_award_id":"22JCYBJC00560","funder_id":"https://openalex.org/F4320326190","funder_display_name":"Tianjin Science and Technology Committee"},{"id":"https://openalex.org/G8415163164","display_name":null,"funder_award_id":"32470193","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G9000211085","display_name":null,"funder_award_id":"32170199","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323021","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75"},{"id":"https://openalex.org/F4320326190","display_name":"Tianjin Science and Technology Committee","ror":"https://ror.org/03wb1xh22"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1558800866","https://openalex.org/W1580935263","https://openalex.org/W1822107923","https://openalex.org/W1933869629","https://openalex.org/W1965282499","https://openalex.org/W1969273581","https://openalex.org/W1970748378","https://openalex.org/W1976820913","https://openalex.org/W1980424738","https://openalex.org/W1998593768","https://openalex.org/W2005960905","https://openalex.org/W2036672952","https://openalex.org/W2040653755","https://openalex.org/W2063848311","https://openalex.org/W2081305186","https://openalex.org/W2104284600","https://openalex.org/W2111967267","https://openalex.org/W2111995639","https://openalex.org/W2116137883","https://openalex.org/W2120295864","https://openalex.org/W2120990040","https://openalex.org/W2124239727","https://openalex.org/W2127671242","https://openalex.org/W2156761184","https://openalex.org/W2791529513","https://openalex.org/W3011459201","https://openalex.org/W3044622849","https://openalex.org/W3089438778","https://openalex.org/W3135384367","https://openalex.org/W3189460332","https://openalex.org/W4205570041","https://openalex.org/W4312122362","https://openalex.org/W4321368285","https://openalex.org/W4392046842","https://openalex.org/W4400823692","https://openalex.org/W4401247113"],"related_works":[],"abstract_inverted_index":{"Ehrlichia":[0],"chaffeensis":[1,88,108,164,174],"is":[2,24,74,109,175],"an":[3,19,148],"obligate":[4],"intracellular":[5,91,115],"bacterium":[6],"that":[7,69,104,123,134,170],"proliferates":[8],"within":[9],"monocytes":[10],"or":[11],"macrophages":[12],"and":[13,55,90,96,111,153],"causes":[14],"human":[15],"monocytic":[16],"ehrlichiosis":[17],"(HME),":[18],"emerging":[20],"life-threatening":[21],"zoonosis.":[22],"Doxycycline":[23],"the":[25,40,45,61,79,136,140,160,181],"choice":[26],"of":[27,63,139,162,183],"treatment":[28],"for":[29,52,60,113,180],"HME,":[30],"yet":[31],"it":[32],"has":[33],"prominent":[34],"side":[35],"effects.":[36],"Host":[37],"cells":[38],"lack":[39],"lysine":[41,80],"biosynthetic":[42,81],"pathway;":[43],"thus,":[44],"enzymes":[46],"in":[47,78,106,128,172],"this":[48],"pathway":[49],"are":[50],"essential":[51,112],"bacterial":[53,114],"growth":[54],"recognized":[56],"as":[57,166,168],"potential":[58,177],"targets":[59],"development":[62,182],"novel":[64,184],"antibiotics.":[65],"Here,":[66],"we":[67,102,121,132],"demonstrated":[68],"inhibitors":[70],"targeting":[71],"DapE,":[72],"which":[73],"a":[75,154,176],"key":[76],"enzyme":[77],"pathway,":[82],"especially":[83],"disulfiram,":[84],"effectively":[85],"inhibit":[86],"E.":[87,107,163,173],"infection":[89],"growth.":[92,116],"Through":[93],"complementation":[94],"experiments":[95],"peptide":[97],"nucleic":[98],"acid-mediated":[99],"dapE":[100,145],"knockdown,":[101],"showed":[103],"DapE":[105,124,171],"functional":[110],"Using":[117],"purified":[118],"recombinant":[119],"protein,":[120],"found":[122],"induces":[125],"IL-8":[126],"expression":[127,146],"host":[129],"cells.":[130],"Finally,":[131],"identified":[133],"NtrX,":[135],"response":[137],"regulator":[138],"two-component":[141],"system":[142],"NtrY/NtrX,":[143],"regulates":[144],"using":[147],"electrophoretic":[149],"mobility":[150],"shift":[151],"assay":[152],"reporter":[155],"assay.":[156],"Our":[157],"findings":[158],"deepen":[159],"understanding":[161],"pathogenesis":[165],"well":[167],"illustrate":[169],"therapeutic":[178],"target":[179],"HME":[185],"treatments.":[186]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-08-26T00:00:00"}