{"id":"https://openalex.org/W7204177576","doi":"https://doi.org/10.1097/lvt.0000000000000982","title":"A randomized prospective study of tacrolimus-sparing basiliximab induction with delayed everolimus addition in high-acuity liver transplantation","display_name":"A randomized prospective study of tacrolimus-sparing basiliximab induction with delayed everolimus addition in high-acuity liver transplantation","publication_year":2026,"publication_date":"2026-08-21","ids":{"openalex":"https://openalex.org/W7204177576","doi":"https://doi.org/10.1097/lvt.0000000000000982","pmid":"https://pubmed.ncbi.nlm.nih.gov/42641082"},"language":"en","primary_location":{"id":"doi:10.1097/lvt.0000000000000982","doi":"https://doi.org/10.1097/lvt.0000000000000982","is_oa":false,"landing_page_url":"https://doi.org/10.1097/lvt.0000000000000982","pdf_url":null,"source":{"id":"https://openalex.org/S205547219","display_name":"Liver Transplantation","issn_l":"1527-6465","issn":["1527-6465","1527-6473"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050958778","display_name":"Reghan L. Conrey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reghan L. Conrey","raw_affiliation_strings":["Division of Liver and Pancreas Transplantation, Department of Surgery, University of California Los Angeles, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Liver and Pancreas Transplantation, Department of Surgery, University of California Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148162950","display_name":"Ryan Ma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryan Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046462019","display_name":"Minah Ha","orcid":"https://orcid.org/0009-0003-5193-5287","observed_orcids":["https://orcid.org/0009-0003-5193-5287","https://orcid.org/0009-0006-2684-5329"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Minah Ha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148136643","display_name":"Sasha Xu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sasha Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148061367","display_name":"Christine Lam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine Lam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148132474","display_name":"Tatsuya Sakamoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tatsuya Sakamoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111000970","display_name":"Samer S. Ebaid","orcid":"https://orcid.org/0009-0005-4397-0482","observed_orcids":["https://orcid.org/0009-0005-4397-0482"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samer S. Ebaid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003777210","display_name":"Vatche Garen Agopian","orcid":"https://orcid.org/0000-0003-0130-9838","observed_orcids":["https://orcid.org/0000-0003-0130-9838"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vatche G. Agopian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068321792","display_name":"Douglas G. Farmer","orcid":"https://orcid.org/0000-0001-9080-0527","observed_orcids":["https://orcid.org/0000-0001-9080-0527"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Douglas G. Farmer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072821864","display_name":"Fady M. Kaldas","orcid":"https://orcid.org/0000-0002-4888-3979","observed_orcids":["https://orcid.org/0000-0002-4888-3979"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fady M. Kaldas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2150,"currency":"USD","value_usd":2150},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.65931216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.037700001150369644,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.023900000378489494,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/basiliximab-induction","display_name":"basiliximab induction","score":0.8679999709129333},{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.7879999876022339},{"id":"https://openalex.org/keywords/everolimus","display_name":"everolimus","score":0.9890000224113464},{"id":"https://openalex.org/keywords/calcineurin-inhibitors","display_name":"calcineurin inhibitors","score":0.8190000057220459},{"id":"https://openalex.org/keywords/renal-replacement-therapy","display_name":"renal replacement therapy","score":0.7590000033378601},{"id":"https://openalex.org/keywords/renal-function-preservation","display_name":"renal function preservation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.8019999861717224},{"id":"https://openalex.org/keywords/graft-survival","display_name":"graft survival","score":0.6340000033378601},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.765999972820282},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7139999866485596},{"id":"https://openalex.org/keywords/meld-score","display_name":"MELD score","score":0.746999979019165},{"id":"https://openalex.org/keywords/vasopressor-support","display_name":"vasopressor therapy","score":0.6890000104904175},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.4490000009536743},{"id":"https://openalex.org/keywords/graft-rejection","display_name":"graft rejection","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9556000232696533},{"id":"https://openalex.org/C2781307858","wikidata":"https://www.wikidata.org/wiki/Q418702","display_name":"Basiliximab","level":4,"score":0.9355999827384949},{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.7717000246047974},{"id":"https://openalex.org/C2779699572","wikidata":"https://www.wikidata.org/wiki/Q421052","display_name":"Everolimus","level":2,"score":0.7608000040054321},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.7468000054359436},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.6776000261306763},{"id":"https://openalex.org/C128057223","wikidata":"https://www.wikidata.org/wiki/Q420566","display_name":"Calcineurin","level":3,"score":0.6388999819755554},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5278000235557556},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5246999859809875},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.47769999504089355},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4616999924182892},{"id":"https://openalex.org/C2779541074","wikidata":"https://www.wikidata.org/wiki/Q185643","display_name":"Renal replacement therapy","level":2,"score":0.45570001006126404},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.44339999556541443},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40540000796318054},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3903000056743622},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.3824999928474426},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3709000051021576},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.3686999976634979},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34119999408721924},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.33000001311302185},{"id":"https://openalex.org/C2780073493","wikidata":"https://www.wikidata.org/wiki/Q7523837","display_name":"Single Center","level":2,"score":0.30149999260902405},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.2840000092983246},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.2653999924659729},{"id":"https://openalex.org/C54847362","wikidata":"https://www.wikidata.org/wiki/Q177635","display_name":"Nephrology","level":2,"score":0.2549000084400177},{"id":"https://openalex.org/C31785415","wikidata":"https://www.wikidata.org/wiki/Q7846541","display_name":"Trough level","level":4,"score":0.25450000166893005},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.25450000166893005}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1097/lvt.0000000000000982","doi":"https://doi.org/10.1097/lvt.0000000000000982","is_oa":false,"landing_page_url":"https://doi.org/10.1097/lvt.0000000000000982","pdf_url":null,"source":{"id":"https://openalex.org/S205547219","display_name":"Liver Transplantation","issn_l":"1527-6465","issn":["1527-6465","1527-6473"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver Transplantation","raw_type":"journal-article"},{"id":"pmid:42641082","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42641082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1965213046","https://openalex.org/W2413728305","https://openalex.org/W4402798316","https://openalex.org/W2885145842","https://openalex.org/W2008054909","https://openalex.org/W2894970244","https://openalex.org/W2345098272","https://openalex.org/W4200337342","https://openalex.org/W2129151761","https://openalex.org/W2038811744"],"abstract_inverted_index":{"Calcineurin":[0],"inhibitors":[1],"(CNIs)":[2],"remain":[3],"the":[4,197,252],"cornerstone":[5],"of":[6,49,124,135,157,176,269],"immunosuppression":[7,92],"after":[8,172],"liver":[9],"transplantation":[10],"(LT)":[11],"but":[12],"contribute":[13],"to":[14,24,34,271],"chronic":[15],"renal":[16,30,55,96,277],"failure,":[17],"increasing":[18],"long-term":[19,36],"morbidity":[20],"and":[21,28,66,81,100,103,122,147,154,213,225,241],"mortality.":[22],"Strategies":[23],"minimize":[25,272],"CNI":[26],"exposure":[27],"preserve":[29,276],"function":[31,278],"are":[32],"necessary":[33],"improve":[35],"outcomes":[37],"in":[38,196,206,251,264],"high-acuity":[39,265],"LT":[40,51,266],"recipients.":[41,267],"We":[42],"conducted":[43],"a":[44],"single-center,":[45],"prospective,":[46],"randomized":[47,61],"trial":[48],"adult":[50],"recipients":[52],"requiring":[53],"pre-LT":[54,158,177],"replacement":[56],"therapy":[57,257],"(RRT).":[58],"Patients":[59],"were":[60,106,110,163,228,234,248],"to:":[62],"(1)":[63],"basiliximab":[64,76,169],"induction":[65,256],"delayed":[67,259],"tacrolimus":[68,78,87,260,273],"starting":[69,79,83],"postoperative":[70],"day":[71],"(POD)":[72],"5":[73],"(BAS);":[74],"(2)":[75],"induction,":[77],"POD5,":[80],"everolimus":[82,270],"POD31,":[84],"followed":[85],"by":[86,140],"minimization":[88],"(BAS-EVR);":[89],"(3)":[90],"standard":[91],"(control).":[93,149],"RRT":[94,138,159,167,178,190,262],"independence,":[95,191],"function,":[97],"rejection,":[98],"graft":[99,226,281],"patient":[101,283],"survival,":[102],"adverse":[104],"events":[105,233],"assessed.":[107],"Seventy":[108],"patients":[109,125,136,187],"analyzed":[111],"(BAS":[112],"n=30;":[113],"BAS-EVR":[114,198,253],"n=28;":[115],"control":[116,214],"n=12).":[117],"Median":[118],"MELD":[119],"was":[120],"40,":[121],"55.7%":[123],"required":[126],"mechanical":[127],"ventilation":[128],"or":[129,282],"vasopressor":[130],"support":[131],"pre-LT.":[132],"Overall,":[133],"68.6%":[134],"achieved":[137,189],"independence":[139,263],"24":[141,222],"weeks:":[142],"73.3%":[143],"(BAS),":[144],"75.0%":[145],"(BAS-EVR),":[146],"41.7%":[148],"Basiliximab":[150,255],"(":[151,160,238,245],"p":[152,161,184,239,246],"=0.04)":[153],"shorter":[155],"duration":[156,175],"=0.02)":[162],"significantly":[164],"associated":[165],"with":[166,258],"independence;":[168],"remained":[170],"significant":[171],"adjusting":[173],"for":[174],"[OR":[179],"3.87":[180],"(95%":[181],"CI":[182],"1.01-14.74),":[183],"=0.048].":[185],"Among":[186],"who":[188],"median":[192],"eGFR":[193],"trended":[194],"higher":[195],"group":[199],"(67":[200],"mL/min/1.73":[201,209,217],"m":[202,210,218],"2":[203,211,219],")":[204,212,220],"than":[205],"BAS":[207],"(52":[208],"groups":[215],"(50":[216],"at":[221],"weeks.":[223],"Patient":[224],"survival":[227],"comparable":[229],"across":[230],"groups.":[231],"Adverse":[232],"similar,":[235],"although":[236],"diarrhea":[237],"=0.004)":[240],"acute":[242],"kidney":[243],"injury":[244],"=0.01)":[247],"more":[249],"frequent":[250],"group.":[254],"promotes":[261],"Addition":[268],"may":[274],"further":[275],"without":[279],"compromising":[280],"survival.":[284]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2026-08-26T00:00:00"}
