{"id":"https://openalex.org/W7204176752","doi":"https://doi.org/10.1080/13685538.2026.2717454","title":"Association between estimated glucose disposal rate and benign prostatic hyperplasia: results from two nationally representative population-based studies","display_name":"Association between estimated glucose disposal rate and benign prostatic hyperplasia: results from two nationally representative population-based studies","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204176752","doi":"https://doi.org/10.1080/13685538.2026.2717454","pmid":"https://pubmed.ncbi.nlm.nih.gov/42640724"},"language":"en","primary_location":{"id":"doi:10.1080/13685538.2026.2717454","doi":"https://doi.org/10.1080/13685538.2026.2717454","is_oa":true,"landing_page_url":"https://doi.org/10.1080/13685538.2026.2717454","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/13685538.2026.2717454?needAccess=true","source":{"id":"https://openalex.org/S172622653","display_name":"The Aging Male","issn_l":"1368-5538","issn":["1368-5538","1473-0790"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Aging Male","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/13685538.2026.2717454?needAccess=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5135226648","display_name":"Haowen Liang","orcid":"https://orcid.org/0009-0008-8195-6907","observed_orcids":["https://orcid.org/0009-0008-8195-6907"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haowen Liang","raw_affiliation_strings":["Department of Urology, Liuzhou Traditional Chinese Medical Hospital"],"raw_orcid":"https://orcid.org/0009-0008-8195-6907","affiliations":[{"raw_affiliation_string":"Department of Urology, Liuzhou Traditional Chinese Medical Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091034284","display_name":"Hengxin Chen","orcid":"https://orcid.org/0000-0001-8312-7952","observed_orcids":["https://orcid.org/0000-0001-8312-7952"]},"institutions":[{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hengxin Chen","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital of Sun Yat-sen University"],"raw_orcid":"https://orcid.org/0000-0001-8312-7952","affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital of Sun Yat-sen University","institution_ids":["https://openalex.org/I4210128921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5135131544","display_name":"Ying Wei","orcid":"https://orcid.org/0009-0004-9746-5388","observed_orcids":["https://orcid.org/0009-0004-9746-5388"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ying Wei","raw_affiliation_strings":["Department of Nephrology, Liuzhou Traditional Chinese Medical Hospital"],"raw_orcid":"https://orcid.org/0009-0004-9746-5388","affiliations":[{"raw_affiliation_string":"Department of Nephrology, Liuzhou Traditional Chinese Medical Hospital","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5135131544"],"corresponding_institution_ids":[],"apc_list":{"value":2085,"currency":"GBP","value_usd":2557},"apc_paid":{"value":2085,"currency":"GBP","value_usd":2557},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.72110984,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"1","first_page":"2717454","last_page":"2717454"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/estimated-glucose-disposal-rate","display_name":"estimated glucose disposal rate","score":0.9520000219345093},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.6320000290870667},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.9300000071525574},{"id":"https://openalex.org/keywords/mediation-analysis","display_name":"mediation analysis","score":0.7739999890327454},{"id":"https://openalex.org/keywords/older-men","display_name":"older men","score":0.8709999918937683},{"id":"https://openalex.org/keywords/chinese-population","display_name":"Chinese population","score":0.4000000059604645},{"id":"https://openalex.org/keywords/us-population","display_name":"United States population","score":0.8320000171661377},{"id":"https://openalex.org/keywords/china-health-and-retirement-longitudinal-study","display_name":"China Health and Retirement Longitudinal Study","score":0.4050000011920929},{"id":"https://openalex.org/keywords/nhanes","display_name":"NHANES","score":1.0}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9523000121116638},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.3955000042915344},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3635999858379364},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.35530000925064087},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3231000006198883},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.31540000438690186},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.31450000405311584},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.2989000082015991},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.2980000078678131},{"id":"https://openalex.org/C3018380654","wikidata":"https://www.wikidata.org/wiki/Q5572348","display_name":"Fasting glucose","level":4,"score":0.2897000014781952},{"id":"https://openalex.org/C2994223898","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate disease","level":4,"score":0.28279998898506165},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.2824999988079071},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.25540000200271606}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009749","descriptor_name":"Nutrition Surveys","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/13685538.2026.2717454","doi":"https://doi.org/10.1080/13685538.2026.2717454","is_oa":true,"landing_page_url":"https://doi.org/10.1080/13685538.2026.2717454","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/13685538.2026.2717454?needAccess=true","source":{"id":"https://openalex.org/S172622653","display_name":"The Aging Male","issn_l":"1368-5538","issn":["1368-5538","1473-0790"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Aging Male","raw_type":"journal-article"},{"id":"pmid:42640724","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42640724","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The aging male : the official journal of the International Society for the Study of the Aging Male","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a2ee60f883df4fdaaf2dbc1c13328a3b","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a2ee60f883df4fdaaf2dbc1c13328a3b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Aging Male, Vol 29, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/13685538.2026.2717454","doi":"https://doi.org/10.1080/13685538.2026.2717454","is_oa":true,"landing_page_url":"https://doi.org/10.1080/13685538.2026.2717454","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/13685538.2026.2717454?needAccess=true","source":{"id":"https://openalex.org/S172622653","display_name":"The Aging Male","issn_l":"1368-5538","issn":["1368-5538","1473-0790"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Aging Male","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.7046757936477661}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204176752.pdf","grobid_xml":"https://content.openalex.org/works/W7204176752.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W2141932304","https://openalex.org/W2512594468","https://openalex.org/W2815167991","https://openalex.org/W2947428547","https://openalex.org/W2966082642","https://openalex.org/W2981753926","https://openalex.org/W3004852950","https://openalex.org/W3024282282","https://openalex.org/W3095578761","https://openalex.org/W3134813148","https://openalex.org/W3190109435","https://openalex.org/W3193595504","https://openalex.org/W4306412265","https://openalex.org/W4307951985","https://openalex.org/W4375859311","https://openalex.org/W4388720543","https://openalex.org/W4391578516","https://openalex.org/W4393113489","https://openalex.org/W4394688768","https://openalex.org/W4394908781","https://openalex.org/W4400668164","https://openalex.org/W4402632102","https://openalex.org/W4403967213","https://openalex.org/W4404124260","https://openalex.org/W4405187673","https://openalex.org/W4405202909","https://openalex.org/W4405922180","https://openalex.org/W4406016203","https://openalex.org/W4406116679","https://openalex.org/W4406253970","https://openalex.org/W4406758093","https://openalex.org/W4407354332","https://openalex.org/W4408185400","https://openalex.org/W4408331409","https://openalex.org/W4408405162","https://openalex.org/W4408966014","https://openalex.org/W4409501827","https://openalex.org/W4410104138","https://openalex.org/W4411974366"],"related_works":[],"abstract_inverted_index":{"Background":[0],"Benign":[1],"prostatic":[2],"hyperplasia":[3],"(BPH),":[4],"a":[5,111,166,187],"prevalent":[6],"condition":[7],"among":[8],"older":[9],"men,":[10],"has":[11],"not":[12],"been":[13],"sufficiently":[14],"explored":[15],"in":[16,102,119,145,176,190],"terms":[17],"of":[18,129,154,174],"its":[19],"association":[20],"with":[21,182],"the":[22,35,44,104,127,138,146,151,172],"estimated":[23],"glucose":[24],"disposal":[25],"rate":[26],"(eGDR)":[27],"within":[28],"American":[29,178],"and":[30,38,43,47,63,74,83,100,106,117,171,179],"Chinese":[31,180],"populations.Methods":[32],"Data":[33],"from":[34],"China":[36],"Health":[37,46],"Retirement":[39],"Longitudinal":[40],"Study":[41],"(CHARLS)":[42],"National":[45],"Nutrition":[48],"Examination":[49],"Survey":[50],"(NHANES)":[51],"were":[52],"examined.":[53],"We":[54],"computed":[55],"indices":[56],"pertinent":[57],"to":[58],"eGDR":[59,99,116,130,170],"for":[60],"every":[61],"participant":[62],"subsequently":[64],"utilized":[65],"multivariate":[66],"regression,":[67],"restricted":[68],"cubic":[69],"splines":[70],"(RCS),":[71],"subgroup":[72],"analysis,":[73],"mediation":[75,142],"analysis.Results":[76],"This":[77],"study":[78,121],"included":[79],"4382":[80],"CHARLS":[81,105],"participants":[82],"3463":[84],"NHANES":[85,107,147],"participants.":[86],"In":[87],"our":[88],"study,":[89],"we":[90],"found":[91,97],"that":[92,126,150],"an":[93],"inverse":[94],"relationship":[95,114],"was":[96,134,156],"between":[98,115,169],"BPH":[101,118,132,175],"both":[103,120],"populations.":[108,122],"RCS":[109],"revealed":[110],"significant":[112,157],"linear":[113],"Subgroup":[123],"analyses":[124],"showed":[125,149],"effect":[128,143,153],"on":[131],"risk":[133,173],"consistent":[135],"across":[136],"all":[137],"examined":[139],"subgroups.":[140],"The":[141],"model":[144],"population":[148],"mediating":[152],"monocyte":[155],"at":[158],"\u221215.14%":[159],"(p":[160],"<":[161],"0.0001).Conclusions":[162],"Our":[163],"research":[164],"shows":[165],"negative":[167],"link":[168],"elderly":[177],"males,":[181],"monocytes":[183],"potentially":[184],"acting":[185],"as":[186],"partial":[188],"mediator":[189],"this":[191],"relationship.":[192]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2026-08-26T00:00:00"}