{"id":"https://openalex.org/W7204173489","doi":"https://doi.org/10.3389/froh.2026.1916570","title":"A novel modified-curcumin 2.24 suppresses MMPs in a periodontal-relevant cell culture model: a pilot study","display_name":"A novel modified-curcumin 2.24 suppresses MMPs in a periodontal-relevant cell culture model: a pilot study","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204173489","doi":"https://doi.org/10.3389/froh.2026.1916570","pmid":"https://pubmed.ncbi.nlm.nih.gov/42712432","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13549869"},"language":"en","primary_location":{"id":"doi:10.3389/froh.2026.1916570","doi":"https://doi.org/10.3389/froh.2026.1916570","is_oa":true,"landing_page_url":"https://doi.org/10.3389/froh.2026.1916570","pdf_url":"https://www.frontiersin.org/journals/oral-health/articles/10.3389/froh.2026.1916570/pdf","source":{"id":"https://openalex.org/S4210201735","display_name":"Frontiers in Oral Health","issn_l":"2673-4842","issn":["2673-4842"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oral Health","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/oral-health/articles/10.3389/froh.2026.1916570/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012308311","display_name":"Isabella Ho","orcid":"https://orcid.org/0000-0001-8052-1217","observed_orcids":["https://orcid.org/0000-0001-8052-1217"]},"institutions":[{"id":"https://openalex.org/I4210087560","display_name":"Stony Brook School","ror":"https://ror.org/003wx9n05","country_code":"US","type":"education","lineage":["https://openalex.org/I4210087560"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Isabella Ho","raw_affiliation_strings":["Department of Oral Biology and Pathology, Stony Brook School of Dental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology and Pathology, Stony Brook School of Dental Medicine","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148077437","display_name":"Cindy Leung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087560","display_name":"Stony Brook School","ror":"https://ror.org/003wx9n05","country_code":"US","type":"education","lineage":["https://openalex.org/I4210087560"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cindy Leung","raw_affiliation_strings":["Department of Oral Biology and Pathology, Stony Brook School of Dental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology and Pathology, Stony Brook School of Dental Medicine","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148142515","display_name":"Nidhi Bhandari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087560","display_name":"Stony Brook School","ror":"https://ror.org/003wx9n05","country_code":"US","type":"education","lineage":["https://openalex.org/I4210087560"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nidhi Bhandari","raw_affiliation_strings":["Department of Oral Biology and Pathology, Stony Brook School of Dental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology and Pathology, Stony Brook School of Dental Medicine","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028541932","display_name":"Hsi\u2010Ming Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087560","display_name":"Stony Brook School","ror":"https://ror.org/003wx9n05","country_code":"US","type":"education","lineage":["https://openalex.org/I4210087560"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hsi-Ming Lee","raw_affiliation_strings":["Department of Oral Biology and Pathology, Stony Brook School of Dental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology and Pathology, Stony Brook School of Dental Medicine","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091815057","display_name":"Lorne M. Golub","orcid":"https://orcid.org/0000-0003-2606-120X","observed_orcids":["https://orcid.org/0000-0003-2606-120X"]},"institutions":[{"id":"https://openalex.org/I4210087560","display_name":"Stony Brook School","ror":"https://ror.org/003wx9n05","country_code":"US","type":"education","lineage":["https://openalex.org/I4210087560"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorne M. Golub","raw_affiliation_strings":["Department of Oral Biology and Pathology, Stony Brook School of Dental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology and Pathology, Stony Brook School of Dental Medicine","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005834490","display_name":"Francis Johnson","orcid":"https://orcid.org/0000-0002-7796-7653","observed_orcids":["https://orcid.org/0000-0002-7796-7653"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis Johnson","raw_affiliation_strings":["Department of Chemistry and Pharmacological Sciences, School of Medicine, Stony Brook University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Pharmacological Sciences, School of Medicine, Stony Brook University","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101466432","display_name":"Ying Gu","orcid":"https://orcid.org/0000-0001-6059-7361","observed_orcids":["https://orcid.org/0000-0001-6059-7361"]},"institutions":[{"id":"https://openalex.org/I4210087560","display_name":"Stony Brook School","ror":"https://ror.org/003wx9n05","country_code":"US","type":"education","lineage":["https://openalex.org/I4210087560"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Gu","raw_affiliation_strings":["Department of General Dentistry, Stony Brook School of Dental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Dentistry, Stony Brook School of Dental Medicine","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I59553526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012308311"],"corresponding_institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I59553526"],"apc_list":{"value":2550,"currency":"CHF","value_usd":3077},"apc_paid":{"value":2550,"currency":"CHF","value_usd":3077},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":null,"first_page":"1916570","last_page":"1916570"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.08889999985694885,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.949999988079071},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9819999933242798},{"id":"https://openalex.org/keywords/collagenase","display_name":"collagenase","score":0.8199999928474426},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.8619999885559082},{"id":"https://openalex.org/keywords/periodontal-inflammation","display_name":"periodontal inflammation","score":0.7329999804496765},{"id":"https://openalex.org/keywords/p38-mapk-signaling","display_name":"p38 MAPK signaling","score":0.9520000219345093},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9449999928474426},{"id":"https://openalex.org/keywords/thp-1-cells","display_name":"THP-1 cells","score":0.9480000138282776},{"id":"https://openalex.org/keywords/mmp-activation","display_name":"MMP activation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/matrix-degradation","display_name":"matrix degradation","score":0.6499999761581421},{"id":"https://openalex.org/keywords/doxycycline","display_name":"doxycycline","score":0.8109999895095825},{"id":"https://openalex.org/keywords/tetracycline-analogs","display_name":"tetracycline analogs","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.7348999977111816},{"id":"https://openalex.org/C2778394429","wikidata":"https://www.wikidata.org/wiki/Q304956","display_name":"Collagenase","level":3,"score":0.7279999852180481},{"id":"https://openalex.org/C2777179404","wikidata":"https://www.wikidata.org/wiki/Q422442","display_name":"Doxycycline","level":3,"score":0.7182000279426575},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.6531999707221985},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6456999778747559},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5443999767303467},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.527999997138977},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5253999829292297},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4603999853134155},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.45159998536109924},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4348999857902527},{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.41510000824928284},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4129999876022339},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.40799999237060547},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.40049999952316284},{"id":"https://openalex.org/C2778823387","wikidata":"https://www.wikidata.org/wiki/Q179254","display_name":"Gelatin","level":2,"score":0.38600000739097595},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.38589999079704285},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3725999891757965},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3700999915599823},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36390000581741333},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.3260999917984009},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.3176000118255615},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.314300000667572},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.313400000333786},{"id":"https://openalex.org/C125209161","wikidata":"https://www.wikidata.org/wiki/Q422816","display_name":"Enzyme activator","level":3,"score":0.29829999804496765},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2806999981403351},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.2754000127315521},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.2703999876976013},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.2696000039577484},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.2637999951839447},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.2556000053882599}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/froh.2026.1916570","doi":"https://doi.org/10.3389/froh.2026.1916570","is_oa":true,"landing_page_url":"https://doi.org/10.3389/froh.2026.1916570","pdf_url":"https://www.frontiersin.org/journals/oral-health/articles/10.3389/froh.2026.1916570/pdf","source":{"id":"https://openalex.org/S4210201735","display_name":"Frontiers in Oral Health","issn_l":"2673-4842","issn":["2673-4842"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oral Health","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13549869","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13549869/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13549869/pdf/froh-07-1916570.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oral Health","raw_type":"Text"},{"id":"pmid:42712432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42712432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oral health","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6693483e688841cda6e8fe76f789c5ec","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/6693483e688841cda6e8fe76f789c5ec","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oral Health, Vol 7 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/froh.2026.1916570","doi":"https://doi.org/10.3389/froh.2026.1916570","is_oa":true,"landing_page_url":"https://doi.org/10.3389/froh.2026.1916570","pdf_url":"https://www.frontiersin.org/journals/oral-health/articles/10.3389/froh.2026.1916570/pdf","source":{"id":"https://openalex.org/S4210201735","display_name":"Frontiers in Oral Health","issn_l":"2673-4842","issn":["2673-4842"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oral Health","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204173489.pdf","grobid_xml":"https://content.openalex.org/works/W7204173489.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W2019740988","https://openalex.org/W2026354657","https://openalex.org/W2051830108","https://openalex.org/W2056733149","https://openalex.org/W2063609459","https://openalex.org/W2076389751","https://openalex.org/W2307480902","https://openalex.org/W2797814777","https://openalex.org/W2911953538","https://openalex.org/W3004428094","https://openalex.org/W3019034047","https://openalex.org/W3028164972","https://openalex.org/W3082805147","https://openalex.org/W3159894538","https://openalex.org/W3162899768","https://openalex.org/W3166667875","https://openalex.org/W3173573873","https://openalex.org/W3205516445","https://openalex.org/W4210622586","https://openalex.org/W4210908826","https://openalex.org/W4220750614","https://openalex.org/W4221013619","https://openalex.org/W4289525788","https://openalex.org/W4292547792","https://openalex.org/W4307569842","https://openalex.org/W4309514856","https://openalex.org/W4312188189","https://openalex.org/W4317680332","https://openalex.org/W4321503661","https://openalex.org/W4361214245","https://openalex.org/W4378083515","https://openalex.org/W4381599141","https://openalex.org/W4384521660","https://openalex.org/W4385399754","https://openalex.org/W4386844700","https://openalex.org/W4394843971","https://openalex.org/W4399872443","https://openalex.org/W4400695792","https://openalex.org/W4402675428","https://openalex.org/W4404866525","https://openalex.org/W4405398362","https://openalex.org/W4406717856","https://openalex.org/W7130648742"],"related_works":["https://openalex.org/W3004428094","https://openalex.org/W2139046503","https://openalex.org/W2619280646","https://openalex.org/W2911953538","https://openalex.org/W7098957137","https://openalex.org/W2765246844","https://openalex.org/W2954973410","https://openalex.org/W3170414573","https://openalex.org/W1989099167","https://openalex.org/W2102982042"],"abstract_inverted_index":{"Background:":[0],"Matrix":[1],"metalloproteinases":[2],"(MMPs)":[3],"play":[4],"critical":[5],"roles":[6],"in":[7,26,34,61,65,102,149,181,279],"periodontal":[8,36],"tissue":[9],"destruction.":[10],"The":[11],"present":[12],"study":[13],"evaluated":[14,90,164],"the":[15,48,62,80,103,150,155,188,273],"efficacy":[16],"of":[17,82,107,154,212,275],"a":[18,35,58,175,241,268],"novel":[19],"chemically":[20],"modified":[21,113],"curcumin":[22],"2.24":[23,84,194,207,221,238,266],"(CMC":[24],"2.24)":[25],"reducing":[27,250],"MMP":[28,161,169,216,251],"levels,":[29,226,252],"activity,":[30,256],"and":[31,75,98,131,136,199,214,229,254],"its":[32],"activation,":[33,253],"relevant":[37],"cell":[38,183],"culture":[39],"model":[40],"involving":[41],"human":[42],"mononuclear":[43],"THP-1":[44,94,168,182],"cells.":[45],"In":[46,139],"addition,":[47,140],"p38":[49,86,178,224],"mitogen-activated":[50],"protein":[51],"kinase":[52],"(p38":[53],"MAPK)":[54],"signaling":[55],"pathway":[56],"played":[57],"key":[59],"role":[60],"inflammatory":[63,281],"process":[64],"response":[66],"to":[67,203],"various":[68],"stimuli":[69],"such":[70,283],"as":[71,91,240,267,284],"cytokines,":[72],"bacterial":[73],"antigens,":[74],"endotoxin":[76],"lipopolysaccharide":[77],"(LPS).":[78],"Therefore,":[79],"effect":[81],"CMC":[83,110,193,206,220,237,265],"on":[85],"MAPK":[87,179,225,260],"levels":[88,133,180,201],"was":[89,163,172],"well.":[92],"Methods:":[93],"monocytes":[95],"were":[96,127,143,185],"cultured":[97],"stimulated":[99],"with":[100,145],"LPS":[101,204],"presence":[104,151],"or":[105,117,121,152,233],"absence":[106,153],"5":[108],"\u00b5M":[109],"2.24,":[111],"Chemically":[112],"tetracycline":[114],"3":[115],"(CMT-3),":[116],"doxycycline":[118,230],"for":[119,129,158,272],"6":[120],"18":[122],"h.":[123],"Conditioned":[124],"media":[125],"(CM)":[126],"analyzed":[128,173],"MMP-9":[130,198,213],"collagenase":[132,200],"using":[134,174,187],"gelatin":[135,166],"collagen":[137],"zymography.":[138,167],"LPS-treated":[141],"CM":[142],"incubated":[144],"4-Aminophenylmercuric":[146],"acetate":[147],"(APMA)":[148],"above":[156],"agents":[157],"an":[159],"hour.":[160],"activation":[162,211],"by":[165],"enzyme":[170],"activity":[171],"fluorogenic":[176],"substrate.":[177],"lysates":[184],"determined":[186],"western":[189],"blot":[190],"technique.":[191],"Results:":[192],"significantly":[195,222],"reduced":[196,215],"elevated":[197],"compared":[202],"controls.":[205],"also":[208,258],"inhibited":[209],"APMA-induced":[210],"enzymatic":[217,255],"activity.":[218],"Further,":[219],"suppressed":[223],"whereas":[227],"CMT-3":[228],"showed":[231],"limited":[232],"no":[234],"effect.":[235],"Conclusions:":[236],"functions":[239],"highly":[242],"pleiotropic":[243],"inhibitor,":[244],"acting":[245],"at":[246],"multiple":[247],"regulatory":[248],"levels:":[249],"while":[257],"downregulating":[259],"signaling.":[261],"These":[262],"findings":[263],"highlight":[264],"promising":[269],"therapeutic":[270],"candidate":[271],"modulation":[274],"inflammation-associated":[276],"matrix":[277],"degradation":[278],"chronic":[280],"diseases":[282],"periodontitis.":[285]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-08-26T00:00:00"}
