{"id":"https://openalex.org/W7204170286","doi":"https://doi.org/10.1016/j.ecoenv.2026.120720","title":"EIF4A3-mediated downregulation of circ_0073586 promotes cadmium-induced lung carcinogenesis through SRSF9-triggered GPX4-dependent ferroptosis resistance","display_name":"EIF4A3-mediated downregulation of circ_0073586 promotes cadmium-induced lung carcinogenesis through SRSF9-triggered GPX4-dependent ferroptosis resistance","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204170286","doi":"https://doi.org/10.1016/j.ecoenv.2026.120720","pmid":"https://pubmed.ncbi.nlm.nih.gov/42641444"},"language":"en","primary_location":{"id":"doi:10.1016/j.ecoenv.2026.120720","doi":"https://doi.org/10.1016/j.ecoenv.2026.120720","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ecoenv.2026.120720","pdf_url":null,"source":{"id":"https://openalex.org/S13733787","display_name":"Ecotoxicology and Environmental Safety","issn_l":"0147-6513","issn":["0147-6513","1090-2414"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecotoxicology and Environmental Safety","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.ecoenv.2026.120720","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038300996","display_name":"Donglei Wang","orcid":"https://orcid.org/0000-0002-5888-7439","observed_orcids":["https://orcid.org/0000-0002-5888-7439"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210160794","display_name":"Baotou Medical College","ror":"https://ror.org/04t44qh67","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160794"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Donglei Wang","raw_affiliation_strings":["School of Public Health, Baotou Medical College, Baotou 014030, China; School of Public Health, Capital Medical University, Beijing 100071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Baotou Medical College, Baotou 014030, China; School of Public Health, Capital Medical University, Beijing 100071, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210160794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042970690","display_name":"Wenyu Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160794","display_name":"Baotou Medical College","ror":"https://ror.org/04t44qh67","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160794"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenyu Wang","raw_affiliation_strings":["School of Public Health, Baotou Medical College, Baotou 014030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Baotou Medical College, Baotou 014030, China","institution_ids":["https://openalex.org/I4210160794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111173128","display_name":"Yueqing Shao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160794","display_name":"Baotou Medical College","ror":"https://ror.org/04t44qh67","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160794"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yueqing Shao","raw_affiliation_strings":["School of Public Health, Baotou Medical College, Baotou 014030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Baotou Medical College, Baotou 014030, China","institution_ids":["https://openalex.org/I4210160794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101589348","display_name":"Yanshu Li","orcid":"https://orcid.org/0000-0002-2902-7034","observed_orcids":["https://orcid.org/0000-0002-2902-7034"]},"institutions":[{"id":"https://openalex.org/I32574673","display_name":"Shantou University","ror":"https://ror.org/01a099706","country_code":"CN","type":"education","lineage":["https://openalex.org/I32574673"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanshu Li","raw_affiliation_strings":["School of Public Health, Shantou University, Shantou 515063, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Shantou University, Shantou 515063, China","institution_ids":["https://openalex.org/I32574673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148124783","display_name":"Yali Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160794","display_name":"Baotou Medical College","ror":"https://ror.org/04t44qh67","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160794"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yali Wang","raw_affiliation_strings":["School of Public Health, Baotou Medical College, Baotou 014030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Baotou Medical College, Baotou 014030, China","institution_ids":["https://openalex.org/I4210160794"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bingyun Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32574673","display_name":"Shantou University","ror":"https://ror.org/01a099706","country_code":"CN","type":"education","lineage":["https://openalex.org/I32574673"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingyun Li","raw_affiliation_strings":["School of Public Health, Shantou University, Shantou 515063, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Shantou University, Shantou 515063, China","institution_ids":["https://openalex.org/I32574673"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069426655","display_name":"Lihua Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32574673","display_name":"Shantou University","ror":"https://ror.org/01a099706","country_code":"CN","type":"education","lineage":["https://openalex.org/I32574673"]},{"id":"https://openalex.org/I4210120522","display_name":"Shantou University Medical College","ror":"https://ror.org/02gxych78","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210120522"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lihua Huang","raw_affiliation_strings":["School of Public Health, Shantou University, Shantou 515063, China; Shantou University Medical College, Shantou 515063, China. Electronic address: huanglh@stu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Shantou University, Shantou 515063, China; Shantou University Medical College, Shantou 515063, China. Electronic address: huanglh@stu.edu.cn","institution_ids":["https://openalex.org/I32574673","https://openalex.org/I4210120522"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5069426655"],"corresponding_institution_ids":["https://openalex.org/I32574673","https://openalex.org/I4210120522"],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":{"value":3650,"currency":"USD","value_usd":3650},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.57954006,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"323","issue":null,"first_page":"120720","last_page":"120720"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cadmium","display_name":"cadmium","score":0.8479999899864197},{"id":"https://openalex.org/keywords/lung-carcinogenesis","display_name":"lung carcinogenesis","score":0.800000011920929},{"id":"https://openalex.org/keywords/eif4a3","display_name":"EIF4A3","score":0.9819999933242798},{"id":"https://openalex.org/keywords/srsf9","display_name":"SRSF9","score":0.9919999837875366},{"id":"https://openalex.org/keywords/gpx4","display_name":"GPX4","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ferroptosis-resistance","display_name":"ferroptosis resistance","score":0.9079999923706055},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.949999988079071},{"id":"https://openalex.org/keywords/circular-rna","display_name":"circular RNA","score":0.7149999737739563},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.7630000114440918},{"id":"https://openalex.org/keywords/heavy-metal-exposure","display_name":"heavy metal exposure","score":0.7549999952316284},{"id":"https://openalex.org/keywords/bronchial-epithelial-cells","display_name":"bronchial epithelial cells","score":0.8389999866485596},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.9111999869346619},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6470999717712402},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6092000007629395},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5950000286102295},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.5817999839782715},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5127000212669373},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.42260000109672546},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40540000796318054},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3702000081539154},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.328000009059906},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.31700000166893005},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3125999867916107},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3059999942779541},{"id":"https://openalex.org/C2779179475","wikidata":"https://www.wikidata.org/wiki/Q3545649","display_name":"Decoy","level":3,"score":0.2761000096797943},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.258899986743927}],"mesh":[{"descriptor_ui":"D000068103","descriptor_name":"Serine-Arginine Splicing Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000068103","descriptor_name":"Serine-Arginine Splicing Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000080662","descriptor_name":"Phospholipid Hydroperoxide Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039601","descriptor_name":"Eukaryotic Initiation Factor-4A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D039601","descriptor_name":"Eukaryotic Initiation Factor-4A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ecoenv.2026.120720","doi":"https://doi.org/10.1016/j.ecoenv.2026.120720","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ecoenv.2026.120720","pdf_url":null,"source":{"id":"https://openalex.org/S13733787","display_name":"Ecotoxicology and Environmental Safety","issn_l":"0147-6513","issn":["0147-6513","1090-2414"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecotoxicology and Environmental Safety","raw_type":"journal-article"},{"id":"pmid:42641444","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42641444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecotoxicology and environmental safety","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:cc1f3ecdfee94bc599e217a60977802d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/cc1f3ecdfee94bc599e217a60977802d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ecotoxicology and Environmental Safety, Vol 323, Iss , Pp 120720- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.ecoenv.2026.120720","doi":"https://doi.org/10.1016/j.ecoenv.2026.120720","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ecoenv.2026.120720","pdf_url":null,"source":{"id":"https://openalex.org/S13733787","display_name":"Ecotoxicology and Environmental Safety","issn_l":"0147-6513","issn":["0147-6513","1090-2414"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecotoxicology and Environmental Safety","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2160233604","display_name":null,"funder_award_id":"82574146","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G773862378","display_name":null,"funder_award_id":"82373624","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1878175360","https://openalex.org/W1991535520","https://openalex.org/W2135598172","https://openalex.org/W2163074585","https://openalex.org/W2169323342","https://openalex.org/W2597894202","https://openalex.org/W2906592796","https://openalex.org/W2981370517","https://openalex.org/W3021534378","https://openalex.org/W3032103849","https://openalex.org/W3034193580","https://openalex.org/W3086824485","https://openalex.org/W3093333012","https://openalex.org/W3105194426","https://openalex.org/W3108493784","https://openalex.org/W3118843576","https://openalex.org/W3169941200","https://openalex.org/W3202990340","https://openalex.org/W3213197079","https://openalex.org/W4200538971","https://openalex.org/W4212803602","https://openalex.org/W4212916881","https://openalex.org/W4229374749","https://openalex.org/W4307195037","https://openalex.org/W4312223097","https://openalex.org/W4313826067","https://openalex.org/W4319773337","https://openalex.org/W4322216828","https://openalex.org/W4323349858","https://openalex.org/W4367595535","https://openalex.org/W4377691791","https://openalex.org/W4378717214","https://openalex.org/W4378980763","https://openalex.org/W4381093822","https://openalex.org/W4385999009","https://openalex.org/W4387580471","https://openalex.org/W4389738634","https://openalex.org/W4391825214","https://openalex.org/W4392379715","https://openalex.org/W4394792829","https://openalex.org/W4407870640","https://openalex.org/W4408957209"],"related_works":[],"abstract_inverted_index":{"Environmental":[0],"heavy":[1,158],"metal":[2],"exposure":[3,66],"represents":[4],"a":[5,69,82,126,135],"well-established":[6],"etiological":[7],"factor":[8],"in":[9,41,60,104,157],"pulmonary":[10,20,147],"carcinogenesis.":[11],"Although":[12],"ferroptosis":[13,56,95],"dysregulation":[14],"contributes":[15],"to":[16],"Cadmium":[17],"(Cd)":[18],"induced":[19,36],"carcinogenesis,":[21,148],"its":[22],"precise":[23],"molecular":[24,83,153],"determinants":[25],"remain":[26],"elusive.":[27],"Here,":[28],"we":[29,53],"demonstrated":[30],"that":[31,55,71],"Cd":[32],"treatment":[33],"(5":[34],"\u03bcM)":[35],"EIF4A3-mediated":[37],"downregulation":[38,115],"of":[39,116,120],"circ_0073586":[40,76,79,117],"human":[42],"bronchial":[43],"epithelial":[44],"(16HBE)":[45],"cells,":[46],"which":[47],"functionally":[48],"promoted":[49],"malignant":[50,61],"transformation.":[51],"Intriguingly,":[52],"observed":[54],"was":[57,72],"markedly":[58],"suppressed":[59],"transformed":[62],"cells":[63],"as":[64,81],"the":[65,86,97,130],"duration":[67],"increased,":[68],"suppression":[70,119],"significantly":[73],"reversed":[74],"by":[75],"overexpression.":[77],"Mechanistically,":[78],"acted":[80],"decoy":[84],"for":[85,155],"RNA-binding":[87],"protein":[88],"SRSF9,":[89],"thereby":[90],"effectively":[91],"suppressing":[92],"GPX4-dependent":[93],"cellular":[94],"through":[96],"Wnt/\u03b2-catenin":[98],"pathway.":[99],"These":[100],"findings":[101],"were":[102],"validated":[103],"vivo,":[105],"where":[106],"Cd-exposed":[107],"murine":[108],"models":[109],"at":[110],"36":[111],"weeks":[112],"exhibited":[113],"concurrent":[114],"and":[118,142],"ferroptosis,":[121],"with":[122],"these":[123],"changes":[124],"showing":[125],"strong":[127],"correlation.":[128],"Thus,":[129],"study":[131],"not":[132],"noly":[133],"reveals":[134],"critical":[136],"crosstalk":[137],"between":[138],"metabolism-associated":[139],"cell":[140],"death":[141],"epigenetic":[143],"regulation":[144],"during":[145],"Cd-induced":[146],"but":[149],"also":[150],"identifies":[151],"potential":[152],"targets":[154],"intervention":[156],"metal-associated":[159],"lung":[160],"cancer.":[161]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-08-26T00:00:00"}