{"id":"https://openalex.org/W7204167487","doi":"https://doi.org/10.3390/md24090297","title":"New Prenylated Isoindolinone Alkaloids and Polyketides from the Mangrove-Derived Fungus Aspergillus sp. SCSIO 41440","display_name":"New Prenylated Isoindolinone Alkaloids and Polyketides from the Mangrove-Derived Fungus Aspergillus sp. SCSIO 41440","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204167487","doi":"https://doi.org/10.3390/md24090297","pmid":"https://pubmed.ncbi.nlm.nih.gov/42783890"},"language":"en","primary_location":{"id":"doi:10.3390/md24090297","doi":"https://doi.org/10.3390/md24090297","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md24090297","pdf_url":null,"source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/md24090297","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012256969","display_name":"Chun Yang","orcid":"https://orcid.org/0000-0001-5813-0914","observed_orcids":["https://orcid.org/0000-0001-5813-0914","https://orcid.org/0000-0002-1892-0740","https://orcid.org/0009-0001-6712-1881","https://orcid.org/0000-0001-7738-1292"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun Yang","raw_affiliation_strings":["School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China"],"raw_orcid":"https://orcid.org/0009-0001-6712-1881","affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126984180","display_name":"Yi Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210103685","display_name":"South China Sea Institute Of Oceanology","ror":"https://ror.org/0192yj155","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210103685"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391768091","display_name":"State Key Laboratory of Tropical Oceanography","ror":"https://ror.org/02b5xr067","country_code":null,"type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210103685","https://openalex.org/I4391768091"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Chen","raw_affiliation_strings":["State Key Laboratory of Tropical Oceanography/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China","University of Chinese Academy of Sciences, Beijing 100049, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Tropical Oceanography/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210103685","https://openalex.org/I4391768091"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing 100049, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113330309","display_name":"Zhifei Xiong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhifei Xiong","raw_affiliation_strings":["School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126044385","display_name":"Jian Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210103685","display_name":"South China Sea Institute Of Oceanology","ror":"https://ror.org/0192yj155","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210103685"]},{"id":"https://openalex.org/I4391768091","display_name":"State Key Laboratory of Tropical Oceanography","ror":"https://ror.org/02b5xr067","country_code":null,"type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210103685","https://openalex.org/I4391768091"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Cai","raw_affiliation_strings":["State Key Laboratory of Tropical Oceanography/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Tropical Oceanography/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210103685","https://openalex.org/I4391768091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125720845","display_name":"Chunmei Chen","orcid":"https://orcid.org/0000-0002-2949-7343","observed_orcids":["https://orcid.org/0000-0002-2949-7343"]},"institutions":[{"id":"https://openalex.org/I187400657","display_name":"South China Normal University","ror":"https://ror.org/01kq0pv72","country_code":"CN","type":"education","lineage":["https://openalex.org/I187400657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunmei Chen","raw_affiliation_strings":["School of Chemistry, South China Normal University, Guangzhou 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry, South China Normal University, Guangzhou 510006, China","institution_ids":["https://openalex.org/I187400657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148087579","display_name":"Bingling Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingling Liu","raw_affiliation_strings":["School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100620728","display_name":"Yonghong Liu","orcid":"https://orcid.org/0000-0001-8327-3108","observed_orcids":["https://orcid.org/0000-0001-8327-3108","https://orcid.org/0009-0003-7509-2157","https://orcid.org/0000-0002-4964-4996"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210103685","display_name":"South China Sea Institute Of Oceanology","ror":"https://ror.org/0192yj155","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210103685"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391768091","display_name":"State Key Laboratory of Tropical Oceanography","ror":"https://ror.org/02b5xr067","country_code":null,"type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210103685","https://openalex.org/I4391768091"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yonghong Liu","raw_affiliation_strings":["State Key Laboratory of Tropical Oceanography/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China","University of Chinese Academy of Sciences, Beijing 100049, China"],"raw_orcid":"https://orcid.org/0000-0001-8327-3108","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Tropical Oceanography/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210103685","https://openalex.org/I4391768091"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing 100049, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068090107","display_name":"Xuefeng Zhou","orcid":"https://orcid.org/0000-0001-9601-4869","observed_orcids":["https://orcid.org/0000-0001-9601-4869"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210103685","display_name":"South China Sea Institute Of Oceanology","ror":"https://ror.org/0192yj155","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210103685"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391768091","display_name":"State Key Laboratory of Tropical Oceanography","ror":"https://ror.org/02b5xr067","country_code":null,"type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210103685","https://openalex.org/I4391768091"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuefeng Zhou","raw_affiliation_strings":["State Key Laboratory of Tropical Oceanography/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China","University of Chinese Academy of Sciences, Beijing 100049, China"],"raw_orcid":"https://orcid.org/0000-0001-9601-4869","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Tropical Oceanography/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210103685","https://openalex.org/I4391768091"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing 100049, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091197566","display_name":"Huaming Tao","orcid":"https://orcid.org/0000-0002-4799-1345","observed_orcids":["https://orcid.org/0000-0002-4799-1345"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huaming Tao","raw_affiliation_strings":["School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China"],"raw_orcid":"https://orcid.org/0000-0002-4799-1345","affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China","institution_ids":["https://openalex.org/I58200834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5091197566"],"corresponding_institution_ids":["https://openalex.org/I58200834"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.69793649,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"9","first_page":"297","last_page":"297"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diketopiperazine-alkaloids","display_name":"diketopiperazine alkaloids","score":0.9179999828338623},{"id":"https://openalex.org/keywords/polyketides","display_name":"polyketides","score":0.9309999942779541},{"id":"https://openalex.org/keywords/mangrove-derived-fungi","display_name":"mangrove-derived fungi","score":0.824999988079071},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibition","display_name":"acetylcholinesterase inhibition","score":0.9580000042915344},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.7329999804496765},{"id":"https://openalex.org/keywords/stereochemical-assignment","display_name":"stereochemical assignment","score":0.9440000057220459},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C57790582","wikidata":"https://www.wikidata.org/wiki/Q901141","display_name":"Prenylation","level":3,"score":0.843500018119812},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.777400016784668},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7225000262260437},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.5888000130653381},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.5270000100135803},{"id":"https://openalex.org/C19549132","wikidata":"https://www.wikidata.org/wiki/Q11141463","display_name":"Two-dimensional nuclear magnetic resonance spectroscopy","level":2,"score":0.506600022315979},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.45019999146461487},{"id":"https://openalex.org/C2779678110","wikidata":"https://www.wikidata.org/wiki/Q764","display_name":"Fungus","level":2,"score":0.4404999911785126},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.4268999993801117},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.421999990940094},{"id":"https://openalex.org/C2779175654","wikidata":"https://www.wikidata.org/wiki/Q335130","display_name":"Aspergillus","level":2,"score":0.40130001306533813},{"id":"https://openalex.org/C2779059548","wikidata":"https://www.wikidata.org/wiki/Q383701","display_name":"Ach\u00e9","level":4,"score":0.3630000054836273},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33820000290870667},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.3280999958515167},{"id":"https://openalex.org/C2780867653","wikidata":"https://www.wikidata.org/wiki/Q574302","display_name":"Anthraquinones","level":2,"score":0.31949999928474426},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.30399999022483826},{"id":"https://openalex.org/C2777752112","wikidata":"https://www.wikidata.org/wiki/Q903238","display_name":"Lead compound","level":3,"score":0.30320000648498535},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.30300000309944153},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.30169999599456787},{"id":"https://openalex.org/C178910836","wikidata":"https://www.wikidata.org/wiki/Q2196961","display_name":"Molecular model","level":2,"score":0.27889999747276306},{"id":"https://openalex.org/C2778635478","wikidata":"https://www.wikidata.org/wiki/Q516751","display_name":"Polyketide","level":4,"score":0.26570001244544983},{"id":"https://openalex.org/C113253001","wikidata":"https://www.wikidata.org/wiki/Q864640","display_name":"Bioorganic chemistry","level":3,"score":0.25699999928474426}],"mesh":[{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054876","descriptor_name":"Prenylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054876","descriptor_name":"Prenylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061065","descriptor_name":"Polyketides","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D061065","descriptor_name":"Polyketides","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D061065","descriptor_name":"Polyketides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D061065","descriptor_name":"Polyketides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D061065","descriptor_name":"Polyketides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D061065","descriptor_name":"Polyketides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/md24090297","doi":"https://doi.org/10.3390/md24090297","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md24090297","pdf_url":null,"source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},{"id":"pmid:42783890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42783890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine drugs","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8930677b964543c182c526b47bb83d2c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8930677b964543c182c526b47bb83d2c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Marine Drugs, Vol 24, Iss 9, p 297 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13608482","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13608482/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mar Drugs","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/md24090297","doi":"https://doi.org/10.3390/md24090297","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md24090297","pdf_url":null,"source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Life below water","score":0.7439923882484436,"id":"https://metadata.un.org/sdg/14"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4793650468","display_name":null,"funder_award_id":"2024A1515011051","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"}],"funders":[{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1971048984","https://openalex.org/W1979783851","https://openalex.org/W2084025984","https://openalex.org/W2091065782","https://openalex.org/W2132525235","https://openalex.org/W2134967712","https://openalex.org/W2256742438","https://openalex.org/W2315231313","https://openalex.org/W2555914015","https://openalex.org/W2723905965","https://openalex.org/W2755160315","https://openalex.org/W2792115058","https://openalex.org/W4287836182","https://openalex.org/W4293331024","https://openalex.org/W4367319801","https://openalex.org/W4387965416","https://openalex.org/W4401916766","https://openalex.org/W4406860708","https://openalex.org/W4410251219","https://openalex.org/W4415230607","https://openalex.org/W4415549076"],"related_works":[],"abstract_inverted_index":{"New":[0],"prenylated":[1],"isoindolinone":[2],"alkaloids,":[3],"aspernidines":[4],"C-E":[5],"(1\u20133),":[6],"a":[7,116],"new":[8,15],"diketopiperazine":[9],"alkaloid,":[10],"protubonine":[11],"C":[12],"(4),":[13],"and":[14,19,23,43,50,62],"polyketides,":[16],"(\u00b1)-asperisocoumarin":[17],"J":[18],"asperisocoumarin":[20],"K":[21],"(5":[22],"6),":[24],"were":[25,56,70],"isolated":[26],"from":[27],"the":[28,59,103],"mangrove-derived":[29],"fungus":[30],"Aspergillus":[31],"sp.":[32],"SCSIO":[33],"41440,":[34],"together":[35],"with":[36,84],"six":[37],"known":[38],"compounds":[39,69],"(7\u201312).":[40],"Comprehensive":[41],"NMR":[42],"mass":[44],"spectrometric":[45],"analysis,":[46],"single-crystal":[47],"X-ray":[48],"diffraction,":[49],"calculated":[51],"electronic":[52],"circular":[53],"dichroism":[54],"(ECD)":[55],"employed":[57],"for":[58,72,119],"structural":[60],"elucidation":[61],"stereochemical":[63],"assignment":[64],"of":[65,88],"these":[66],"compounds.":[67],"All":[68],"evaluated":[71],"their":[73],"acetylcholinesterase":[74],"(AChE)":[75],"inhibitory":[76],"activity.":[77],"Compound":[78],"10":[79,99,114],"exhibited":[80],"potent":[81],"AChE":[82,104,124],"inhibition":[83],"an":[85,123],"IC50":[86],"value":[87],"3.16":[89],"\u00b1":[90],"1.16":[91],"\u03bcM.":[92],"Molecular":[93],"docking":[94],"analysis":[95],"further":[96,120],"revealed":[97],"that":[98,112],"binds":[100],"strongly":[101],"to":[102],"active":[105],"site":[106],"(PDB:":[107],"4EY7).":[108],"These":[109],"findings":[110],"suggest":[111],"compound":[113],"represents":[115],"candidate":[117],"scaffold":[118],"investigation":[121],"as":[122],"inhibitor.":[125]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2026-08-26T00:00:00"}