{"id":"https://openalex.org/W7204167486","doi":"https://doi.org/10.21203/rs.3.rs-10658918/v1","title":"Humic Substances as Master Regulators of Plant Stress Resilience: From Supramolecular Chemistry to Climate-Smart Agriculture","display_name":"Humic Substances as Master Regulators of Plant Stress Resilience: From Supramolecular Chemistry to Climate-Smart Agriculture","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204167486","doi":"https://doi.org/10.21203/rs.3.rs-10658918/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-10658918/v1","doi":"https://doi.org/10.21203/rs.3.rs-10658918/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10658918/v1","pdf_url":"https://www.researchsquare.com/article/rs-10658918/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"parent_works":[],"lineage":["https://openalex.org/W7204167486"],"child_works_count":0,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-10658918/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101717732","display_name":"Mehedi Amin","orcid":"https://orcid.org/0009-0004-2515-5452","observed_orcids":["https://orcid.org/0009-0004-2515-5452"]},"institutions":[{"id":"https://openalex.org/I200606013","display_name":"Daffodil International University","ror":"https://ror.org/052t4a858","country_code":"BD","type":"education","lineage":["https://openalex.org/I200606013"]}],"countries":["BD"],"is_corresponding":true,"raw_author_name":"Mehedi Amin","raw_affiliation_strings":["Daffodil International University"],"raw_orcid":"https://orcid.org/0009-0004-2515-5452","affiliations":[{"raw_affiliation_string":"Daffodil International University","institution_ids":["https://openalex.org/I200606013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148093066","display_name":"Md Motasim Billah Sagor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90340485","display_name":"Sher-e-Bangla Agricultural University","ror":"https://ror.org/03ht0cf17","country_code":"BD","type":"education","lineage":["https://openalex.org/I90340485"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Md Motasim Billah Sagor","raw_affiliation_strings":["Sher-e-Bangla Agricultural University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sher-e-Bangla Agricultural University","institution_ids":["https://openalex.org/I90340485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143689032","display_name":"Muhammad Abdul Mannan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muhammad Abdul Mannan","raw_affiliation_strings":["EXIM Bank Agricultural University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EXIM Bank Agricultural University","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063854199","display_name":"Sayed Mohammad Mohsin","orcid":"https://orcid.org/0000-0002-1769-6767","observed_orcids":["https://orcid.org/0000-0002-1769-6767"]},"institutions":[{"id":"https://openalex.org/I90340485","display_name":"Sher-e-Bangla Agricultural University","ror":"https://ror.org/03ht0cf17","country_code":"BD","type":"education","lineage":["https://openalex.org/I90340485"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Sayed Mohammad Mohsin","raw_affiliation_strings":["Sher-e-Bangla Agricultural University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sher-e-Bangla Agricultural University","institution_ids":["https://openalex.org/I90340485"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062855140","display_name":"Abu Noman Faruq Ahmmed","orcid":"https://orcid.org/0000-0003-1784-6558","observed_orcids":["https://orcid.org/0000-0003-1784-6558"]},"institutions":[{"id":"https://openalex.org/I90340485","display_name":"Sher-e-Bangla Agricultural University","ror":"https://ror.org/03ht0cf17","country_code":"BD","type":"education","lineage":["https://openalex.org/I90340485"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Abu Noman Faruq Ahmmed","raw_affiliation_strings":["Sher-e-Bangla Agricultural University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sher-e-Bangla Agricultural University","institution_ids":["https://openalex.org/I90340485"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101717732"],"corresponding_institution_ids":["https://openalex.org/I200606013"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12407","display_name":"Plant Growth Enhancement Techniques","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12407","display_name":"Plant Growth Enhancement Techniques","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10014","display_name":"Plant Stress Responses and Tolerance","score":0.013399999588727951,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10076","display_name":"Plant-Microbe Interactions and Immunity","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/humic-substances","display_name":"humic substances","score":1.0},{"id":"https://openalex.org/keywords/plant-stress-resilience","display_name":"plant stress resilience","score":0.8799999952316284},{"id":"https://openalex.org/keywords/abiotic-stress-tolerance","display_name":"abiotic stress tolerance","score":0.9520000219345093},{"id":"https://openalex.org/keywords/chemical-priming","display_name":"chemical priming","score":0.8679999709129333},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7059999704360962},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.9929999709129333},{"id":"https://openalex.org/keywords/phytohormone-crosstalk","display_name":"phytohormone crosstalk","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rhizosphere-microbiome","display_name":"rhizosphere microbiome","score":0.9110000133514404},{"id":"https://openalex.org/keywords/plant-microbe-interactions","display_name":"plant-microbe interactions","score":0.7689999938011169},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.7059999704360962},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.6629999876022339},{"id":"https://openalex.org/keywords/osmotic-adjustment","display_name":"osmotic adjustment","score":0.843999981880188},{"id":"https://openalex.org/keywords/plant-growth-promoting-microorganisms","display_name":"plant growth-promoting microorganisms","score":0.8669999837875366},{"id":"https://openalex.org/keywords/biostimulants","display_name":"biostimulants","score":0.8429999947547913},{"id":"https://openalex.org/keywords/climate-smart-agriculture","display_name":"climate-smart agriculture","score":0.8690000176429749},{"id":"https://openalex.org/keywords/drought-stress","display_name":"drought stress","score":0.8569999933242798},{"id":"https://openalex.org/keywords/salt-stress","display_name":"salt stress","score":0.9769999980926514},{"id":"https://openalex.org/keywords/heat-stress","display_name":"heat stress","score":0.8180000185966492},{"id":"https://openalex.org/keywords/heavy-metal-stress","display_name":"heavy metal stress","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.576200008392334},{"id":"https://openalex.org/C89519541","wikidata":"https://www.wikidata.org/wiki/Q4667893","display_name":"Abiotic stress","level":3,"score":0.5673999786376953},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.5422999858856201},{"id":"https://openalex.org/C86626682","wikidata":"https://www.wikidata.org/wiki/Q1124578","display_name":"Rhizosphere","level":3,"score":0.5058000087738037},{"id":"https://openalex.org/C93275456","wikidata":"https://www.wikidata.org/wiki/Q756449","display_name":"Supramolecular chemistry","level":3,"score":0.44369998574256897},{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.43779999017715454},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3970000147819519},{"id":"https://openalex.org/C78604142","wikidata":"https://www.wikidata.org/wiki/Q1640582","display_name":"Fight-or-flight response","level":3,"score":0.3750999867916107},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.35690000653266907},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3529999852180481},{"id":"https://openalex.org/C2992992772","wikidata":"https://www.wikidata.org/wiki/Q185973","display_name":"Plant metabolism","level":4,"score":0.35040000081062317},{"id":"https://openalex.org/C118518473","wikidata":"https://www.wikidata.org/wiki/Q11451","display_name":"Agriculture","level":2,"score":0.34599998593330383},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.3425000011920929},{"id":"https://openalex.org/C146926016","wikidata":"https://www.wikidata.org/wiki/Q3500367","display_name":"Biotic stress","level":4,"score":0.33959999680519104},{"id":"https://openalex.org/C54924851","wikidata":"https://www.wikidata.org/wiki/Q2751054","display_name":"Sustainable agriculture","level":3,"score":0.32010000944137573},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.31139999628067017},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.28700000047683716},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2856000065803528},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.2838999927043915},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.2777000069618225},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.26440000534057617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2639999985694885},{"id":"https://openalex.org/C132215390","wikidata":"https://www.wikidata.org/wiki/Q461335","display_name":"Abiotic component","level":2,"score":0.26089999079704285}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-10658918/v1","doi":"https://doi.org/10.21203/rs.3.rs-10658918/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10658918/v1","pdf_url":"https://www.researchsquare.com/article/rs-10658918/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-10658918/v1","doi":"https://doi.org/10.21203/rs.3.rs-10658918/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10658918/v1","pdf_url":"https://www.researchsquare.com/article/rs-10658918/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.5365999937057495,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204167486.pdf","grobid_xml":"https://content.openalex.org/works/W7204167486.grobid-xml"},"referenced_works_count":109,"referenced_works":["https://openalex.org/W110528625","https://openalex.org/W1566631867","https://openalex.org/W1804315542","https://openalex.org/W1973442181","https://openalex.org/W1979159948","https://openalex.org/W1980438150","https://openalex.org/W1989979841","https://openalex.org/W1992564751","https://openalex.org/W2002928635","https://openalex.org/W2011985691","https://openalex.org/W2018064975","https://openalex.org/W2019312501","https://openalex.org/W2020169650","https://openalex.org/W2034768703","https://openalex.org/W2038600840","https://openalex.org/W2039437600","https://openalex.org/W2042262771","https://openalex.org/W2060703066","https://openalex.org/W2072430487","https://openalex.org/W2076580959","https://openalex.org/W2091380003","https://openalex.org/W2103217892","https://openalex.org/W2103773833","https://openalex.org/W2108073176","https://openalex.org/W2130927178","https://openalex.org/W2142903202","https://openalex.org/W2154727723","https://openalex.org/W2164002713","https://openalex.org/W2164028795","https://openalex.org/W2196956735","https://openalex.org/W2277067747","https://openalex.org/W2312012597","https://openalex.org/W2321548141","https://openalex.org/W2582935604","https://openalex.org/W2608847763","https://openalex.org/W2713360516","https://openalex.org/W2772882865","https://openalex.org/W2782136314","https://openalex.org/W2789207181","https://openalex.org/W2793530189","https://openalex.org/W2799416903","https://openalex.org/W2799565879","https://openalex.org/W2890534284","https://openalex.org/W2905243383","https://openalex.org/W2946683140","https://openalex.org/W2946713098","https://openalex.org/W2954210028","https://openalex.org/W2966723708","https://openalex.org/W2969669855","https://openalex.org/W2979444457","https://openalex.org/W3005410571","https://openalex.org/W3023096953","https://openalex.org/W3033675662","https://openalex.org/W3036706354","https://openalex.org/W3037221578","https://openalex.org/W3038775630","https://openalex.org/W3084962071","https://openalex.org/W3113365025","https://openalex.org/W3119604295","https://openalex.org/W3127914846","https://openalex.org/W3134923192","https://openalex.org/W3146500235","https://openalex.org/W3154537483","https://openalex.org/W3155576793","https://openalex.org/W3165343199","https://openalex.org/W3190048544","https://openalex.org/W3197885037","https://openalex.org/W3203501137","https://openalex.org/W3210048302","https://openalex.org/W4200211458","https://openalex.org/W4205648884","https://openalex.org/W4205724815","https://openalex.org/W4225106919","https://openalex.org/W4225268917","https://openalex.org/W4282940583","https://openalex.org/W4285010571","https://openalex.org/W4293368062","https://openalex.org/W4309845598","https://openalex.org/W4313420918","https://openalex.org/W4318052566","https://openalex.org/W4362604645","https://openalex.org/W4365138989","https://openalex.org/W4367625048","https://openalex.org/W4368376748","https://openalex.org/W4387902684","https://openalex.org/W4388139583","https://openalex.org/W4388468275","https://openalex.org/W4390111285","https://openalex.org/W4396708153","https://openalex.org/W4396931855","https://openalex.org/W4399443193","https://openalex.org/W4402423500","https://openalex.org/W4405921369","https://openalex.org/W4407212195","https://openalex.org/W4407223226","https://openalex.org/W4410875385","https://openalex.org/W4411554140","https://openalex.org/W4413000792","https://openalex.org/W4414130836","https://openalex.org/W4417100318","https://openalex.org/W4417421171","https://openalex.org/W7118128694","https://openalex.org/W7128504598","https://openalex.org/W7134066433","https://openalex.org/W7136900336","https://openalex.org/W7139103125","https://openalex.org/W7158203610","https://openalex.org/W7160302886","https://openalex.org/W7171648584"],"related_works":["https://openalex.org/W7135236772","https://openalex.org/W7164856019","https://openalex.org/W2790085580","https://openalex.org/W3088811194","https://openalex.org/W7160302886","https://openalex.org/W3155576793","https://openalex.org/W4396708153","https://openalex.org/W4407223226","https://openalex.org/W7168146174","https://openalex.org/W4397049279"],"abstract_inverted_index":{"Abstract":[0],"Humic":[1],"substances":[2],"(HS)":[3],"are":[4],"increasingly":[5],"recognized":[6],"not":[7],"merely":[8],"as":[9,13,35,105,138,227],"soil":[10],"conditioners":[11],"but":[12],"dynamic":[14],"biological":[15],"regulators":[16,37],"that":[17,79,102,114],"orchestrate":[18],"plant":[19,39,176,189,218],"resilience":[20],"through":[21,134],"complex":[22],"signaling":[23,67],"networks.":[24],"This":[25,129],"review":[26,224],"synthesizes":[27],"recent":[28],"advances":[29],"in":[30,166],"understanding":[31],"how":[32],"HS":[33,58,81,103,167,174,190,204,226,241],"function":[34],"master":[36],"of":[38,57,112,161,173,188,195,203,230],"adaptation":[40],"to":[41,62,120,144],"abiotic":[42],"stress.":[43,128],"We":[44,155],"present":[45],"a":[46,110,228,235],"mechanistic":[47],"framework":[48],"integrating":[49],"three":[50],"interconnected":[51],"themes:":[52],"(1)":[53],"the":[54,65,89,96,158,163,170,186,192,201],"supramolecular":[55,216],"chemistry":[56],"and":[59,76,87,95,125,141,152,169,200,209,220,233],"its":[60],"relationship":[61],"bioactivity,":[63],"(2)":[64],"early":[66],"events,":[68],"encompassing":[69],"reactive":[70],"oxygen":[71],"species":[72],"(ROS),":[73],"calcium":[74],"(Ca\u00b2\u207a),":[75],"phytohormone":[77],"crosstalk":[78],"translate":[80],"perception":[82],"into":[83],"systemic":[84],"stress":[85,207],"responses,":[86],"(3)":[88],"tripartite":[90],"interaction":[91],"among":[92],"plants,":[93],"HS,":[94,162],"rhizosphere":[97],"microbiome.":[98],"Emerging":[99],"evidence":[100],"demonstrates":[101],"act":[104],"chemical":[106],"priming":[107],"agents,":[108],"inducing":[109],"state":[111],"\"eustress\"":[113],"preconditions":[115],"plants":[116],"for":[117,237],"enhanced":[118,145],"tolerance":[119],"subsequent":[121],"drought,":[122],"salinity,":[123],"heat,":[124],"heavy":[126],"metal":[127],"preconditioning":[130],"involves":[131],"transcriptional":[132],"reprogramming":[133],"transcription":[135],"factors":[136],"such":[137],"WRKY,":[139],"NAC,":[140],"MYB,":[142],"leading":[143],"antioxidant":[146],"defenses,":[147],"osmotic":[148],"adjustment,":[149],"photosynthetic":[150],"protection,":[151],"nutrient":[153],"homeostasis.":[154],"critically":[156],"evaluate":[157],"structure-function":[159],"relationships":[160],"molecular":[164],"players":[165],"signaling,":[168],"synergistic":[171],"potential":[172],"with":[175],"growth-promoting":[177],"microorganisms.":[178],"Finally,":[179],"we":[180],"identify":[181],"critical":[182],"knowledge":[183],"gaps,":[184],"including":[185],"identity":[187],"receptors,":[191],"relative":[193],"contribution":[194],"direct":[196],"versus":[197],"microbiome-mediated":[198],"effects,":[199],"performance":[202],"under":[205],"multifactorial":[206],"combinations":[208],"propose":[210],"future":[211],"research":[212],"directions.":[213],"By":[214],"bridging":[215],"chemistry,":[217],"physiology,":[219],"microbiome":[221],"science,":[222],"this":[223],"positions":[225],"cornerstone":[229],"climate-smart":[231],"agriculture":[232],"provides":[234],"roadmap":[236],"developing":[238],"next-generation,":[239],"mechanism-based":[240],"biostimulants.":[242]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-08-26T00:00:00"}
