{"id":"https://openalex.org/W7204165981","doi":"https://doi.org/10.1016/j.apsb.2026.08.019","title":"TP53 mutation promotes sunitinib resistance in gallbladder cancer via the ARHGEF7-AS2/miR-326/AXL pathway","display_name":"TP53 mutation promotes sunitinib resistance in gallbladder cancer via the ARHGEF7-AS2/miR-326/AXL pathway","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204165981","doi":"https://doi.org/10.1016/j.apsb.2026.08.019","pmid":"https://pubmed.ncbi.nlm.nih.gov/42979428","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13729714"},"language":"en","primary_location":{"id":"doi:10.1016/j.apsb.2026.08.019","doi":"https://doi.org/10.1016/j.apsb.2026.08.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apsb.2026.08.019","pdf_url":null,"source":{"id":"https://openalex.org/S2736993989","display_name":"Acta Pharmaceutica Sinica B","issn_l":"2211-3835","issn":["2211-3835","2211-3843"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmaceutica Sinica B","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.apsb.2026.08.019","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5148117927","display_name":"Linhua Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Linhua Yang","raw_affiliation_strings":["Department of Biliary-Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China","Shanghai Cancer Institute, State Key Laboratory of Oncogenes and Related Genes, Shanghai 200011, China","Shanghai Key Laboratory of Biliary Tract Disease, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biliary-Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]},{"raw_affiliation_string":"Shanghai Cancer Institute, State Key Laboratory of Oncogenes and Related Genes, Shanghai 200011, China","institution_ids":["https://openalex.org/I4210110011","https://openalex.org/I4210138900"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Biliary Tract Disease, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028221595","display_name":"Ming Zhan","orcid":"https://orcid.org/0000-0002-4668-727X","observed_orcids":["https://orcid.org/0000-0002-4668-727X","https://orcid.org/0000-0003-0122-4834"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]},{"id":"https://openalex.org/I4392021104","display_name":"State Key Laboratory of Medical Genomics","ror":"https://ror.org/04m0qde81","country_code":"CN","type":"facility","lineage":["https://openalex.org/I183067930","https://openalex.org/I4392021104"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Ming Zhan","raw_affiliation_strings":["Department of Systems Biology, Beckman Research Institute, City of Hope, Monrovia, CA 91016, USA","The Core Laboratory in Medical Center of Clinical Research, Shanghai Ninth People's Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China"],"raw_orcid":"https://orcid.org/0000-0002-4668-727X","affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Beckman Research Institute, City of Hope, Monrovia, CA 91016, USA","institution_ids":["https://openalex.org/I4210110459","https://openalex.org/I4387156432"]},{"raw_affiliation_string":"The Core Laboratory in Medical Center of Clinical Research, Shanghai Ninth People's Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066","https://openalex.org/I4392021104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100979292","display_name":"Ruifeng Yang","orcid":"https://orcid.org/0009-0007-4177-7923","observed_orcids":["https://orcid.org/0009-0007-4177-7923"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4392021104","display_name":"State Key Laboratory of Medical Genomics","ror":"https://ror.org/04m0qde81","country_code":"CN","type":"facility","lineage":["https://openalex.org/I183067930","https://openalex.org/I4392021104"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Ruifeng Yang","raw_affiliation_strings":["Department of Pathology, City of Hope, Duarte, CA 91010, USA","Department of Urology, Fudan University Shanghai Cancer Center, Shanghai 200032, China","The Core Laboratory in Medical Center of Clinical Research, Shanghai Ninth People's Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, City of Hope, Duarte, CA 91010, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"raw_affiliation_string":"Department of Urology, Fudan University Shanghai Cancer Center, Shanghai 200032, China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"The Core Laboratory in Medical Center of Clinical Research, Shanghai Ninth People's Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066","https://openalex.org/I4392021104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148046111","display_name":"Miaomiao Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]},{"id":"https://openalex.org/I4392021104","display_name":"State Key Laboratory of Medical Genomics","ror":"https://ror.org/04m0qde81","country_code":"CN","type":"facility","lineage":["https://openalex.org/I183067930","https://openalex.org/I4392021104"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Miaomiao Guo","raw_affiliation_strings":["The Core Laboratory in Medical Center of Clinical Research, Shanghai Ninth People's Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Core Laboratory in Medical Center of Clinical Research, Shanghai Ninth People's Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066","https://openalex.org/I4392021104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148123514","display_name":"Min He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min He","raw_affiliation_strings":["Department of Biliary-Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China","Shanghai Cancer Institute, State Key Laboratory of Oncogenes and Related Genes, Shanghai 200011, China","Shanghai Key Laboratory of Biliary Tract Disease, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biliary-Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]},{"raw_affiliation_string":"Shanghai Cancer Institute, State Key Laboratory of Oncogenes and Related Genes, Shanghai 200011, China","institution_ids":["https://openalex.org/I4210110011","https://openalex.org/I4210138900"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Biliary Tract Disease, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102689822","display_name":"Yixiang Gu","orcid":"https://orcid.org/0009-0000-0012-3535","observed_orcids":["https://orcid.org/0009-0000-0012-3535"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yixiang Gu","raw_affiliation_strings":["Department of Biliary-Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China","Shanghai Cancer Institute, State Key Laboratory of Oncogenes and Related Genes, Shanghai 200011, China","Shanghai Key Laboratory of Biliary Tract Disease, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biliary-Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]},{"raw_affiliation_string":"Shanghai Cancer Institute, State Key Laboratory of Oncogenes and Related Genes, Shanghai 200011, China","institution_ids":["https://openalex.org/I4210110011","https://openalex.org/I4210138900"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Biliary Tract Disease, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148141359","display_name":"Yang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Zhang","raw_affiliation_strings":["Department of Biliary-Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China","Shanghai Cancer Institute, State Key Laboratory of Oncogenes and Related Genes, Shanghai 200011, China","Shanghai Key Laboratory of Biliary Tract Disease, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biliary-Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]},{"raw_affiliation_string":"Shanghai Cancer Institute, State Key Laboratory of Oncogenes and Related Genes, Shanghai 200011, China","institution_ids":["https://openalex.org/I4210110011","https://openalex.org/I4210138900"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Biliary Tract Disease, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148071488","display_name":"Zhilian Jia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhilian Jia","raw_affiliation_strings":["Department of Systems Biology, Beckman Research Institute, City of Hope, Monrovia, CA 91016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Beckman Research Institute, City of Hope, Monrovia, CA 91016, USA","institution_ids":["https://openalex.org/I4210110459","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148076957","display_name":"Xiaohua Huang","orcid":"https://orcid.org/0009-0001-7972-2393","observed_orcids":["https://orcid.org/0009-0001-7972-2393"]},"institutions":[{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaohua Huang","raw_affiliation_strings":["Department of Systems Biology, Beckman Research Institute, City of Hope, Monrovia, CA 91016, USA"],"raw_orcid":"https://orcid.org/0009-0001-7972-2393","affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Beckman Research Institute, City of Hope, Monrovia, CA 91016, USA","institution_ids":["https://openalex.org/I4210110459","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080998623","display_name":"Bingyu Li","orcid":"https://orcid.org/0000-0002-9222-951X","observed_orcids":["https://orcid.org/0000-0002-9222-951X"]},"institutions":[{"id":"https://openalex.org/I1324220072","display_name":"Mount Sinai Hospital","ror":"https://ror.org/01zkyz108","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I1324220072"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bingyu Li","raw_affiliation_strings":["Department of Pathology, Mount Sinai West/Morningside Hospitals, New York, NY 10025, USA"],"raw_orcid":"https://orcid.org/0000-0002-9222-951X","affiliations":[{"raw_affiliation_string":"Department of Pathology, Mount Sinai West/Morningside Hospitals, New York, NY 10025, USA","institution_ids":["https://openalex.org/I1324220072"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148079780","display_name":"Hui Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hui Wang","raw_affiliation_strings":["Department of Biliary-Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China","Shanghai Cancer Institute, State Key Laboratory of Oncogenes and Related Genes, Shanghai 200011, China","Shanghai Key Laboratory of Biliary Tract Disease, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biliary-Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]},{"raw_affiliation_string":"Shanghai Cancer Institute, State Key Laboratory of Oncogenes and Related Genes, Shanghai 200011, China","institution_ids":["https://openalex.org/I4210110011","https://openalex.org/I4210138900"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Biliary Tract Disease, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148173365","display_name":"Ruimeng Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4392021104","display_name":"State Key Laboratory of Medical Genomics","ror":"https://ror.org/04m0qde81","country_code":"CN","type":"facility","lineage":["https://openalex.org/I183067930","https://openalex.org/I4392021104"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Ruimeng Yang","raw_affiliation_strings":["Department of Pathology, City of Hope, Duarte, CA 91010, USA","Department of Urology, Fudan University Shanghai Cancer Center, Shanghai 200032, China","The Core Laboratory in Medical Center of Clinical Research, Shanghai Ninth People's Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, City of Hope, Duarte, CA 91010, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"raw_affiliation_string":"Department of Urology, Fudan University Shanghai Cancer Center, Shanghai 200032, China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"The Core Laboratory in Medical Center of Clinical Research, Shanghai Ninth People's Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066","https://openalex.org/I4392021104"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5148101865","display_name":"Yingbin Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yingbin Liu","raw_affiliation_strings":["Department of Biliary-Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China","Shanghai Cancer Institute, State Key Laboratory of Oncogenes and Related Genes, Shanghai 200011, China","Shanghai Key Laboratory of Biliary Tract Disease, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biliary-Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]},{"raw_affiliation_string":"Shanghai Cancer Institute, State Key Laboratory of Oncogenes and Related Genes, Shanghai 200011, China","institution_ids":["https://openalex.org/I4210110011","https://openalex.org/I4210138900"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Biliary Tract Disease, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5100979292","https://openalex.org/A5148079780","https://openalex.org/A5148101865","https://openalex.org/A5148117927","https://openalex.org/A5148173365"],"corresponding_institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I183067930","https://openalex.org/I2800570007","https://openalex.org/I4210093194","https://openalex.org/I4210097066","https://openalex.org/I4210110011","https://openalex.org/I4210110459","https://openalex.org/I4210138900","https://openalex.org/I4392021104"],"apc_list":{"value":2600,"currency":"USD","value_usd":2600},"apc_paid":{"value":2600,"currency":"USD","value_usd":2600},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.61647799,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"11","first_page":"7325","last_page":"7343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.8744999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.8744999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.12250000238418579,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gallbladder-cancer","display_name":"gallbladder cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sunitinib-resistance","display_name":"sunitinib resistance","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9480000138282776},{"id":"https://openalex.org/keywords/mir-326","display_name":"miR-326","score":0.972000002861023},{"id":"https://openalex.org/keywords/axl","display_name":"AXL","score":0.8669999837875366},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9049999713897705},{"id":"https://openalex.org/keywords/competing-endogenous-rna","display_name":"competing endogenous RNA","score":0.9769999980926514},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase-inhibitors","display_name":"receptor tyrosine kinase inhibitors","score":0.9010000228881836},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C2779490328","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib","level":3,"score":0.7365999817848206},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6739000082015991},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6331999897956848},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.49549999833106995},{"id":"https://openalex.org/C2776534502","wikidata":"https://www.wikidata.org/wiki/Q977787","display_name":"Gallbladder cancer","level":3,"score":0.4844000041484833},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39649999141693115},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3393999934196472},{"id":"https://openalex.org/C2777148285","wikidata":"https://www.wikidata.org/wiki/Q64386","display_name":"Gallbladder","level":2,"score":0.32659998536109924},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.29510000348091125},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2872999906539917},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2597000002861023},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.2583000063896179},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.25760000944137573},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.25529998540878296}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.apsb.2026.08.019","doi":"https://doi.org/10.1016/j.apsb.2026.08.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apsb.2026.08.019","pdf_url":null,"source":{"id":"https://openalex.org/S2736993989","display_name":"Acta Pharmaceutica Sinica B","issn_l":"2211-3835","issn":["2211-3835","2211-3843"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmaceutica Sinica B","raw_type":"journal-article"},{"id":"pmid:42979428","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42979428","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmaceutica Sinica. B","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13729714","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13729714/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharm Sin B","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:be8619dd24484fd9a77f8981e0e7b996","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/be8619dd24484fd9a77f8981e0e7b996","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Pharmaceutica Sinica B, Vol 16, Iss 11, Pp 7325-7343 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.apsb.2026.08.019","doi":"https://doi.org/10.1016/j.apsb.2026.08.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apsb.2026.08.019","pdf_url":null,"source":{"id":"https://openalex.org/S2736993989","display_name":"Acta Pharmaceutica Sinica B","issn_l":"2211-3835","issn":["2211-3835","2211-3843"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmaceutica Sinica B","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2969610278","display_name":null,"funder_award_id":"82072668","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5656171160","display_name":null,"funder_award_id":"2020YFA0210800","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8300155670","display_name":null,"funder_award_id":"2019XH004","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W950232622","https://openalex.org/W1604623807","https://openalex.org/W1988896110","https://openalex.org/W1989350280","https://openalex.org/W1996336635","https://openalex.org/W1998666145","https://openalex.org/W2013218770","https://openalex.org/W2020444289","https://openalex.org/W2026076390","https://openalex.org/W2042619042","https://openalex.org/W2061417824","https://openalex.org/W2061705235","https://openalex.org/W2073597876","https://openalex.org/W2103174054","https://openalex.org/W2132577566","https://openalex.org/W2146860018","https://openalex.org/W2148686659","https://openalex.org/W2162547088","https://openalex.org/W2162550834","https://openalex.org/W2169788363","https://openalex.org/W2237254160","https://openalex.org/W2332408216","https://openalex.org/W2342038157","https://openalex.org/W2506963569","https://openalex.org/W2566748307","https://openalex.org/W2795353688","https://openalex.org/W2811483470","https://openalex.org/W2883265123","https://openalex.org/W2890150480","https://openalex.org/W2928665623","https://openalex.org/W2981987970","https://openalex.org/W2982128960","https://openalex.org/W2987630755","https://openalex.org/W3006985331","https://openalex.org/W3025708034","https://openalex.org/W3059618284","https://openalex.org/W3093417536","https://openalex.org/W3111588936","https://openalex.org/W3156669770","https://openalex.org/W3177339179","https://openalex.org/W4213418392","https://openalex.org/W4307359779","https://openalex.org/W4311230084","https://openalex.org/W4362517443","https://openalex.org/W4382138752","https://openalex.org/W4389373612","https://openalex.org/W4389739104","https://openalex.org/W4395085287","https://openalex.org/W4408083832","https://openalex.org/W4410981184","https://openalex.org/W7092368896"],"related_works":["https://openalex.org/W3172408146","https://openalex.org/W4408339622","https://openalex.org/W2991905085","https://openalex.org/W3086278575","https://openalex.org/W3042358368","https://openalex.org/W2342038157","https://openalex.org/W4205317695","https://openalex.org/W4306914214","https://openalex.org/W2612911334","https://openalex.org/W3048860997"],"abstract_inverted_index":{"Gallbladder":[0],"cancer":[1],"(GBC)":[2],"is":[3,21],"an":[4],"aggressive":[5],"digestive":[6],"malignancy":[7],"with":[8,78],"poor":[9],"prognosis":[10],"and":[11,25,40,58,74,131,191],"frequent":[12],"treatment":[13],"resistance.":[14,80],"Aberrant":[15],"receptor":[16],"tyrosine":[17],"kinase":[18],"(RTK)":[19],"signaling":[20,136,178],"common":[22],"in":[23,100,145,185,197],"GBC":[24,57,146],"supports":[26],"use":[27],"of":[28,56,104,110,126,150,155,166],"RTK":[29],"inhibitors":[30],"(RTKis)":[31],"such":[32],"as":[33,113],"sunitinib,":[34],"yet":[35],"clinical":[36],"responses":[37],"remain":[38],"limited":[39],"the":[41,95,105,133,156,163],"mechanisms":[42],"driving":[43],"resistance":[44,86,142,184],"are":[45],"unclear.":[46],"In":[47],"this":[48,168],"study,":[49],"we":[50],"utilized":[51],"patient-derived":[52],"xenograft":[53],"(PDX)":[54],"models":[55],"conducted":[59],"RNA":[60,117],"microarray":[61],"profiling":[62],"alongside":[63],"whole-exome":[64],"sequencing":[65],"to":[66,94,143,182],"identify":[67],"differentially":[68],"expressed":[69],"long":[70],"non-coding":[71],"RNAs":[72],"(lncRNAs)":[73],"gene":[75,129],"mutations":[76],"associated":[77],"sunitinib":[79,144,160,183],"Our":[81],"findings":[82],"reveal":[83],"a":[84,114,174],"novel":[85],"mechanism":[87],"whereby":[88],"TP53":[89],"loss":[90],"impairs":[91],"its":[92,127],"binding":[93],"transcription":[96],"factor":[97],"SP1,":[98],"resulting":[99],"SP1-mediated":[101],"transcriptional":[102],"activation":[103],"lncRNA":[106],"ARHGEF7-AS2":[107,111,151],".":[108],"Upregulation":[109],"functions":[112],"competing":[115],"endogenous":[116],"(ceRNA)":[118],"that":[119,180],"sequesters":[120],"miR-326":[121],",":[122],"thereby":[123],"relieving":[124],"repression":[125],"target":[128],"AXL":[130],"activating":[132],"downstream":[134],"AKT":[135],"cascade.":[137],"This":[138],"regulatory":[139],"axis":[140,179],"promotes":[141],"cells.":[147],"Importantly,":[148],"inhibition":[149],"or":[152],"pharmacological":[153],"blockade":[154],"AXL/AKT":[157],"pathway":[158],"restored":[159],"sensitivity,":[161],"underscoring":[162],"therapeutic":[164,195],"potential":[165,192],"targeting":[167],"pathway.":[169],"Collectively,":[170],"our":[171],"study":[172],"identifies":[173],"previously":[175],"unrecognized":[176],"TP53/ARHGEF7-AS2/miR-326/AXL":[177],"contributes":[181],"GBC,":[186],"providing":[187],"new":[188],"mechanistic":[189],"insights":[190],"avenues":[193],"for":[194],"intervention":[196],"advanced":[198],"disease.":[199]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-08-26T00:00:00"}
