{"id":"https://openalex.org/W7204162698","doi":"https://doi.org/10.1016/j.joen.2026.08.015","title":"Stability, Efficacy, and Immunomodulatory Impact of Nanoemulsion-encapsulated Lipoxin A4 in the Context of Pulpal Inflammation","display_name":"Stability, Efficacy, and Immunomodulatory Impact of Nanoemulsion-encapsulated Lipoxin A4 in the Context of Pulpal Inflammation","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7204162698","doi":"https://doi.org/10.1016/j.joen.2026.08.015","pmid":"https://pubmed.ncbi.nlm.nih.gov/42641944"},"language":"en","primary_location":{"id":"doi:10.1016/j.joen.2026.08.015","doi":"https://doi.org/10.1016/j.joen.2026.08.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.joen.2026.08.015","pdf_url":null,"source":{"id":"https://openalex.org/S90605627","display_name":"Journal of Endodontics","issn_l":"0099-2399","issn":["0099-2399","1878-3554"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endodontics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.joen.2026.08.015","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065013696","display_name":"L\u00e9na Guyon","orcid":"https://orcid.org/0000-0002-1752-5255","observed_orcids":["https://orcid.org/0000-0002-1752-5255"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I4210157468","display_name":"Oniris","ror":"https://ror.org/05q0ncs32","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210157468"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L\u00e9na Guyon","raw_affiliation_strings":["Nantes Universit\u00e9, Oniris, CHU Nantes, Inserm, Regenerative Medicine and Skeleton, RMeS, UMR 1229, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nantes Universit\u00e9, Oniris, CHU Nantes, Inserm, Regenerative Medicine and Skeleton, RMeS, UMR 1229, Nantes, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4210157468","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062589369","display_name":"Sol\u00e8ne Tessier","orcid":"https://orcid.org/0009-0002-5317-6993","observed_orcids":["https://orcid.org/0009-0002-5317-6993"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I4210157468","display_name":"Oniris","ror":"https://ror.org/05q0ncs32","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210157468"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sol\u00e8ne Tessier","raw_affiliation_strings":["Nantes Universit\u00e9, Oniris, CHU Nantes, Inserm, Regenerative Medicine and Skeleton, RMeS, UMR 1229, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nantes Universit\u00e9, Oniris, CHU Nantes, Inserm, Regenerative Medicine and Skeleton, RMeS, UMR 1229, Nantes, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4210157468","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071168732","display_name":"Mika\u00ebl Croyal","orcid":"https://orcid.org/0000-0002-5449-5817","observed_orcids":["https://orcid.org/0000-0002-5449-5817"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I4210144168","display_name":"Institut du Thorax","ror":"https://ror.org/049kkt456","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210096427","https://openalex.org/I4210144168","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I4400009061","display_name":"Structure F\u00e9d\u00e9rative de Recherche Bonamy","ror":"https://ror.org/03p6ach34","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4392021198","https://openalex.org/I4400009061","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I4405260337","display_name":"Universit\u00e9 de Nantes","ror":"https://ror.org/03kjmz544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mika\u00ebl Croyal","raw_affiliation_strings":["Nantes Universit\u00e9, CNRS, INSERM, l'institut du thorax, Nantes, France; Nantes Universit\u00e9, CHU Nantes, Inserm CNRS, SFR Sant\u00e9, Inserm, UMS 016, Nantes, France; CRNH-Ouest Mass Spectrometry Core Facility, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nantes Universit\u00e9, CNRS, INSERM, l'institut du thorax, Nantes, France; Nantes Universit\u00e9, CHU Nantes, Inserm CNRS, SFR Sant\u00e9, Inserm, UMS 016, Nantes, France; CRNH-Ouest Mass Spectrometry Core Facility, Nantes, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4210144168","https://openalex.org/I4400009061","https://openalex.org/I4405260337","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044722439","display_name":"Mathilde Gourdel","orcid":"https://orcid.org/0000-0001-9272-6797","observed_orcids":["https://orcid.org/0000-0001-9272-6797"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I4400009061","display_name":"Structure F\u00e9d\u00e9rative de Recherche Bonamy","ror":"https://ror.org/03p6ach34","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4392021198","https://openalex.org/I4400009061","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mathilde Gourdel","raw_affiliation_strings":["Nantes Universit\u00e9, CHU Nantes, Inserm CNRS, SFR Sant\u00e9, Inserm, UMS 016, Nantes, France; CRNH-Ouest Mass Spectrometry Core Facility, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nantes Universit\u00e9, CHU Nantes, Inserm CNRS, SFR Sant\u00e9, Inserm, UMS 016, Nantes, France; CRNH-Ouest Mass Spectrometry Core Facility, Nantes, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4400009061","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050363515","display_name":"H\u00e9l\u00e8ne Terrisse","orcid":"https://orcid.org/0000-0002-9338-6939","observed_orcids":["https://orcid.org/0000-0002-9338-6939"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210091049","display_name":"Institut des Mat\u00e9riaux Jean Rouxel","ror":"https://ror.org/00cqpd580","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210091049","https://openalex.org/I4210128300","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H\u00e9l\u00e8ne Terrisse","raw_affiliation_strings":["Nantes Universit\u00e9, CNRS, Institut des Mat\u00e9riaux de Nantes Jean Rouxel, IMN, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nantes Universit\u00e9, CNRS, Institut des Mat\u00e9riaux de Nantes Jean Rouxel, IMN, Nantes, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210091049","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089581017","display_name":"Jo\u00eblle V\u00e9ziers","orcid":"https://orcid.org/0000-0002-2182-5103","observed_orcids":["https://orcid.org/0000-0002-2182-5103"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I4210157468","display_name":"Oniris","ror":"https://ror.org/05q0ncs32","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210157468"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Joelle Veziers","raw_affiliation_strings":["Nantes Universit\u00e9, Oniris, CHU Nantes, Inserm, Regenerative Medicine and Skeleton, RMeS, UMR 1229, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nantes Universit\u00e9, Oniris, CHU Nantes, Inserm, Regenerative Medicine and Skeleton, RMeS, UMR 1229, Nantes, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4210157468","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081108436","display_name":"H Gautier","orcid":"https://orcid.org/0000-0002-7945-5723","observed_orcids":["https://orcid.org/0000-0002-7945-5723"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I4210157468","display_name":"Oniris","ror":"https://ror.org/05q0ncs32","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210157468"]},{"id":"https://openalex.org/I4405260337","display_name":"Universit\u00e9 de Nantes","ror":"https://ror.org/03kjmz544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H\u00e9l\u00e8ne Gautier","raw_affiliation_strings":["Nantes Universit\u00e9, Oniris, CHU Nantes, Inserm, Regenerative Medicine and Skeleton, RMeS, UMR 1229, Nantes, France; Nantes Universit\u00e9, UFR Sciences Biologiques et Pharmaceutiques, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nantes Universit\u00e9, Oniris, CHU Nantes, Inserm, Regenerative Medicine and Skeleton, RMeS, UMR 1229, Nantes, France; Nantes Universit\u00e9, UFR Sciences Biologiques et Pharmaceutiques, Nantes, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4210157468","https://openalex.org/I4405260337","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051328709","display_name":"Pierre Weiss","orcid":"https://orcid.org/0000-0002-6159-8590","observed_orcids":["https://orcid.org/0000-0002-6159-8590"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I4210157468","display_name":"Oniris","ror":"https://ror.org/05q0ncs32","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210157468"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Weiss","raw_affiliation_strings":["Nantes Universit\u00e9, Oniris, CHU Nantes, Inserm, Regenerative Medicine and Skeleton, RMeS, UMR 1229, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nantes Universit\u00e9, Oniris, CHU Nantes, Inserm, Regenerative Medicine and Skeleton, RMeS, UMR 1229, Nantes, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4210157468","https://openalex.org/I97188460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028231017","display_name":"Alexis Gaudin","orcid":"https://orcid.org/0000-0003-4139-8927","observed_orcids":["https://orcid.org/0000-0003-4139-8927"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I4210157468","display_name":"Oniris","ror":"https://ror.org/05q0ncs32","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210157468"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Alexis Gaudin","raw_affiliation_strings":["Nantes Universit\u00e9, Oniris, CHU Nantes, Inserm, Regenerative Medicine and Skeleton, RMeS, UMR 1229, Nantes, France. Electronic address: alexis.gaudin@univ-nantes.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nantes Universit\u00e9, Oniris, CHU Nantes, Inserm, Regenerative Medicine and Skeleton, RMeS, UMR 1229, Nantes, France. Electronic address: alexis.gaudin@univ-nantes.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4210157468","https://openalex.org/I97188460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5028231017"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4210157468","https://openalex.org/I97188460"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.55979434,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.28540000319480896,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.28540000319480896,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.260699987411499,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.08160000294446945,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipoxin-a4","display_name":"lipoxin A4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nanoemulsions","display_name":"nanoemulsions","score":0.8709999918937683},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.6600000262260437},{"id":"https://openalex.org/keywords/pulpitis","display_name":"pulpitis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/specialized-pro-resolving-mediators","display_name":"specialized pro-resolving mediators","score":0.8820000290870667},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.8880000114440918},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.8939999938011169},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.7730000019073486},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9240000247955322},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.843999981880188},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9419999718666077},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.7080000042915344},{"id":"https://openalex.org/keywords/endodontics","display_name":"endodontics","score":0.8080000281333923},{"id":"https://openalex.org/keywords/air-pouch-model","display_name":"air pouch model","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.8011000156402588},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7954999804496765},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6101999878883362},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4196000099182129},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.3321000039577484},{"id":"https://openalex.org/C2910850605","wikidata":"https://www.wikidata.org/wiki/Q210352","display_name":"Mucosal inflammation","level":3,"score":0.29010000824928284},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.28040000796318054},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.24940000474452972},{"id":"https://openalex.org/C2780415110","wikidata":"https://www.wikidata.org/wiki/Q4329","display_name":"Lipoxin","level":3,"score":0.23829999566078186},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.22100000083446503}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.joen.2026.08.015","doi":"https://doi.org/10.1016/j.joen.2026.08.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.joen.2026.08.015","pdf_url":null,"source":{"id":"https://openalex.org/S90605627","display_name":"Journal of Endodontics","issn_l":"0099-2399","issn":["0099-2399","1878-3554"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endodontics","raw_type":"journal-article"},{"id":"pmid:42641944","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42641944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of endodontics","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05740610v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-05740610","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Endodontics, 2026, ⟨10.1016/j.joen.2026.08.015⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.joen.2026.08.015","doi":"https://doi.org/10.1016/j.joen.2026.08.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.joen.2026.08.015","pdf_url":null,"source":{"id":"https://openalex.org/S90605627","display_name":"Journal of Endodontics","issn_l":"0099-2399","issn":["0099-2399","1878-3554"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endodontics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4110203128","display_name":"Immunoth\u00e9rapies Grand Ouest","funder_award_id":"ANR-11-LABX-0016","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W146275619","https://openalex.org/W1975531685","https://openalex.org/W2000554262","https://openalex.org/W2004536682","https://openalex.org/W2023447919","https://openalex.org/W2055901626","https://openalex.org/W2061336460","https://openalex.org/W2097147259","https://openalex.org/W2150546514","https://openalex.org/W2162166699","https://openalex.org/W2172990556","https://openalex.org/W2276073028","https://openalex.org/W2579756956","https://openalex.org/W2802901067","https://openalex.org/W2990630547","https://openalex.org/W3109047528","https://openalex.org/W3116921441","https://openalex.org/W3200982602","https://openalex.org/W4205320788","https://openalex.org/W4281646020","https://openalex.org/W4281676746","https://openalex.org/W4308189795","https://openalex.org/W4310379590","https://openalex.org/W4310772613","https://openalex.org/W4317567765","https://openalex.org/W4382048162","https://openalex.org/W4386221477","https://openalex.org/W4391141110","https://openalex.org/W4393405006","https://openalex.org/W4407040059","https://openalex.org/W4407297217"],"related_works":["https://openalex.org/W4393405006","https://openalex.org/W7163385827","https://openalex.org/W2530088436","https://openalex.org/W4310721787","https://openalex.org/W2899675785","https://openalex.org/W7096373905","https://openalex.org/W2011702606","https://openalex.org/W3142759667","https://openalex.org/W2012870263","https://openalex.org/W2609885834"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Lipoxin":[1],"A4":[2],"(LXA4)":[3],"is":[4,21],"a":[5,39,112,118,231],"specialized":[6],"proresolving":[7],"mediator":[8],"with":[9,56,175,211],"the":[10,197,208],"potential":[11],"to":[12,31,42,95,214],"modulate":[13],"dental":[14,242],"pulp":[15,243],"inflammation.":[16],"However,":[17],"its":[18],"therapeutic":[19],"use":[20],"limited":[22],"by":[23,60,149],"instability":[24],"and":[25,33,49,58,72,80,91,97,102,117,124,128,135,152,166,180,185,201,204,222,233],"rapid":[26],"degradation.":[27],"This":[28,248],"study":[29],"aimed":[30],"develop":[32],"evaluate":[34],"LXA4-loaded":[35],"nanoemulsions":[36],"(NELX)":[37],"as":[38],"delivery":[40,235],"system":[41,236],"promote":[43],"inflammation":[44,244],"resolution":[45,240],"both":[46],"in":[47,50,111,196,207,258],"vitro":[48],"vivo.":[51],"METHODS:":[52],"NELX":[53,140,162,192,229],"were":[54,83,93,104,137],"formulated":[55],"LXA4":[57,148],"characterized":[59],"dynamic":[61],"light":[62],"scattering,":[63],"tunable":[64],"resistive":[65],"pulse":[66],"sensing,":[67],"scanning":[68],"transmission":[69],"electron":[70],"microscopy,":[71],"liquid":[73],"chromatography-tandem":[74],"mass":[75],"spectrometry.":[76],"Encapsulation":[77],"efficiency,":[78],"stability,":[79],"drug":[81],"payload":[82],"determined.":[84],"In":[85,106,160,190],"vitro,":[86,161],"THP-1-derived":[87],"macrophages":[88],"(M0,":[89],"M1,":[90],"M2)":[92],"exposed":[94],"NELX,":[96],"metabolic":[98,164],"activity,":[99],"cytokine":[100],"expression,":[101],"secretion":[103,206],"assessed.":[105],"vivo":[107],"efficacy":[108],"was":[109],"investigated":[110],"murine":[113],"air":[114,198],"pouch":[115,199],"model":[116,200],"rat":[119],"molar":[120],"pulpitis":[121,209],"model.":[122],"Histologic":[123],"immunohistochemical":[125],"analyses":[126],"(hematoxylin":[127],"eosin,":[129],"cluster":[130],"of":[131,145,225,241],"differentiation":[132],"[CD]":[133],"CD68,":[134],"CD163)":[136],"performed.":[138],"RESULTS:":[139],"achieved":[141],"complete":[142],"encapsulation":[143],"(100%)":[144],"20":[146],"\u03bcM":[147],"day":[150],"3":[151],"remained":[153],"stable":[154,232],"for":[155,237,252],"45":[156],"days":[157],"at":[158],"4\u00b0C.":[159],"preserved":[163],"activity":[165],"promoted":[167],"macrophage":[168],"polarization":[169],"toward":[170],"an":[171],"anti-inflammatory":[172,256],"M2":[173],"phenotype,":[174],"increased":[176],"interleukin":[177],"(IL)":[178],"10":[179],"IL-1":[181,186],"receptor":[182,187],"antagonist":[183,188],"expression":[184],"secretion.":[189],"vivo,":[191],"reduced":[193,219],"IL-6":[194,203],"levels":[195],"suppressed":[202],"IL-1\u03b2":[205],"model,":[210],"effects":[212],"comparable":[213],"Ledermix":[215],"Paste.":[216],"Histology":[217],"confirmed":[218],"inflammatory":[220],"infiltration":[221],"enhanced":[223],"recruitment":[224],"CD163+":[226],"macrophages.":[227],"CONCLUSIONS:":[228],"provide":[230],"effective":[234],"LXA4,":[238],"promoting":[239],"through":[245],"targeted":[246],"immunomodulation.":[247],"strategy":[249],"holds":[250],"promise":[251],"novel":[253],"biologically":[254],"based":[255],"therapies":[257],"endodontics.":[259]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2026-08-26T00:00:00"}