{"id":"https://openalex.org/W7204157601","doi":"https://doi.org/10.1016/j.phymed.2026.158756","title":"Antitumor potential of pacific plant extracts revealed using tumor spheroids and untargeted metabolomics","display_name":"Antitumor potential of pacific plant extracts revealed using tumor spheroids and untargeted metabolomics","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204157601","doi":"https://doi.org/10.1016/j.phymed.2026.158756","pmid":"https://pubmed.ncbi.nlm.nih.gov/42731452"},"language":"en","primary_location":{"id":"doi:10.1016/j.phymed.2026.158756","doi":"https://doi.org/10.1016/j.phymed.2026.158756","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phymed.2026.158756","pdf_url":null,"source":{"id":"https://openalex.org/S180051340","display_name":"Phytomedicine","issn_l":"0944-7113","issn":["0944-7113","1618-095X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.phymed.2026.158756","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043073781","display_name":"Paul Huched\u00e9","orcid":"https://orcid.org/0009-0004-6846-0289","observed_orcids":["https://orcid.org/0009-0004-6846-0289"]},"institutions":[{"id":"https://openalex.org/I4210151973","display_name":"Institut Pasteur de Nouvelle Cal\u00e9donie","ror":"https://ror.org/04sqtjj61","country_code":"NC","type":"facility","lineage":["https://openalex.org/I4210151973"]},{"id":"https://openalex.org/I4405266640","display_name":"Pasteur Network","ror":"https://ror.org/04cb2ne58","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4405266640"]}],"countries":["FR","NC"],"is_corresponding":true,"raw_author_name":"Paul Huched\u00e9","raw_affiliation_strings":["Group BIOactivities of NAtural products and derivatives (BIONA), Institut Pasteur of New Caledonia, Member of the Pasteur Network, Noumea, New Caledonia. Electronic address: phuchede@pasteur.nc"],"raw_orcid":"https://orcid.org/0009-0004-6846-0289","affiliations":[{"raw_affiliation_string":"Group BIOactivities of NAtural products and derivatives (BIONA), Institut Pasteur of New Caledonia, Member of the Pasteur Network, Noumea, New Caledonia. Electronic address: phuchede@pasteur.nc","institution_ids":["https://openalex.org/I4210151973","https://openalex.org/I4405266640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148090437","display_name":"Hugo Abalam","orcid":"https://orcid.org/0009-0005-2453-9283","observed_orcids":["https://orcid.org/0009-0005-2453-9283"]},"institutions":[{"id":"https://openalex.org/I4210151973","display_name":"Institut Pasteur de Nouvelle Cal\u00e9donie","ror":"https://ror.org/04sqtjj61","country_code":"NC","type":"facility","lineage":["https://openalex.org/I4210151973"]},{"id":"https://openalex.org/I4405266640","display_name":"Pasteur Network","ror":"https://ror.org/04cb2ne58","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4405266640"]}],"countries":["FR","NC"],"is_corresponding":false,"raw_author_name":"Hugo Abalam","raw_affiliation_strings":["Group BIOactivities of NAtural products and derivatives (BIONA), Institut Pasteur of New Caledonia, Member of the Pasteur Network, Noumea, New Caledonia"],"raw_orcid":"https://orcid.org/0009-0005-2453-9283","affiliations":[{"raw_affiliation_string":"Group BIOactivities of NAtural products and derivatives (BIONA), Institut Pasteur of New Caledonia, Member of the Pasteur Network, Noumea, New Caledonia","institution_ids":["https://openalex.org/I4210151973","https://openalex.org/I4405266640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063408898","display_name":"Vincent Dumontet","orcid":"https://orcid.org/0000-0002-1770-6566","observed_orcids":["https://orcid.org/0000-0002-1770-6566"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1298838906","display_name":"Institut de Chimie des Substances Naturelles","ror":"https://ror.org/02st4q439","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1298838906","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Vincent Dumontet","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles (ICSN), UPR 2301, 91198 Gif-sur-Yvette, France"],"raw_orcid":"https://orcid.org/0000-0002-1770-6566","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles (ICSN), UPR 2301, 91198 Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I1298838906","https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148051984","display_name":"Jade Leal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151973","display_name":"Institut Pasteur de Nouvelle Cal\u00e9donie","ror":"https://ror.org/04sqtjj61","country_code":"NC","type":"facility","lineage":["https://openalex.org/I4210151973"]},{"id":"https://openalex.org/I4405266640","display_name":"Pasteur Network","ror":"https://ror.org/04cb2ne58","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4405266640"]}],"countries":["FR","NC"],"is_corresponding":false,"raw_author_name":"Jade Leal","raw_affiliation_strings":["Group BIOactivities of NAtural products and derivatives (BIONA), Institut Pasteur of New Caledonia, Member of the Pasteur Network, Noumea, New Caledonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Group BIOactivities of NAtural products and derivatives (BIONA), Institut Pasteur of New Caledonia, Member of the Pasteur Network, Noumea, New Caledonia","institution_ids":["https://openalex.org/I4210151973","https://openalex.org/I4405266640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148119299","display_name":"Prisca Eatene-Roland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151973","display_name":"Institut Pasteur de Nouvelle Cal\u00e9donie","ror":"https://ror.org/04sqtjj61","country_code":"NC","type":"facility","lineage":["https://openalex.org/I4210151973"]},{"id":"https://openalex.org/I4405266640","display_name":"Pasteur Network","ror":"https://ror.org/04cb2ne58","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4405266640"]}],"countries":["FR","NC"],"is_corresponding":false,"raw_author_name":"Prisca Eatene-Roland","raw_affiliation_strings":["Group BIOactivities of NAtural products and derivatives (BIONA), Institut Pasteur of New Caledonia, Member of the Pasteur Network, Noumea, New Caledonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Group BIOactivities of NAtural products and derivatives (BIONA), Institut Pasteur of New Caledonia, Member of the Pasteur Network, Noumea, New Caledonia","institution_ids":["https://openalex.org/I4210151973","https://openalex.org/I4405266640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015425234","display_name":"Fran\u00e7ois Chassagne","orcid":"https://orcid.org/0000-0003-4179-7995","observed_orcids":["https://orcid.org/0000-0003-4179-7995"]},"institutions":[{"id":"https://openalex.org/I4210107956","display_name":"Institut de Recherche pour le D\u00e9veloppement","ror":"https://ror.org/01j4h9t83","country_code":"NC","type":"education","lineage":["https://openalex.org/I2802818602","https://openalex.org/I4210090127","https://openalex.org/I4210107956","https://openalex.org/I4210131494","https://openalex.org/I4210166444"]},{"id":"https://openalex.org/I4210166444","display_name":"Institut de Recherche pour le D\u00e9veloppement","ror":"https://ror.org/05q3vnk25","country_code":"FR","type":"government","lineage":["https://openalex.org/I2802818602","https://openalex.org/I4210090127","https://openalex.org/I4210131494","https://openalex.org/I4210166444"]}],"countries":["FR","NC"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Chassagne","raw_affiliation_strings":["UMR152 PharmaDev, IRD, Noumea, New Caledonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR152 PharmaDev, IRD, Noumea, New Caledonia","institution_ids":["https://openalex.org/I4210107956","https://openalex.org/I4210166444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110419802","display_name":"Edouard Hnawia","orcid":"https://orcid.org/0009-0003-4690-6692","observed_orcids":["https://orcid.org/0009-0003-4690-6692"]},"institutions":[{"id":"https://openalex.org/I102190016","display_name":"University of New Caledonia","ror":"https://ror.org/02jrgcx64","country_code":"NC","type":"education","lineage":["https://openalex.org/I102190016"]},{"id":"https://openalex.org/I4210107956","display_name":"Institut de Recherche pour le D\u00e9veloppement","ror":"https://ror.org/01j4h9t83","country_code":"NC","type":"education","lineage":["https://openalex.org/I2802818602","https://openalex.org/I4210090127","https://openalex.org/I4210107956","https://openalex.org/I4210131494","https://openalex.org/I4210166444"]},{"id":"https://openalex.org/I4210166444","display_name":"Institut de Recherche pour le D\u00e9veloppement","ror":"https://ror.org/05q3vnk25","country_code":"FR","type":"government","lineage":["https://openalex.org/I2802818602","https://openalex.org/I4210090127","https://openalex.org/I4210131494","https://openalex.org/I4210166444"]},{"id":"https://openalex.org/I4405258534","display_name":"Institut de sciences exactes et appliqu\u00e9es","ror":"https://ror.org/00vdhyk55","country_code":"NC","type":"facility","lineage":["https://openalex.org/I102190016","https://openalex.org/I4405258534"]}],"countries":["FR","NC"],"is_corresponding":false,"raw_author_name":"Edouard Hnawia","raw_affiliation_strings":["UMR152 PharmaDev, IRD, Noumea, New Caledonia; Institut des Sciences Exactes et Appliqu\u00e9s (ISEA), EA7484, Universit\u00e9 de la Nouvelle Cal\u00e9donie, Noumea Cedex, New Caledonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR152 PharmaDev, IRD, Noumea, New Caledonia; Institut des Sciences Exactes et Appliqu\u00e9s (ISEA), EA7484, Universit\u00e9 de la Nouvelle Cal\u00e9donie, Noumea Cedex, New Caledonia","institution_ids":["https://openalex.org/I102190016","https://openalex.org/I4210107956","https://openalex.org/I4210166444","https://openalex.org/I4405258534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015876579","display_name":"Mohamed Haddad","orcid":"https://orcid.org/0000-0001-5599-9980","observed_orcids":["https://orcid.org/0000-0001-5599-9980","https://orcid.org/0000-0003-2790-4635"]},"institutions":[{"id":"https://openalex.org/I4210140430","display_name":"Pharmacochimie et Biologie pour le D\u00e9veloppement","ror":"https://ror.org/03p7xrr08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2802818602","https://openalex.org/I4210090127","https://openalex.org/I4210131494","https://openalex.org/I4210140430","https://openalex.org/I4210166444","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210166444","display_name":"Institut de Recherche pour le D\u00e9veloppement","ror":"https://ror.org/05q3vnk25","country_code":"FR","type":"government","lineage":["https://openalex.org/I2802818602","https://openalex.org/I4210090127","https://openalex.org/I4210131494","https://openalex.org/I4210166444"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mohamed Haddad","raw_affiliation_strings":["UMR152 PharmaDev, Universit\u00e9 de Toulouse, IRD, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR152 PharmaDev, Universit\u00e9 de Toulouse, IRD, Toulouse, France","institution_ids":["https://openalex.org/I4210140430","https://openalex.org/I4210166444","https://openalex.org/I4405258862"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017902061","display_name":"Mariko Matsui","orcid":"https://orcid.org/0000-0001-8091-8521","observed_orcids":["https://orcid.org/0000-0001-8091-8521"]},"institutions":[{"id":"https://openalex.org/I4210151973","display_name":"Institut Pasteur de Nouvelle Cal\u00e9donie","ror":"https://ror.org/04sqtjj61","country_code":"NC","type":"facility","lineage":["https://openalex.org/I4210151973"]},{"id":"https://openalex.org/I4405266640","display_name":"Pasteur Network","ror":"https://ror.org/04cb2ne58","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4405266640"]}],"countries":["FR","NC"],"is_corresponding":false,"raw_author_name":"Mariko Matsui","raw_affiliation_strings":["Group BIOactivities of NAtural products and derivatives (BIONA), Institut Pasteur of New Caledonia, Member of the Pasteur Network, Noumea, New Caledonia"],"raw_orcid":"https://orcid.org/0000-0001-8091-8521","affiliations":[{"raw_affiliation_string":"Group BIOactivities of NAtural products and derivatives (BIONA), Institut Pasteur of New Caledonia, Member of the Pasteur Network, Noumea, New Caledonia","institution_ids":["https://openalex.org/I4210151973","https://openalex.org/I4405266640"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5043073781"],"corresponding_institution_ids":["https://openalex.org/I4210151973","https://openalex.org/I4405266640"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":1.4971,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.72285487,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"161","issue":null,"first_page":"158756","last_page":"158756"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.5264000296592712,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.5264000296592712,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.33009999990463257,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.03799999877810478,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/new-caledonian-flora","display_name":"New Caledonia flora","score":0.8270000219345093},{"id":"https://openalex.org/keywords/scaevola-taccada","display_name":"Scaevola taccada","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-spheroids","display_name":"tumor spheroids","score":0.921999990940094},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7350000143051147},{"id":"https://openalex.org/keywords/anticancer-drug-synergy","display_name":"anticancer drug synergy","score":0.640999972820282},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9319999814033508},{"id":"https://openalex.org/keywords/imatinib-mesylate","display_name":"imatinib mesylate","score":0.9639999866485596},{"id":"https://openalex.org/keywords/diterpenes","display_name":"diterpenoids","score":0.8420000076293945},{"id":"https://openalex.org/keywords/abietane-diterpenoids","display_name":"abietane diterpenoids","score":0.8159999847412109},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.6660000085830688},{"id":"https://openalex.org/keywords/anticancer-drug-discovery","display_name":"anticancer drug discovery","score":0.5339999794960022},{"id":"https://openalex.org/keywords/untargeted-metabolomics","display_name":"untargeted metabolomics","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5547999739646912},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4943999946117401},{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.4607999920845032},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43220001459121704},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35010001063346863},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.3393000066280365},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.27219998836517334},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.2703999876976013},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.26919999718666077},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.259799987077713}],"mesh":[{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009510","descriptor_name":"New Caledonia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018874","descriptor_name":"Spheroids, Cellular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054336","descriptor_name":"Xylopia","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.phymed.2026.158756","doi":"https://doi.org/10.1016/j.phymed.2026.158756","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phymed.2026.158756","pdf_url":null,"source":{"id":"https://openalex.org/S180051340","display_name":"Phytomedicine","issn_l":"0944-7113","issn":["0944-7113","1618-095X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine","raw_type":"journal-article"},{"id":"pmid:42731452","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42731452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine : international journal of phytotherapy and phytopharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:pasteur-05729520v1","doi":null,"is_oa":false,"landing_page_url":"https://riip.hal.science/pasteur-05729520","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Phytomedicine, In press, pp.158756. ⟨10.1016/j.phymed.2026.158756⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.phymed.2026.158756","doi":"https://doi.org/10.1016/j.phymed.2026.158756","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phymed.2026.158756","pdf_url":null,"source":{"id":"https://openalex.org/S180051340","display_name":"Phytomedicine","issn_l":"0944-7113","issn":["0944-7113","1618-095X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322141","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W36932084","https://openalex.org/W576064119","https://openalex.org/W1535315318","https://openalex.org/W1543068333","https://openalex.org/W1560261783","https://openalex.org/W1561441286","https://openalex.org/W1696775091","https://openalex.org/W1963626725","https://openalex.org/W1965144000","https://openalex.org/W1967864396","https://openalex.org/W1968454650","https://openalex.org/W1970118880","https://openalex.org/W1970813608","https://openalex.org/W1973492593","https://openalex.org/W1978763455","https://openalex.org/W1978936452","https://openalex.org/W1988226150","https://openalex.org/W1996890826","https://openalex.org/W2005879544","https://openalex.org/W2007413492","https://openalex.org/W2011248032","https://openalex.org/W2012462606","https://openalex.org/W2018185888","https://openalex.org/W2018830273","https://openalex.org/W2037490361","https://openalex.org/W2037682422","https://openalex.org/W2044804221","https://openalex.org/W2064239913","https://openalex.org/W2071251338","https://openalex.org/W2083376186","https://openalex.org/W2099595899","https://openalex.org/W2104319332","https://openalex.org/W2111020949","https://openalex.org/W2156007499","https://openalex.org/W2167279371","https://openalex.org/W2209368665","https://openalex.org/W2238009938","https://openalex.org/W2332147202","https://openalex.org/W2399089228","https://openalex.org/W2428815629","https://openalex.org/W2473139211","https://openalex.org/W2511141662","https://openalex.org/W2593972269","https://openalex.org/W2606980922","https://openalex.org/W2810870519","https://openalex.org/W2840763348","https://openalex.org/W2938871627","https://openalex.org/W2943248099","https://openalex.org/W2964932621","https://openalex.org/W2980245695","https://openalex.org/W2989313910","https://openalex.org/W2996391333","https://openalex.org/W3000068511","https://openalex.org/W3004274353","https://openalex.org/W3011366455","https://openalex.org/W3015646919","https://openalex.org/W3035184015","https://openalex.org/W3037653626","https://openalex.org/W3100448112","https://openalex.org/W3102445373","https://openalex.org/W3112320269","https://openalex.org/W3119952098","https://openalex.org/W3133807070","https://openalex.org/W3136529045","https://openalex.org/W3167529791","https://openalex.org/W3185301797","https://openalex.org/W3208204329","https://openalex.org/W3213301621","https://openalex.org/W4200192079","https://openalex.org/W4200496867","https://openalex.org/W4206907302","https://openalex.org/W4211210151","https://openalex.org/W4213441241","https://openalex.org/W4297538938","https://openalex.org/W4311548784","https://openalex.org/W4313488530","https://openalex.org/W4313827765","https://openalex.org/W4366529414","https://openalex.org/W4384203035","https://openalex.org/W4394565516","https://openalex.org/W4394578957","https://openalex.org/W4394836207","https://openalex.org/W4395011469","https://openalex.org/W4399785885","https://openalex.org/W4400019027","https://openalex.org/W4400966386","https://openalex.org/W4401526145","https://openalex.org/W4404784379","https://openalex.org/W4405186773","https://openalex.org/W4405424886","https://openalex.org/W4407206753","https://openalex.org/W4414590999","https://openalex.org/W4415668444","https://openalex.org/W4417329034","https://openalex.org/W7151310498"],"related_works":["https://openalex.org/W7118159513","https://openalex.org/W7084445929","https://openalex.org/W2084482510","https://openalex.org/W2800913543","https://openalex.org/W2586148444","https://openalex.org/W2156333157","https://openalex.org/W5696781","https://openalex.org/W2190197126","https://openalex.org/W2483820722","https://openalex.org/W3025205893"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,31,238,358],"discovery":[2],"of":[3,16,26,28,52,72,78,96,103,109,118,127,134,175,193,217,265,283,331,337,343,346,360,379],"novel":[4,341,380],"antitumor":[5,54,67,329],"compounds":[6],"remains":[7],"a":[8,38,46,70,125],"pressing":[9],"need":[10],"to":[11,19,62,81,312,372],"address":[12],"the":[13,24,42,64,75,92,100,107,114,163,213,248,274,284,295,303,328,334,344,361],"global":[14],"burden":[15],"cancer,":[17],"particularly":[18],"fight":[20],"treatment":[21],"resistance":[22],"and":[23,48,80,94,113,116,143,148,166,198,215,219,254,262,318,339,367],"lack":[25],"specificity":[27],"conventional":[29,167,249],"therapies.":[30],"terrestrial":[32,76,335],"flora":[33,77,336],"from":[34,74,91,333],"New":[35],"Caledonia":[36],"(NC),":[37],"biodiversity":[39],"hotspot":[40],"in":[41,308,315,321,351,365],"South":[43],"Pacific,":[44],"represents":[45],"rich":[47],"largely":[49],"underexplored":[50],"source":[51],"candidate":[53],"natural":[55],"products":[56],"(NPs).":[57],"PURPOSE:":[58],"This":[59,325],"study":[60,326],"aimed":[61],"identify":[63],"most":[65,297,362],"potent":[66],"extracts":[68,89,165,177,192,211,240,305,364],"among":[69,273],"selection":[71],"plants":[73],"NC":[79,338],"further":[82,300,370],"characterize":[83],"their":[84],"pharmacological":[85],"potential.":[86],"METHODS:":[87],"Ten":[88],"prepared":[90],"leaves":[93,115,201],"bark":[95,108,117],"Alphitonia":[97],"neocaledonica":[98],"(Rhamnaceae),":[99],"aerial":[101,196],"parts":[102,197,282],"Coleus":[104],"forsteri":[105,195,317],"(Lamiaceae),":[106],"Scaevola":[110],"taccada":[111],"(Goodeniaceae),":[112],"Xylopia":[119],"pancheri":[120,200],"(Annonaceae)":[121],"were":[122,170,306],"evaluated":[123],"across":[124],"panel":[126],"six":[128],"tumor":[129,146,207,221,355],"cell":[130,208],"lines.":[131,209],"Cytotoxic":[132],"activity":[133,204,345],"identified":[135],"hits":[136],"was":[137,150,178],"assessed":[138],"against":[139,205],"HCT116":[140,218],"colorectal":[141],"carcinoma":[142],"Huh-7":[144,220],"hepatocarcinoma":[145],"spheroids,":[147,222],"selectivity":[149,226],"investigated":[151],"ex":[152,235],"vivo":[153,236],"using":[154,180],"peripheral":[155],"blood":[156],"mononuclear":[157],"cells":[158,233],"(PBMCs).":[159],"Pharmacological":[160],"interactions":[161,246],"between":[162,279],"active":[164,176,239,304,363],"anticancer":[168,250,381],"agents":[169,251],"subsequently":[171],"evaluated.":[172],"Metabolomic":[173],"profiling":[174],"performed":[179],"ultra-high-performance":[181],"liquid":[182],"chromatography":[183],"coupled":[184],"with":[185,247],"high-resolution":[186],"mass":[187],"spectrometry":[188],"(UHPLCHRMS).":[189],"RESULTS:":[190],"Cyclohexane":[191],"C.":[194,316],"X.":[199,322],"exhibited":[202],"cytotoxic":[203],"several":[206],"Both":[210],"reduced":[212],"area":[214],"viability":[216],"while":[223],"displaying":[224],"moderate":[225],"toward":[227],"K562":[228],"chronic":[229],"myeloid":[230],"leukemia":[231],"(CML)":[232],"over":[234],"PBMCs.":[237],"displayed":[241],"dose-dependent":[242],"synergistic":[243],"or":[244],"antagonistic":[245],"5-fluorouracil":[252],"(5-FU)":[253],"imatinib":[255],"mesylate":[256],"(IM).":[257],"Principal":[258],"component":[259],"analysis":[260,291],"(PCA)":[261],"heatmap":[263],"visualization":[264],"UHPLCHRMS":[266],"profiles":[267],"revealed":[268],"markedly":[269],"distinct":[270],"chemical":[271],"signatures":[272],"ten":[275],"plant":[276,281,348],"extracts,":[277,349],"including":[278,350],"different":[280],"same":[285],"species.":[286],"Partial":[287],"least":[288],"squares":[289],"discriminant":[290],"(PLS-DA)":[292],"based":[293],"on":[294],"30":[296],"discriminating":[298],"features":[299,309],"showed":[301],"that":[302],"enriched":[307],"putatively":[310],"annotated":[311],"abietane-type":[313],"diterpenoids":[314,320,369],"kaurene/trachylobane-type":[319,368],"pancheri.":[323],"CONCLUSION:":[324],"highlights":[327],"potential":[330],"NPs":[332],"provides":[340],"evidence":[342],"selected":[347],"physiologically":[352],"relevant":[353],"3D":[354],"spheroid":[356],"models.":[357],"enrichment":[359],"abietane-":[366],"points":[371],"these":[373],"metabolite":[374],"families":[375],"as":[376],"promising":[377],"sources":[378],"agents.":[382]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-08-26T00:00:00"}