{"id":"https://openalex.org/W7204157419","doi":"https://doi.org/10.1016/j.stem.2026.07.012","title":"Spatial profiling of the spleen in mouse and human myelofibrosis reveals complement-driven immune-stromal interactions as a therapeutic target","display_name":"Spatial profiling of the spleen in mouse and human myelofibrosis reveals complement-driven immune-stromal interactions as a therapeutic target","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204157419","doi":"https://doi.org/10.1016/j.stem.2026.07.012","pmid":"https://pubmed.ncbi.nlm.nih.gov/42641607"},"language":"en","primary_location":{"id":"doi:10.1016/j.stem.2026.07.012","doi":"https://doi.org/10.1016/j.stem.2026.07.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.stem.2026.07.012","pdf_url":null,"source":{"id":"https://openalex.org/S128124174","display_name":"Cell stem cell","issn_l":"1875-9777","issn":["1875-9777","1934-5909"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Stem Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.stem.2026.07.012","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5120486298","display_name":"B\u00e9r\u00e9nice Dugu\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387154723","display_name":"Biologie des maladies cardiovasculaires","ror":"https://ror.org/0463z7496","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4387154723"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B\u00e9r\u00e9nice Dugu\u00e9","raw_affiliation_strings":["University of Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, 33600 Pessac, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, 33600 Pessac, France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4387154723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006030861","display_name":"Pia Wanner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Pia Wanner","raw_affiliation_strings":["RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059565805","display_name":"Mayra L. Ruiz Tejada Segura","orcid":"https://orcid.org/0000-0003-4217-4458","observed_orcids":["https://orcid.org/0000-0003-4217-4458"]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mayra L. Ruiz Tejada Segura","raw_affiliation_strings":["RWTH Aachen University, Institute for Computational Genomics, Faculty of Medicine, Aachen 52074, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University, Institute for Computational Genomics, Faculty of Medicine, Aachen 52074, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125117417","display_name":"Mohamed Saad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mohamed Saad","raw_affiliation_strings":["RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120486310","display_name":"Lucas Greven","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lucas Greven","raw_affiliation_strings":["RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018963061","display_name":"Katrin G\u00f6tz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katrin G\u00f6tz","raw_affiliation_strings":["RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077350273","display_name":"Carmen Schalla","orcid":"https://orcid.org/0000-0002-0810-4774","observed_orcids":["https://orcid.org/0000-0002-0810-4774"]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carmen Schalla","raw_affiliation_strings":["RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080104144","display_name":"Stijn N. R. Fuchs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Stijn Fuchs","raw_affiliation_strings":["Erasmus Medical Center, Department of Developmental Biology, Rotterdam 3015GD, the Netherlands; Oncode Institute, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Erasmus Medical Center, Department of Developmental Biology, Rotterdam 3015GD, the Netherlands; Oncode Institute, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002426057","display_name":"Gerjanne Vroeg in de Wei","orcid":"https://orcid.org/0000-0002-6853-6720","observed_orcids":["https://orcid.org/0000-0002-6853-6720"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gerjanne Vroeg in de wei","raw_affiliation_strings":["Erasmus Medical Center, Department of Developmental Biology, Rotterdam 3015GD, the Netherlands; Oncode Institute, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Erasmus Medical Center, Department of Developmental Biology, Rotterdam 3015GD, the Netherlands; Oncode Institute, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069137050","display_name":"H\u00e9l\u00e8ne F.E. Gleitz","orcid":"https://orcid.org/0000-0001-6138-8916","observed_orcids":["https://orcid.org/0000-0001-6138-8916"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE","NL"],"is_corresponding":false,"raw_author_name":"H\u00e9l\u00e8ne F.E. Gleitz","raw_affiliation_strings":["RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany; Erasmus Medical Center, Department of Developmental Biology, Rotterdam 3015GD, the Netherlands; Oncode Institute, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany; Erasmus Medical Center, Department of Developmental Biology, Rotterdam 3015GD, the Netherlands; Oncode Institute, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062290051","display_name":"Anna Katharina Galyga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anna Katharina Galyga","raw_affiliation_strings":["RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088038876","display_name":"Jessica Ellen Pritchard","orcid":"https://orcid.org/0000-0002-8971-7336","observed_orcids":["https://orcid.org/0000-0002-8971-7336"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE","NL"],"is_corresponding":false,"raw_author_name":"Jessica Ellen Pritchard","raw_affiliation_strings":["RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany; Erasmus Medical Center, Department of Developmental Biology, Rotterdam 3015GD, the Netherlands; Oncode Institute, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany; Erasmus Medical Center, Department of Developmental Biology, Rotterdam 3015GD, the Netherlands; Oncode Institute, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148157698","display_name":"Tobias Schlangen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Schlangen","raw_affiliation_strings":["RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031173557","display_name":"Niklas Lutterbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Niklas Lutterbach","raw_affiliation_strings":["RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087049696","display_name":"Salim Atakhanov","orcid":"https://orcid.org/0009-0008-4633-1047","observed_orcids":["https://orcid.org/0009-0008-4633-1047"]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Salim Atakhanov","raw_affiliation_strings":["RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130112367","display_name":"Lina Schmidt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lina Schmidt","raw_affiliation_strings":["RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113059672","display_name":"Marie Parrens","orcid":"https://orcid.org/0000-0002-4335-4138","observed_orcids":["https://orcid.org/0000-0002-4335-4138"]},"institutions":[{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie Parrens","raw_affiliation_strings":["CHU Bordeaux, Department of Pathology, 33000 Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU Bordeaux, Department of Pathology, 33000 Bordeaux, France","institution_ids":["https://openalex.org/I3018323443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120486299","display_name":"Armelle Peyrat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Armelle Peyrat","raw_affiliation_strings":["CHU Bordeaux, Department of Pathology, 33000 Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU Bordeaux, Department of Pathology, 33000 Bordeaux, France","institution_ids":["https://openalex.org/I3018323443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084155868","display_name":"Damien Luque Paz","orcid":"https://orcid.org/0000-0002-4523-675X","observed_orcids":["https://orcid.org/0000-0002-4523-675X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210092509","display_name":"Centre de Recherche en Canc\u00e9rologie et Immunologie Int\u00e9gr\u00e9e Nantes Angers","ror":"https://ror.org/003g1aw90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4210092509","https://openalex.org/I4210096427","https://openalex.org/I4210106090","https://openalex.org/I4210112910","https://openalex.org/I49451733","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I4210112910","display_name":"Centre Hospitalier Universitaire d'Angers","ror":"https://ror.org/0250ngj72","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210112910"]},{"id":"https://openalex.org/I49451733","display_name":"Universit\u00e9 d'Angers","ror":"https://ror.org/04yrqp957","country_code":"FR","type":"education","lineage":["https://openalex.org/I49451733"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Damien Luque Paz","raw_affiliation_strings":["Angers University, Nantes University, CHU Angers, Inserm, CNRS, CRCI2NA, 49000 Angers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Angers University, Nantes University, CHU Angers, Inserm, CNRS, CRCI2NA, 49000 Angers, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210092509","https://openalex.org/I4210112910","https://openalex.org/I49451733","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027654738","display_name":"Marie\u2010Christine Copin","orcid":"https://orcid.org/0000-0002-4729-7054","observed_orcids":["https://orcid.org/0000-0002-4729-7054"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210092509","display_name":"Centre de Recherche en Canc\u00e9rologie et Immunologie Int\u00e9gr\u00e9e Nantes Angers","ror":"https://ror.org/003g1aw90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4210092509","https://openalex.org/I4210096427","https://openalex.org/I4210106090","https://openalex.org/I4210112910","https://openalex.org/I49451733","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I4210112910","display_name":"Centre Hospitalier Universitaire d'Angers","ror":"https://ror.org/0250ngj72","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210112910"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-Christine Copin","raw_affiliation_strings":["Angers University, Nantes University, CHU Angers, Inserm, CNRS, CRCI2NA, 49000 Angers, France; CHU Angers, Department of Pathology, 49000 Angers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Angers University, Nantes University, CHU Angers, Inserm, CNRS, CRCI2NA, 49000 Angers, France; CHU Angers, Department of Pathology, 49000 Angers, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210092509","https://openalex.org/I4210112910","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018537573","display_name":"Alexandre Guy","orcid":"https://orcid.org/0000-0002-8727-4615","observed_orcids":["https://orcid.org/0000-0002-8727-4615"]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]},{"id":"https://openalex.org/I4387154723","display_name":"Biologie des maladies cardiovasculaires","ror":"https://ror.org/0463z7496","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4387154723"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alexandre Guy","raw_affiliation_strings":["University of Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, 33600 Pessac, France; CHU Bordeaux, Laboratory of Hematology, 33000 Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, 33600 Pessac, France; CHU Bordeaux, Laboratory of Hematology, 33000 Bordeaux, France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I3018323443","https://openalex.org/I4387154723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003443627","display_name":"Victor\u2010Emmanuel Brett","orcid":"https://orcid.org/0000-0002-9811-5003","observed_orcids":["https://orcid.org/0000-0002-9811-5003"]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]},{"id":"https://openalex.org/I4387154723","display_name":"Biologie des maladies cardiovasculaires","ror":"https://ror.org/0463z7496","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4387154723"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Victor-Emmanuel Brett","raw_affiliation_strings":["University of Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, 33600 Pessac, France; CHU Bordeaux, Laboratory of Hematology, 33000 Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, 33600 Pessac, France; CHU Bordeaux, Laboratory of Hematology, 33000 Bordeaux, France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I3018323443","https://openalex.org/I4387154723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034054835","display_name":"Olivier Mansier","orcid":"https://orcid.org/0000-0002-7943-8800","observed_orcids":["https://orcid.org/0000-0002-7943-8800"]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]},{"id":"https://openalex.org/I4387154723","display_name":"Biologie des maladies cardiovasculaires","ror":"https://ror.org/0463z7496","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4387154723"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Mansier","raw_affiliation_strings":["University of Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, 33600 Pessac, France; CHU Bordeaux, Laboratory of Hematology, 33000 Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, 33600 Pessac, France; CHU Bordeaux, Laboratory of Hematology, 33000 Bordeaux, France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I3018323443","https://openalex.org/I4387154723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104107574","display_name":"Susanne Schmitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE","NL"],"is_corresponding":false,"raw_author_name":"Susanne Schmitz","raw_affiliation_strings":["Erasmus Medical Center, Department of Developmental Biology, Rotterdam 3015GD, the Netherlands; Oncode Institute, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands","RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Erasmus Medical Center, Department of Developmental Biology, Rotterdam 3015GD, the Netherlands; Oncode Institute, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040328173","display_name":"Paul Wanek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Paul Wanek","raw_affiliation_strings":["RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001432177","display_name":"Bella Banjanin","orcid":"https://orcid.org/0000-0001-6166-4490","observed_orcids":["https://orcid.org/0000-0001-6166-4490"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bella Banjanin","raw_affiliation_strings":["Erasmus Medical Center, Department of Developmental Biology, Rotterdam 3015GD, the Netherlands; Oncode Institute, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Erasmus Medical Center, Department of Developmental Biology, Rotterdam 3015GD, the Netherlands; Oncode Institute, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078277089","display_name":"Stephani Schmitz","orcid":"https://orcid.org/0000-0003-1188-2750","observed_orcids":["https://orcid.org/0000-0003-1188-2750"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE","NL"],"is_corresponding":false,"raw_author_name":"Stephani Schmitz","raw_affiliation_strings":["Erasmus Medical Center, Department of Developmental Biology, Rotterdam 3015GD, the Netherlands; Oncode Institute, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands","RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Erasmus Medical Center, Department of Developmental Biology, Rotterdam 3015GD, the Netherlands; Oncode Institute, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090648381","display_name":"Martina Margrit Crysandt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martina Crysandt","raw_affiliation_strings":["RWTH Aachen University, Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, 52074 Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University, Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, 52074 Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038813258","display_name":"Marian C. Clahsen\u2010van Groningen","orcid":"https://orcid.org/0000-0003-0565-9560","observed_orcids":["https://orcid.org/0000-0003-0565-9560"]},"institutions":[{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I4387152854","display_name":"Erasmus MC Transplant Institute","ror":"https://ror.org/0585v6057","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4387152854"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE","NL"],"is_corresponding":false,"raw_author_name":"Marian C. Clahsen-van Groningen","raw_affiliation_strings":["University Hospital RWTH Aachen, Department of Nephrology, 52074 Aachen, Germany; Department of Pathology and Clinical Bioinformatics, Erasmus MC Transplant Institute, Rotterdam 3015GD, the Netherlands; Laboratory for Pathology (PAL), 3318 AL Dordrecht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital RWTH Aachen, Department of Nephrology, 52074 Aachen, Germany; Department of Pathology and Clinical Bioinformatics, Erasmus MC Transplant Institute, Rotterdam 3015GD, the Netherlands; Laboratory for Pathology (PAL), 3318 AL Dordrecht, the Netherlands","institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I4387152854","https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025898022","display_name":"Konnie M. Hebeda","orcid":"https://orcid.org/0000-0002-4181-3302","observed_orcids":["https://orcid.org/0000-0002-4181-3302"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Konnie M. Hebeda","raw_affiliation_strings":["Radboud University Medical Center, Department of Pathology, 6525 GA Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud University Medical Center, Department of Pathology, 6525 GA Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058238162","display_name":"Sascha Dietrich","orcid":"https://orcid.org/0000-0002-0648-1832","observed_orcids":["https://orcid.org/0000-0002-0648-1832"]},"institutions":[{"id":"https://openalex.org/I4210089242","display_name":"D\u00fcsseldorf University Hospital","ror":"https://ror.org/006k2kk72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210089242"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sascha Dietrich","raw_affiliation_strings":["University Hospital D\u00fcsseldorf, Heinrich Heine University, Department of Hematology, Oncology and Clinical Immunology, 40225 D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital D\u00fcsseldorf, Heinrich Heine University, Department of Hematology, Oncology and Clinical Immunology, 40225 D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I4210089242","https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022607933","display_name":"Harald S. V\u00f6hringer","orcid":"https://orcid.org/0000-0003-2513-4518","observed_orcids":["https://orcid.org/0000-0003-2513-4518"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Harald Voehringer","raw_affiliation_strings":["European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany; Molecular Medicine Partnership Unit (MMPU), 69117 Heidelberg, Germany; Department of Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany; Molecular Medicine Partnership Unit (MMPU), 69117 Heidelberg, Germany; Department of Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210138560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085654685","display_name":"Matthias Meyer-Bender","orcid":"https://orcid.org/0000-0002-0448-4546","observed_orcids":["https://orcid.org/0000-0002-0448-4546"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Meyer-Bender","raw_affiliation_strings":["European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany; Molecular Medicine Partnership Unit (MMPU), 69117 Heidelberg, Germany; Department of Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany; Molecular Medicine Partnership Unit (MMPU), 69117 Heidelberg, Germany; Department of Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210138560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064774607","display_name":"Kristin Ser\u00e9","orcid":"https://orcid.org/0000-0002-8397-4526","observed_orcids":["https://orcid.org/0000-0002-8397-4526"]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kristin S\u00e9r\u00e9","raw_affiliation_strings":["RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008564530","display_name":"Chlo\u00e9 James","orcid":"https://orcid.org/0000-0001-9553-2701","observed_orcids":["https://orcid.org/0000-0001-9553-2701"]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]},{"id":"https://openalex.org/I4387154723","display_name":"Biologie des maladies cardiovasculaires","ror":"https://ror.org/0463z7496","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4387154723"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Chlo\u00e9 James","raw_affiliation_strings":["University of Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, 33600 Pessac, France; CHU Bordeaux, Laboratory of Hematology, 33000 Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, 33600 Pessac, France; CHU Bordeaux, Laboratory of Hematology, 33000 Bordeaux, France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I3018323443","https://openalex.org/I4387154723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052889210","display_name":"Adam Benabid","orcid":"https://orcid.org/0000-0003-3405-4333","observed_orcids":["https://orcid.org/0000-0003-3405-4333"]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Adam Benabid","raw_affiliation_strings":["RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057250270","display_name":"Ivan G. Costa","orcid":"https://orcid.org/0000-0003-2890-8697","observed_orcids":["https://orcid.org/0000-0003-2890-8697"]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ivan Costa","raw_affiliation_strings":["RWTH Aachen University, Institute for Computational Genomics, Faculty of Medicine, Aachen 52074, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University, Institute for Computational Genomics, Faculty of Medicine, Aachen 52074, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084488460","display_name":"Charles Dussiau","orcid":"https://orcid.org/0000-0003-0646-0617","observed_orcids":["https://orcid.org/0000-0003-0646-0617"]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]},{"id":"https://openalex.org/I4210111092","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/01zjc6908","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210111092","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210151150","display_name":"Heidelberg Institute for Stem Cell Technology and Experimental Medicine","ror":"https://ror.org/049yqqs33","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210151150"]},{"id":"https://openalex.org/I4387154723","display_name":"Biologie des maladies cardiovasculaires","ror":"https://ror.org/0463z7496","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4387154723"]}],"countries":["DE","FR"],"is_corresponding":true,"raw_author_name":"Charles Dussiau","raw_affiliation_strings":["University of Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, 33600 Pessac, France; CHU Bordeaux, Laboratory of Hematology, 33000 Bordeaux, France; European Molecular Biology Laboratory, Molecular Systems Biology Unit, 69117 Heidelberg, Germany; German Cancer Research Center (DKFZ), Division of Experimental Hematology, 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany. Electronic address: charles.dussiau@embl.de"],"raw_orcid":"https://orcid.org/0000-0003-0646-0617","affiliations":[{"raw_affiliation_string":"University of Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, 33600 Pessac, France; CHU Bordeaux, Laboratory of Hematology, 33000 Bordeaux, France; European Molecular Biology Laboratory, Molecular Systems Biology Unit, 69117 Heidelberg, Germany; German Cancer Research Center (DKFZ), Division of Experimental Hematology, 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany. Electronic address: charles.dussiau@embl.de","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I17937529","https://openalex.org/I3018323443","https://openalex.org/I4210111092","https://openalex.org/I4210138560","https://openalex.org/I4210151150","https://openalex.org/I4387154723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073561254","display_name":"Rebekka K. Schneider","orcid":"https://orcid.org/0000-0002-0749-1565","observed_orcids":["https://orcid.org/0000-0002-0749-1565"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE","NL"],"is_corresponding":true,"raw_author_name":"Rebekka K. Schneider","raw_affiliation_strings":["RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany; Erasmus Medical Center, Department of Developmental Biology, Rotterdam 3015GD, the Netherlands; Oncode Institute, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands. Electronic address: reschneider@ukaachen.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University, Department of Cell and Tumor Biology, Faculty of Medicine, 52074 Aachen, Germany; Erasmus Medical Center, Department of Developmental Biology, Rotterdam 3015GD, the Netherlands; Oncode Institute, Erasmus Medical Center, Rotterdam 3015GD, the Netherlands. Electronic address: reschneider@ukaachen.de","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I887968799"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":21,"corresponding_author_ids":["https://openalex.org/A5073561254","https://openalex.org/A5084488460"],"corresponding_institution_ids":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I17937529","https://openalex.org/I2801952686","https://openalex.org/I3018323443","https://openalex.org/I4210111092","https://openalex.org/I4210138560","https://openalex.org/I4210151150","https://openalex.org/I4387154723","https://openalex.org/I887968799"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":{"value":10400,"currency":"USD","value_usd":10400},"fwci":8.3425,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.97807349,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"33","issue":"9","first_page":"1477","last_page":"1494.e14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myelofibrosis","display_name":"myelofibrosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.9480000138282776},{"id":"https://openalex.org/keywords/extramedullary-hematopoiesis","display_name":"extramedullary hematopoiesis","score":0.8610000014305115},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-niche","display_name":"hematopoietic niche","score":0.7730000019073486},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.4779999852180481},{"id":"https://openalex.org/keywords/stromal-remodeling","display_name":"stromal remodeling","score":0.8119999766349792},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7649999856948853},{"id":"https://openalex.org/keywords/megakaryocytes","display_name":"megakaryocytes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8360000252723694},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9929999709129333},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8519999980926514},{"id":"https://openalex.org/keywords/thrombospondin-1","display_name":"thrombospondin-1","score":0.9789999723434448},{"id":"https://openalex.org/keywords/bone-marrow-fibrosis","display_name":"bone marrow fibrosis","score":0.8870000243186951}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8378000259399414},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7235000133514404},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6909000277519226},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.6908000111579895},{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.6761999726295471},{"id":"https://openalex.org/C143689837","wikidata":"https://www.wikidata.org/wiki/Q1421408","display_name":"Reticular cell","level":3,"score":0.6421999931335449},{"id":"https://openalex.org/C2779921676","wikidata":"https://www.wikidata.org/wiki/Q6760434","display_name":"Marginal zone","level":4,"score":0.5367000102996826},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5267999768257141},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.4952999949455261},{"id":"https://openalex.org/C2778080410","wikidata":"https://www.wikidata.org/wiki/Q5422215","display_name":"Extramedullary hematopoiesis","level":4,"score":0.49470001459121704},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48339998722076416},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.47940000891685486},{"id":"https://openalex.org/C2777092883","wikidata":"https://www.wikidata.org/wiki/Q1093858","display_name":"Red pulp","level":3,"score":0.46380001306533813},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43540000915527344},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41830000281333923},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.38449999690055847},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35670000314712524},{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.3443000018596649},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.3343000113964081},{"id":"https://openalex.org/C95190701","wikidata":"https://www.wikidata.org/wiki/Q3268002","display_name":"Reticular connective tissue","level":2,"score":0.3240000009536743},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.32120001316070557},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.3165000081062317},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.31610000133514404},{"id":"https://openalex.org/C2778232189","wikidata":"https://www.wikidata.org/wiki/Q626936","display_name":"White pulp","level":3,"score":0.3133000135421753},{"id":"https://openalex.org/C2779380147","wikidata":"https://www.wikidata.org/wiki/Q3832900","display_name":"Splenic marginal zone lymphoma","level":4,"score":0.29809999465942383},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.2976999878883362},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.2930000126361847},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2703000009059906},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.26429998874664307},{"id":"https://openalex.org/C2779705218","wikidata":"https://www.wikidata.org/wiki/Q821701","display_name":"Megakaryocyte","level":4,"score":0.26159998774528503},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.25940001010894775},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.25519999861717224},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.25270000100135803},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.25}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006411","descriptor_name":"Hematopoiesis, Extramedullary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055728","descriptor_name":"Primary Myelofibrosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055728","descriptor_name":"Primary Myelofibrosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D055728","descriptor_name":"Primary Myelofibrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.stem.2026.07.012","doi":"https://doi.org/10.1016/j.stem.2026.07.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.stem.2026.07.012","pdf_url":null,"source":{"id":"https://openalex.org/S128124174","display_name":"Cell stem cell","issn_l":"1875-9777","issn":["1875-9777","1934-5909"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Stem Cell","raw_type":"journal-article"},{"id":"pmid:42641607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42641607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell stem cell","raw_type":"Journal Article"},{"id":"pmh:oai:pure.eur.nl:openaire/f5892d92-5293-46a9-835c-1629652ba1b1","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/f5892d92-5293-46a9-835c-1629652ba1b1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-05745596v1","doi":null,"is_oa":true,"landing_page_url":"https://nantes-universite.hal.science/hal-05745596","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Stem Cell, 2026, 33 (9), pp.1477-1494.e14. &#x27E8;10.1016/j.stem.2026.07.012&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/335898","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2066/335898","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"}],"best_oa_location":{"id":"doi:10.1016/j.stem.2026.07.012","doi":"https://doi.org/10.1016/j.stem.2026.07.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.stem.2026.07.012","pdf_url":null,"source":{"id":"https://openalex.org/S128124174","display_name":"Cell stem cell","issn_l":"1875-9777","issn":["1875-9777","1934-5909"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Stem Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309752","display_name":"Association Laurette Fugain","ror":"https://ror.org/00x20kz95"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320328394","display_name":"Fonds de dotation CSL Behring pour la recherche","ror":"https://ror.org/04k6ep477"},{"id":"https://openalex.org/F4320334322","display_name":"HORIZON EUROPE Framework Programme","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W348648225","https://openalex.org/W2022874119","https://openalex.org/W2033653350","https://openalex.org/W2109999727","https://openalex.org/W2145941207","https://openalex.org/W2149053153","https://openalex.org/W2177185177","https://openalex.org/W2190545194","https://openalex.org/W2294057964","https://openalex.org/W2507655048","https://openalex.org/W2545964391","https://openalex.org/W2557833574","https://openalex.org/W2607959672","https://openalex.org/W2613365198","https://openalex.org/W2616922646","https://openalex.org/W2779950914","https://openalex.org/W2796616220","https://openalex.org/W2807500664","https://openalex.org/W2952391626","https://openalex.org/W2953151710","https://openalex.org/W2984472267","https://openalex.org/W2997280954","https://openalex.org/W3007935255","https://openalex.org/W3010766518","https://openalex.org/W3015161665","https://openalex.org/W3035498579","https://openalex.org/W3036206386","https://openalex.org/W3036435839","https://openalex.org/W3112914139","https://openalex.org/W3114078084","https://openalex.org/W3136167138","https://openalex.org/W3157991631","https://openalex.org/W3163061470","https://openalex.org/W3164659906","https://openalex.org/W3164692211","https://openalex.org/W3166197489","https://openalex.org/W3176444924","https://openalex.org/W3184541259","https://openalex.org/W3203240306","https://openalex.org/W3204003752","https://openalex.org/W3212637549","https://openalex.org/W3214596602","https://openalex.org/W4205534476","https://openalex.org/W4205817967","https://openalex.org/W4214876469","https://openalex.org/W4281716326","https://openalex.org/W4283271244","https://openalex.org/W4313199162","https://openalex.org/W4360999182","https://openalex.org/W4366351220","https://openalex.org/W4376133764","https://openalex.org/W4389937204","https://openalex.org/W4391219795","https://openalex.org/W4393188438","https://openalex.org/W4403277918","https://openalex.org/W4403467063","https://openalex.org/W4405030588","https://openalex.org/W4411077976","https://openalex.org/W7130646599","https://openalex.org/W7131088910"],"related_works":["https://openalex.org/W7207624126","https://openalex.org/W7172302659","https://openalex.org/W2788015113","https://openalex.org/W7204184819","https://openalex.org/W2589098958","https://openalex.org/W2979543469","https://openalex.org/W4417016585","https://openalex.org/W2591320606","https://openalex.org/W2109999727","https://openalex.org/W4386056511"],"abstract_inverted_index":{"Splenomegaly":[0],"is":[1,61],"a":[2,76,143,150],"defining":[3],"feature":[4],"of":[5,10,25,38],"myelofibrosis,":[6],"yet":[7],"the":[8],"contribution":[9],"splenic":[11,127],"mesenchymal":[12],"stroma":[13],"to":[14,41,83],"disease":[15,60],"progression":[16],"remains":[17],"unclear.":[18],"We":[19],"combined":[20],"spatial":[21,29],"and":[22,30,55,58,85,91,97,111,129,132,148],"single-nucleus":[23],"transcriptomics":[24],"patient":[26],"spleens":[27,40],"with":[28,67],"single-cell":[31],"transcriptomics,":[32],"as":[33,35,142,149],"well":[34],"imaging":[36],"analyses,":[37],"murine":[39],"map":[42],"extramedullary":[43],"hematopoiesis":[44],"niches.":[45],"Activated":[46],"red":[47],"pulp":[48],"reticular":[49,79],"cells":[50,80],"localize":[51],"near":[52],"hematopoietic":[53,146],"stem":[54],"progenitor":[56],"cells,":[57],"early":[59],"characterized":[62],"by":[63,89],"marginal":[64],"zone":[65],"disruption":[66],"lymphoid":[68],"depletion":[69],"preceding":[70],"stromal":[71,140],"remodeling.":[72],"Trajectory":[73],"analyses":[74],"reveal":[75],"shift":[77],"in":[78,153],"from":[81],"hematopoiesis-supportive":[82],"inflammatory":[84],"pro-fibrotic":[86],"states,":[87],"driven":[88],"macrophage-":[90],"megakaryocyte-derived":[92],"signals":[93],"that":[94],"activate":[95],"complement":[96,115],"induce":[98],"tumor":[99],"necrosis":[100],"factor":[101,106],"\u03b1":[102],"(TNF-\u03b1),":[103],"transforming":[104],"growth":[105],"\u03b2":[107],"(TGF-\u03b2),":[108],"extracellular":[109],"matrix,":[110],"Thbs1":[112],"programs.":[113],"Non-hematopoietic":[114],"component":[116],"C3":[117,121],"deficiency":[118],"or":[119],"pharmacological":[120],"inhibition":[122],"suppresses":[123],"these":[124],"pathways,":[125],"restores":[126],"architecture,":[128],"reduces":[130],"splenomegaly":[131],"bone":[133],"marrow":[134],"fibrosis.":[135],"These":[136],"findings":[137],"identify":[138],"complement-dependent":[139],"reprogramming":[141],"mechanism":[144],"governing":[145],"niches":[147],"targetable":[151],"axis":[152],"myelofibrosis.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-08-26T00:00:00"}
