{"id":"https://openalex.org/W7204148751","doi":"https://doi.org/10.1128/aac.00639-26","title":"Training a phage to expand its host range: directed evolution against Staphylococcus aureus from diabetic foot infections","display_name":"Training a phage to expand its host range: directed evolution against Staphylococcus aureus from diabetic foot infections","publication_year":2026,"publication_date":"2026-08-24","ids":{"openalex":"https://openalex.org/W7204148751","doi":"https://doi.org/10.1128/aac.00639-26","pmid":"https://pubmed.ncbi.nlm.nih.gov/42635480"},"language":"en","primary_location":{"id":"doi:10.1128/aac.00639-26","doi":"https://doi.org/10.1128/aac.00639-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00639-26","pdf_url":"https://journals.asm.org/doi/pdf/10.1128/aac.00639-26?download=true","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.asm.org/doi/pdf/10.1128/aac.00639-26?download=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069818222","display_name":"Lucile Plumet","orcid":"https://orcid.org/0000-0002-2128-8010","observed_orcids":["https://orcid.org/0000-0002-2128-8010"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lucile Plumet","raw_affiliation_strings":["VBIC, INSERM U1047, Department of Microbiology and Hospital Hygiene, University of Montpellier, CHU N\u00eemes"],"raw_orcid":"https://orcid.org/0000-0002-2128-8010","affiliations":[{"raw_affiliation_string":"VBIC, INSERM U1047, Department of Microbiology and Hospital Hygiene, University of Montpellier, CHU N\u00eemes","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076500447","display_name":"Chlo\u00e9 Magnan","orcid":"https://orcid.org/0000-0002-2330-212X","observed_orcids":["https://orcid.org/0000-0002-2330-212X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Chlo\u00e9 Magnan","raw_affiliation_strings":["VBIC, INSERM U1047, Department of Microbiology and Hospital Hygiene, University of Montpellier, CHU N\u00eemes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VBIC, INSERM U1047, Department of Microbiology and Hospital Hygiene, University of Montpellier, CHU N\u00eemes","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090109387","display_name":"Madjid Morsli","orcid":"https://orcid.org/0000-0002-8074-1794","observed_orcids":["https://orcid.org/0000-0002-8074-1794"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Madjid Morsli","raw_affiliation_strings":["VBIC, INSERM U1047, Department of Microbiology and Hospital Hygiene, University of Montpellier, CHU N\u00eemes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VBIC, INSERM U1047, Department of Microbiology and Hospital Hygiene, University of Montpellier, CHU N\u00eemes","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120523470","display_name":"Marion Richardoz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marion Richardoz","raw_affiliation_strings":["VBIC, INSERM U1047, Department of Microbiology and Hospital Hygiene, University of Montpellier, CHU N\u00eemes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VBIC, INSERM U1047, Department of Microbiology and Hospital Hygiene, University of Montpellier, CHU N\u00eemes","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045080230","display_name":"Nadia Ga\u00efa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nadia Ga\u00efa","raw_affiliation_strings":["Genomic Research Laboratory, University Hospitals of Geneva, Service of Infectious Diseases and Faculty of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomic Research Laboratory, University Hospitals of Geneva, Service of Infectious Diseases and Faculty of Medicine","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010055797","display_name":"Patrice Fran\u00e7ois","orcid":"https://orcid.org/0000-0002-0540-750X","observed_orcids":["https://orcid.org/0000-0002-0540-750X"]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Patrice Fran\u00e7ois","raw_affiliation_strings":["Genomic Research Laboratory, University Hospitals of Geneva, Service of Infectious Diseases and Faculty of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomic Research Laboratory, University Hospitals of Geneva, Service of Infectious Diseases and Faculty of Medicine","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049289579","display_name":"Jean\u2010Philippe Lavigne","orcid":"https://orcid.org/0000-0002-9484-0304","observed_orcids":["https://orcid.org/0000-0002-9484-0304"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Philippe Lavigne","raw_affiliation_strings":["VBIC, INSERM U1047, Department of Microbiology and Hospital Hygiene, University of Montpellier, CHU N\u00eemes"],"raw_orcid":"https://orcid.org/0000-0002-9484-0304","affiliations":[{"raw_affiliation_string":"VBIC, INSERM U1047, Department of Microbiology and Hospital Hygiene, University of Montpellier, CHU N\u00eemes","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033469741","display_name":"Denis Costechareyre","orcid":"https://orcid.org/0000-0002-9258-7421","observed_orcids":["https://orcid.org/0000-0002-9258-7421"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Denis Costechareyre","raw_affiliation_strings":["Greenphage, Cap Alpha"],"raw_orcid":"https://orcid.org/0000-0002-9258-7421","affiliations":[{"raw_affiliation_string":"Greenphage, Cap Alpha","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064157453","display_name":"Virginie Molle","orcid":"https://orcid.org/0000-0002-6573-3411","observed_orcids":["https://orcid.org/0000-0002-6573-3411"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Virginie Molle","raw_affiliation_strings":["VBIC, INSERM U1047, Department of Microbiology and Hospital Hygiene, University of Montpellier, CHU N\u00eemes"],"raw_orcid":"https://orcid.org/0000-0002-6573-3411","affiliations":[{"raw_affiliation_string":"VBIC, INSERM U1047, Department of Microbiology and Hospital Hygiene, University of Montpellier, CHU N\u00eemes","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.63954843,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"10","first_page":"e0063926","last_page":"e0063926"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phage-therapy","display_name":"phage therapy","score":0.9110000133514404},{"id":"https://openalex.org/keywords/host-range-expansion","display_name":"host range expansion","score":0.875},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9800000190734863},{"id":"https://openalex.org/keywords/diabetic-foot-infection","display_name":"diabetic foot infection","score":0.847000002861023},{"id":"https://openalex.org/keywords/directed-evolution","display_name":"directed evolution","score":0.7379999756813049},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.7509999871253967},{"id":"https://openalex.org/keywords/coagulase-negative-staphylococci","display_name":"coagulase-negative staphylococci","score":0.9660000205039978},{"id":"https://openalex.org/keywords/zebrafish-embryo-model","display_name":"zebrafish embryo model","score":0.8289999961853027},{"id":"https://openalex.org/keywords/chronic-infection","display_name":"chronic infection","score":0.5139999985694885},{"id":"https://openalex.org/keywords/antibiotic-alternatives","display_name":"antibiotic alternatives","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.7961999773979187},{"id":"https://openalex.org/C2779256223","wikidata":"https://www.wikidata.org/wiki/Q611870","display_name":"Phage therapy","level":5,"score":0.7792999744415283},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6757000088691711},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.48030000925064087},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.4758000075817108},{"id":"https://openalex.org/C87590526","wikidata":"https://www.wikidata.org/wiki/Q3592884","display_name":"Experimental evolution","level":3,"score":0.44350001215934753},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.438400000333786},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.4092999994754791},{"id":"https://openalex.org/C2777334864","wikidata":"https://www.wikidata.org/wiki/Q34879","display_name":"Staphylococcal infections","level":4,"score":0.38350000977516174},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.3628000020980835},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3303999900817871},{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.32510000467300415},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.32280001044273376},{"id":"https://openalex.org/C2777890099","wikidata":"https://www.wikidata.org/wiki/Q7169345","display_name":"Permissiveness","level":4,"score":0.3151000142097473},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.31439998745918274},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.3140999972820282},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.3059000074863434},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.30239999294281006},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.2962999939918518},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29580000042915344},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.2782999873161316},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26409998536109924},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.2581000030040741},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2551000118255615},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2540000081062317},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25200000405311584},{"id":"https://openalex.org/C2779288629","wikidata":"https://www.wikidata.org/wiki/Q199695","display_name":"Staphylococcus","level":4,"score":0.2515999972820282}],"mesh":[{"descriptor_ui":"D000071059","descriptor_name":"Phage Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000071059","descriptor_name":"Phage Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D013204","descriptor_name":"Staphylococcus Phages","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013204","descriptor_name":"Staphylococcus Phages","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013204","descriptor_name":"Staphylococcus Phages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013204","descriptor_name":"Staphylococcus Phages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017719","descriptor_name":"Diabetic Foot","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D017719","descriptor_name":"Diabetic Foot","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D017719","descriptor_name":"Diabetic Foot","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D017719","descriptor_name":"Diabetic Foot","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D058507","descriptor_name":"Host Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058507","descriptor_name":"Host Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/aac.00639-26","doi":"https://doi.org/10.1128/aac.00639-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00639-26","pdf_url":"https://journals.asm.org/doi/pdf/10.1128/aac.00639-26?download=true","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmid:42635480","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42635480","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1c2c9653f1bc42b6b65d79009d353b0f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/1c2c9653f1bc42b6b65d79009d353b0f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antimicrobial Agents and Chemotherapy, Vol 70, Iss 10 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1128/aac.00639-26","doi":"https://doi.org/10.1128/aac.00639-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00639-26","pdf_url":"https://journals.asm.org/doi/pdf/10.1128/aac.00639-26?download=true","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6364813446998596,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320328356","display_name":"R\u00e9gion Occitanie Pyr\u00e9n\u00e9es-M\u00e9diterran\u00e9e","ror":"https://ror.org/05mzwwx48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204148751.pdf","grobid_xml":"https://content.openalex.org/works/W7204148751.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W2015789053","https://openalex.org/W2062436856","https://openalex.org/W2075138421","https://openalex.org/W2081160508","https://openalex.org/W2125349610","https://openalex.org/W2152157304","https://openalex.org/W2626354203","https://openalex.org/W2741628575","https://openalex.org/W2796428137","https://openalex.org/W2797398310","https://openalex.org/W2887350091","https://openalex.org/W2922498192","https://openalex.org/W2971996162","https://openalex.org/W3012095315","https://openalex.org/W3082973737","https://openalex.org/W3143070288","https://openalex.org/W3165265585","https://openalex.org/W3181998104","https://openalex.org/W4223506823","https://openalex.org/W4229443239","https://openalex.org/W4283023479","https://openalex.org/W4296381497","https://openalex.org/W4296803708","https://openalex.org/W4303183519","https://openalex.org/W4307493886","https://openalex.org/W4309836734","https://openalex.org/W4311724598","https://openalex.org/W4313468814","https://openalex.org/W4360860759","https://openalex.org/W4379114384","https://openalex.org/W4388901502","https://openalex.org/W4389687764","https://openalex.org/W4392939795","https://openalex.org/W4394621578","https://openalex.org/W4399857161","https://openalex.org/W4402364559","https://openalex.org/W4402364622","https://openalex.org/W4402815517","https://openalex.org/W4403098193","https://openalex.org/W4409714622","https://openalex.org/W4410369179","https://openalex.org/W4415873340","https://openalex.org/W7148607753"],"related_works":[],"abstract_inverted_index":{"ABSTRACT":[0],"Diabetic":[1],"foot":[2],"infections":[3],"(DFIs)":[4],"are":[5],"a":[6,34,54,73,140,148],"major":[7],"complication":[8],"of":[9,49,76,95,183],"diabetes":[10],"frequently":[11],"involving":[12],"multidrug-resistant":[13],"Staphylococcus":[14],"aureus":[15,81,98],".":[16],"Their":[17],"persistence":[18],"and":[19,78,100,120,128,170,180,190],"therapeutic":[20,145,188],"complexity":[21],"underscore":[22],"the":[23,45,83,164,178,181,192],"urgent":[24],"need":[25,193],"for":[26,206],"alternatives":[27],"to":[28,112,186,194,202],"conventional":[29],"antibiotics.":[30],"Phage":[31],"therapy":[32,205],"offers":[33],"promising":[35],"solution,":[36],"though":[37],"its":[38],"clinical":[39],"application":[40],"is":[41],"often":[42],"limited":[43],"by":[44],"narrow":[46],"host":[47],"range":[48],"individual":[50],"phages.":[51],"Here,":[52],"SAVM02,":[53],"recently":[55],"characterized":[56],"staphylococcal":[57],"Kayvirus":[58],",":[59],"was":[60,110],"trained":[61,84],"using":[62],"directed":[63],"evolution":[64],"against":[65,105,147,157],"DFI":[66],"isolates.":[67],"After":[68],"20":[69],"iterative":[70],"passages":[71],"on":[72],"mixed":[74],"panel":[75],"susceptible":[77,150],"non-susceptible":[79],"S.":[80,97],"strains,":[82],"phage":[85,184,204],"pool":[86],"(SAVM02-P20)":[87],"displayed":[88],"markedly":[89],"enhanced":[90],"activity,":[91],"infecting":[92],"approximately":[93],"77%":[94],"tested":[96],"isolates":[99],"showing":[101],"partial":[102],"cross-species":[103],"activity":[104],"coagulase-negative":[106],"staphylococci.":[107],"Improved":[108],"infectivity":[109],"linked":[111],"increased":[113],"replication":[114],"efficiency":[115],"rather":[116],"than":[117],"adsorption.":[118],"Genomic":[119],"phylogenetic":[121],"analyses":[122],"further":[123],"suggested":[124],"recurrent":[125],"adaptive":[126],"changes":[127],"preferential":[129],"host-range":[130],"expansion":[131],"within":[132],"genetically":[133],"related":[134],"lineages.":[135],"In":[136],"vivo":[137,172],"testing":[138],"in":[139,167,171],"zebrafish":[141],"embryo":[142],"model":[143],"confirmed":[144],"efficacy":[146],"fully":[149],"strain":[151],"but":[152],"revealed":[153],"no":[154],"survival":[155],"benefit":[156],"an":[158],"initially":[159],"poorly":[160],"permissive":[161],"isolate,":[162],"highlighting":[163],"gap":[165],"between":[166],"vitro":[168],"adaptation":[169],"efficacy.":[173],"These":[174],"findings":[175],"demonstrate":[176],"both":[177],"potential":[179],"limitations":[182],"training":[185],"expand":[187],"coverage":[189],"emphasize":[191],"integrate":[195],"evolutionary":[196],"approaches":[197],"with":[198],"physiologically":[199],"relevant":[200],"models":[201],"optimize":[203],"chronic":[207],"infections,":[208],"such":[209],"as":[210],"DFIs.":[211]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-08-25T00:00:00"}