{"id":"https://openalex.org/W7204139149","doi":"https://doi.org/10.1186/s43162-026-00704-0","title":"Association between biotin deficiency and FOXP3 gene polymorphism (rs3761548) in patients with rheumatoid arthritis","display_name":"Association between biotin deficiency and FOXP3 gene polymorphism (rs3761548) in patients with rheumatoid arthritis","publication_year":2026,"publication_date":"2026-08-24","ids":{"openalex":"https://openalex.org/W7204139149","doi":"https://doi.org/10.1186/s43162-026-00704-0"},"language":"en","primary_location":{"id":"doi:10.1186/s43162-026-00704-0","doi":"https://doi.org/10.1186/s43162-026-00704-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43162-026-00704-0","pdf_url":"https://link.springer.com/content/pdf/10.1186/s43162-026-00704-0.pdf","source":{"id":"https://openalex.org/S2764563886","display_name":"The Egyptian Journal of Internal Medicine","issn_l":"1110-7782","issn":["1110-7782","2090-9098"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Egyptian Journal of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://link.springer.com/content/pdf/10.1186/s43162-026-00704-0.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147948557","display_name":"Arjeen Abdullah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405253865","display_name":"Erbil Polytechnic University","ror":"https://ror.org/015m6h915","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4405253865"]}],"countries":["IQ"],"is_corresponding":true,"raw_author_name":"Arjeen Abdullah","raw_affiliation_strings":["Medical Laboratory Technology Department, Erbil Technical Health and Medical College, Erbil Polytechnic University, Erbil, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Laboratory Technology Department, Erbil Technical Health and Medical College, Erbil Polytechnic University, Erbil, Iraq","institution_ids":["https://openalex.org/I4405253865"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038790153","display_name":"Najat Jabbar Ahmed Berwary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405253865","display_name":"Erbil Polytechnic University","ror":"https://ror.org/015m6h915","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4405253865"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Najat Berwary","raw_affiliation_strings":["Medical Laboratory Technology Department, Erbil Technical Health and Medical College, Erbil Polytechnic University, Erbil, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Laboratory Technology Department, Erbil Technical Health and Medical College, Erbil Polytechnic University, Erbil, Iraq","institution_ids":["https://openalex.org/I4405253865"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5147948557"],"corresponding_institution_ids":["https://openalex.org/I4405253865"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.68570112,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/biotin-deficiency","display_name":"biotin deficiency","score":0.9940000176429749},{"id":"https://openalex.org/keywords/foxp3-gene","display_name":"FOXP3 gene","score":0.8939999938011169},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8389999866485596},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.9300000071525574},{"id":"https://openalex.org/keywords/das28","display_name":"DAS28","score":0.9919999837875366},{"id":"https://openalex.org/keywords/biotin-metabolism","display_name":"biotin metabolism","score":0.8199999928474426},{"id":"https://openalex.org/keywords/iraqi-patients","display_name":"Iraqi patients","score":0.8339999914169312},{"id":"https://openalex.org/keywords/genetic-association-studies","display_name":"genetic association studies","score":0.4059999883174896},{"id":"https://openalex.org/keywords/vitamin-b6-deficiency","display_name":"vitamin B6 deficiency","score":0.4180000126361847},{"id":"https://openalex.org/keywords/vitamin-b12-deficiency","display_name":"vitamin B12 deficiency","score":0.5329999923706055},{"id":"https://openalex.org/keywords/folate-deficiency","display_name":"folate deficiency","score":0.6320000290870667},{"id":"https://openalex.org/keywords/vitamin-d-deficiency","display_name":"vitamin D deficiency","score":0.4569999873638153},{"id":"https://openalex.org/keywords/vitamin-c-deficiency","display_name":"scurvy","score":0.41999998688697815},{"id":"https://openalex.org/keywords/vitamin-e-deficiency","display_name":"vitamin E deficiency","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.824999988079071},{"id":"https://openalex.org/C2778204606","wikidata":"https://www.wikidata.org/wiki/Q181354","display_name":"Biotin","level":2,"score":0.7723000049591064},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.755299985408783},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5709999799728394},{"id":"https://openalex.org/C76252995","wikidata":"https://www.wikidata.org/wiki/Q3395645","display_name":"Gene polymorphism","level":4,"score":0.5135999917984009},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46000000834465027},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.45489999651908875},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.44269999861717224},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.41359999775886536},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4018999934196472},{"id":"https://openalex.org/C2776294945","wikidata":"https://www.wikidata.org/wiki/Q10264745","display_name":"Biotin deficiency","level":3,"score":0.3935999870300293},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.391400009393692},{"id":"https://openalex.org/C2776232647","wikidata":"https://www.wikidata.org/wiki/Q702883","display_name":"Rheumatoid factor","level":3,"score":0.3702000081539154},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.36559998989105225},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.36309999227523804},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3418000042438507},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.33970001339912415},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.3098999857902527},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2971999943256378},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.28439998626708984},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.2565000057220459},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.25589999556541443},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.2500999867916107}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/s43162-026-00704-0","doi":"https://doi.org/10.1186/s43162-026-00704-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43162-026-00704-0","pdf_url":"https://link.springer.com/content/pdf/10.1186/s43162-026-00704-0.pdf","source":{"id":"https://openalex.org/S2764563886","display_name":"The Egyptian Journal of Internal Medicine","issn_l":"1110-7782","issn":["1110-7782","2090-9098"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Egyptian Journal of Internal Medicine","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:6481fbd22f4d4f0eb24801f833b0184d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/6481fbd22f4d4f0eb24801f833b0184d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Egyptian Journal of Internal Medicine, Vol 38, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s43162-026-00704-0","doi":"https://doi.org/10.1186/s43162-026-00704-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43162-026-00704-0","pdf_url":"https://link.springer.com/content/pdf/10.1186/s43162-026-00704-0.pdf","source":{"id":"https://openalex.org/S2764563886","display_name":"The Egyptian Journal of Internal Medicine","issn_l":"1110-7782","issn":["1110-7782","2090-9098"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Egyptian Journal of Internal Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6957471370697021,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204139149.pdf","grobid_xml":"https://content.openalex.org/works/W7204139149.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W2123674181","https://openalex.org/W2320569320","https://openalex.org/W2471862261","https://openalex.org/W2516599843","https://openalex.org/W2791502366","https://openalex.org/W2938918172","https://openalex.org/W2993430745","https://openalex.org/W3130260997","https://openalex.org/W3155740597","https://openalex.org/W3165036066","https://openalex.org/W3175615054","https://openalex.org/W3201597969","https://openalex.org/W4214610062","https://openalex.org/W4226504248","https://openalex.org/W4285257599","https://openalex.org/W4382196365","https://openalex.org/W4388951857","https://openalex.org/W4389472389","https://openalex.org/W4390050176","https://openalex.org/W4390940890","https://openalex.org/W4399673289","https://openalex.org/W4401088064","https://openalex.org/W4410860891","https://openalex.org/W4410906070"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Rheumatoid":[2],"arthritis":[3],"(RA)":[4],"is":[5,54,84],"a":[6,27,55,85,116,235,266,302,312],"common":[7],"inflammatory":[8],"disease":[9,42,66,177,251,282],"characterized":[10],"by":[11,124,133],"synovial":[12],"tissue":[13],"swelling":[14],"and":[15,22,38,68,92,101,113,136,188,273,320,335],"inflammation":[16],"that":[17,299],"results":[18],"in":[19,34,57,74,150,159,171,200,241,318,323],"joint":[20],"destruction":[21],"dysfunction.":[23],"This":[24,103],"study":[25,48,105,232],"was":[26,122,131,139,174,204,263,274,290],"first":[28],"evaluation":[29],"of":[30,109,198,326],"serum":[31,58,97,147,222,245,295],"biotin":[32,59,98,120,148,172,223,239,246,296,307,321],"levels":[33,149,173,247],"patients":[35,89,112,211],"with":[36,41,65,90,243,249,276,293],"RA":[37,91,111,210,271],"the":[39,72,75,107,137,151,160,201,254,258,287,324],"relationships":[40],"activity":[43,283],"score":[44],"(DAS28).":[45],"The":[46,146,195,231],"current":[47],"aimed":[49],"to":[50,61,69,181],"determine":[51],"whether":[52,71],"there":[53],"deficiency":[56,240],"concentration,":[60],"explore":[62],"its":[63,336],"relationship":[64,334],"severity,":[67],"investigate":[70],"polymorphism":[73,95,218],"forkhead":[76],"box":[77],"P3":[78],"(":[79,163,183,190,212,225],"FOXP3":[80,202,259,319],")":[81],"gene":[82,203],"(rs3761548)":[83,219,260],"risk":[86,268],"factor":[87,269],"among":[88,208,284],"if":[93],"this":[94,333],"influences":[96,221],"concentration.":[99],"Materials":[100],"methods":[102],"case-control":[104],"involved":[106],"examination":[108],"136":[110],"85":[114],"as":[115,265],"control":[117,152],"group.":[118],"Serum":[119],"concentration":[121],"measured":[123],"Enzyme-Linked":[125],"Immunosorbent":[126],"Assay":[127],"(ELISA),":[128],"DNA":[129],"sequencing":[130],"performed":[132],"Sanger":[134],"sequencing,":[135],"DAS28":[138,278],"also":[140,291],"evaluated":[141],"for":[142,238,270],"all":[143],"patients.":[144],"Results":[145],"group":[153,162],"were":[154],"significantly":[155,205,220],"higher":[156,281,294],"than":[157],"those":[158],"patient":[161],"p":[164,184,191,213,226],"-value:":[165],"<0.001).":[166],"A":[167,196],"statistically":[168],"significant":[169,267,303],"difference":[170],"observed":[175],"across":[176],"severity":[178],"groups":[179],"according":[180],"DAS28/ESR":[182],"-value":[185,192,214,227],"=":[186,193,215,228],"0.034)":[187],"DAS28/CRP":[189],"0.021).":[194],"allele":[197],"rs3761548":[199,300],"more":[206],"prevalent":[207],"Iraqi":[209],"0.001).":[216],"Genetic":[217],"concentrations":[224],"0.019).":[229],"Conclusions":[230],"findings":[233,310],"support":[234],"pathophysiological":[236],"role":[237],"RA,":[242,327],"reduced":[244],"associated":[248,275,292],"increased":[250],"severity.":[252],"Under":[253],"recessive":[255],"genetic":[256,316],"model,":[257],"AA":[261,288],"genotype":[262,289],"identified":[264],"susceptibility":[272],"elevated":[277],"scores,":[279],"reflecting":[280],"carriers.":[285],"Interestingly,":[286],"concentrations,":[297],"indicating":[298],"exerts":[301],"influence":[304],"on":[305],"circulating":[306],"levels.":[308],"These":[309],"suggest":[311],"complex":[313],"interplay":[314],"between":[315],"variation":[317],"metabolism":[322],"pathogenesis":[325],"warranting":[328],"further":[329],"mechanistic":[330],"investigation":[331],"into":[332],"potential":[337],"clinical":[338],"implications.":[339]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-08-25T00:00:00"}
