{"id":"https://openalex.org/W7204138357","doi":"https://doi.org/10.21203/rs.3.rs-9565218/v1","title":"Metabolic rewiring promotes metastasis while enhancing NK cell recognition","display_name":"Metabolic rewiring promotes metastasis while enhancing NK cell recognition","publication_year":2026,"publication_date":"2026-08-24","ids":{"openalex":"https://openalex.org/W7204138357","doi":"https://doi.org/10.21203/rs.3.rs-9565218/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-9565218/v1","doi":"https://doi.org/10.21203/rs.3.rs-9565218/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-9565218/v1","pdf_url":"https://www.researchsquare.com/article/rs-9565218/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-9565218/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5094010784","display_name":"Sara Zemiti","orcid":"https://orcid.org/0009-0008-7141-8398","observed_orcids":["https://orcid.org/0009-0008-7141-8398"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sara Zemiti","raw_affiliation_strings":["Inserm U1183"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1183","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060432507","display_name":"Susana Prieto","orcid":"https://orcid.org/0000-0002-9746-2396","observed_orcids":["https://orcid.org/0000-0002-9746-2396"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210114166","display_name":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","ror":"https://ror.org/02785qs39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210114166"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Susana Prieto","raw_affiliation_strings":["CNRS UMR 5535"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS UMR 5535","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210114166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119482987","display_name":"Steffy Escayg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Steffy Escayg","raw_affiliation_strings":["Inserm U1183"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1183","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010928658","display_name":"Benjamin Hay","orcid":"https://orcid.org/0000-0001-7851-8393","observed_orcids":["https://orcid.org/0000-0001-7851-8393"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Benjamin Hay","raw_affiliation_strings":["Inserm U1183"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1183","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091088729","display_name":"Amel Bouzid","orcid":"https://orcid.org/0000-0002-8375-8022","observed_orcids":["https://orcid.org/0000-0002-8375-8022"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Amel Bouzid","raw_affiliation_strings":["Inserm U1183"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1183","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080984417","display_name":"Catherine Alexia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Catherine Alexia","raw_affiliation_strings":["University of Montpellier"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Montpellier","institution_ids":["https://openalex.org/I19894307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074516115","display_name":"Carine Jacquard","orcid":"https://orcid.org/0000-0003-0972-8455","observed_orcids":["https://orcid.org/0000-0003-0972-8455"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Carine Jacquard","raw_affiliation_strings":["Inserm U1183"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1183","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147953912","display_name":"Noemie Dudzinska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Noemie Dudzinska","raw_affiliation_strings":["Inserm U1183"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1183","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132593096","display_name":"Ananya Sen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ananya Sen","raw_affiliation_strings":["Inserm U1183"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1183","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148009979","display_name":"Jose Prudenciano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jose Prudenciano","raw_affiliation_strings":["Inserm U1183"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1183","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079308466","display_name":"Daouda Abba Moussa","orcid":"https://orcid.org/0000-0001-5841-4474","observed_orcids":["https://orcid.org/0000-0001-5841-4474"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Daouda Abba Moussa","raw_affiliation_strings":["Inserm U1183"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1183","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087869204","display_name":"Mauricio Campos\u2010Mora","orcid":"https://orcid.org/0000-0003-3736-8055","observed_orcids":["https://orcid.org/0000-0003-3736-8055"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mauricio Campos Mora","raw_affiliation_strings":["Inserm U1183"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1183","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025780107","display_name":"Sabine Gerbal\u2010Chaloin","orcid":"https://orcid.org/0000-0002-2549-7899","observed_orcids":["https://orcid.org/0000-0002-2549-7899"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sabine Gerbal-Chaloin","raw_affiliation_strings":["Institut de Recherche en Bioth\u00e9rapie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherche en Bioth\u00e9rapie","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057361924","display_name":"Michael G. Constantinides","orcid":"https://orcid.org/0000-0003-4770-7751","observed_orcids":["https://orcid.org/0000-0003-4770-7751"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michael Constantinides","raw_affiliation_strings":["Inserm U1183"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1183","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059782439","display_name":"Alberto Anel","orcid":"https://orcid.org/0000-0002-5175-8394","observed_orcids":["https://orcid.org/0000-0002-5175-8394"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alberto Anel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051740109","display_name":"Marion de Toledo","orcid":"https://orcid.org/0000-0002-7638-0041","observed_orcids":["https://orcid.org/0000-0002-7638-0041"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210114166","display_name":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","ror":"https://ror.org/02785qs39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210114166"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marion De Toledo","raw_affiliation_strings":["CNRS UMR 5535"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS UMR 5535","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210114166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049475672","display_name":"Oc\u00e9ane Paris","orcid":"https://orcid.org/0000-0003-3575-2117","observed_orcids":["https://orcid.org/0000-0003-3575-2117","https://orcid.org/0000-0002-3349-8250"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guillaume Bossis","raw_affiliation_strings":["CNRS"],"raw_orcid":"https://orcid.org/0000-0002-3349-8250","affiliations":[{"raw_affiliation_string":"CNRS","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109678046","display_name":"Ana Bella Aznar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210114166","display_name":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier","ror":"https://ror.org/02785qs39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210114166"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ana-Bella Aznar","raw_affiliation_strings":["CNRS UMR 5535"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS UMR 5535","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210114166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107220891","display_name":"Daniel Fisher","orcid":"https://orcid.org/0000-0002-0822-3482","observed_orcids":["https://orcid.org/0000-0002-0822-3482","https://orcid.org/0009-0002-6991-4567","https://orcid.org/0000-0002-5788-5861"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Daniel Fisher","raw_affiliation_strings":["CNRS"],"raw_orcid":"https://orcid.org/0000-0002-0822-3482","affiliations":[{"raw_affiliation_string":"CNRS","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025907859","display_name":"Farida Djouad","orcid":"https://orcid.org/0000-0001-8248-6822","observed_orcids":["https://orcid.org/0000-0001-8248-6822"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"farida djouad","raw_affiliation_strings":["INSERM U1183"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U1183","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075404589","display_name":"Yoan Arribat","orcid":"https://orcid.org/0000-0003-0952-5279","observed_orcids":["https://orcid.org/0000-0003-0952-5279"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yoan Arribat","raw_affiliation_strings":["Inserm U1183"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1183","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047257257","display_name":"Jean\u2010Fran\u00e7ois Rossi","orcid":"https://orcid.org/0000-0003-1562-8848","observed_orcids":["https://orcid.org/0000-0003-1562-8848"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Fran\u00e7ois Rossi","raw_affiliation_strings":["Institut du Cancer Avignon-Provence Sainte Catherine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut du Cancer Avignon-Provence Sainte Catherine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106124877","display_name":"Mart\u00edn Villalba","orcid":"https://orcid.org/0000-0002-4385-4888","observed_orcids":["https://orcid.org/0000-0002-4385-4888"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210095750","display_name":"Institute for Regenerative Medicine & Biotherapy","ror":"https://ror.org/00b8mh310","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210095750"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Martin Villalba","raw_affiliation_strings":["INSERM U1183 - Institute for Regenerative Medicine & Biotherapy"],"raw_orcid":"https://orcid.org/0000-0002-4385-4888","affiliations":[{"raw_affiliation_string":"INSERM U1183 - Institute for Regenerative Medicine & Biotherapy","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210095750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064705293","display_name":"Delphine Gitenay","orcid":"https://orcid.org/0000-0002-6043-4519","observed_orcids":["https://orcid.org/0000-0002-6043-4519"]},"institutions":[{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Delphine Gitenay","raw_affiliation_strings":["University of Montpellier"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Montpellier","institution_ids":["https://openalex.org/I19894307"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.017999999225139618,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.5},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9559999704360962},{"id":"https://openalex.org/keywords/dichloroacetate","display_name":"dichloroacetate","score":0.9409999847412109},{"id":"https://openalex.org/keywords/pyruvate-dehydrogenase-kinase-1","display_name":"pyruvate dehydrogenase kinase 1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/erk5","display_name":"ERK5","score":0.8399999737739563},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6290000081062317},{"id":"https://openalex.org/keywords/tumor-cell-migration-and-invasion","display_name":"tumor cell migration and invasion","score":0.781000018119812},{"id":"https://openalex.org/keywords/lipid-droplets","display_name":"lipid droplets","score":0.8650000095367432},{"id":"https://openalex.org/keywords/palmitic-acid","display_name":"palmitic acid","score":0.7300000190734863},{"id":"https://openalex.org/keywords/stearic-acid","display_name":"stearic acid","score":0.9639999866485596},{"id":"https://openalex.org/keywords/tumor-spheroids","display_name":"tumor spheroids","score":0.6840000152587891},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6700000166893005},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.41200000047683716}],"concepts":[{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.7376999855041504},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.6176000237464905},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5823000073432922},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4706999957561493},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.46709999442100525},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44510000944137573},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43970000743865967},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.43470001220703125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4284999966621399},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4099000096321106},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.4077000021934509},{"id":"https://openalex.org/C2778160063","wikidata":"https://www.wikidata.org/wiki/Q1532402","display_name":"Glutaminolysis","level":4,"score":0.40389999747276306},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.3993000090122223},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3937000036239624},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.35670000314712524},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.35190001130104065},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3499000072479248},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.3343000113964081},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3253999948501587},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.30649998784065247},{"id":"https://openalex.org/C2778050619","wikidata":"https://www.wikidata.org/wiki/Q6058567","display_name":"Intravasation","level":4,"score":0.2930000126361847},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.28929999470710754},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.28349998593330383},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.26989999413490295},{"id":"https://openalex.org/C2778867473","wikidata":"https://www.wikidata.org/wiki/Q17544382","display_name":"NKG2D","level":4,"score":0.2689000070095062},{"id":"https://openalex.org/C9506865","wikidata":"https://www.wikidata.org/wiki/Q6321025","display_name":"Pyruvate dehydrogenase kinase","level":4,"score":0.2590999901294708},{"id":"https://openalex.org/C2776991927","wikidata":"https://www.wikidata.org/wiki/Q14860867","display_name":"Fatty acid metabolism","level":3,"score":0.2578999996185303},{"id":"https://openalex.org/C55885012","wikidata":"https://www.wikidata.org/wiki/Q4750801","display_name":"Anaerobic glycolysis","level":4,"score":0.2551000118255615},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.25360000133514404},{"id":"https://openalex.org/C10730799","wikidata":"https://www.wikidata.org/wiki/Q18030568","display_name":"PKM2","level":5,"score":0.2515000104904175}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-9565218/v1","doi":"https://doi.org/10.21203/rs.3.rs-9565218/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-9565218/v1","pdf_url":"https://www.researchsquare.com/article/rs-9565218/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-9565218/v1","doi":"https://doi.org/10.21203/rs.3.rs-9565218/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-9565218/v1","pdf_url":"https://www.researchsquare.com/article/rs-9565218/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1190173965","display_name":null,"funder_award_id":"France2030","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G1765343022","display_name":"Next generation metabolomics and fluxomics, from population to single cells","funder_award_id":"ANR-21-ESRE-0035","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2450198060","display_name":null,"funder_award_id":"10-INBS-04","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G4291823705","display_name":null,"funder_award_id":"10-LABX-53","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G5802621812","display_name":null,"funder_award_id":"ANR-11-INBS","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7080048889","display_name":null,"funder_award_id":"ANR-23","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7240651115","display_name":null,"funder_award_id":"ANR-10","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7320293343","display_name":"MetaboHUB National Infrastructure of metabolomics and fluxomics","funder_award_id":"ANR-24-INBS-0012","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7376787254","display_name":null,"funder_award_id":"ANR-10-LABX","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7740977694","display_name":null,"funder_award_id":"ANR\u201010\u2010LABX\u201053","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7834527590","display_name":"Generation of iChondrocytes to regenerate articular cartilage","funder_award_id":"ANR-22-PEBI-0002","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8832936257","display_name":null,"funder_award_id":"2021-014","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8907031238","display_name":"D\u00e9veloppement d'une infrastructure fran\u00e7aise distribu\u00e9e pour la m\u00e9tabolomique d\u00e9di\u00e9e \u00e0 l'innovation","funder_award_id":"ANR-11-INBS-0010","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320323183","display_name":"Centre Hospitalier R\u00e9gional Universitaire de Montpellier","ror":"https://ror.org/00mthsf17"},{"id":"https://openalex.org/F4320323807","display_name":"Institut National Du Cancer","ror":"https://ror.org/03m8vkq32"},{"id":"https://openalex.org/F4320324952","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72"},{"id":"https://openalex.org/F4320325668","display_name":"Direction G\u00e9n\u00e9rale de l\u2019offre de Soins","ror":null},{"id":"https://openalex.org/F4320328356","display_name":"R\u00e9gion Occitanie Pyr\u00e9n\u00e9es-M\u00e9diterran\u00e9e","ror":"https://ror.org/05mzwwx48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204138357.pdf","grobid_xml":"https://content.openalex.org/works/W7204138357.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1656032348","https://openalex.org/W1958915959","https://openalex.org/W1975538229","https://openalex.org/W1993021622","https://openalex.org/W2018971639","https://openalex.org/W2022101765","https://openalex.org/W2042037279","https://openalex.org/W2056633943","https://openalex.org/W2057001750","https://openalex.org/W2073300038","https://openalex.org/W2078950332","https://openalex.org/W2094093571","https://openalex.org/W2100723895","https://openalex.org/W2119634636","https://openalex.org/W2137906256","https://openalex.org/W2142256141","https://openalex.org/W2151260260","https://openalex.org/W2158062858","https://openalex.org/W2161956550","https://openalex.org/W2266814182","https://openalex.org/W2295060570","https://openalex.org/W2475419192","https://openalex.org/W2560396365","https://openalex.org/W2586098317","https://openalex.org/W2605607341","https://openalex.org/W2753117160","https://openalex.org/W2767005279","https://openalex.org/W2782792215","https://openalex.org/W2793012188","https://openalex.org/W2793124274","https://openalex.org/W2800106575","https://openalex.org/W2808995183","https://openalex.org/W2892839743","https://openalex.org/W2896220657","https://openalex.org/W2907544179","https://openalex.org/W2923005485","https://openalex.org/W2929374192","https://openalex.org/W2939811893","https://openalex.org/W2964245665","https://openalex.org/W2969502145","https://openalex.org/W2990278574","https://openalex.org/W2995413550","https://openalex.org/W3001496296","https://openalex.org/W3001738994","https://openalex.org/W3009639434","https://openalex.org/W3116612664","https://openalex.org/W3138521592","https://openalex.org/W4214656594","https://openalex.org/W4220734200","https://openalex.org/W4220811415","https://openalex.org/W4224233962","https://openalex.org/W4225252352","https://openalex.org/W4225434005","https://openalex.org/W4226098344","https://openalex.org/W4319736966","https://openalex.org/W4380987185","https://openalex.org/W4385461115","https://openalex.org/W4400839103","https://openalex.org/W4401354247","https://openalex.org/W4414925096"],"related_works":["https://openalex.org/W4413843120","https://openalex.org/W4414925096","https://openalex.org/W4411937492","https://openalex.org/W4214656594","https://openalex.org/W2782792215","https://openalex.org/W4406253302","https://openalex.org/W4311116429","https://openalex.org/W4409632556","https://openalex.org/W4392388371","https://openalex.org/W3139876210"],"abstract_inverted_index":{"Abstract":[0],"To":[1],"colonize":[2],"new":[3],"environments,":[4],"cancer":[5,28,65,158],"cells":[6,29,66,133,146,159,199],"undergo":[7],"epithelial-to-mesenchymal":[8],"transition":[9],"(EMT),":[10],"enabling":[11],"detachment":[12],"and":[13,48,82,118,122,189,200,206],"migration,":[14],"but":[15],"this":[16],"phenomenon":[17],"remains":[18],"largely":[19],"controlled":[20],"by":[21,70,166,208],"Natural":[22],"Killer":[23],"(NK)":[24],"cells.":[25],"During":[26],"EMT,":[27],"shift":[30,218],"their":[31,86,181],"metabolism":[32],"toward":[33],"fatty":[34],"acid":[35],"oxidation":[36],"(FAO),":[37],"partly":[38],"replacing":[39],"glycolysis":[40],"to":[41,67,107,176],"meet":[42],"the":[43,92,194],"energy":[44],"demands":[45],"for":[46],"migration":[47,121,149],"invasion.":[49,123],"This":[50],"may":[51],"impact":[52],"NK":[53,129,132,213],"cell-mediated":[54],"surveillance":[55],"through":[56],"an":[57],"unclear":[58],"mechanism.":[59],"Here,":[60],"we":[61],"demonstrate":[62],"that":[63,219],"forcing":[64],"perform":[68],"FAO":[69,89,125,185],"inhibiting":[71],"pyruvate":[72],"dehydrogenase":[73],"kinase":[74],"1":[75],"with":[76],"dichloroacetate":[77],"(DCA)":[78],"decreases":[79],"intracellular":[80],"palmitic":[81],"stearic":[83],"acids,":[84],"reflecting":[85],"utilization":[87],"as":[88,212],"substrates,":[90],"whereas":[91,154],"rise":[93],"in":[94,150],"neutral":[95],"lipids":[96],"reflects":[97],"compensatory":[98],"lipid-droplet":[99],"formation,":[100],"a":[101,151,216],"hallmark":[102],"of":[103,197],"FAO-driven":[104],"states":[105],"linked":[106],"EMT.":[108],"Moreover,":[109],"DCA":[110],"activates":[111],"extracellular":[112],"signal-regulated":[113],"kinase-5":[114],"(ERK5),":[115],"triggering":[116],"EMT":[117],"tumor":[119,138,191],"cell":[120,130],"Concomitantly,":[124],"induces":[126],"ligands":[127],"mediating":[128],"recognition.":[131],"better":[134],"infiltrated":[135],"DCA-treated":[136,145],"3D":[137],"spheroids,":[139],"where":[140],"they":[141],"exerted":[142],"cytotoxic":[143],"effects.":[144],"showed":[147],"increased":[148,174],"zebrafish":[152],"model,":[153],"metastasis":[155,188],"from":[156],"mammary":[157],"grafted":[160],"into":[161],"immune-deficient":[162],"mice":[163],"was":[164],"enhanced":[165],"DCA.":[167],"Cells":[168],"undergoing":[169],"DCA-induced":[170],"migratory":[171],"reprogramming":[172],"exhibit":[173],"susceptibility":[175],"NK-cell-mediated":[177],"control,":[178],"which":[179],"limit":[180],"invasive":[182],"potential.":[183],"Hence,":[184],"promotes":[186],"both":[187],"NK-mediated":[190],"surveillance,":[192],"highlighting":[193],"Achilles\u2019":[195],"heel":[196],"metastatic":[198],"therapeutic":[201],"opportunities.":[202],"Teaser":[203],"Metastasis":[204],"recognition":[205],"killing":[207],"immune":[209],"cells,":[210,214],"such":[211],"requires":[215],"metabolic":[217],"relies":[220],"on":[221],"lipid":[222],"metabolism.":[223]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-08-25T00:00:00"}
