{"id":"https://openalex.org/W7204137084","doi":"https://doi.org/10.1016/j.isci.2026.117277","title":"NF-\u03baB-driven immune checkpoint knockdown and cytokine expression in cancer cells for tumor immunotherapy","display_name":"NF-\u03baB-driven immune checkpoint knockdown and cytokine expression in cancer cells for tumor immunotherapy","publication_year":2026,"publication_date":"2026-08-24","ids":{"openalex":"https://openalex.org/W7204137084","doi":"https://doi.org/10.1016/j.isci.2026.117277","pmid":"https://pubmed.ncbi.nlm.nih.gov/42699051","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13542514"},"language":"en","primary_location":{"id":"doi:10.1016/j.isci.2026.117277","doi":"https://doi.org/10.1016/j.isci.2026.117277","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2026.117277","pdf_url":null,"source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.isci.2026.117277","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017375944","display_name":"Yile Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yile Wang","raw_affiliation_strings":["School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148021481","display_name":"Ziyan Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyan Kong","raw_affiliation_strings":["School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059039993","display_name":"Yunqi Zhao","orcid":"https://orcid.org/0000-0001-5471-6125","observed_orcids":["https://orcid.org/0000-0001-5471-6125"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunqi Zhao","raw_affiliation_strings":["School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5155231830","display_name":"Bing Pei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing Pei","raw_affiliation_strings":["Suqian Clinical College, Xuzhou Medical University, Xuzhou, China","Suqian First People's Hospital, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suqian Clinical College, Xuzhou Medical University, Xuzhou, China","institution_ids":[]},{"raw_affiliation_string":"Suqian First People's Hospital, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147942664","display_name":"Jian Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Sun","raw_affiliation_strings":["Suqian First People's Hospital, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suqian First People's Hospital, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130612317","display_name":"Xueyuan Mao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xueyuan Mao","raw_affiliation_strings":["Suqian Clinical College, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suqian Clinical College, Xuzhou Medical University, Xuzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101791680","display_name":"Weida Gong","orcid":"https://orcid.org/0000-0003-3589-5185","observed_orcids":["https://orcid.org/0000-0003-3589-5185"]},"institutions":[{"id":"https://openalex.org/I4210139780","display_name":"Yixing People's Hospital","ror":"https://ror.org/049avne82","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weida Gong","raw_affiliation_strings":["Yixing People's Hospital, Yixing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yixing People's Hospital, Yixing, China","institution_ids":["https://openalex.org/I4210139780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148001680","display_name":"Ying Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Chen","raw_affiliation_strings":["School of Medical Technology, Xuzhou Medical University, Xuzhou 221004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Technology, Xuzhou Medical University, Xuzhou 221004, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132856422","display_name":"Rong Yin","orcid":"https://orcid.org/0000-0002-9744-4251","observed_orcids":["https://orcid.org/0000-0002-9744-4251"]},"institutions":[{"id":"https://openalex.org/I4210128482","display_name":"Jiangsu Cancer Hospital","ror":"https://ror.org/03108sf43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128482"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Yin","raw_affiliation_strings":["Jiangsu Cancer Hospital, Nanjing Medical University, Nanjing 21009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Cancer Hospital, Nanjing Medical University, Nanjing 21009, China","institution_ids":["https://openalex.org/I4210128482","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152986164","display_name":"Meng Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Cao","raw_affiliation_strings":["Division of Breast Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Breast Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090613548","display_name":"Jinke Wang","orcid":"https://orcid.org/0000-0002-3352-4690","observed_orcids":["https://orcid.org/0000-0002-3352-4690"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jinke Wang","raw_affiliation_strings":["School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China"],"raw_orcid":"https://orcid.org/0000-0002-3352-4690","affiliations":[{"raw_affiliation_string":"School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I76569877"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5090613548"],"corresponding_institution_ids":["https://openalex.org/I76569877"],"apc_list":{"value":3240,"currency":"USD","value_usd":3240},"apc_paid":{"value":3240,"currency":"USD","value_usd":3240},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"9","first_page":"117277","last_page":"117277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5386000275611877,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5386000275611877,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.3801000118255615,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.06300000101327896,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8500000238418579},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.640999972820282},{"id":"https://openalex.org/keywords/il-15","display_name":"IL-15","score":0.8700000047683716},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.968999981880188},{"id":"https://openalex.org/keywords/cd47","display_name":"CD47","score":0.9980000257492065},{"id":"https://openalex.org/keywords/microrna-knockdown","display_name":"microRNA knockdown","score":0.7739999890327454},{"id":"https://openalex.org/keywords/adeno-associated-virus-vectors","display_name":"adeno-associated virus vectors","score":0.6800000071525574},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8799999952316284},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.7379999756813049},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.5690000057220459},{"id":"https://openalex.org/keywords/biosafety","display_name":"biosafety","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.6690000295639038},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6502000093460083},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6341999769210815},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6039000153541565},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.5138000249862671},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5113999843597412},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5047000050544739},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.413100004196167},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.3806999921798706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3743000030517578},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3732999861240387},{"id":"https://openalex.org/C3017712846","wikidata":"https://www.wikidata.org/wiki/Q4891747","display_name":"Tumor immunology","level":4,"score":0.3714999854564667},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34380000829696655},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3140999972820282},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.28999999165534973},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2874999940395355},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.26649999618530273}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.isci.2026.117277","doi":"https://doi.org/10.1016/j.isci.2026.117277","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2026.117277","pdf_url":null,"source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},{"id":"doi:10.1101/2025.03.14.643237","doi":"https://doi.org/10.1101/2025.03.14.643237","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.03.14.643237","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13542514","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13542514/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13542514/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Text"},{"id":"pmid:42699051","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42699051","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b709a0f92b514e4da13d945565328fff","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b709a0f92b514e4da13d945565328fff","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"iScience, Vol 29, Iss 9, Pp 117277- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.isci.2026.117277","doi":"https://doi.org/10.1016/j.isci.2026.117277","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2026.117277","pdf_url":null,"source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5972688414","display_name":null,"funder_award_id":"62371126","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6000001051","display_name":null,"funder_award_id":"SY202201","funder_id":"https://openalex.org/F4320326708","funder_display_name":"Suzhou Municipal Science and Technology Bureau"},{"id":"https://openalex.org/G6490087079","display_name":null,"funder_award_id":"2022YFA1205802","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8078570750","display_name":null,"funder_award_id":"2022YFA1205802","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326708","display_name":"Suzhou Municipal Science and Technology Bureau","ror":"https://ror.org/02vpk4745"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204137084.pdf","grobid_xml":"https://content.openalex.org/works/W7204137084.grobid-xml"},"referenced_works_count":107,"referenced_works":["https://openalex.org/W1541696647","https://openalex.org/W1930470734","https://openalex.org/W1975047479","https://openalex.org/W1985981664","https://openalex.org/W1990602451","https://openalex.org/W1991235944","https://openalex.org/W1998887003","https://openalex.org/W2066671159","https://openalex.org/W2082025265","https://openalex.org/W2083982805","https://openalex.org/W2089881927","https://openalex.org/W2103746815","https://openalex.org/W2125010485","https://openalex.org/W2341432578","https://openalex.org/W2411413300","https://openalex.org/W2509486054","https://openalex.org/W2756648224","https://openalex.org/W2767343890","https://openalex.org/W2784099979","https://openalex.org/W2790574591","https://openalex.org/W2795318100","https://openalex.org/W2804840825","https://openalex.org/W2887249435","https://openalex.org/W2889258202","https://openalex.org/W2891486030","https://openalex.org/W2891771728","https://openalex.org/W2899044337","https://openalex.org/W2899259030","https://openalex.org/W2911897655","https://openalex.org/W2914335731","https://openalex.org/W2923939395","https://openalex.org/W2934922729","https://openalex.org/W2940759533","https://openalex.org/W2952065098","https://openalex.org/W2965639414","https://openalex.org/W2974280214","https://openalex.org/W2981768007","https://openalex.org/W2982130750","https://openalex.org/W3005012213","https://openalex.org/W3012961639","https://openalex.org/W3021099711","https://openalex.org/W3032166296","https://openalex.org/W3084246765","https://openalex.org/W3087030402","https://openalex.org/W3094924173","https://openalex.org/W3101474684","https://openalex.org/W3118995603","https://openalex.org/W3124855491","https://openalex.org/W3189195217","https://openalex.org/W3196581634","https://openalex.org/W3203459564","https://openalex.org/W3216844160","https://openalex.org/W4205683421","https://openalex.org/W4220762010","https://openalex.org/W4225349156","https://openalex.org/W4282830693","https://openalex.org/W4296373959","https://openalex.org/W4308000162","https://openalex.org/W4308595111","https://openalex.org/W4309438509","https://openalex.org/W4315643308","https://openalex.org/W4318672176","https://openalex.org/W4319320281","https://openalex.org/W4327571871","https://openalex.org/W4360978581","https://openalex.org/W4367834077","https://openalex.org/W4376506371","https://openalex.org/W4377221253","https://openalex.org/W4383301908","https://openalex.org/W4385798580","https://openalex.org/W4386165685","https://openalex.org/W4387077130","https://openalex.org/W4387475882","https://openalex.org/W4388002844","https://openalex.org/W4388515908","https://openalex.org/W4388860142","https://openalex.org/W4390946922","https://openalex.org/W4391671392","https://openalex.org/W4391757110","https://openalex.org/W4391973023","https://openalex.org/W4392462230","https://openalex.org/W4392814800","https://openalex.org/W4393251580","https://openalex.org/W4393935425","https://openalex.org/W4394596037","https://openalex.org/W4394855104","https://openalex.org/W4394933704","https://openalex.org/W4396547546","https://openalex.org/W4396703026","https://openalex.org/W4399568528","https://openalex.org/W4399775085","https://openalex.org/W4399790396","https://openalex.org/W4400372296","https://openalex.org/W4400748356","https://openalex.org/W4401044812","https://openalex.org/W4402185680","https://openalex.org/W4403539506","https://openalex.org/W4403734664","https://openalex.org/W4403918309","https://openalex.org/W4403954808","https://openalex.org/W4403963399","https://openalex.org/W4404640937","https://openalex.org/W4404749043","https://openalex.org/W4407394330","https://openalex.org/W4407922316","https://openalex.org/W4412378589","https://openalex.org/W7124854533"],"related_works":["https://openalex.org/W4408610502","https://openalex.org/W4392292468","https://openalex.org/W2891771728","https://openalex.org/W2234770040","https://openalex.org/W4415333108","https://openalex.org/W3110771880","https://openalex.org/W2589987575","https://openalex.org/W4206952776","https://openalex.org/W2739636520","https://openalex.org/W4229444633"],"abstract_inverted_index":{"Cancer":[0],"immunotherapy":[1,141],"has":[2],"made":[3],"significant":[4,116],"advancements,":[5],"as":[6],"immune":[7,34,61],"checkpoint":[8],"inhibitors":[9],"and":[10,56,64,80,83,101,104,122,139],"cytokines":[11],"are":[12,21],"widely":[13],"applied":[14],"in":[15,69,93,144],"the":[16,33,75,90,113,145],"clinic.":[17],"Nonetheless,":[18],"these":[19],"therapies":[20],"often":[22],"challenged":[23],"by":[24,50],"severe":[25],"side":[26],"effects":[27],"arising":[28],"from":[29],"inappropriate":[30],"activation":[31],"of":[32,74],"system":[35],"or":[36],"systemic":[37],"toxicity.":[38],"Herein,":[39],"we":[40],"constructed":[41],"a":[42,135],"tumor-selective,":[43],"safe":[44],"therapeutic":[45],"gene":[46],"cassette":[47,76,91,114],"specifically":[48],"activated":[49,100],"NF-\u03baB":[51,67,88],"to":[52,77],"produce":[53,78],"cytokine":[54],"IL-15":[55,79],"microRNAs":[57],"silencing":[58],"two":[59],"key":[60],"checkpoints,":[62],"PD-L1":[63,82],"CD47.":[65],"High":[66],"activity":[68],"cancer":[70],"cells":[71],"drove":[72],"expression":[73],"suppress":[81],"CD47,":[84],"while":[85],"low":[86],"basal":[87],"rendered":[89],"silent":[92],"most":[94],"normal":[95],"cells.":[96],"This":[97],"design":[98],"simultaneously":[99],"enhanced":[102],"adaptive":[103],"innate":[105],"immunity.":[106],"A":[107],"recombinant":[108],"adeno-associated":[109],"virus":[110],"(AAV2)":[111],"delivering":[112],"showed":[115],"antitumor":[117],"effects,":[118],"favorable":[119],"tumor":[120,128],"selectivity,":[121],"biosafety":[123],"across":[124],"multiple":[125],"murine":[126],"solid":[127],"models.":[129],"Consequently,":[130],"this":[131],"treatment":[132],"may":[133],"offer":[134],"potentially":[136],"more":[137],"effective":[138],"safer":[140],"against":[142],"cancers":[143],"future.":[146]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-08-25T00:00:00"}
