{"id":"https://openalex.org/W7204135609","doi":"https://doi.org/10.1038/s41598-026-68028-1","title":"Embryonic loss of hexokinase 2 promotes cortical progenitor proliferation and causes autism-like behaviors in mice","display_name":"Embryonic loss of hexokinase 2 promotes cortical progenitor proliferation and causes autism-like behaviors in mice","publication_year":2026,"publication_date":"2026-08-24","ids":{"openalex":"https://openalex.org/W7204135609","doi":"https://doi.org/10.1038/s41598-026-68028-1"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-68028-1","doi":"https://doi.org/10.1038/s41598-026-68028-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-68028-1","pdf_url":"https://www.nature.com/articles/s41598-026-68028-1_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-68028-1_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147965637","display_name":"Lijuan Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178232147","display_name":"Guizhou University","ror":"https://ror.org/02wmsc916","country_code":"CN","type":"education","lineage":["https://openalex.org/I178232147"]},{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210149412","display_name":"Second Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/047aw1y82","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149412"]},{"id":"https://openalex.org/I4210154454","display_name":"Guizhou Provincial People's Hospital","ror":"https://ror.org/046q1bp69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154454"]},{"id":"https://openalex.org/I4405259434","display_name":"Guangdong Institute of Intelligence Science and Technology","ror":"https://ror.org/027v2y954","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405259434"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijuan Zhang","raw_affiliation_strings":["Department of Pathology, Guizhou Provincial People\u2019s Hospital, Guizhou University, Guiyang, 550002, Guizhou, China","Department of Pathology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, China","Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, 519031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Guizhou Provincial People\u2019s Hospital, Guizhou University, Guiyang, 550002, Guizhou, China","institution_ids":["https://openalex.org/I178232147","https://openalex.org/I4210154454"]},{"raw_affiliation_string":"Department of Pathology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, China","institution_ids":["https://openalex.org/I197869895","https://openalex.org/I4210149412"]},{"raw_affiliation_string":"Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, 519031, China","institution_ids":["https://openalex.org/I4405259434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073592705","display_name":"Mingchun Liao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204512498","display_name":"University of Macau","ror":"https://ror.org/01r4q9n85","country_code":"MO","type":"education","lineage":["https://openalex.org/I204512498"]},{"id":"https://openalex.org/I4405259434","display_name":"Guangdong Institute of Intelligence Science and Technology","ror":"https://ror.org/027v2y954","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405259434"]}],"countries":["CN","MO"],"is_corresponding":false,"raw_author_name":"Mingchun Liao","raw_affiliation_strings":["Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, 519031, China","The State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, 519031, China","institution_ids":["https://openalex.org/I4405259434"]},{"raw_affiliation_string":"The State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China","institution_ids":["https://openalex.org/I204512498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136013070","display_name":"Yichen Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405259434","display_name":"Guangdong Institute of Intelligence Science and Technology","ror":"https://ror.org/027v2y954","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405259434"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yichen Wu","raw_affiliation_strings":["Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, 519031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, 519031, China","institution_ids":["https://openalex.org/I4405259434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121064493","display_name":"Dandan Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405259434","display_name":"Guangdong Institute of Intelligence Science and Technology","ror":"https://ror.org/027v2y954","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405259434"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dandan Zheng","raw_affiliation_strings":["Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, 519031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, 519031, China","institution_ids":["https://openalex.org/I4405259434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121088108","display_name":"Yuxiang Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405259434","display_name":"Guangdong Institute of Intelligence Science and Technology","ror":"https://ror.org/027v2y954","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405259434"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxiang Pan","raw_affiliation_strings":["Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, 519031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, 519031, China","institution_ids":["https://openalex.org/I4405259434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147963851","display_name":"Wei Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405259434","display_name":"Guangdong Institute of Intelligence Science and Technology","ror":"https://ror.org/027v2y954","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405259434"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Liu","raw_affiliation_strings":["Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, 519031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, 519031, China","institution_ids":["https://openalex.org/I4405259434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101987668","display_name":"Xiaohui Deng","orcid":"https://orcid.org/0000-0003-0030-439X","observed_orcids":["https://orcid.org/0000-0003-0030-439X"]},"institutions":[{"id":"https://openalex.org/I4405259434","display_name":"Guangdong Institute of Intelligence Science and Technology","ror":"https://ror.org/027v2y954","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405259434"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohui Deng","raw_affiliation_strings":["Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, 519031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, 519031, China","institution_ids":["https://openalex.org/I4405259434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100776874","display_name":"Yiyang Li","orcid":"https://orcid.org/0000-0002-5791-9371","observed_orcids":["https://orcid.org/0000-0002-5791-9371"]},"institutions":[{"id":"https://openalex.org/I204512498","display_name":"University of Macau","ror":"https://ror.org/01r4q9n85","country_code":"MO","type":"education","lineage":["https://openalex.org/I204512498"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Yiyang Li","raw_affiliation_strings":["The State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China","institution_ids":["https://openalex.org/I204512498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153018050","display_name":"Yonghua Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204512498","display_name":"University of Macau","ror":"https://ror.org/01r4q9n85","country_code":"MO","type":"education","lineage":["https://openalex.org/I204512498"]}],"countries":["MO"],"is_corresponding":true,"raw_author_name":"Yonghua Zhao","raw_affiliation_strings":["Department of Urology, The First People\u2019s Hospital of Jinzhong, Jinzhong, 030600, Shanxi, China","The State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First People\u2019s Hospital of Jinzhong, Jinzhong, 030600, Shanxi, China","institution_ids":[]},{"raw_affiliation_string":"The State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China","institution_ids":["https://openalex.org/I204512498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153018050","display_name":"Yonghua Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204512498","display_name":"University of Macau","ror":"https://ror.org/01r4q9n85","country_code":"MO","type":"education","lineage":["https://openalex.org/I204512498"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Yonghua Zhao","raw_affiliation_strings":["Department of Urology, The First People\u2019s Hospital of Jinzhong, Jinzhong, 030600, Shanxi, China","The State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First People\u2019s Hospital of Jinzhong, Jinzhong, 030600, Shanxi, China","institution_ids":[]},{"raw_affiliation_string":"The State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China","institution_ids":["https://openalex.org/I204512498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147930476","display_name":"Yun Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204512498","display_name":"University of Macau","ror":"https://ror.org/01r4q9n85","country_code":"MO","type":"education","lineage":["https://openalex.org/I204512498"]}],"countries":["MO"],"is_corresponding":true,"raw_author_name":"Yun Zhao","raw_affiliation_strings":["Department of Urology, The First People\u2019s Hospital of Jinzhong, Jinzhong, 030600, Shanxi, China","The State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First People\u2019s Hospital of Jinzhong, Jinzhong, 030600, Shanxi, China","institution_ids":[]},{"raw_affiliation_string":"The State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China","institution_ids":["https://openalex.org/I204512498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147930476","display_name":"Yun Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204512498","display_name":"University of Macau","ror":"https://ror.org/01r4q9n85","country_code":"MO","type":"education","lineage":["https://openalex.org/I204512498"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Yun Zhao","raw_affiliation_strings":["Department of Urology, The First People\u2019s Hospital of Jinzhong, Jinzhong, 030600, Shanxi, China","The State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First People\u2019s Hospital of Jinzhong, Jinzhong, 030600, Shanxi, China","institution_ids":[]},{"raw_affiliation_string":"The State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China","institution_ids":["https://openalex.org/I204512498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147947772","display_name":"Qiang Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210149412","display_name":"Second Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/047aw1y82","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149412"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qiang Wu","raw_affiliation_strings":["Department of Pathology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, China","institution_ids":["https://openalex.org/I197869895","https://openalex.org/I4210149412"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100372311","display_name":"Bin Wang","orcid":"https://orcid.org/0000-0001-7862-6853","observed_orcids":["https://orcid.org/0000-0001-7862-6853"]},"institutions":[{"id":"https://openalex.org/I4405259434","display_name":"Guangdong Institute of Intelligence Science and Technology","ror":"https://ror.org/027v2y954","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405259434"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bin Wang","raw_affiliation_strings":["Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, 519031, China"],"raw_orcid":"https://orcid.org/0000-0001-7862-6853","affiliations":[{"raw_affiliation_string":"Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, 519031, China","institution_ids":["https://openalex.org/I4405259434"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100372311","https://openalex.org/A5147930476","https://openalex.org/A5147947772","https://openalex.org/A5153018050"],"corresponding_institution_ids":["https://openalex.org/I197869895","https://openalex.org/I204512498","https://openalex.org/I4210149412","https://openalex.org/I4405259434"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.69897711,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hexokinase-2","display_name":"hexokinase 2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cortical-progenitor-cells","display_name":"cortical progenitor cells","score":0.6980000138282776},{"id":"https://openalex.org/keywords/cortical-development","display_name":"cortical development","score":0.5260000228881836},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/neurodevelopmental-disorders","display_name":"neurodevelopmental disorders","score":0.8209999799728394},{"id":"https://openalex.org/keywords/autism-like-behavior","display_name":"autism-like behavior","score":0.8899999856948853},{"id":"https://openalex.org/keywords/neural-progenitor-cell-proliferation","display_name":"neural progenitor proliferation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.7570000290870667},{"id":"https://openalex.org/keywords/txnip","display_name":"TXNIP","score":0.9559999704360962},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/conditional-knockout-mice","display_name":"conditional knockout mice","score":0.6269999742507935},{"id":"https://openalex.org/keywords/social-interaction-deficits","display_name":"social interaction deficits","score":0.6600000262260437},{"id":"https://openalex.org/keywords/repetitive-behavior","display_name":"repetitive behavior","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C108619961","wikidata":"https://www.wikidata.org/wiki/Q5173281","display_name":"Corticogenesis","level":4,"score":0.8072999715805054},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.7713000178337097},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6550999879837036},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.652899980545044},{"id":"https://openalex.org/C164659718","wikidata":"https://www.wikidata.org/wiki/Q5159266","display_name":"Conditional gene knockout","level":4,"score":0.6195999979972839},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6173999905586243},{"id":"https://openalex.org/C2779715522","wikidata":"https://www.wikidata.org/wiki/Q507027","display_name":"Forebrain","level":3,"score":0.6132000088691711},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.5889000296592712},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.5727999806404114},{"id":"https://openalex.org/C2779076967","wikidata":"https://www.wikidata.org/wiki/Q21122281","display_name":"TXNIP","level":4,"score":0.5001000165939331},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.4921000003814697},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.4584999978542328},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.4465000033378601},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38350000977516174},{"id":"https://openalex.org/C2779826832","wikidata":"https://www.wikidata.org/wiki/Q982914","display_name":"Hexokinase","level":4,"score":0.37880000472068787},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.349700003862381},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.334199994802475},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.32589998841285706},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.3179999887943268},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.31290000677108765},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3091000020503998},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.30149999260902405},{"id":"https://openalex.org/C461258","wikidata":"https://www.wikidata.org/wiki/Q1345738","display_name":"Neural development","level":3,"score":0.30000001192092896},{"id":"https://openalex.org/C2780561631","wikidata":"https://www.wikidata.org/wiki/Q421331","display_name":"Sirtuin","level":4,"score":0.2800000011920929},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.27160000801086426},{"id":"https://openalex.org/C2777222312","wikidata":"https://www.wikidata.org/wiki/Q726562","display_name":"Neocortex","level":2,"score":0.2624000012874603},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.257099986076355},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2547999918460846},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2522999942302704}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41598-026-68028-1","doi":"https://doi.org/10.1038/s41598-026-68028-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-68028-1","pdf_url":"https://www.nature.com/articles/s41598-026-68028-1_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-68028-1","doi":"https://doi.org/10.1038/s41598-026-68028-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-68028-1","pdf_url":"https://www.nature.com/articles/s41598-026-68028-1_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.538695216178894}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3364685375","display_name":null,"funder_award_id":"32471018 and 32070967","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7574952076","display_name":null,"funder_award_id":"2023M730753","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204135609.pdf","grobid_xml":"https://content.openalex.org/works/W7204135609.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Neurodevelopmental":[0],"disorders":[1],"are":[2],"increasingly":[3],"associated":[4,199],"with":[5,57,200],"metabolic":[6,10,197,209],"abnormalities,":[7,167],"but":[8],"how":[9],"pathways":[11],"regulate":[12],"cortical":[13,52,94,202],"development":[14,62],"remains":[15],"unclear.":[16],"In":[17],"particular,":[18],"whether":[19],"glycolytic":[20],"enzymes":[21],"control":[22],"neural":[23,53,72],"progenitor":[24,54,203],"behavior":[25],"during":[26],"embryonic":[27,45,88,151,201],"corticogenesis":[28],"is":[29],"still":[30],"poorly":[31],"understood.":[32],"Here,":[33],"we":[34,69],"first":[35],"found":[36,82],"that":[37,83,207],"HK2":[38,86,113,137,193],"was":[39],"highly":[40],"expressed":[41],"in":[42,51,97,149],"the":[43,101],"early":[44,208],"mouse":[46,76],"cortex":[47],"and":[48,81,99,109,128,131,145,154,172,181,184,205],"selectively":[49],"enriched":[50],"cells":[55,127],"(NPCs),":[56],"expression":[58,67,142],"progressively":[59],"declining":[60],"as":[61,118,194],"proceeded.":[63],"Based":[64],"on":[65],"this":[66],"pattern,":[68],"generated":[70],"a":[71],"progenitor-specific":[73],"conditional":[74],"knockout":[75],"model":[77],"(":[78],"Hk2":[79,158],"-cKO)":[80],"loss":[84],"of":[85,103,143],"at":[87],"day":[89],"12":[90],"(E12)":[91],"unexpectedly":[92],"enhanced":[93,146],"NPC":[95],"proliferation":[96],"vivo":[98],"increased":[100,129,173],"production":[102],"deep-layer":[104],"projection":[105],"neurons,":[106],"including":[107,168],"CTIP2-positive":[108],"TBR1-positive":[110],"neurons.":[111],"Furthermore,":[112],"deficiency":[114,138],"altered":[115],"cell-cycle":[116],"distribution,":[117],"reflected":[119],"by":[120],"reduced":[121,141],"G":[122,132],"0":[123],"/G":[124],"1":[125],"-phase":[126],"S-":[130],"2":[133],"/M-phase":[134],"cells.":[135],"Mechanistically,":[136],"led":[139],"to":[140,213],"TXNIP":[144],"AKT":[147],"signaling":[148],"both":[150],"forebrain":[152],"tissue":[153],"cultured":[155],"neurospheres.":[156],"Importantly,":[157],"-cKO":[159],"adult":[160],"male":[161],"mice":[162],"displayed":[163],"core":[164],"autism-like":[165],"behavioral":[166],"impaired":[169],"social":[170],"interaction":[171],"repetitive":[174],"behaviors,":[175],"while":[176],"locomotor":[177],"activity,":[178],"anxiety-like":[179],"behavior,":[180],"spatial":[182],"learning":[183],"memory":[185],"were":[186],"largely":[187],"unaffected.":[188],"Together,":[189],"these":[190],"findings":[191],"identify":[192],"an":[195],"important":[196],"regulator":[198],"homeostasis":[204],"suggest":[206],"disruption":[210],"can":[211],"contribute":[212],"autism-related":[214],"phenotypes.":[215]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2026-08-25T00:00:00"}