{"id":"https://openalex.org/W7204128347","doi":"https://doi.org/10.1186/s44342-026-00090-7","title":"Exploratory integrative machine learning analysis of miRNA datasets identifies a candidate miRNA signature for oral squamous cell carcinoma","display_name":"Exploratory integrative machine learning analysis of miRNA datasets identifies a candidate miRNA signature for oral squamous cell carcinoma","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7204128347","doi":"https://doi.org/10.1186/s44342-026-00090-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/42995630","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13741416"},"language":"en","primary_location":{"id":"doi:10.1186/s44342-026-00090-7","doi":"https://doi.org/10.1186/s44342-026-00090-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s44342-026-00090-7","pdf_url":"https://link.springer.com/content/pdf/10.1186/s44342-026-00090-7.pdf","source":{"id":"https://openalex.org/S2764452186","display_name":"Genomics & Informatics","issn_l":"1598-866X","issn":["1598-866X","2234-0742"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319432","host_organization_name":"Korea Genome Organization","host_organization_lineage":["https://openalex.org/P4310319432"],"host_organization_lineage_names":["Korea Genome Organization"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics &amp; Informatics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s44342-026-00090-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147970937","display_name":"Rida Naveed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195024194","display_name":"Riphah International University","ror":"https://ror.org/02kdm5630","country_code":"PK","type":"education","lineage":["https://openalex.org/I195024194"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Rida Naveed","raw_affiliation_strings":["Department of Medical Lab Sciences, Riphah International University, Lahore, Pakistan. ridanaveed2004@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Lab Sciences, Riphah International University, Lahore, Pakistan. ridanaveed2004@gmail.com","institution_ids":["https://openalex.org/I195024194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055958280","display_name":"Hafiz Ghulam Murtaza Saleem","orcid":"https://orcid.org/0000-0003-1477-0113","observed_orcids":["https://orcid.org/0000-0003-1477-0113"]},"institutions":[{"id":"https://openalex.org/I195024194","display_name":"Riphah International University","ror":"https://ror.org/02kdm5630","country_code":"PK","type":"education","lineage":["https://openalex.org/I195024194"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Hafiz Ghulam Murtaza Saleem","raw_affiliation_strings":["Department of Medical Lab Sciences, Riphah International University, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Lab Sciences, Riphah International University, Lahore, Pakistan","institution_ids":["https://openalex.org/I195024194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046922522","display_name":"Safia Firdous","orcid":"https://orcid.org/0000-0003-4568-041X","observed_orcids":["https://orcid.org/0000-0003-4568-041X"]},"institutions":[{"id":"https://openalex.org/I195024194","display_name":"Riphah International University","ror":"https://ror.org/02kdm5630","country_code":"PK","type":"education","lineage":["https://openalex.org/I195024194"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Safia Firdous","raw_affiliation_strings":["Department of Medical Lab Sciences, Riphah International University, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Lab Sciences, Riphah International University, Lahore, Pakistan","institution_ids":["https://openalex.org/I195024194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126238551","display_name":"Muhammad Sohail","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195024194","display_name":"Riphah International University","ror":"https://ror.org/02kdm5630","country_code":"PK","type":"education","lineage":["https://openalex.org/I195024194"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Sohail","raw_affiliation_strings":["Department of Medical Lab Sciences, Riphah International University, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Lab Sciences, Riphah International University, Lahore, Pakistan","institution_ids":["https://openalex.org/I195024194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147965493","display_name":"Qainaat Faiz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195024194","display_name":"Riphah International University","ror":"https://ror.org/02kdm5630","country_code":"PK","type":"education","lineage":["https://openalex.org/I195024194"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Qainaat Faiz","raw_affiliation_strings":["Department of Medical Lab Sciences, Riphah International University, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Lab Sciences, Riphah International University, Lahore, Pakistan","institution_ids":["https://openalex.org/I195024194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120954800","display_name":"Iman Asif","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195024194","display_name":"Riphah International University","ror":"https://ror.org/02kdm5630","country_code":"PK","type":"education","lineage":["https://openalex.org/I195024194"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Iman Asif","raw_affiliation_strings":["Department of Medical Lab Sciences, Riphah International University, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Lab Sciences, Riphah International University, Lahore, Pakistan","institution_ids":["https://openalex.org/I195024194"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5124703115","display_name":"Moeez Khalid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195024194","display_name":"Riphah International University","ror":"https://ror.org/02kdm5630","country_code":"PK","type":"education","lineage":["https://openalex.org/I195024194"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Moeez Khalid","raw_affiliation_strings":["Department of Medical Lab Sciences, Riphah International University, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Lab Sciences, Riphah International University, Lahore, Pakistan","institution_ids":["https://openalex.org/I195024194"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5147970937"],"corresponding_institution_ids":["https://openalex.org/I195024194"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/circulating-micrornas","display_name":"circulating microRNAs","score":0.9129999876022339},{"id":"https://openalex.org/keywords/microrna-biomarkers","display_name":"microRNA biomarkers","score":0.8009999990463257},{"id":"https://openalex.org/keywords/microrna-signature","display_name":"microRNA signature","score":0.7749999761581421},{"id":"https://openalex.org/keywords/tumor-classification","display_name":"tumor classification","score":0.42500001192092896},{"id":"https://openalex.org/keywords/serum-mirna","display_name":"serum microRNA","score":0.6629999876022339},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.7009999752044678},{"id":"https://openalex.org/keywords/mir-21","display_name":"miR-21","score":0.9319999814033508},{"id":"https://openalex.org/keywords/mir-146b-5p","display_name":"miR-146b-5p","score":0.968999981880188},{"id":"https://openalex.org/keywords/shap","display_name":"SHAP","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.7152000069618225},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6639000177383423},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5932999849319458},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5375999808311462},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4738999903202057},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.4528999924659729},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41130000352859497},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.3993000090122223},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3698999881744385},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.350600004196167},{"id":"https://openalex.org/C3020225094","wikidata":"https://www.wikidata.org/wiki/Q80091","display_name":"Area under curve","level":3,"score":0.34310001134872437},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.33250001072883606},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3181000053882599},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3172999918460846},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.31380000710487366},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.30720001459121704},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.30230000615119934},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.3018999993801117},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29980000853538513},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.2904999852180481},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.289900004863739},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27459999918937683},{"id":"https://openalex.org/C2994119904","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Drug response","level":3,"score":0.27309998869895935},{"id":"https://openalex.org/C2909289247","wikidata":"https://www.wikidata.org/wiki/Q1143025","display_name":"Oral Cancers","level":3,"score":0.25690001249313354},{"id":"https://openalex.org/C2994491419","wikidata":"https://www.wikidata.org/wiki/Q681817","display_name":"Squamous carcinoma","level":3,"score":0.2558000087738037},{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.2533999979496002}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s44342-026-00090-7","doi":"https://doi.org/10.1186/s44342-026-00090-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s44342-026-00090-7","pdf_url":"https://link.springer.com/content/pdf/10.1186/s44342-026-00090-7.pdf","source":{"id":"https://openalex.org/S2764452186","display_name":"Genomics & Informatics","issn_l":"1598-866X","issn":["1598-866X","2234-0742"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319432","host_organization_name":"Korea Genome Organization","host_organization_lineage":["https://openalex.org/P4310319432"],"host_organization_lineage_names":["Korea Genome Organization"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics &amp; Informatics","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-10656303/v1","doi":"https://doi.org/10.21203/rs.3.rs-10656303/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10656303/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13741416","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13741416/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13741416/pdf/44342_2026_Article_90.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics Inform","raw_type":"Text"},{"id":"pmid:42995630","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42995630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics & informatics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/s44342-026-00090-7","doi":"https://doi.org/10.1186/s44342-026-00090-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s44342-026-00090-7","pdf_url":"https://link.springer.com/content/pdf/10.1186/s44342-026-00090-7.pdf","source":{"id":"https://openalex.org/S2764452186","display_name":"Genomics & Informatics","issn_l":"1598-866X","issn":["1598-866X","2234-0742"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319432","host_organization_name":"Korea Genome Organization","host_organization_lineage":["https://openalex.org/P4310319432"],"host_organization_lineage_names":["Korea Genome Organization"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics &amp; Informatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204128347.pdf","grobid_xml":"https://content.openalex.org/works/W7204128347.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W2059357290","https://openalex.org/W2084980412","https://openalex.org/W2097233439","https://openalex.org/W2107665951","https://openalex.org/W2108420460","https://openalex.org/W2115093090","https://openalex.org/W2118258530","https://openalex.org/W2120040038","https://openalex.org/W2154981570","https://openalex.org/W2329659234","https://openalex.org/W2563469203","https://openalex.org/W2736520162","https://openalex.org/W2776332611","https://openalex.org/W2898440040","https://openalex.org/W3122187153","https://openalex.org/W3151286594","https://openalex.org/W3200445016","https://openalex.org/W4282832296","https://openalex.org/W4295678697","https://openalex.org/W4309267632","https://openalex.org/W4319080474","https://openalex.org/W4367834072","https://openalex.org/W4386945111","https://openalex.org/W4387389324"],"related_works":["https://openalex.org/W3122187153","https://openalex.org/W7154880943","https://openalex.org/W4309267632","https://openalex.org/W2808635653","https://openalex.org/W4400283955","https://openalex.org/W4417451304","https://openalex.org/W2754900873","https://openalex.org/W2996586323","https://openalex.org/W2781679716","https://openalex.org/W4403500661"],"abstract_inverted_index":{"BACKGROUND:":[0],"Oral":[1],"squamous":[2],"cell":[3],"carcinoma":[4],"(OSCC)":[5],"is":[6,16,274],"typically":[7],"diagnosed":[8],"at":[9],"an":[10,197,275],"advanced":[11],"stage":[12],"and":[13,81,86,119,187,195,210,216,233,302,310],"thus":[14],"there":[15,39],"a":[17,144,234,252,285,291,320],"need":[18],"for":[19,21,91,265],"biomarkers":[20,240,270],"OSCC":[22,68,76,162],"which":[23],"can":[24,256,316],"be":[25,245,257,282,305,317],"detected":[26],"with":[27,48,161],"minimum":[28],"invasiveness.":[29],"Although":[30],"circulating":[31,44,135,268,312],"microRNAs":[32],"(miRNAs)":[33],"have":[34],"demonstrated":[35],"great":[36],"diagnostic":[37,321],"promise,":[38],"are":[40],"limited":[41,297],"publicly":[42,132],"available":[43,133],"miRNA":[45,56,72,137,263,269],"datasets":[46,57,78,264],"associated":[47,160],"OSCC.":[49,272],"OBJECTIVE:":[50],"To":[51],"exploratively":[52],"integrate":[53,260],"public":[54,261],"tissue":[55,77,174,262],"using":[58,109,153],"machine":[59,253],"learning":[60,105,254],"methods":[61],"to":[62,100,129,143,244,259,299,304,319],"identify":[63],"candidate":[64,158,239,293],"miRNAs":[65,230],"as":[66,284],"potential":[67],"biomarkers.":[69],"METHODS:":[70],"The":[71,139,148,177,204,224,248],"profiling":[73],"of":[74,113,199,236,267],"multiple":[75],"from":[79,172],"GEO":[80],"TCGA":[82],"containing":[83],"both":[84],"tumor":[85,171],"control":[87],"samples":[88,95,301,313],"were":[89,97,107,117],"integrated":[90],"biomarker":[92],"discovery.":[93],"Tumor":[94],"only":[96,131],"excluded":[98],"prior":[99],"the":[101,120,130,168,182,217,278],"model":[102,122,149,180],"development.":[103],"Machine":[104],"models":[106],"developed":[108],"differentially":[110],"expressed":[111],"set":[112],"miRNAs.":[114],"Five":[115],"classifiers":[116],"evaluated":[118],"best":[121],"was":[123,141,151,163,208,221],"externally":[124],"validated":[125,286,306],"by":[126],"applying":[127],"it":[128,315],"independent":[134,311],"serum":[136,219,287,300],"dataset.":[138],"signature":[140,159,279],"subjected":[142],"continuous":[145],"probability":[146],"score.":[147],"interpretation":[150],"performed":[152],"SHAP.":[154],"RESULTS:":[155],"A":[156],"30-miRNA":[157],"identified.":[164],"In":[165],"internal":[166],"cross-validation,":[167],"panel":[169,225,294],"separated":[170],"normal":[173],"(AUC":[175,212],"0.96).":[176],"logistic":[178],"regression":[179],"had":[181,189],"highest":[183],"AUC,":[184],"while":[185],"XGBoost":[186],"SVM-RBF":[188],"slightly":[190],"higher":[191],"accuracy":[192],"(Table":[193],"5)":[194],"gave":[196],"AUC":[198,220],"0.67":[200],"in":[201,271,307],"external":[202,218],"validation.":[203],"held-out":[205],"tissue-level":[206],"performance":[207],"variable":[209],"lower":[211],"0.54-0.88,":[213],"Table":[214],"7)":[215],"modest":[222],"(0.67).":[223],"identified":[226],"included":[227],"known":[228],"OSCC-related":[229],"(miR-21,":[231],"miR-146b-5p)":[232],"number":[235],"less":[237],"studied":[238],"whose":[241],"function":[242],"remains":[243],"tested.":[246],"CONCLUSION:":[247],"study":[249],"demonstrates":[250],"that":[251,295],"method":[255],"applied":[258,318],"identification":[266],"This":[273],"exploratory":[276],"study;":[277],"should":[280],"not":[281],"considered":[283],"test,":[288],"but":[289],"rather":[290],"tissue-derived":[292],"offers":[296],"transferability":[298],"needs":[303],"more,":[308],"larger,":[309],"before":[314],"purpose.":[322]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-08-25T00:00:00"}
