{"id":"https://openalex.org/W7204127774","doi":"https://doi.org/10.64898/2026.08.21.746268","title":"K2P Channels Regulate Presynaptic Organisation through a Membrane Potential-Independent Mechanism","display_name":"K2P Channels Regulate Presynaptic Organisation through a Membrane Potential-Independent Mechanism","publication_year":2026,"publication_date":"2026-08-24","ids":{"openalex":"https://openalex.org/W7204127774","doi":"https://doi.org/10.64898/2026.08.21.746268"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.21.746268","doi":"https://doi.org/10.64898/2026.08.21.746268","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.21.746268","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/24/2026.08.21.746268.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/24/2026.08.21.746268.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003152420","display_name":"Jun Meng","orcid":"https://orcid.org/0000-0002-4165-8496","observed_orcids":["https://orcid.org/0000-0002-4165-8496"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jun Meng","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-4165-8496","affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034696587","display_name":"Neeraja Ramakrishnan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Neeraja Ramakrishnan","raw_affiliation_strings":["Department of Physiology, University of Toronto, Toronto, ON, Canada","Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I210557978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148017248","display_name":"Yi Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CA","CN"],"is_corresponding":false,"raw_author_name":"Yi Li","raw_affiliation_strings":["College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China","Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I210557978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043259469","display_name":"Thomas Boulin","orcid":"https://orcid.org/0000-0002-1734-1915","observed_orcids":["https://orcid.org/0000-0002-1734-1915"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405258652","display_name":"M\u00e9canismes en sciences int\u00e9gratives du vivant","ror":"https://ror.org/01138xk88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4405258652"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thomas Boulin","raw_affiliation_strings":["University Claude Bernard Lyon 1, MeLiS, CNRS UMR 5284, INSERM U1314, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Claude Bernard Lyon 1, MeLiS, CNRS UMR 5284, INSERM U1314, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4405258652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035431023","display_name":"Shangbang Gao","orcid":"https://orcid.org/0000-0001-5431-4628","observed_orcids":["https://orcid.org/0000-0001-5431-4628"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shangbang Gao","raw_affiliation_strings":["College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":"https://orcid.org/0000-0001-5431-4628","affiliations":[{"raw_affiliation_string":"College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063768132","display_name":"Mei Zhen","orcid":"https://orcid.org/0000-0003-0086-9622","observed_orcids":["https://orcid.org/0000-0003-0086-9622"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mei Zhen","raw_affiliation_strings":["Department of Physiology, University of Toronto, Toronto, ON, Canada","Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada"],"raw_orcid":"https://orcid.org/0000-0003-0086-9622","affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I210557978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070285020","display_name":"Isabel Beets","orcid":"https://orcid.org/0000-0002-0968-4360","observed_orcids":["https://orcid.org/0000-0002-0968-4360"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Isabel Beets","raw_affiliation_strings":["Department of Biology, KU Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050316172","display_name":"William R Schafer","orcid":"https://orcid.org/0000-0002-6676-8034","observed_orcids":["https://orcid.org/0000-0002-6676-8034"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE","GB"],"is_corresponding":false,"raw_author_name":"William R Schafer","raw_affiliation_strings":["Department of Biology, KU Leuven, Leuven, Belgium","MRC Laboratory of Molecular Biology, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-6676-8034","affiliations":[{"raw_affiliation_string":"Department of Biology, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I170203145"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5003152420"],"corresponding_institution_ids":["https://openalex.org/I170203145"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7660999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7660999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.2240000069141388,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/k2p-channels","display_name":"K2P channels","score":0.8510000109672546},{"id":"https://openalex.org/keywords/two-pore-domain-potassium-channels","display_name":"two-pore domain potassium channels","score":0.8840000033378601},{"id":"https://openalex.org/keywords/synaptic-transmission","display_name":"synaptic transmission","score":0.7250000238418579},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.8740000128746033},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8629999756813049},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6272000074386597},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.6165000200271606},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.5758000016212463},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5480999946594238},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5468999743461609},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.49639999866485596},{"id":"https://openalex.org/C145314362","wikidata":"https://www.wikidata.org/wiki/Q6804689","display_name":"Stretch-activated ion channel","level":5,"score":0.4738999903202057},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.44690001010894775},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.44290000200271606},{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.3889999985694885},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.37299999594688416},{"id":"https://openalex.org/C2993285035","wikidata":"https://www.wikidata.org/wiki/Q2643251","display_name":"Synaptic cleft","level":4,"score":0.3707999885082245},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3522000014781952},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.3425000011920929},{"id":"https://openalex.org/C61144316","wikidata":"https://www.wikidata.org/wiki/Q4835827","display_name":"BK channel","level":3,"score":0.33869999647140503},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.3303999900817871},{"id":"https://openalex.org/C173424598","wikidata":"https://www.wikidata.org/wiki/Q106939566","display_name":"Voltage-gated potassium channel","level":3,"score":0.3262999951839447},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.3125999867916107},{"id":"https://openalex.org/C37088560","wikidata":"https://www.wikidata.org/wiki/Q354550","display_name":"Voltage-gated ion channel","level":4,"score":0.31060001254081726},{"id":"https://openalex.org/C82617044","wikidata":"https://www.wikidata.org/wiki/Q418536","display_name":"Ligand-gated ion channel","level":4,"score":0.31029999256134033},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.30790001153945923},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.30090001225471497},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2978000044822693},{"id":"https://openalex.org/C94924445","wikidata":"https://www.wikidata.org/wiki/Q841456","display_name":"Inward-rectifier potassium ion channel","level":4,"score":0.2969000041484833},{"id":"https://openalex.org/C149786707","wikidata":"https://www.wikidata.org/wiki/Q7390712","display_name":"SK channel","level":4,"score":0.2964000105857849},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.2955999970436096},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2897000014781952},{"id":"https://openalex.org/C57947595","wikidata":"https://www.wikidata.org/wiki/Q7886088","display_name":"Membrane transport","level":3,"score":0.2827000021934509},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.2759000062942505},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.27559998631477356},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.26570001244544983},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25850000977516174},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.25769999623298645}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.21.746268","doi":"https://doi.org/10.64898/2026.08.21.746268","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.21.746268","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/24/2026.08.21.746268.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.21.746268","doi":"https://doi.org/10.64898/2026.08.21.746268","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.21.746268","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/24/2026.08.21.746268.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2759934476","display_name":"Extrasynaptic circuit plasticity in a hypometabolic state","funder_award_id":"C16/25/005","funder_id":"https://openalex.org/F4320327336","funder_display_name":"Vlaamse regering"},{"id":"https://openalex.org/G4243366647","display_name":null,"funder_award_id":"RGPIN-2024-06020","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G5177159269","display_name":"Functional characterization of novel ligand-gated ion channels.","funder_award_id":"G079521N","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G6978125255","display_name":null,"funder_award_id":"MC-M102-M1421","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7509335664","display_name":null,"funder_award_id":"32371189","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320321999","display_name":"Lundbeckfonden","ror":"https://ror.org/03hz8wd80"},{"id":"https://openalex.org/F4320322015","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087"},{"id":"https://openalex.org/F4320322308","display_name":"KU Leuven","ror":"https://ror.org/05f950310"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null},{"id":"https://openalex.org/F4320327675","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786"},{"id":"https://openalex.org/F4320327918","display_name":"H. Lundbeck A/S","ror":"https://ror.org/0564cd633"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204127774.pdf","grobid_xml":"https://content.openalex.org/works/W7204127774.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7132983428","https://openalex.org/W2006994969","https://openalex.org/W206588688","https://openalex.org/W4223630616","https://openalex.org/W4399589660","https://openalex.org/W2769783976","https://openalex.org/W3008386562","https://openalex.org/W1974563056","https://openalex.org/W2106201037","https://openalex.org/W3125189663"],"abstract_inverted_index":{"Abstract":[0],"Neuronal":[1],"ion":[2],"channels":[3],"have":[4],"well-established":[5],"effects":[6,48,86,100],"on":[7,18,46,49,87,101,115],"synaptic":[8,73,144],"plasticity,":[9],"in":[10,55],"many":[11],"cases":[12],"by":[13,80,93],"influencing":[14],"pathways":[15],"that":[16,24,83,97,106],"depend":[17],"membrane":[19,39,102],"excitability.":[20,103],"Here":[21],"we":[22],"find":[23],"a":[25,38,120,130],"C.":[26],"elegans":[27],"two-pore":[28],"domain":[29],"potassium":[30,51,89,108,135],"(K2P)":[31],"channel,":[32],"TWK-40,":[33],"regulates":[34],"presynaptic":[35,60,69,110,141],"organisation":[36,142],"through":[37],"potential-independent":[40],"mechanism.":[41],"Instead,":[42],"this":[43],"mechanism":[44],"depends":[45,114],"TWK-40\u2019s":[47,85],"intracellular":[50,88],"levels.":[52],"Loss-of-function":[53],"mutations":[54,65,82,96],"TWK-40":[56],"lead":[57,66],"to":[58,67,137],"excessive":[59],"protein":[61],"accumulation,":[62],"while":[63],"gain-of-function":[64],"depleted":[68],"components":[70],"and":[71,123,143],"cause":[72],"transmission":[74],"deficits.":[75],"These":[76,127],"abnormalities":[77],"are":[78],"phenocopied":[79],"transporter":[81],"mimic":[84,98],"concentration,":[90],"but":[91],"not":[92],"sodium":[94],"channel":[95],"its":[99],"This":[104,112],"indicates":[105],"cytoplasmic":[107],"promotes":[109],"assembly.":[111],"process":[113],"the":[116,138],"PYK-1":[117],"pyruvate":[118],"kinase,":[119],"potassium-sensitive":[121],"enzyme,":[122],"three":[124],"transcription":[125],"factors.":[126],"findings":[128],"establish":[129],"new":[131],"pathway":[132],"linking":[133],"neuronal":[134],"homeostasis":[136],"control":[139],"of":[140],"function.":[145]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-25T00:00:00"}