{"id":"https://openalex.org/W7204126494","doi":"https://doi.org/10.64898/2026.08.23.746552","title":"Design and Application of a \u00b5SiM Outer Blood-Retinal Barrier (OBRB) Model as a Drug Development Tool","display_name":"Design and Application of a \u00b5SiM Outer Blood-Retinal Barrier (OBRB) Model as a Drug Development Tool","publication_year":2026,"publication_date":"2026-08-24","ids":{"openalex":"https://openalex.org/W7204126494","doi":"https://doi.org/10.64898/2026.08.23.746552"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.23.746552","doi":"https://doi.org/10.64898/2026.08.23.746552","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.23.746552","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/24/2026.08.23.746552.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/24/2026.08.23.746552.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007091762","display_name":"Kevin C. Ling","orcid":"https://orcid.org/0000-0001-5784-2311","observed_orcids":["https://orcid.org/0000-0001-5784-2311"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin C. Ling","raw_affiliation_strings":["University of Rochester, Department of Biomedical Engineering, 204 Robert B. Goergen Hall, P.O. Box 270168, Rochester, NY 14627, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester, Department of Biomedical Engineering, 204 Robert B. Goergen Hall, P.O. Box 270168, Rochester, NY 14627, USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135454841","display_name":"Jordan Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan Jones","raw_affiliation_strings":["University of Rochester, Department of Biomedical Engineering, 204 Robert B. Goergen Hall, P.O. Box 270168, Rochester, NY 14627, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester, Department of Biomedical Engineering, 204 Robert B. Goergen Hall, P.O. Box 270168, Rochester, NY 14627, USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092066327","display_name":"Gram Hepner","orcid":"https://orcid.org/0009-0005-6899-1132","observed_orcids":["https://orcid.org/0009-0005-6899-1132"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gram Hepner","raw_affiliation_strings":["University of Rochester, Department of Biomedical Engineering, 204 Robert B. Goergen Hall, P.O. Box 270168, Rochester, NY 14627, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester, Department of Biomedical Engineering, 204 Robert B. Goergen Hall, P.O. Box 270168, Rochester, NY 14627, USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116091061","display_name":"Ahmet Gurcan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmet Gurcan","raw_affiliation_strings":["University of Rochester, Department of Biomedical Engineering, 204 Robert B. Goergen Hall, P.O. Box 270168, Rochester, NY 14627, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester, Department of Biomedical Engineering, 204 Robert B. Goergen Hall, P.O. Box 270168, Rochester, NY 14627, USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147929918","display_name":"Rufaro Gamariel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rufaro Gamariel","raw_affiliation_strings":["University of Rochester, Department of Biomedical Engineering, 204 Robert B. Goergen Hall, P.O. Box 270168, Rochester, NY 14627, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester, Department of Biomedical Engineering, 204 Robert B. Goergen Hall, P.O. Box 270168, Rochester, NY 14627, USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114849587","display_name":"Andres F. Muriel\u2010Torres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andres Muriel-Torres","raw_affiliation_strings":["University of Rochester, Department of Biomedical Engineering, 204 Robert B. Goergen Hall, P.O. Box 270168, Rochester, NY 14627, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester, Department of Biomedical Engineering, 204 Robert B. Goergen Hall, P.O. Box 270168, Rochester, NY 14627, USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063424798","display_name":"Meng-Chun Hsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155173764","display_name":"Rochester Institute of Technology","ror":"https://ror.org/00v4yb702","country_code":"US","type":"education","lineage":["https://openalex.org/I155173764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meng-chun Hsu","raw_affiliation_strings":["Rochester Institute of Technology, Department of Biomedical Engineering, 77 Lomb Memorial Drive, Rochester, NY 14623, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rochester Institute of Technology, Department of Biomedical Engineering, 77 Lomb Memorial Drive, Rochester, NY 14623, USA","institution_ids":["https://openalex.org/I155173764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081664086","display_name":"Mehran Mansouri","orcid":"https://orcid.org/0000-0002-2949-1857","observed_orcids":["https://orcid.org/0000-0002-2949-1857"]},"institutions":[{"id":"https://openalex.org/I155173764","display_name":"Rochester Institute of Technology","ror":"https://ror.org/00v4yb702","country_code":"US","type":"education","lineage":["https://openalex.org/I155173764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehran Mansouri","raw_affiliation_strings":["Rochester Institute of Technology, Department of Biomedical Engineering, 77 Lomb Memorial Drive, Rochester, NY 14623, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rochester Institute of Technology, Department of Biomedical Engineering, 77 Lomb Memorial Drive, Rochester, NY 14623, USA","institution_ids":["https://openalex.org/I155173764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119455747","display_name":"Sami Farajollahi","orcid":"https://orcid.org/0009-0000-4420-3617","observed_orcids":["https://orcid.org/0009-0000-4420-3617"]},"institutions":[{"id":"https://openalex.org/I155173764","display_name":"Rochester Institute of Technology","ror":"https://ror.org/00v4yb702","country_code":"US","type":"education","lineage":["https://openalex.org/I155173764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sami Farajollahi","raw_affiliation_strings":["Rochester Institute of Technology, Department of Biomedical Engineering, 77 Lomb Memorial Drive, Rochester, NY 14623, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rochester Institute of Technology, Department of Biomedical Engineering, 77 Lomb Memorial Drive, Rochester, NY 14623, USA","institution_ids":["https://openalex.org/I155173764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027788297","display_name":"Vinay V. Abhyankar","orcid":"https://orcid.org/0000-0002-8462-3920","observed_orcids":["https://orcid.org/0000-0002-8462-3920"]},"institutions":[{"id":"https://openalex.org/I155173764","display_name":"Rochester Institute of Technology","ror":"https://ror.org/00v4yb702","country_code":"US","type":"education","lineage":["https://openalex.org/I155173764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vinay Abhyankar","raw_affiliation_strings":["Rochester Institute of Technology, Department of Biomedical Engineering, 77 Lomb Memorial Drive, Rochester, NY 14623, USA"],"raw_orcid":"https://orcid.org/0000-0002-8462-3920","affiliations":[{"raw_affiliation_string":"Rochester Institute of Technology, Department of Biomedical Engineering, 77 Lomb Memorial Drive, Rochester, NY 14623, USA","institution_ids":["https://openalex.org/I155173764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062843351","display_name":"Ruchira Singh","orcid":"https://orcid.org/0000-0002-3821-1538","observed_orcids":["https://orcid.org/0000-0002-3821-1538"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruchira Singh","raw_affiliation_strings":["University of Rochester Medical Center, Department of Biomedical Genetics, 601 Elmwood Avenue, Box 633, Rochester, NY 14642, USA","University of Rochester Medical Center, Department of Ophthalmology, Flaum Eye Institute, 210 Crittenden Boulevard, Rochester, NY 14642, USA","University of Rochester, Center for Visual Science, Meliora Hall, P.O. Box 270270, Rochester, NY 14627, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester Medical Center, Department of Biomedical Genetics, 601 Elmwood Avenue, Box 633, Rochester, NY 14642, USA","institution_ids":["https://openalex.org/I28792581"]},{"raw_affiliation_string":"University of Rochester Medical Center, Department of Ophthalmology, Flaum Eye Institute, 210 Crittenden Boulevard, Rochester, NY 14642, USA","institution_ids":["https://openalex.org/I28792581"]},{"raw_affiliation_string":"University of Rochester, Center for Visual Science, Meliora Hall, P.O. Box 270270, Rochester, NY 14627, USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015274437","display_name":"Danielle S. W. Benoit","orcid":"https://orcid.org/0000-0001-7137-8164","observed_orcids":["https://orcid.org/0000-0001-7137-8164"]},"institutions":[{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danielle Benoit","raw_affiliation_strings":["University of Oregon, Knight Campus, Department of Bioengineering, 6231 University of Oregon, Eugene, OR 97403, USA","University of Rochester, Department of Biomedical Engineering, 204 Robert B. Goergen Hall, P.O. Box 270168, Rochester, NY 14627, USA"],"raw_orcid":"https://orcid.org/0000-0001-7137-8164","affiliations":[{"raw_affiliation_string":"University of Oregon, Knight Campus, Department of Bioengineering, 6231 University of Oregon, Eugene, OR 97403, USA","institution_ids":["https://openalex.org/I181233156"]},{"raw_affiliation_string":"University of Rochester, Department of Biomedical Engineering, 204 Robert B. Goergen Hall, P.O. Box 270168, Rochester, NY 14627, USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100730245","display_name":"James L. McGrath","orcid":"https://orcid.org/0000-0003-2017-8335","observed_orcids":["https://orcid.org/0000-0003-2017-8335"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James McGrath","raw_affiliation_strings":["University of Rochester, Department of Biomedical Engineering, 204 Robert B. Goergen Hall, P.O. Box 270168, Rochester, NY 14627, USA"],"raw_orcid":"https://orcid.org/0000-0003-2017-8335","affiliations":[{"raw_affiliation_string":"University of Rochester, Department of Biomedical Engineering, 204 Robert B. Goergen Hall, P.O. Box 270168, Rochester, NY 14627, USA","institution_ids":["https://openalex.org/I5388228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100730245"],"corresponding_institution_ids":["https://openalex.org/I5388228"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.8080999851226807,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.8080999851226807,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.0812000036239624,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.03350000083446503,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/outer-blood-retinal-barrier","display_name":"outer blood-retinal barrier","score":0.9980000257492065},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.8349999785423279},{"id":"https://openalex.org/keywords/retinal-drug-delivery","display_name":"retinal drug delivery","score":0.6290000081062317},{"id":"https://openalex.org/keywords/arpe-19-cells","display_name":"ARPE-19 cells","score":0.8220000267028809},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.9739999771118164},{"id":"https://openalex.org/keywords/digoxin-toxicity","display_name":"digoxin toxicity","score":0.7300000190734863},{"id":"https://openalex.org/keywords/neovascular-amd","display_name":"neovascular AMD","score":0.9129999876022339},{"id":"https://openalex.org/keywords/drug-bioavailability","display_name":"drug bioavailability","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.5748000144958496},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.5551000237464905},{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.5302000045776367},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5085999965667725},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48590001463890076},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.448199987411499},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.4242999851703644},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.40849998593330383},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39259999990463257},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37209999561309814},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.36340001225471497},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.36340001225471497},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.36079999804496765},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.35910001397132874},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.3562000095844269},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.3325999975204468},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32179999351501465},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3010999858379364},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.2985000014305115},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2969000041484833},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.28929999470710754},{"id":"https://openalex.org/C2989209122","wikidata":"https://www.wikidata.org/wiki/Q178512","display_name":"Mass transport","level":2,"score":0.28790000081062317},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.28769999742507935},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.287200003862381},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.2856999933719635},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.2824000120162964},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.27810001373291016},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.27399998903274536},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2687000036239624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.263700008392334},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.2606000006198883}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.23.746552","doi":"https://doi.org/10.64898/2026.08.23.746552","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.23.746552","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/24/2026.08.23.746552.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.23.746552","doi":"https://doi.org/10.64898/2026.08.23.746552","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.23.746552","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/24/2026.08.23.746552.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5063399912","display_name":"Using hiPSCs to develop physiologically-relevant outer retina tissue mimetics","funder_award_id":"R01EY033192","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310246","display_name":"University of Rochester","ror":"https://ror.org/022kthw22"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337871","display_name":"Wilmot Cancer Institute, University of Rochester Medical Center","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204126494.pdf","grobid_xml":"https://content.openalex.org/works/W7204126494.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3005746276","https://openalex.org/W4400591756","https://openalex.org/W3113185340","https://openalex.org/W2113382079","https://openalex.org/W4404501235","https://openalex.org/W4226256996","https://openalex.org/W4414184631","https://openalex.org/W7095588815","https://openalex.org/W3096146625","https://openalex.org/W2916409741"],"abstract_inverted_index":{"Abstract":[0],"The":[1,161,195,237],"outer":[2],"blood-retinal":[3],"barrier":[4,25],"(OBRB)":[5],"is":[6],"the":[7,16,28,40,46,66,81,171,212,229],"primary":[8],"interface":[9],"through":[10,59,170],"which":[11,84],"systemically":[12],"circulating":[13],"drugs":[14,43,57],"reach":[15,45],"retina.":[17],"A":[18],"tool":[19,54],"that":[20,44],"measures":[21],"delivery":[22],"across":[23,65,92],"this":[24],"would":[26],"support":[27],"development":[29,111],"of":[30,42,121,140,228,246],"targeted":[31],"therapies":[32],"as":[33,48,110,191,232],"alternatives":[34],"to":[35,76],"repeated":[36],"intravitreal":[37],"injection,":[38],"and":[39,71,87,101,131,183,217,250],"screening":[41],"retina":[47],"an":[49,164,177],"off-target":[50],"toxicity.":[51],"Such":[52],"a":[53,60,93,117,137,153,205,221],"should":[55],"deliver":[56],"fluidically":[58],"vascular":[61,173],"compartment,":[62],"measure":[63],"transport":[64,187],"retinal":[67],"pigment":[68],"epithelium":[69,86],"(RPE),":[70],"display":[72],"disease":[73],"phenotypes":[74],"relevant":[75,201],"efficacy.":[77,251],"Here":[78],"we":[79],"adapt":[80],"\u00b5SiM":[82],"platform,":[83],"places":[85],"endothelium":[88],"in":[89,193,211,234],"direct":[90],"juxtaposition":[91],"permeable,":[94],"optically":[95],"transparent":[96],"silicon":[97],"nitride":[98],"nanomembrane.":[99],"ARPE-19":[100,114,132],"human":[102],"umbilical":[103],"vein":[104],"endothelial":[105,226],"cells":[106],"(HUVECs)":[107],"were":[108],"used":[109],"cell":[112],"sources.":[113],"monocultures":[115],"reached":[116,136],"transepithelial":[118],"electrical":[119],"resistance":[120],"68":[122],"\u00b1":[123,142],"26":[124],"\u03a9":[125],"cm":[126,147],"2":[127],"by":[128,214],"28":[129],"days,":[130,152],"+":[133],"HUVEC":[134],"co-cultures":[135],"small-molecule":[138],"permeability":[139],"6.34":[141],"1.3":[143],"\u00d7":[144],"10":[145],"\u22124":[146],"min":[148],"\u22121":[149],"within":[150],"14":[151],"state":[154],"reported":[155,192],"elsewhere":[156],"only":[157],"after":[158],"longer":[159],"culture.":[160],"barriers":[162],"developed":[163],"intervening":[165],"basement":[166],"membrane.":[167],"Drugs":[168],"perfused":[169],"basal":[172],"channel":[174],"crossed":[175],"into":[176],"open":[178],"apical":[179],"well,":[180],"where":[181],"sampling":[182],"mass":[184],"spectrometry":[185],"showed":[186],"correlating":[188],"with":[189],"lipophilicity,":[190],"vivo.":[194],"device":[196],"also":[197],"displayed":[198],"two":[199],"clinically":[200,206],"phenotypes.":[202],"Digoxin":[203],"at":[204],"toxic":[207],"concentration":[208],"reduced":[209],"viability":[210],"co-barrier":[213],"about":[215],"half":[216],"doubled":[218],"permeability.":[219],"In":[220],"vascularized":[222],"configuration,":[223],"VEGF":[224],"drove":[225],"invasion":[227],"RPE":[230],"layer,":[231],"seen":[233],"neovascular":[235],"AMD.":[236],"\u00b5SiM-OBRB":[238],"therefore":[239],"satisfies":[240],"basic":[241],"design":[242],"criteria":[243],"for":[244],"measurement":[245],"drug":[247],"bioavailability,":[248],"toxicity,":[249]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-25T00:00:00"}