{"id":"https://openalex.org/W7204123568","doi":"https://doi.org/10.15407/exp-oncology.2026.02.098","title":"MINIMAL RESIDUAL DISEASE ASSESSMENT IN ACUTE LYMPHOBLASTIC LEUKEMIA: METHODS FOR DETECTION AND QUANTIFICATION","display_name":"MINIMAL RESIDUAL DISEASE ASSESSMENT IN ACUTE LYMPHOBLASTIC LEUKEMIA: METHODS FOR DETECTION AND QUANTIFICATION","publication_year":2026,"publication_date":"2026-08-21","ids":{"openalex":"https://openalex.org/W7204123568","doi":"https://doi.org/10.15407/exp-oncology.2026.02.098","pmid":"https://pubmed.ncbi.nlm.nih.gov/42634847"},"language":"en","primary_location":{"id":"doi:10.15407/exp-oncology.2026.02.098","doi":"https://doi.org/10.15407/exp-oncology.2026.02.098","is_oa":true,"landing_page_url":"https://doi.org/10.15407/exp-oncology.2026.02.098","pdf_url":"https://exp-oncology.com.ua/index.php/Exp/article/download/640/470","source":{"id":"https://openalex.org/S22800154","display_name":"Experimental Oncology","issn_l":"0204-3564","issn":["0204-3564","1812-9269","2312-8852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Oncology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://exp-oncology.com.ua/index.php/Exp/article/download/640/470","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085815804","display_name":"Sara Addakiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Sara Addakiri","raw_affiliation_strings":["Hassan II University of Medicine and Pharmacy, Casablanca, Morocco. saraaddakiri1995@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hassan II University of Medicine and Pharmacy, Casablanca, Morocco. saraaddakiri1995@gmail.com","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052913884","display_name":"Hanaa Bencharef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Hanaa Bencharef","raw_affiliation_strings":["Hassan II University of Medicine and Pharmacy, Casablanca, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hassan II University of Medicine and Pharmacy, Casablanca, Morocco","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070402654","display_name":"Asmaa Harrach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Asmaa Harrach","raw_affiliation_strings":["Hassan II University of Medicine and Pharmacy, Casablanca, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hassan II University of Medicine and Pharmacy, Casablanca, Morocco","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033455171","display_name":"Samiha Jaddaoui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Samiha Jaddaoui","raw_affiliation_strings":["Hassan II University of Medicine and Pharmacy, Casablanca, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hassan II University of Medicine and Pharmacy, Casablanca, Morocco","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092861697","display_name":"Khadija Ait-Ichou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138534","display_name":"Centre Hospitalier Universitaire Ibn Rochd","ror":"https://ror.org/03sbc8x80","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210138534"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Khadija Ait-Ichou","raw_affiliation_strings":["IBN ROCHD Hospital Centre, Casablanca, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBN ROCHD Hospital Centre, Casablanca, Morocco","institution_ids":["https://openalex.org/I4210138534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006108568","display_name":"Bouchra Oukkache","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Bouchra Oukkache","raw_affiliation_strings":["Hassan II University of Medicine and Pharmacy, Casablanca, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hassan II University of Medicine and Pharmacy, Casablanca, Morocco","institution_ids":["https://openalex.org/I99297268"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":"2","first_page":"98","last_page":"107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":1.0},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":1.0},{"id":"https://openalex.org/keywords/mrd-detection","display_name":"MRD detection","score":0.8460000157356262},{"id":"https://openalex.org/keywords/mrd-quantification","display_name":"MRD quantification","score":0.9509999752044678},{"id":"https://openalex.org/keywords/flow-cytometry","display_name":"flow cytometry","score":0.9269999861717224},{"id":"https://openalex.org/keywords/karyology","display_name":"karyology","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cytogenetics","display_name":"cytogenetics","score":0.9940000176429749},{"id":"https://openalex.org/keywords/molecular-genetic-techniques","display_name":"molecular genetic techniques","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C155512373","wikidata":"https://www.wikidata.org/wiki/Q287450","display_name":"Residual","level":2,"score":0.7439000010490417},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.7121999859809875},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.49149999022483826},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48590001463890076},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.47429999709129333},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4052000045776367},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37439998984336853},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3560999929904938},{"id":"https://openalex.org/C2993153387","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic diagnosis","level":3,"score":0.35179999470710754},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.33340001106262207},{"id":"https://openalex.org/C38349280","wikidata":"https://www.wikidata.org/wiki/Q1434290","display_name":"Flow (mathematics)","level":2,"score":0.3206000030040741},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.31360000371932983},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31299999356269836},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.30820000171661377},{"id":"https://openalex.org/C8880873","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.3001999855041504},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.2939999997615814},{"id":"https://openalex.org/C3018877446","wikidata":"https://www.wikidata.org/wiki/Q1421432","display_name":"Disease monitoring","level":3,"score":0.2793000042438507},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.2761000096797943},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.25369998812675476}],"mesh":[{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018365","descriptor_name":"Neoplasm, Residual","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.15407/exp-oncology.2026.02.098","doi":"https://doi.org/10.15407/exp-oncology.2026.02.098","is_oa":true,"landing_page_url":"https://doi.org/10.15407/exp-oncology.2026.02.098","pdf_url":"https://exp-oncology.com.ua/index.php/Exp/article/download/640/470","source":{"id":"https://openalex.org/S22800154","display_name":"Experimental Oncology","issn_l":"0204-3564","issn":["0204-3564","1812-9269","2312-8852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Oncology","raw_type":"journal-article"},{"id":"pmid:42634847","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42634847","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.15407/exp-oncology.2026.02.098","doi":"https://doi.org/10.15407/exp-oncology.2026.02.098","is_oa":true,"landing_page_url":"https://doi.org/10.15407/exp-oncology.2026.02.098","pdf_url":"https://exp-oncology.com.ua/index.php/Exp/article/download/640/470","source":{"id":"https://openalex.org/S22800154","display_name":"Experimental Oncology","issn_l":"0204-3564","issn":["0204-3564","1812-9269","2312-8852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204123568.pdf","grobid_xml":"https://content.openalex.org/works/W7204123568.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1239385015","https://openalex.org/W1485389706","https://openalex.org/W1490840859","https://openalex.org/W1557439734","https://openalex.org/W1967533397","https://openalex.org/W1978319844","https://openalex.org/W1983900466","https://openalex.org/W1985012922","https://openalex.org/W1997503220","https://openalex.org/W2007208181","https://openalex.org/W2007904492","https://openalex.org/W2010519729","https://openalex.org/W2014716518","https://openalex.org/W2015018636","https://openalex.org/W2017785657","https://openalex.org/W2019471283","https://openalex.org/W2020206419","https://openalex.org/W2023882066","https://openalex.org/W2028435079","https://openalex.org/W2043436291","https://openalex.org/W2045807214","https://openalex.org/W2051804704","https://openalex.org/W2053067769","https://openalex.org/W2053908817","https://openalex.org/W2059139947","https://openalex.org/W2069904949","https://openalex.org/W2070993076","https://openalex.org/W2071899049","https://openalex.org/W2072078686","https://openalex.org/W2073469891","https://openalex.org/W2078148381","https://openalex.org/W2081906522","https://openalex.org/W2084781910","https://openalex.org/W2092925278","https://openalex.org/W2103225182","https://openalex.org/W2107721849","https://openalex.org/W2119685895","https://openalex.org/W2120204058","https://openalex.org/W2134091917","https://openalex.org/W2138265677","https://openalex.org/W2141250302","https://openalex.org/W2144236207","https://openalex.org/W2152088258","https://openalex.org/W2166306614","https://openalex.org/W2272628964","https://openalex.org/W2289275218","https://openalex.org/W2296850598","https://openalex.org/W2310716991","https://openalex.org/W2328540973","https://openalex.org/W2558502346","https://openalex.org/W2579739608","https://openalex.org/W2591601716","https://openalex.org/W2604777364","https://openalex.org/W2611177651","https://openalex.org/W2779241561","https://openalex.org/W2901920890","https://openalex.org/W2948502175","https://openalex.org/W2964177223","https://openalex.org/W3004666691","https://openalex.org/W3124589259","https://openalex.org/W4232414730","https://openalex.org/W4313648848"],"related_works":["https://openalex.org/W4391752105","https://openalex.org/W3013717001","https://openalex.org/W7167803812","https://openalex.org/W4411456422","https://openalex.org/W2334440363","https://openalex.org/W3004666691","https://openalex.org/W2901920890","https://openalex.org/W4313196653","https://openalex.org/W3118392606","https://openalex.org/W2755856848"],"abstract_inverted_index":{"Recently,":[0],"the":[1,20,32,60,63],"identification":[2],"of":[3],"minimal":[4],"residual":[5,12],"disease":[6],"(MRD),":[7],"also":[8],"known":[9],"as":[10],"measurable":[11],"disease,":[13],"has":[14,34],"seen":[15],"significant":[16],"advances":[17],"driven":[18],"by":[19,66],"evolving":[21],"technological":[22],"landscape":[23],"in":[24],"this":[25],"field.":[26],"Initially":[27],"based":[28],"on":[29],"raw":[30],"morphology,":[31],"field":[33],"since":[35],"evolved":[36],"to":[37],"incorporate":[38],"karyotyping,":[39],"cytogenetics,":[40],"flow":[41,67],"cytometry,":[42],"and":[43,69],"other":[44],"sensitive":[45],"methods.":[46],"This":[47],"updated":[48],"review":[49],"discusses":[50],"key":[51],"technical":[52],"considerations":[53],"for":[54],"successful":[55],"MRD":[56],"detection.":[57],"We":[58],"explore":[59],"correlation":[61],"between":[62],"results":[64],"obtained":[65],"cytometry":[68],"molecular":[70],"genetic":[71],"techniques.":[72]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-25T00:00:00"}
