{"id":"https://openalex.org/W7204118436","doi":"https://doi.org/10.1590/1980-5764-dn-2025-0472","title":"Evaluating the safety of investigational anti-Alzheimer\u2019s drugs: a comprehensive meta-analysis in the past to current decade","display_name":"Evaluating the safety of investigational anti-Alzheimer\u2019s drugs: a comprehensive meta-analysis in the past to current decade","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7204118436","doi":"https://doi.org/10.1590/1980-5764-dn-2025-0472","pmid":"https://pubmed.ncbi.nlm.nih.gov/42643967","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13506175"},"language":"en","primary_location":{"id":"doi:10.1590/1980-5764-dn-2025-0472","doi":"https://doi.org/10.1590/1980-5764-dn-2025-0472","is_oa":true,"landing_page_url":"https://doi.org/10.1590/1980-5764-dn-2025-0472","pdf_url":"https://www.scielo.br/j/dn/a/vxRt3d34HynjLwcjD9ZMMft/?lang=en&format=pdf","source":{"id":"https://openalex.org/S2736711785","display_name":"Dementia & Neuropsychologia","issn_l":"1980-5764","issn":["1980-5764"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-20","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310312171","host_organization_name":"Associa\u00e7\u00e3o Neurologia Cognitiva e do Comportamento","host_organization_lineage":["https://openalex.org/P4310312171"],"host_organization_lineage_names":["Associa\u00e7\u00e3o Neurologia Cognitiva e do Comportamento"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia &amp; Neuropsychologia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.scielo.br/j/dn/a/vxRt3d34HynjLwcjD9ZMMft/?lang=en&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116172660","display_name":"Neelufar Shama Shaik","orcid":"https://orcid.org/0000-0002-5607-3466","observed_orcids":["https://orcid.org/0000-0002-5607-3466"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Neelufar Shama Shaik","raw_affiliation_strings":["Scient Institute of Pharmacy,  India"],"raw_orcid":"https://orcid.org/0000-0002-5607-3466","affiliations":[{"raw_affiliation_string":"Scient Institute of Pharmacy,  India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048311916","display_name":"Harika Balya","orcid":"https://orcid.org/0000-0002-8229-0405","observed_orcids":["https://orcid.org/0000-0002-8229-0405"]},"institutions":[{"id":"https://openalex.org/I4405252669","display_name":"Fujairah University","ror":"https://ror.org/05h1fqt10","country_code":"AE","type":"education","lineage":["https://openalex.org/I4405252669"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Harika Balya","raw_affiliation_strings":["Fujairah University,  UAE"],"raw_orcid":"https://orcid.org/0000-0002-8229-0405","affiliations":[{"raw_affiliation_string":"Fujairah University,  UAE","institution_ids":["https://openalex.org/I4405252669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084255098","display_name":"S Ramamurthy","orcid":"https://orcid.org/0000-0002-8434-151X","observed_orcids":["https://orcid.org/0000-0002-8434-151X"]},"institutions":[{"id":"https://openalex.org/I4405252669","display_name":"Fujairah University","ror":"https://ror.org/05h1fqt10","country_code":"AE","type":"education","lineage":["https://openalex.org/I4405252669"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Srinivasan Ramamurthy","raw_affiliation_strings":["Fujairah University,  UAE"],"raw_orcid":"https://orcid.org/0000-0002-8434-151X","affiliations":[{"raw_affiliation_string":"Fujairah University,  UAE","institution_ids":["https://openalex.org/I4405252669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070833403","display_name":"Balaji Pandiyan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138876546","display_name":"Vels University","ror":"https://ror.org/00tscx035","country_code":"IN","type":"education","lineage":["https://openalex.org/I138876546"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Balaji Pandiyan","raw_affiliation_strings":["Vels Institute of Science, Technology and Advanced Studies (VISTAS),  India"],"raw_orcid":"https://orcid.org/0000-0001-5317-1661","affiliations":[{"raw_affiliation_string":"Vels Institute of Science, Technology and Advanced Studies (VISTAS),  India","institution_ids":["https://openalex.org/I138876546"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106135791","display_name":"E. Joel Mart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138876546","display_name":"Vels University","ror":"https://ror.org/00tscx035","country_code":"IN","type":"education","lineage":["https://openalex.org/I138876546"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Joel Mart Elias","raw_affiliation_strings":["Vels Institute of Science, Technology and Advanced Studies (VISTAS),  India"],"raw_orcid":"https://orcid.org/0009-0000-9560-674X","affiliations":[{"raw_affiliation_string":"Vels Institute of Science, Technology and Advanced Studies (VISTAS),  India","institution_ids":["https://openalex.org/I138876546"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5140242080","display_name":"Suvarna Lakshmi Gunturu","orcid":"https://orcid.org/0009-0002-4377-6784","observed_orcids":["https://orcid.org/0009-0002-4377-6784"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suvarnalakshmi Gunturu","raw_affiliation_strings":["The Oxford College of Pharmacy,  India"],"raw_orcid":"https://orcid.org/0009-0002-4377-6784","affiliations":[{"raw_affiliation_string":"The Oxford College of Pharmacy,  India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5116172660"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":null,"first_page":"e20250472","last_page":"e20250472"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.1712999939918518,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0763000026345253,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anti-alzheimer-drugs","display_name":"anti-Alzheimer agents","score":0.8970000147819519},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.9819999933242798},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cholinesterase-inhibitors","display_name":"cholinesterase inhibitors","score":0.949999988079071},{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.9120000004768372},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9399999976158142},{"id":"https://openalex.org/keywords/drug-class-comparison","display_name":"drug class comparison","score":0.7839999794960022},{"id":"https://openalex.org/keywords/post-approval-monitoring","display_name":"post-approval monitoring","score":0.6769999861717224},{"id":"https://openalex.org/keywords/investigational-drugs","display_name":"investigational drugs","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6787999868392944},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.6431999802589417},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5390999913215637},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4921000003814697},{"id":"https://openalex.org/C2778176773","wikidata":"https://www.wikidata.org/wiki/Q2976049","display_name":"Drug class","level":3,"score":0.48010000586509705},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4661000072956085},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.4618000090122223},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41519999504089355},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4115999937057495},{"id":"https://openalex.org/C31896038","wikidata":"https://www.wikidata.org/wiki/Q415635","display_name":"Cholinesterase","level":2,"score":0.40149998664855957},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3959999978542328},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3668999969959259},{"id":"https://openalex.org/C2992092908","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Drug toxicity","level":3,"score":0.36579999327659607},{"id":"https://openalex.org/C2779328685","wikidata":"https://www.wikidata.org/wiki/Q1475557","display_name":"Patient safety","level":3,"score":0.35580000281333923},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3517000079154968},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.33880001306533813},{"id":"https://openalex.org/C2910824759","wikidata":"https://www.wikidata.org/wiki/Q6060674","display_name":"Investigational Drugs","level":3,"score":0.33250001072883606},{"id":"https://openalex.org/C3018359032","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Safety profile","level":3,"score":0.33219999074935913},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.33160001039505005},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3224000036716461},{"id":"https://openalex.org/C148482608","wikidata":"https://www.wikidata.org/wiki/Q17007018","display_name":"Clinical study design","level":3,"score":0.32190001010894775},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.2806999981403351},{"id":"https://openalex.org/C57658597","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Pharmacovigilance","level":3,"score":0.2791999876499176},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2768000066280365},{"id":"https://openalex.org/C3018260909","wikidata":"https://www.wikidata.org/wiki/Q1322871","display_name":"Exploratory analysis","level":2,"score":0.26980000734329224},{"id":"https://openalex.org/C83867959","wikidata":"https://www.wikidata.org/wiki/Q371467","display_name":"Scopus","level":3,"score":0.266400009393692},{"id":"https://openalex.org/C2777488183","wikidata":"https://www.wikidata.org/wiki/Q6900510","display_name":"Safety monitoring","level":2,"score":0.2615000009536743},{"id":"https://openalex.org/C2993432071","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Drug reaction","level":3,"score":0.2565000057220459}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1590/1980-5764-dn-2025-0472","doi":"https://doi.org/10.1590/1980-5764-dn-2025-0472","is_oa":true,"landing_page_url":"https://doi.org/10.1590/1980-5764-dn-2025-0472","pdf_url":"https://www.scielo.br/j/dn/a/vxRt3d34HynjLwcjD9ZMMft/?lang=en&format=pdf","source":{"id":"https://openalex.org/S2736711785","display_name":"Dementia & Neuropsychologia","issn_l":"1980-5764","issn":["1980-5764"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-20","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310312171","host_organization_name":"Associa\u00e7\u00e3o Neurologia Cognitiva e do Comportamento","host_organization_lineage":["https://openalex.org/P4310312171"],"host_organization_lineage_names":["Associa\u00e7\u00e3o Neurologia Cognitiva e do Comportamento"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia &amp; Neuropsychologia","raw_type":"journal-article"},{"id":"pmid:42643967","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42643967","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia & neuropsychologia","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13506175","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13506175/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dement Neuropsychol","raw_type":"Text"},{"id":"pmh:oai:redalyc.org:339584217057","doi":null,"is_oa":true,"landing_page_url":"https://www.redalyc.org/articulo.oa?id=339584217057","pdf_url":"https://www.redalyc.org/journal/3395/339584217057/339584217057.pdf","source":{"id":"https://openalex.org/S4377196100","display_name":"Redalyc (Universidad Aut\u00f3noma del Estado de M\u00e9xico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179647637","host_organization_name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","host_organization_lineage":["https://openalex.org/I179647637"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dementia & Neuropsychologia (Brasil) Vol.20","raw_type":"art\u00edculo cient\u00edfico"},{"id":"pmh:oai:doaj.org/article:ceb9de780e564d48988743b1b75edd93","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ceb9de780e564d48988743b1b75edd93","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dementia & Neuropsychologia, Vol 20 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1590/1980-5764-dn-2025-0472","doi":"https://doi.org/10.1590/1980-5764-dn-2025-0472","is_oa":true,"landing_page_url":"https://doi.org/10.1590/1980-5764-dn-2025-0472","pdf_url":"https://www.scielo.br/j/dn/a/vxRt3d34HynjLwcjD9ZMMft/?lang=en&format=pdf","source":{"id":"https://openalex.org/S2736711785","display_name":"Dementia & Neuropsychologia","issn_l":"1980-5764","issn":["1980-5764"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-20","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310312171","host_organization_name":"Associa\u00e7\u00e3o Neurologia Cognitiva e do Comportamento","host_organization_lineage":["https://openalex.org/P4310312171"],"host_organization_lineage_names":["Associa\u00e7\u00e3o Neurologia Cognitiva e do Comportamento"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia &amp; Neuropsychologia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204118436.pdf","grobid_xml":"https://content.openalex.org/works/W7204118436.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W8541533","https://openalex.org/W170237590","https://openalex.org/W365522285","https://openalex.org/W1486207314","https://openalex.org/W1987908556","https://openalex.org/W1995739462","https://openalex.org/W2002993996","https://openalex.org/W2015484447","https://openalex.org/W2046432652","https://openalex.org/W2048780418","https://openalex.org/W2063808031","https://openalex.org/W2067777747","https://openalex.org/W2073075722","https://openalex.org/W2077633683","https://openalex.org/W2086572083","https://openalex.org/W2109891655","https://openalex.org/W2122867853","https://openalex.org/W2129267808","https://openalex.org/W2142699659","https://openalex.org/W2144363852","https://openalex.org/W2153284686","https://openalex.org/W2161874115","https://openalex.org/W2197001618","https://openalex.org/W2290076360","https://openalex.org/W2466890096","https://openalex.org/W2552332095","https://openalex.org/W2755313511","https://openalex.org/W2770424213","https://openalex.org/W2895816045","https://openalex.org/W2989656389","https://openalex.org/W3006150517","https://openalex.org/W3027232257","https://openalex.org/W3118615836","https://openalex.org/W4232629811","https://openalex.org/W4233035841","https://openalex.org/W4282547758","https://openalex.org/W4296286739","https://openalex.org/W4377220584","https://openalex.org/W4388424077","https://openalex.org/W4402692973","https://openalex.org/W4403527763","https://openalex.org/W4404024063","https://openalex.org/W4404162061","https://openalex.org/W4404467777","https://openalex.org/W4405498183","https://openalex.org/W4405960374","https://openalex.org/W4407684595","https://openalex.org/W4407852562","https://openalex.org/W4408005577"],"related_works":["https://openalex.org/W2562816318","https://openalex.org/W4226073657","https://openalex.org/W4392359588","https://openalex.org/W4394950934","https://openalex.org/W4226047279","https://openalex.org/W4417479752","https://openalex.org/W4394601505","https://openalex.org/W3092619605","https://openalex.org/W7165800450","https://openalex.org/W4407824859"],"abstract_inverted_index":{"Alzheimer's":[0,20,70,176],"disease":[1,21],"is":[2],"a":[3,67,159,217],"progressive":[4],"illness":[5],"that":[6,110,178,237],"results":[7],"in":[8,146,172,201],"the":[9,38,45,59,83,98,162,173,240],"degeneration":[10],"of":[11,52,64,69,103,123,164,175,192,220,245],"neurons":[12],"with":[13,94],"considerable":[14,170],"burden.":[15],"The":[16,56,152,167,187],"pharmacological":[17],"treatments":[18],"for":[19,44,87,161],"include":[22],"cholinesterase":[23],"inhibitors,":[24],"monoclonal":[25],"antibodies,":[26],"NMDA":[27],"receptor":[28],"antagonists":[29],"despite":[30],"having":[31],"different":[32,50],"adverse":[33,221],"drug":[34,156,222],"reactions":[35,223],"(ADR)":[36],"alongside":[37],"health":[39],"benefits.":[40],"Limited":[41],"data":[42],"exists":[43],"complete":[46],"safety":[47,75,174,193,235],"evaluation":[48,194],"across":[49,76,224],"classes":[51],"anti-Alzheimer's":[53,124,229],"drugs.":[54,125],"Objective:":[55],"meta-analysis":[57,81],"evaluated":[58],"severity,":[60],"frequency":[61],"and":[62,90,108,117,142,227,242],"variability":[63],"ADR":[65],"as":[66,158,195,197],"result":[68],"drugs":[71,177],"to":[72,134,148],"determine":[73],"relative":[74],"various":[77],"classes.":[78],"Methods:":[79],"This":[80],"followed":[82],"Preferred":[84],"Reporting":[85],"Items":[86],"Systematic":[88],"Reviews":[89],"Meta-Analyses":[91],"(PRISMA)":[92],"guidelines":[93],"studies":[95,119],"derived":[96],"from":[97],"United":[99],"States":[100],"National":[101],"Library":[102],"Medicine":[104],"(PubMed),":[105],"Embase,":[106],"Scopus":[107],"ClinicalTrials.gov":[109],"focus":[111],"on":[112,210],"randomized":[113],"controlled":[114],"trials":[115],"(RCTs)":[116],"observational":[118],"which":[120],"detailed":[121],"ADRs":[122],"Jeffrey's":[126],"Amazing":[127],"Statistics":[128],"Program":[129],"(JASP)":[130],"software":[131],"was":[132],"used":[133],"conduct":[135],"heterogeneity":[136],"assessment":[137],"(I2),":[138],"risk":[139],"ratio":[140],"(RR)":[141],"publication":[143],"bias":[144],"analysis":[145,154,219],"addition":[147],"meta-regression.":[149],"Results:":[150],">50%).":[151],"meta-regression":[153],"indicated":[155],"class":[157],"predictor":[160],"type":[163],"ADR.":[165],"Conclusion:":[166],"research":[168],"demonstrates":[169],"variations":[171],"need":[179],"tailored":[180],"treatment":[181,199],"supported":[182],"by":[183],"post-approval":[184],"monitoring":[185],"systems.":[186],"literature":[188],"needs":[189],"extended":[190],"investigations":[191,200],"well":[196],"practical":[198],"actual":[202],"clinical":[203,243],"settings.":[204],"Unlike":[205],"conventional":[206],"reviews":[207],"focusing":[208],"solely":[209],"currently":[211],"approved":[212],"therapies,":[213],"this":[214],"study":[215],"provides":[216],"cross-generational":[218],"both":[225],"historical":[226],"investigational":[228],"agents,":[230],"offering":[231],"insights":[232],"into":[233],"mechanism-related":[234],"patterns":[236],"may":[238],"inform":[239],"development":[241],"use":[244],"emerging":[246],"therapies.":[247]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-08-25T00:00:00"}
