{"id":"https://openalex.org/W7204111871","doi":"https://doi.org/10.2169/internalmedicine.7265-26","title":"Systemic AA Amyloidosis Following Immune Checkpoint Inhibitor Therapy for Lung Carcinosarcoma: An Autopsy Case and Review of the Literature","display_name":"Systemic AA Amyloidosis Following Immune Checkpoint Inhibitor Therapy for Lung Carcinosarcoma: An Autopsy Case and Review of the Literature","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7204111871","doi":"https://doi.org/10.2169/internalmedicine.7265-26","pmid":"https://pubmed.ncbi.nlm.nih.gov/42649055"},"language":"en","primary_location":{"id":"doi:10.2169/internalmedicine.7265-26","doi":"https://doi.org/10.2169/internalmedicine.7265-26","is_oa":true,"landing_page_url":"https://doi.org/10.2169/internalmedicine.7265-26","pdf_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7265-26/_pdf","source":{"id":"https://openalex.org/S154471048","display_name":"Internal Medicine","issn_l":"0918-2918","issn":["0918-2918","1349-7235"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313351","host_organization_name":"The Japanese Society of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310313351"],"host_organization_lineage_names":["The Japanese Society of Internal Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7265-26/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092365228","display_name":"Shinobu Onishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinobu Onishi","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine, Hokkaido University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine, Hokkaido University, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102936541","display_name":"Sari Iwasaki","orcid":"https://orcid.org/0000-0002-2075-1122","observed_orcids":["https://orcid.org/0000-0002-2075-1122"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sari Iwasaki","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine, Hokkaido University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine, Hokkaido University, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112714471","display_name":"Shimpei Nakagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shimpei Nakagawa","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine, Hokkaido University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine, Hokkaido University, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066944629","display_name":"Takuya Otsuka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Otsuka","raw_affiliation_strings":["Department of Surgical Pathology, Hokkaido University Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Pathology, Hokkaido University Hospital, Japan","institution_ids":["https://openalex.org/I4210141669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122263635","display_name":"Yuko Katayama","orcid":"https://orcid.org/0009-0003-1088-5607","observed_orcids":["https://orcid.org/0009-0003-1088-5607"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuko Katayama","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine, Hokkaido University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine, Hokkaido University, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130548615","display_name":"Satoshi Aoyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Aoyama","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine, Hokkaido University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine, Hokkaido University, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108695404","display_name":"Tetsuaki Shoji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuaki Shoji","raw_affiliation_strings":["Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158002717","display_name":"Satoshi Tanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Tanaka","raw_affiliation_strings":["Center for Cause of Death Investigation, Hokkaido University, Japan","Department of Cancer Pathology, Faculty of Medicine, Hokkaido University, Japan","Department of Surgical Pathology, Hokkaido University Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cause of Death Investigation, Hokkaido University, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Department of Cancer Pathology, Faculty of Medicine, Hokkaido University, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Department of Surgical Pathology, Hokkaido University Hospital, Japan","institution_ids":["https://openalex.org/I4210141669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121102265","display_name":"J. Sakakibara-Konishi","orcid":"https://orcid.org/0000-0003-4333-8100","observed_orcids":["https://orcid.org/0000-0003-4333-8100"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Sakakibara-Konishi","raw_affiliation_strings":["Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077400696","display_name":"Yoshihiro Matsuno","orcid":"https://orcid.org/0000-0003-3426-1674","observed_orcids":["https://orcid.org/0000-0003-3426-1674"]},"institutions":[{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Matsuno","raw_affiliation_strings":["Department of Surgical Pathology, Hokkaido University Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Pathology, Hokkaido University Hospital, Japan","institution_ids":["https://openalex.org/I4210141669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057784648","display_name":"Shinya Tanaka","orcid":"https://orcid.org/0000-0001-6470-3301","observed_orcids":["https://orcid.org/0000-0001-6470-3301"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinya Tanaka","raw_affiliation_strings":["Center for Cause of Death Investigation, Hokkaido University, Japan","Department of Cancer Pathology, Faculty of Medicine, Hokkaido University, Japan","Department of Surgical Pathology, Hokkaido University Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cause of Death Investigation, Hokkaido University, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Department of Cancer Pathology, Faculty of Medicine, Hokkaido University, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Department of Surgical Pathology, Hokkaido University Hospital, Japan","institution_ids":["https://openalex.org/I4210141669"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009265963","display_name":"Koji Taniguchi","orcid":"https://orcid.org/0000-0002-8091-6005","observed_orcids":["https://orcid.org/0000-0002-8091-6005"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Taniguchi","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine, Hokkaido University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine, Hokkaido University, Japan","institution_ids":["https://openalex.org/I205349734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0436,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.89899429,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11576","display_name":"IgG4-Related and Inflammatory Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aa-amyloidosis","display_name":"AA amyloidosis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9750000238418579},{"id":"https://openalex.org/keywords/intestinal-pseudo-obstruction","display_name":"intestinal pseudo-obstruction","score":0.9359999895095825},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.7379999756813049},{"id":"https://openalex.org/keywords/aspiration-pneumonia","display_name":"aspiration pneumonia","score":0.7950000166893005},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.6349999904632568},{"id":"https://openalex.org/keywords/tubulointerstitial-nephritis","display_name":"interstitial nephritis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/chronic-thyroiditis","display_name":"chronic thyroiditis","score":0.8569999933242798},{"id":"https://openalex.org/keywords/c-reactive-protein-elevation","display_name":"C-reactive protein elevation","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9629999995231628},{"id":"https://openalex.org/C2777007455","wikidata":"https://www.wikidata.org/wiki/Q2844591","display_name":"AA amyloidosis","level":4,"score":0.7918000221252441},{"id":"https://openalex.org/C2779504383","wikidata":"https://www.wikidata.org/wiki/Q41482","display_name":"Autopsy","level":2,"score":0.6434999704360962},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6122999787330627},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5443000197410583},{"id":"https://openalex.org/C169382597","wikidata":"https://www.wikidata.org/wiki/Q21208025","display_name":"Programmed cell death 1","level":5,"score":0.5159000158309937},{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.4410000145435333},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.3977000117301941},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.396699994802475},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.34929999709129333},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.30550000071525574},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.305400013923645},{"id":"https://openalex.org/C2779551797","wikidata":"https://www.wikidata.org/wiki/Q4652470","display_name":"AL amyloidosis","level":4,"score":0.29660001397132874},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27730000019073486},{"id":"https://openalex.org/C2777543607","wikidata":"https://www.wikidata.org/wiki/Q1153419","display_name":"Interstitial lung disease","level":3,"score":0.27399998903274536},{"id":"https://openalex.org/C9418649","wikidata":"https://www.wikidata.org/wiki/Q5275407","display_name":"Diffuse alveolar damage","level":4,"score":0.2736000120639801},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.272599995136261},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.263700008392334}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2169/internalmedicine.7265-26","doi":"https://doi.org/10.2169/internalmedicine.7265-26","is_oa":true,"landing_page_url":"https://doi.org/10.2169/internalmedicine.7265-26","pdf_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7265-26/_pdf","source":{"id":"https://openalex.org/S154471048","display_name":"Internal Medicine","issn_l":"0918-2918","issn":["0918-2918","1349-7235"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313351","host_organization_name":"The Japanese Society of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310313351"],"host_organization_lineage_names":["The Japanese Society of Internal Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine","raw_type":"journal-article"},{"id":"pmid:42649055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42649055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal medicine (Tokyo, Japan)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2169/internalmedicine.7265-26","doi":"https://doi.org/10.2169/internalmedicine.7265-26","is_oa":true,"landing_page_url":"https://doi.org/10.2169/internalmedicine.7265-26","pdf_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7265-26/_pdf","source":{"id":"https://openalex.org/S154471048","display_name":"Internal Medicine","issn_l":"0918-2918","issn":["0918-2918","1349-7235"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313351","host_organization_name":"The Japanese Society of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310313351"],"host_organization_lineage_names":["The Japanese Society of Internal Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204111871.pdf","grobid_xml":"https://content.openalex.org/works/W7204111871.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7203547142","https://openalex.org/W3012183696","https://openalex.org/W2301851804","https://openalex.org/W7106285214","https://openalex.org/W4286587064","https://openalex.org/W7154777810","https://openalex.org/W2125996397","https://openalex.org/W4231147719","https://openalex.org/W4406362197","https://openalex.org/W2037101669"],"abstract_inverted_index":{"AA":[0,68,98],"amyloidosis":[1],"is":[2],"a":[3,17,21,33,50],"rare":[4],"but":[5],"serious":[6],"complication":[7],"of":[8,16,24],"chronic":[9,51,77],"inflammation.":[10],"We":[11],"report":[12],"an":[13],"autopsy":[14],"case":[15,83],"68-year-old":[18],"man":[19],"without":[20],"documented":[22],"history":[23],"inflammatory":[25],"disease":[26],"who":[27],"developed":[28,49],"lung":[29],"carcinosarcoma":[30],"and":[31,61,75,79,91],"achieved":[32],"durable":[34],"complete":[35],"response":[36],"after":[37,92],"sequential":[38],"immune":[39],"checkpoint":[40],"inhibitor":[41],"(ICI)":[42],"therapy.":[43],"Despite":[44],"tumor":[45],"control,":[46],"the":[47,73,85],"patient":[48],"intestinal":[52],"pseudo-obstruction,":[53],"persistent":[54],"C-reactive":[55],"protein":[56],"elevation,":[57],"progressive":[58],"renal":[59],"dysfunction,":[60],"later":[62],"aspiration":[63],"pneumonia.":[64],"Autopsy":[65],"revealed":[66],"systemic":[67,97],"amyloid":[69],"deposition,":[70],"predominantly":[71],"in":[72],"intestines":[74],"kidneys,":[76],"thyroiditis,":[78],"tubulointerstitial":[80],"nephritis.":[81],"This":[82],"raises":[84],"possibility":[86],"that":[87],"prolonged":[88],"inflammation":[89],"during":[90],"ICI":[93],"therapy":[94],"contributes":[95],"to":[96],"amyloidosis.":[99]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-08-25T00:00:00"}