{"id":"https://openalex.org/W7204111042","doi":"https://doi.org/10.1093/schbul/sbag107","title":"Prolonged Childhood and Adolescent Loneliness in First-Episode Psychosis: Synergistic Polygenic Effects and Functional Outcomes","display_name":"Prolonged Childhood and Adolescent Loneliness in First-Episode Psychosis: Synergistic Polygenic Effects and Functional Outcomes","publication_year":2026,"publication_date":"2026-05-27","ids":{"openalex":"https://openalex.org/W7204111042","doi":"https://doi.org/10.1093/schbul/sbag107","pmid":"https://pubmed.ncbi.nlm.nih.gov/42636467","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13502900"},"language":"en","primary_location":{"id":"doi:10.1093/schbul/sbag107","doi":"https://doi.org/10.1093/schbul/sbag107","is_oa":false,"landing_page_url":"https://doi.org/10.1093/schbul/sbag107","pdf_url":null,"source":{"id":"https://openalex.org/S117485531","display_name":"Schizophrenia Bulletin","issn_l":"0586-7614","issn":["0586-7614","1745-1701","1745-1707"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Schizophrenia Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pubmed.ncbi.nlm.nih.gov/42636467/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087102006","display_name":"\u00c1lvaro Andreu-Bernabeu","orcid":"https://orcid.org/0000-0002-1467-7341","observed_orcids":["https://orcid.org/0000-0002-1467-7341"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4210090703","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","ror":"https://ror.org/009byq155","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4405268975","display_name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/02p8e3h61","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4405268975"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"\u00c1lvaro Andreu-Bernabeu","raw_affiliation_strings":["Biomedical Research Networking Centre in Mental Health (CIBERSAM) ,","Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM) , Madrid ,","School of Medicine, Universidad Complutense de Madrid , Madrid ,"],"raw_orcid":"https://orcid.org/0000-0002-1467-7341","affiliations":[{"raw_affiliation_string":"Biomedical Research Networking Centre in Mental Health (CIBERSAM) ,","institution_ids":["https://openalex.org/I4210090703"]},{"raw_affiliation_string":"Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM) , Madrid ,","institution_ids":["https://openalex.org/I2960094004","https://openalex.org/I4405268975"]},{"raw_affiliation_string":"School of Medicine, Universidad Complutense de Madrid , Madrid ,","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125989829","display_name":"Javier Gonzalez-Pe\u00f1as","orcid":"https://orcid.org/0000-0002-3850-3012","observed_orcids":["https://orcid.org/0000-0002-3850-3012"]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4210090703","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","ror":"https://ror.org/009byq155","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4405268975","display_name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/02p8e3h61","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4405268975"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Gonz\u00e1lez-Pe\u00f1as","raw_affiliation_strings":["Biomedical Research Networking Centre in Mental Health (CIBERSAM) ,","Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM) , Madrid ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Networking Centre in Mental Health (CIBERSAM) ,","institution_ids":["https://openalex.org/I4210090703"]},{"raw_affiliation_string":"Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM) , Madrid ,","institution_ids":["https://openalex.org/I2960094004","https://openalex.org/I4405268975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025453526","display_name":"Miquel Bernardo","orcid":"https://orcid.org/0000-0001-8748-6717","observed_orcids":["https://orcid.org/0000-0001-8748-6717"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel Bernardo","raw_affiliation_strings":["Barcelona Cl\u00ednic Schizophrenia Unit, Hospital Cl\u00ednic de Barcelona , Barcelona ,","Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer , Barcelona ,"],"raw_orcid":"https://orcid.org/0000-0001-8748-6717","affiliations":[{"raw_affiliation_string":"Barcelona Cl\u00ednic Schizophrenia Unit, Hospital Cl\u00ednic de Barcelona , Barcelona ,","institution_ids":["https://openalex.org/I4210115097"]},{"raw_affiliation_string":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer , Barcelona ,","institution_ids":["https://openalex.org/I4210160192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051851273","display_name":"S\u00edlvia Amoretti","orcid":"https://orcid.org/0000-0001-6017-2734","observed_orcids":["https://orcid.org/0000-0001-6017-2734"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210090703","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","ror":"https://ror.org/009byq155","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]},{"id":"https://openalex.org/I4405284846","display_name":"Institut d'Investigaci\u00f3 Sanit\u00e0ria Acreditat Institut de Recerca - Hospital Universitari Vall d'Hebron","ror":"https://ror.org/04a30t809","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4405284846"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Silvia Amoretti","raw_affiliation_strings":["Psychiatry, Mental Health and Addictions Group, Vall d'Hebron Research Institute (VHIR), Instituto de Investigaci\u00f3n Sanitaria Acreditado Instituto de Investigaci\u00f3n - Hospital Universitario Vall d'Hebron (IR-HUVH), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental, Instituto de Salud Carlos III , Madrid ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatry, Mental Health and Addictions Group, Vall d'Hebron Research Institute (VHIR), Instituto de Investigaci\u00f3n Sanitaria Acreditado Instituto de Investigaci\u00f3n - Hospital Universitario Vall d'Hebron (IR-HUVH), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental, Instituto de Salud Carlos III , Madrid ,","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I4210102407","https://openalex.org/I4210127641","https://openalex.org/I4405284846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083202579","display_name":"Julio Bobes","orcid":"https://orcid.org/0000-0003-2187-4033","observed_orcids":["https://orcid.org/0000-0003-2187-4033"]},"institutions":[{"id":"https://openalex.org/I165339363","display_name":"Universidad de Oviedo","ror":"https://ror.org/006gksa02","country_code":"ES","type":"education","lineage":["https://openalex.org/I165339363"]},{"id":"https://openalex.org/I4210090703","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","ror":"https://ror.org/009byq155","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210166274","display_name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias","ror":"https://ror.org/05xzb7x97","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2800212897","https://openalex.org/I4210166274"]},{"id":"https://openalex.org/I4405258403","display_name":"Servicio de Salud del Principado de Asturias","ror":"https://ror.org/00kj4ev13","country_code":"ES","type":"government","lineage":["https://openalex.org/I2800212897","https://openalex.org/I4405258403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Julio Bobes","raw_affiliation_strings":["Biomedical Research Networking Centre in Mental Health (CIBERSAM) ,","Department of Psychiatry, School of Medicine, University of Oviedo , Oviedo ,","Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA) , Oviedo ,","Mental Health Services of Principado de Asturias (SESPA) , Oviedo ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Networking Centre in Mental Health (CIBERSAM) ,","institution_ids":["https://openalex.org/I4210090703"]},{"raw_affiliation_string":"Department of Psychiatry, School of Medicine, University of Oviedo , Oviedo ,","institution_ids":["https://openalex.org/I165339363"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA) , Oviedo ,","institution_ids":["https://openalex.org/I4210166274"]},{"raw_affiliation_string":"Mental Health Services of Principado de Asturias (SESPA) , Oviedo ,","institution_ids":["https://openalex.org/I4405258403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053783509","display_name":"Manuel Arrojo","orcid":"https://orcid.org/0000-0002-5609-7134","observed_orcids":["https://orcid.org/0000-0002-5609-7134"]},"institutions":[{"id":"https://openalex.org/I4210096311","display_name":"Complejo Hospitalario Universitario de Santiago","ror":"https://ror.org/00mpdg388","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096311"]},{"id":"https://openalex.org/I4210148771","display_name":"Instituto de Investigaci\u00f3n Sanitaria de Santiago","ror":"https://ror.org/05n7xcf53","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210148771"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuel Arrojo","raw_affiliation_strings":["Department of Psychiatry, Instituto de Investigaci\u00f3n Sanitaria, Complejo Hospitalario Universitario de Santiago de Compostela , Santiago de Compostela ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Instituto de Investigaci\u00f3n Sanitaria, Complejo Hospitalario Universitario de Santiago de Compostela , Santiago de Compostela ,","institution_ids":["https://openalex.org/I4210096311","https://openalex.org/I4210148771"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027816426","display_name":"Mara Parellada","orcid":"https://orcid.org/0000-0001-7977-3601","observed_orcids":["https://orcid.org/0000-0001-7977-3601"]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4210090703","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","ror":"https://ror.org/009byq155","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4405268975","display_name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/02p8e3h61","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4405268975"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mara Parellada","raw_affiliation_strings":["Biomedical Research Networking Centre in Mental Health (CIBERSAM) ,","Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM) , Madrid ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Networking Centre in Mental Health (CIBERSAM) ,","institution_ids":["https://openalex.org/I4210090703"]},{"raw_affiliation_string":"Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM) , Madrid ,","institution_ids":["https://openalex.org/I2960094004","https://openalex.org/I4405268975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059458620","display_name":"Michael C. O\u2019Donovan","orcid":"https://orcid.org/0000-0001-7073-2379","observed_orcids":["https://orcid.org/0000-0001-7073-2379"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael O'Donovan","raw_affiliation_strings":["Cardiff University Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University , Cardiff ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiff University Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University , Cardiff ,","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024796415","display_name":"Jim van Os","orcid":"https://orcid.org/0000-0002-7245-1586","observed_orcids":["https://orcid.org/0000-0002-7245-1586"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210144767","display_name":"GGNet","ror":"https://ror.org/041g5fr04","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210144767"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jim van Os","raw_affiliation_strings":["Department of Psychiatry, UMC Utrecht Brain Centre, University Medical Centre Utrecht, Utrecht University , Utrecht ,","Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University , Utrecht ,","GGNet Mental Health , Apeldoorn ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, UMC Utrecht Brain Centre, University Medical Centre Utrecht, Utrecht University , Utrecht ,","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University , Utrecht ,","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916"]},{"raw_affiliation_string":"GGNet Mental Health , Apeldoorn ,","institution_ids":["https://openalex.org/I4210144767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032232964","display_name":"Bart P. F. Rutten","orcid":"https://orcid.org/0000-0002-9834-6346","observed_orcids":["https://orcid.org/0000-0002-9834-6346"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bart P F Rutten","raw_affiliation_strings":["Department of Psychiatry and Neuropsychology, Mental Health and Neuroscience Research Institute, Maastricht University Medical Centre , Maastricht ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Neuropsychology, Mental Health and Neuroscience Research Institute, Maastricht University Medical Centre , Maastricht ,","institution_ids":["https://openalex.org/I2800191616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029413844","display_name":"Robin M. Murray","orcid":"https://orcid.org/0000-0003-0829-0519","observed_orcids":["https://orcid.org/0000-0003-0829-0519"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robin M Murray","raw_affiliation_strings":["Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London , London ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London , London ,","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100701393","display_name":"Marta Di Forti","orcid":"https://orcid.org/0000-0002-3218-6925","observed_orcids":["https://orcid.org/0000-0002-3218-6925"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marta Di Forti","raw_affiliation_strings":["Social, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London , London ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Social, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London , London ,","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073051979","display_name":"Evangelos Vassos","orcid":"https://orcid.org/0000-0001-6363-0438","observed_orcids":["https://orcid.org/0000-0001-6363-0438"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Evangelos Vassos","raw_affiliation_strings":["Social, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London , London ,"],"raw_orcid":"https://orcid.org/0000-0001-6363-0438","affiliations":[{"raw_affiliation_string":"Social, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London , London ,","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002872855","display_name":"Celso Arango","orcid":"https://orcid.org/0000-0003-3382-4754","observed_orcids":["https://orcid.org/0000-0003-3382-4754"]},"institutions":[{"id":"https://openalex.org/I2800562746","display_name":"Hospital Universitario La Paz","ror":"https://ror.org/01s1q0w69","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800562746"]},{"id":"https://openalex.org/I4210090703","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","ror":"https://ror.org/009byq155","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Celso Arango","raw_affiliation_strings":["Biomedical Research Networking Centre in Mental Health (CIBERSAM) ,","Department of Psychiatry, Clinical Psychology, and Mental Health, Hospital Universitario La Paz, Universidad Aut\u00f3noma de Madrid, School of Medicine , Madrid ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Networking Centre in Mental Health (CIBERSAM) ,","institution_ids":["https://openalex.org/I4210090703"]},{"raw_affiliation_string":"Department of Psychiatry, Clinical Psychology, and Mental Health, Hospital Universitario La Paz, Universidad Aut\u00f3noma de Madrid, School of Medicine , Madrid ,","institution_ids":["https://openalex.org/I2800562746","https://openalex.org/I63634437"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036133231","display_name":"Covadonga M. D\u00edaz\u2010Caneja","orcid":"https://orcid.org/0000-0001-8538-3175","observed_orcids":["https://orcid.org/0000-0001-8538-3175"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4210090703","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","ror":"https://ror.org/009byq155","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4405268975","display_name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/02p8e3h61","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4405268975"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Covadonga M D\u00edaz-Caneja","raw_affiliation_strings":["Biomedical Research Networking Centre in Mental Health (CIBERSAM) ,","Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM) , Madrid ,","School of Medicine, Universidad Complutense de Madrid , Madrid ,"],"raw_orcid":"https://orcid.org/0000-0001-8538-3175","affiliations":[{"raw_affiliation_string":"Biomedical Research Networking Centre in Mental Health (CIBERSAM) ,","institution_ids":["https://openalex.org/I4210090703"]},{"raw_affiliation_string":"Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM) , Madrid ,","institution_ids":["https://openalex.org/I2960094004","https://openalex.org/I4405268975"]},{"raw_affiliation_string":"School of Medicine, Universidad Complutense de Madrid , Madrid ,","institution_ids":["https://openalex.org/I121748325"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":23,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4981,"currency":"USD","value_usd":4981},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.63253266,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"52","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/childhood-loneliness","display_name":"childhood loneliness","score":0.7990000247955322},{"id":"https://openalex.org/keywords/adolescent-loneliness","display_name":"adolescent loneliness","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C2779998236","wikidata":"https://www.wikidata.org/wiki/Q223270","display_name":"Loneliness","level":2,"score":0.753600001335144},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.7437999844551086},{"id":"https://openalex.org/C2993137441","wikidata":"https://www.wikidata.org/wiki/Q28135712","display_name":"Polygenic risk score","level":5,"score":0.7186999917030334},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.7092999815940857},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.5968999862670898},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5547000169754028},{"id":"https://openalex.org/C143095724","wikidata":"https://www.wikidata.org/wiki/Q515895","display_name":"Odds","level":3,"score":0.517799973487854},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.512499988079071},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.49239999055862427},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.483599990606308},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.48159998655319214},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.43070000410079956},{"id":"https://openalex.org/C95713431","wikidata":"https://www.wikidata.org/wiki/Q631425","display_name":"Vulnerability (computing)","level":2,"score":0.36340001225471497},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.3441999852657318},{"id":"https://openalex.org/C123273963","wikidata":"https://www.wikidata.org/wiki/Q624758","display_name":"Psychopathology","level":2,"score":0.33009999990463257},{"id":"https://openalex.org/C3018432486","wikidata":"https://www.wikidata.org/wiki/Q7575316","display_name":"Schizophrenia spectrum","level":3,"score":0.3224000036716461},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3167000114917755},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.29510000348091125},{"id":"https://openalex.org/C130947863","wikidata":"https://www.wikidata.org/wiki/Q5533121","display_name":"Gene\u2013environment interaction","level":4,"score":0.2793000042438507},{"id":"https://openalex.org/C2780325297","wikidata":"https://www.wikidata.org/wiki/Q834047","display_name":"Schizoaffective disorder","level":3,"score":0.2574999928474426},{"id":"https://openalex.org/C2777727901","wikidata":"https://www.wikidata.org/wiki/Q3099410","display_name":"Schizotypy","level":3,"score":0.25110000371932983}],"mesh":[{"descriptor_ui":"D000076783","descriptor_name":"Adverse Childhood Experiences","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D000096442","descriptor_name":"Genetic Risk Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008132","descriptor_name":"Loneliness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059647","descriptor_name":"Gene-Environment Interaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1093/schbul/sbag107","doi":"https://doi.org/10.1093/schbul/sbag107","is_oa":false,"landing_page_url":"https://doi.org/10.1093/schbul/sbag107","pdf_url":null,"source":{"id":"https://openalex.org/S117485531","display_name":"Schizophrenia Bulletin","issn_l":"0586-7614","issn":["0586-7614","1745-1701","1745-1707"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Schizophrenia Bulletin","raw_type":"journal-article"},{"id":"pmid:42636467","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42636467","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Schizophrenia bulletin","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13502900","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42636467/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Schizophr Bull","raw_type":"Text"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:189266","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/view/cardiffauthors/A038895E.html>","pdf_url":null,"source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire_cris_publications/1530e9c0-cc15-4d80-b54e-3b63d2b2b9cc","doi":null,"is_oa":false,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/1530e9c0-cc15-4d80-b54e-3b63d2b2b9cc","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Andreu-Bernabeu, \u00c1, Gonz\u00e1lez-Pe\u00f1as, J, Bernardo, M, Amoretti, S, Bobes, J, Arrojo, M, Parellada, M, O'Donovan, M, van Os, J, Rutten, B P F, Murray, R M, Di Forti, M, Vassos, E, Arango, C & D\u00edaz-Caneja, C M 2026, 'Prolonged Childhood and Adolescent Loneliness in First-Episode Psychosis : Synergistic Polygenic Effects and Functional Outcomes', Schizophrenia Bulletin, vol. 52, no. 5, sbag107. https://doi.org/10.1093/schbul/sbag107","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/489989","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/489989","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13502900","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42636467/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Schizophr Bull","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G4520805168","display_name":"The impact of social isolation on aging health in schizophrenia","funder_award_id":"5r01mh128971-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8564942905","display_name":"ProNET: Psychosis-Risk Outcomes Network","funder_award_id":"U01MH124639","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G9000895199","display_name":"Laboratory for Early Psychosis Research (LEAP)","funder_award_id":"P50MH115846","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1870518772","https://openalex.org/W1900061083","https://openalex.org/W2004367892","https://openalex.org/W2018054716","https://openalex.org/W2097940171","https://openalex.org/W2113487283","https://openalex.org/W2139333064","https://openalex.org/W2329373217","https://openalex.org/W2332877535","https://openalex.org/W2415762599","https://openalex.org/W2559815495","https://openalex.org/W2587074482","https://openalex.org/W2592379749","https://openalex.org/W2599899556","https://openalex.org/W2775459139","https://openalex.org/W2783109045","https://openalex.org/W2924438810","https://openalex.org/W2944746345","https://openalex.org/W2951553270","https://openalex.org/W2951834781","https://openalex.org/W2972698755","https://openalex.org/W3007735197","https://openalex.org/W3044721886","https://openalex.org/W3081255729","https://openalex.org/W3136202165","https://openalex.org/W3161573550","https://openalex.org/W3199251285","https://openalex.org/W3204609501","https://openalex.org/W4205384593","https://openalex.org/W4210720798","https://openalex.org/W4211106541","https://openalex.org/W4223520055","https://openalex.org/W4327550262","https://openalex.org/W4385661711","https://openalex.org/W4386588065","https://openalex.org/W4392344609","https://openalex.org/W4399183373","https://openalex.org/W4400131384","https://openalex.org/W4405263865","https://openalex.org/W4406365831","https://openalex.org/W4406715937","https://openalex.org/W4411353668","https://openalex.org/W4412519958","https://openalex.org/W4414461651","https://openalex.org/W7125418574"],"related_works":["https://openalex.org/W4411353668","https://openalex.org/W7171539488","https://openalex.org/W4401920134","https://openalex.org/W4414824209","https://openalex.org/W4403784355","https://openalex.org/W3204609501","https://openalex.org/W2513402838","https://openalex.org/W2603478895","https://openalex.org/W4414181841","https://openalex.org/W4405263865"],"abstract_inverted_index":{"BACKGROUND:":[0],"Prolonged":[1,243],"childhood":[2],"and":[3,16,35,37,50,80,101,112,123,136,154,225,227,230,259],"adolescent":[4],"loneliness":[5],"(CAL)":[6],"may":[7],"mark":[8],"an":[9],"early":[10],"socio-emotional":[11],"vulnerability":[12],"relevant":[13],"to":[14,32,142,247],"psychosis":[15,29,188,254],"interact":[17],"with":[18,39,88,120,164,184,209,212],"genetic":[19],"liability.":[20,264],"We":[21,56],"examined":[22,132],"whether":[23],"CAL":[24,72,119,171,205,244],"increases":[25],"odds":[26,174],"of":[27,93,118,167,250,262],"first-episode":[28],"(FEP),":[30],"relates":[31],"diagnostic":[33],"subtype":[34],"functioning,":[36,124,211,258],"interacts":[38],"polygenic":[40,106,263],"risk":[41,107,249],"scores":[42],"(PGS)":[43],"for":[44,98],"schizophrenia":[45],"(SCZ),":[46],"bipolar":[47],"disorder":[48],"(BIP),":[49],"major":[51],"depression":[52],"(MDD).":[53],"STUDY":[54,144],"METHODS:":[55],"analyzed":[57],"2565":[58],"participants":[59],"(1084":[60],"FEP,":[61,121,165,251],"1481":[62],"controls)":[63],"from":[64],"European":[65],"Gene-Environment":[66],"Interactions":[67],"in":[68,175,197,238,255],"Schizophrenia":[69],"(EU-GEI)":[70],"study.":[71],"was":[73,86,131,182,206],"assessed":[74],"retrospectively":[75],"before":[76],"age":[77],"12":[78],"(LNL12)":[79],"at":[81],"12-16":[82],"years":[83],"(LNL12-16).":[84],"Functioning":[85,94],"rated":[87],"a":[89],"modified":[90],"Global":[91],"Assessment":[92],"(GAF).":[95],"Genome-wide":[96],"PGS":[97,135],"SCZ,":[99],"BIP,":[100],"MDD":[102],"were":[103,162,221],"calculated":[104],"using":[105,133],"score-continuous":[108],"shrinkage.":[109],"Mixed-effects":[110],"logistic":[111],"linear":[113],"regression":[114],"models":[115],"tested":[116],"associations":[117],"subtype,":[122],"including":[125],"sex-stratified":[126],"analyses.":[127,241],"Additive":[128],"gene-environment":[129],"interaction":[130],"dichotomized":[134],"the":[137,233],"Relative":[138],"Excess":[139],"Risk":[140],"due":[141],"Interaction.":[143],"RESULTS:":[145],"Both":[146],"LNL12":[147,229],"(OR":[148,156,189,199],"=":[149,157,190,200],"2.90,":[150],"95%":[151,159,192,202],"CI,":[152,160,193,203],"2.30-3.66)":[153],"LNL12-16":[155,224],"2.34,":[158],"1.94-2.84)":[161],"associated":[163,183,208],"independent":[166],"premorbid":[168],"social":[169],"isolation.":[170],"increased":[172],"FEP":[173],"both":[176],"sexes.":[177],"LNL12-16,":[178],"but":[179],"not":[180,236],"LNL12,":[181],"affective":[185,253],"versus":[186],"non-affective":[187],"1.37,":[191],"1.02-1.83),":[194],"more":[195],"clearly":[196],"females":[198],"1.79,":[201],"1.16-2.77).":[204],"also":[207],"poorer":[210,257],"3-4-point":[213],"lower":[214],"GAF":[215],"Disability":[216],"scores.":[217],"Significant":[218],"additive":[219],"interactions":[220],"observed":[222],"between":[223,228],"SCZ-PGS,":[226],"MDD-PGS,":[231],"although":[232],"latter":[234],"did":[235],"replicate":[237],"European-ancestry":[239],"sensitivity":[240],"CONCLUSIONS:":[242],"is":[245],"linked":[246],"higher":[248],"preferentially":[252],"females,":[256],"developmental":[260],"potentiation":[261]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-08-25T00:00:00"}