{"id":"https://openalex.org/W7204108349","doi":"https://doi.org/10.64898/2026.08.18.745347","title":"TRAPPC8 Is an Endogenous Brake on UFMylation That Suppresses Tauopathy","display_name":"TRAPPC8 Is an Endogenous Brake on UFMylation That Suppresses Tauopathy","publication_year":2026,"publication_date":"2026-08-23","ids":{"openalex":"https://openalex.org/W7204108349","doi":"https://doi.org/10.64898/2026.08.18.745347"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.18.745347","doi":"https://doi.org/10.64898/2026.08.18.745347","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.18.745347","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/23/2026.08.18.745347.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/23/2026.08.18.745347.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102885701","display_name":"Yuansong Wan","orcid":"https://orcid.org/0000-0001-9318-9145","observed_orcids":["https://orcid.org/0000-0001-9318-9145"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuansong Wan","raw_affiliation_strings":["Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0001-9318-9145","affiliations":[{"raw_affiliation_string":"Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002948259","display_name":"Ethan Cordes","orcid":"https://orcid.org/0009-0007-3039-1523","observed_orcids":["https://orcid.org/0009-0007-3039-1523"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ethan Cordes","raw_affiliation_strings":["Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126891300","display_name":"Weixi Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weixi Feng","raw_affiliation_strings":["Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135604044","display_name":"Se-In Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Se-In Lee","raw_affiliation_strings":["Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007267576","display_name":"Katie Munechika","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katie Munechika","raw_affiliation_strings":["BME Department, Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA","Weill Institute for Cellular and Molecular Biology, Cornell University, Ithaca, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BME Department, Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Weill Institute for Cellular and Molecular Biology, Cornell University, Ithaca, New York, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129421175","display_name":"Yu Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Sun","raw_affiliation_strings":["Department of Computational Biology, Cornell University, Ithaca, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Biology, Cornell University, Ithaca, New York, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147344787","display_name":"Zhisong Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhisong Gao","raw_affiliation_strings":["Department of Pharmacology and Toxicology, R Ken Coit College of Pharmacy, 1703 E Mabel St, Tucson AZ, 85721-0207, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, R Ken Coit College of Pharmacy, 1703 E Mabel St, Tucson AZ, 85721-0207, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135622325","display_name":"Beichen Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beichen Gao","raw_affiliation_strings":["Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123202963","display_name":"Jingjie Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingjie Zhu","raw_affiliation_strings":["Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007457497","display_name":"Man Ying Wong","orcid":"https://orcid.org/0000-0002-2165-9328","observed_orcids":["https://orcid.org/0000-0002-2165-9328"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Man Ying Wong","raw_affiliation_strings":["Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104283822","display_name":"Kendra Norman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kendra Norman","raw_affiliation_strings":["Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147973841","display_name":"Siyu Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siyu Wang","raw_affiliation_strings":["Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148041428","display_name":"hao chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Chen","raw_affiliation_strings":["Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079593038","display_name":"Bangyan Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bangyan Liu","raw_affiliation_strings":["Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147971926","display_name":"Zhong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhong Li","raw_affiliation_strings":["Department of Pharmacology and Toxicology, R Ken Coit College of Pharmacy, 1703 E Mabel St, Tucson AZ, 85721-0207, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, R Ken Coit College of Pharmacy, 1703 E Mabel St, Tucson AZ, 85721-0207, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024410023","display_name":"Mahalashmi Srinivasan","orcid":"https://orcid.org/0009-0006-0386-1334","observed_orcids":["https://orcid.org/0009-0006-0386-1334"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mahalashmi Srinivasan","raw_affiliation_strings":["Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058025793","display_name":"Sadaf Amin","orcid":"https://orcid.org/0000-0002-3758-6485","observed_orcids":["https://orcid.org/0000-0002-3758-6485"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sadaf Amin","raw_affiliation_strings":["Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042842689","display_name":"Xiaomu Wei","orcid":"https://orcid.org/0000-0001-8331-6112","observed_orcids":["https://orcid.org/0000-0001-8331-6112"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaomu Wei","raw_affiliation_strings":["Weill Institute for Cellular and Molecular Biology, Cornell University, Ithaca, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Institute for Cellular and Molecular Biology, Cornell University, Ithaca, New York, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074964983","display_name":"Sue\u2010Ann Mok","orcid":"https://orcid.org/0000-0003-4593-3368","observed_orcids":["https://orcid.org/0000-0003-4593-3368"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sue-Ann Mok","raw_affiliation_strings":["Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005082513","display_name":"Rong Shen","orcid":"https://orcid.org/0000-0002-7155-1876","observed_orcids":["https://orcid.org/0000-0002-7155-1876","https://orcid.org/0009-0006-0935-6339"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Shen","raw_affiliation_strings":["Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074374069","display_name":"Wenjie Luo","orcid":"https://orcid.org/0000-0003-3752-8266","observed_orcids":["https://orcid.org/0000-0003-3752-8266"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenjie Luo","raw_affiliation_strings":["Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069571923","display_name":"Shiaoching Gong","orcid":"https://orcid.org/0000-0002-5907-5539","observed_orcids":["https://orcid.org/0000-0002-5907-5539"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shiaoching Gong","raw_affiliation_strings":["Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100700811","display_name":"Hongmin Li","orcid":"https://orcid.org/0000-0002-8684-5308","observed_orcids":["https://orcid.org/0000-0002-8684-5308"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4388891792","display_name":"BIO5 Institute","ror":"https://ror.org/023drta67","country_code":"US","type":"facility","lineage":["https://openalex.org/I138006243","https://openalex.org/I4388891792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongmin Li","raw_affiliation_strings":["Biological Chemistry Program, Department of Chemistry and Biochemistry, College of Science & College of Medicine, The University of Arizona, Tucson, AZ 85721, USA","Department of Molecular & Cellular Biology, College of Science, The University of Arizona, Tucson, AZ 85721, USA","Department of Pharmacology and Toxicology, R Ken Coit College of Pharmacy, 1703 E Mabel St, Tucson AZ, 85721-0207, USA","The BIO5 Institute, The University of Arizona, Tucson, AZ 85721, USA"],"raw_orcid":"https://orcid.org/0000-0002-8684-5308","affiliations":[{"raw_affiliation_string":"Biological Chemistry Program, Department of Chemistry and Biochemistry, College of Science & College of Medicine, The University of Arizona, Tucson, AZ 85721, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Molecular & Cellular Biology, College of Science, The University of Arizona, Tucson, AZ 85721, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, R Ken Coit College of Pharmacy, 1703 E Mabel St, Tucson AZ, 85721-0207, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"The BIO5 Institute, The University of Arizona, Tucson, AZ 85721, USA","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4388891792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067174340","display_name":"Haiyuan Yu","orcid":"https://orcid.org/0000-0001-7597-6049","observed_orcids":["https://orcid.org/0000-0001-7597-6049"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haiyuan Yu","raw_affiliation_strings":["BME Department, Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA","Weill Institute for Cellular and Molecular Biology, Cornell University, Ithaca, New York, USA"],"raw_orcid":"https://orcid.org/0000-0001-7597-6049","affiliations":[{"raw_affiliation_string":"BME Department, Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Weill Institute for Cellular and Molecular Biology, Cornell University, Ithaca, New York, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101086789","display_name":"Li Gan","orcid":"https://orcid.org/0000-0003-4600-275X","observed_orcids":["https://orcid.org/0000-0003-4600-275X"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Li Gan","raw_affiliation_strings":["Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen and Robert Appel Institute for Alzheimer\u2019s Disease Research, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101086789"],"corresponding_institution_ids":["https://openalex.org/I4387153466"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ufmylation","display_name":"UFMylation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/tauopathy","display_name":"tauopathy","score":0.8109999895095825},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9300000071525574},{"id":"https://openalex.org/keywords/uba5","display_name":"UBA5","score":0.9309999942779541},{"id":"https://openalex.org/keywords/e1-enzyme","display_name":"E1 enzyme","score":0.515999972820282},{"id":"https://openalex.org/keywords/tau-aggregation","display_name":"tau aggregation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/tau-spread","display_name":"tau spread","score":0.8479999899864197},{"id":"https://openalex.org/keywords/lysosome-function","display_name":"lysosomal function","score":0.925000011920929},{"id":"https://openalex.org/keywords/cln8","display_name":"CLN8","score":0.9810000061988831},{"id":"https://openalex.org/keywords/lipid-homeostasis","display_name":"lipid homeostasis","score":0.6660000085830688},{"id":"https://openalex.org/keywords/ipsc-derived-neurons","display_name":"iPSC-derived neurons","score":0.9580000042915344},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9589999914169312}],"concepts":[{"id":"https://openalex.org/C2777739294","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tauopathy","level":4,"score":0.9330999851226807},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.597000002861023},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5555999875068665},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5460000038146973},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5092999935150146},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45080000162124634},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.4311000108718872},{"id":"https://openalex.org/C2780999251","wikidata":"https://www.wikidata.org/wiki/Q17022503","display_name":"Brake","level":2,"score":0.42100000381469727},{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.39899998903274536},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36309999227523804},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.35929998755455017},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3427000045776367},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3084000051021576},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.2912999987602234},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.2906000018119812},{"id":"https://openalex.org/C105951970","wikidata":"https://www.wikidata.org/wiki/Q1036748","display_name":"Loss function","level":4,"score":0.28870001435279846},{"id":"https://openalex.org/C2777041782","wikidata":"https://www.wikidata.org/wiki/Q14878336","display_name":"UBE3A","level":5,"score":0.2847999930381775},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.2696000039577484},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.258899986743927}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.18.745347","doi":"https://doi.org/10.64898/2026.08.18.745347","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.18.745347","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/23/2026.08.18.745347.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.18.745347","doi":"https://doi.org/10.64898/2026.08.18.745347","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.18.745347","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/23/2026.08.18.745347.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000910617","display_name":"Study of Selective Cell and System Vulnerability in Alzheimer's Disease","funder_award_id":"R01AG079291","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204108349.pdf","grobid_xml":"https://content.openalex.org/works/W7204108349.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4406050019","https://openalex.org/W4390198530","https://openalex.org/W4405541257","https://openalex.org/W6958279941","https://openalex.org/W7144101286","https://openalex.org/W2978630201","https://openalex.org/W7203603138","https://openalex.org/W4393995174","https://openalex.org/W3021166500","https://openalex.org/W4413911693"],"abstract_inverted_index":{"Abstract":[0],"UFMylation,":[1,32],"a":[2,28,120],"ubiquitin-like":[3],"protein":[4,91],"modification,":[5],"drives":[6],"tau":[7,70,99,113],"spread":[8,73],"through":[9,88],"the":[10,36,89,104],"brain,":[11],"but":[12],"what":[13],"keeps":[14],"this":[15,57],"process":[16],"in":[17,65,115],"check":[18],"has":[19],"remained":[20],"unclear.":[21],"We":[22],"show":[23],"that":[24],"TRAPPC8":[25,49,108],"acts":[26],"as":[27,60,119],"natural":[29],"brake":[30,58],"on":[31],"binding":[33,84],"directly":[34],"to":[35,40,111],"E1":[37],"enzyme":[38],"UBA5":[39,83],"dampen":[41],"pathway":[42],"activity.":[43],"In":[44],"Alzheimer\u2019s":[45],"disease":[46,61],"brain":[47],"tissue,":[48],"is":[50,54],"reduced":[51,98],"while":[52,74],"UFMylation":[53,64],"elevated,":[55],"suggesting":[56],"fails":[59],"progresses.":[62],"Sustaining":[63],"human":[66],"iPSC-derived":[67],"neurons":[68],"increased":[69],"aggregation":[71],"and":[72,78,97],"disrupting":[75],"lysosomal":[76,90,95],"function":[77,96],"lipid":[79],"balance.":[80],"Restoring":[81],"TRAPPC8\u2013":[82],"reversed":[85],"these":[86],"defects":[87],"CLN8,":[92],"which":[93],"restored":[94],"pathology.":[100],"Notably,":[101],"expressing":[102],"just":[103],"UBA5-binding":[105],"region":[106],"of":[107],"was":[109],"enough":[110],"suppress":[112],"pathology":[114],"vivo,":[116],"marking":[117],"it":[118],"promising":[121],"therapeutic":[122],"target.":[123]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-25T00:00:00"}