{"id":"https://openalex.org/W7204104375","doi":"https://doi.org/10.1016/j.tice.2026.103901","title":"Beyond dose enhancement: Multi-level nanoparticle strategies to overcome biological barriers of cancer radioresistance","display_name":"Beyond dose enhancement: Multi-level nanoparticle strategies to overcome biological barriers of cancer radioresistance","publication_year":2026,"publication_date":"2026-08-24","ids":{"openalex":"https://openalex.org/W7204104375","doi":"https://doi.org/10.1016/j.tice.2026.103901","pmid":"https://pubmed.ncbi.nlm.nih.gov/42648256"},"language":"en","primary_location":{"id":"doi:10.1016/j.tice.2026.103901","doi":"https://doi.org/10.1016/j.tice.2026.103901","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tice.2026.103901","pdf_url":null,"source":{"id":"https://openalex.org/S165572755","display_name":"Tissue and Cell","issn_l":"0040-8166","issn":["0040-8166","1532-3072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue and Cell","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116069775","display_name":"Khongorzul Enkhtaivan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Khongorzul Enkhtaivan","raw_affiliation_strings":["School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea","institution_ids":["https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100462888","display_name":"Jiwon Kim","orcid":"https://orcid.org/0000-0002-7412-161X","observed_orcids":["https://orcid.org/0000-0002-7412-161X","https://orcid.org/0009-0009-5266-5008"]},"institutions":[{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jiwon Kim","raw_affiliation_strings":["School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea","institution_ids":["https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063448355","display_name":"Jaewoo Son","orcid":"https://orcid.org/0009-0001-6418-0675","observed_orcids":["https://orcid.org/0009-0001-6418-0675"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaewoo Son","raw_affiliation_strings":["School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109441107","display_name":"Jaehee Jang","orcid":"https://orcid.org/0009-0000-9787-9186","observed_orcids":["https://orcid.org/0009-0000-9787-9186"]},"institutions":[{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jaehee Jang","raw_affiliation_strings":["School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea","institution_ids":["https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113936606","display_name":"Yonghyun Choi","orcid":"https://orcid.org/0009-0000-0920-6775","observed_orcids":["https://orcid.org/0009-0000-0920-6775"]},"institutions":[{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yonghyun Choi","raw_affiliation_strings":["School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea; Feynman Institute of Technology, Nanomedicine Corporation, Seoul 06974, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea; Feynman Institute of Technology, Nanomedicine Corporation, Seoul 06974, Republic of Korea","institution_ids":["https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100709322","display_name":"Hee\u2010Young Lee","orcid":"https://orcid.org/0000-0002-1335-7186","observed_orcids":["https://orcid.org/0000-0002-1335-7186"]},"institutions":[{"id":"https://openalex.org/I113409471","display_name":"Kumoh National Institute of Technology","ror":"https://ror.org/05dkjfz60","country_code":"KR","type":"education","lineage":["https://openalex.org/I113409471"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hee-Young Lee","raw_affiliation_strings":["Feynman Institute of Technology, Nanomedicine Corporation, Seoul 06974, Republic of Korea; Department of Chemical Engineering, Kumoh National Institute of Technology, Gumi 39177, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Feynman Institute of Technology, Nanomedicine Corporation, Seoul 06974, Republic of Korea; Department of Chemical Engineering, Kumoh National Institute of Technology, Gumi 39177, Republic of Korea","institution_ids":["https://openalex.org/I113409471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147934924","display_name":"Shin Hyuk Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153376","display_name":"Chung-Ang University Hospital","ror":"https://ror.org/04gr4mh63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Shin Hyuk Kang","raw_affiliation_strings":["Department of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul 06974, Republic of Korea; Biomedical Research Institute, Chung-Ang University Hospital, Seoul 06974, Republic of Korea. Electronic address: kangshinhyeok@cau.ac.kr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul 06974, Republic of Korea; Biomedical Research Institute, Chung-Ang University Hospital, Seoul 06974, Republic of Korea. Electronic address: kangshinhyeok@cau.ac.kr","institution_ids":["https://openalex.org/I4210153376","https://openalex.org/I67900169"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012952224","display_name":"Jonghoon H. Choi","orcid":"https://orcid.org/0000-0003-3554-7033","observed_orcids":["https://orcid.org/0000-0003-3554-7033","https://orcid.org/0000-0003-1873-6254"]},"institutions":[{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["KR","US"],"is_corresponding":true,"raw_author_name":"Jonghoon Choi","raw_affiliation_strings":["School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea; Feynman Institute of Technology, Nanomedicine Corporation, Seoul 06974, Republic of Korea; Molecular Science and Software Engineering (MSSE) Program, College of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: nanomed@cau.ac.kr"],"raw_orcid":"https://orcid.org/0000-0003-3554-7033","affiliations":[{"raw_affiliation_string":"School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea; Feynman Institute of Technology, Nanomedicine Corporation, Seoul 06974, Republic of Korea; Molecular Science and Software Engineering (MSSE) Program, College of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: nanomed@cau.ac.kr","institution_ids":["https://openalex.org/I67900169","https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5012952224","https://openalex.org/A5113936606","https://openalex.org/A5147934924"],"corresponding_institution_ids":["https://openalex.org/I4210153376","https://openalex.org/I67900169","https://openalex.org/I95457486"],"apc_list":{"value":2680,"currency":"USD","value_usd":2680},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.43573668,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"104","issue":"Pt 2","first_page":"103901","last_page":"103901"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-radioresistance","display_name":"tumor radioresistance","score":0.8259999752044678},{"id":"https://openalex.org/keywords/nanoparticle-radiosensitizers","display_name":"nanoparticle radiosensitizers","score":0.9729999899864197},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.7289999723434448},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8050000071525574},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.859000027179718},{"id":"https://openalex.org/keywords/cancer-stem-like-cells","display_name":"cancer stem-like cells","score":0.859000027179718},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9350000023841858},{"id":"https://openalex.org/keywords/gold-nanoparticles","display_name":"gold nanoparticles","score":0.8059999942779541},{"id":"https://openalex.org/keywords/hafnium-oxide","display_name":"hafnium oxide","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cgas-sting-pathway","display_name":"cGAS-STING pathway","score":0.9010000228881836},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.925000011920929},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8259999752044678},{"id":"https://openalex.org/keywords/multifunctional-nanoparticles","display_name":"multifunctional nanoparticles","score":0.8539999723434448},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C58962609","wikidata":"https://www.wikidata.org/wiki/Q2353022","display_name":"Radioresistance","level":3,"score":0.7797999978065491},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5185999870300293},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4959000051021576},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.374099999666214},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3675999939441681},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.35850000381469727},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.351500004529953},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30390000343322754},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.2782000005245209},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.2669000029563904},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2605000138282776},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2596000134944916},{"id":"https://openalex.org/C2987992536","wikidata":"https://www.wikidata.org/wiki/Q3026015","display_name":"Radiation tolerance","level":3,"score":0.258899986743927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25859999656677246},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2567000091075897},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.2533999979496002}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tice.2026.103901","doi":"https://doi.org/10.1016/j.tice.2026.103901","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tice.2026.103901","pdf_url":null,"source":{"id":"https://openalex.org/S165572755","display_name":"Tissue and Cell","issn_l":"0040-8166","issn":["0040-8166","1532-3072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue and Cell","raw_type":"journal-article"},{"id":"pmid:42648256","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42648256","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue & cell","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2977350506","display_name":null,"funder_award_id":"RS-2020-NR049537","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G6204791577","display_name":null,"funder_award_id":"RS-2026-25517984","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G8411119037","display_name":null,"funder_award_id":"2022002980003","funder_id":"https://openalex.org/F4320322007","funder_display_name":"Ministry of Environment"}],"funders":[{"id":"https://openalex.org/F4320321681","display_name":"Ministry of Trade, Industry and Energy","ror":"https://ror.org/008nkqk13"},{"id":"https://openalex.org/F4320322007","display_name":"Ministry of Environment","ror":"https://ror.org/04xmt0833"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"},{"id":"https://openalex.org/F4320334877","display_name":"Korea Environmental Industry and Technology Institute","ror":"https://ror.org/022r1q746"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1561786195","https://openalex.org/W2007263630","https://openalex.org/W2012276721","https://openalex.org/W2020261953","https://openalex.org/W2060551076","https://openalex.org/W2103596198","https://openalex.org/W2104500888","https://openalex.org/W2137918402","https://openalex.org/W2142483254","https://openalex.org/W2178095202","https://openalex.org/W2238041893","https://openalex.org/W2487062077","https://openalex.org/W2555255741","https://openalex.org/W2625452721","https://openalex.org/W2783641815","https://openalex.org/W2898862691","https://openalex.org/W2947916475","https://openalex.org/W2952051913","https://openalex.org/W2961319233","https://openalex.org/W2963673559","https://openalex.org/W2990561242","https://openalex.org/W2999204989","https://openalex.org/W3011940221","https://openalex.org/W3016523061","https://openalex.org/W3022486080","https://openalex.org/W3043932136","https://openalex.org/W3135045895","https://openalex.org/W3159142974","https://openalex.org/W3173290336","https://openalex.org/W4200449126","https://openalex.org/W4206166760","https://openalex.org/W4206253471","https://openalex.org/W4214638479","https://openalex.org/W4220682400","https://openalex.org/W4220717410","https://openalex.org/W4281754245","https://openalex.org/W4283823492","https://openalex.org/W4290694926","https://openalex.org/W4306729946","https://openalex.org/W4308712275","https://openalex.org/W4309244981","https://openalex.org/W4311662840","https://openalex.org/W4315767707","https://openalex.org/W4317508845","https://openalex.org/W4318003493","https://openalex.org/W4353072679","https://openalex.org/W4362703431","https://openalex.org/W4380872525","https://openalex.org/W4383265707","https://openalex.org/W4385999759","https://openalex.org/W4387079714","https://openalex.org/W4387332943","https://openalex.org/W4387614294","https://openalex.org/W4387651879","https://openalex.org/W4387951183","https://openalex.org/W4389791310","https://openalex.org/W4389793431","https://openalex.org/W4391682719","https://openalex.org/W4391815907","https://openalex.org/W4394908683","https://openalex.org/W4396765487","https://openalex.org/W4398236869","https://openalex.org/W4398241252","https://openalex.org/W4399188329","https://openalex.org/W4401170468","https://openalex.org/W4401819943","https://openalex.org/W4402364171","https://openalex.org/W4403869585","https://openalex.org/W4404855546","https://openalex.org/W4405263861","https://openalex.org/W4405414785","https://openalex.org/W4405528326","https://openalex.org/W4407032411","https://openalex.org/W4409195464","https://openalex.org/W4409523151","https://openalex.org/W4414557897","https://openalex.org/W7126057503","https://openalex.org/W7127052060","https://openalex.org/W7128436353","https://openalex.org/W7149255438"],"related_works":["https://openalex.org/W4321101781","https://openalex.org/W7168169147","https://openalex.org/W1914225880","https://openalex.org/W2136677910","https://openalex.org/W7212004507","https://openalex.org/W7162641589","https://openalex.org/W4405356106","https://openalex.org/W7204915957","https://openalex.org/W4407814121","https://openalex.org/W4415958691"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2026-08-25T00:00:00"}