{"id":"https://openalex.org/W7204103650","doi":"https://doi.org/10.1177/17588359261483547","title":"Risk stratification and boost dose optimization for locoregionally advanced nasopharyngeal carcinoma with residual lesions based on clinical stage and post-radiotherapy EBV DNA","display_name":"Risk stratification and boost dose optimization for locoregionally advanced nasopharyngeal carcinoma with residual lesions based on clinical stage and post-radiotherapy EBV DNA","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7204103650","doi":"https://doi.org/10.1177/17588359261483547","pmid":"https://pubmed.ncbi.nlm.nih.gov/42643794","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13504137"},"language":"en","primary_location":{"id":"doi:10.1177/17588359261483547","doi":"https://doi.org/10.1177/17588359261483547","is_oa":true,"landing_page_url":"https://doi.org/10.1177/17588359261483547","pdf_url":null,"source":{"id":"https://openalex.org/S41085503","display_name":"Therapeutic Advances in Medical Oncology","issn_l":"1758-8340","issn":["1758-8340","1758-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Advances in Medical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/17588359261483547","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025790235","display_name":"Xinyi Hong","orcid":"https://orcid.org/0000-0001-5563-6055","observed_orcids":["https://orcid.org/0000-0001-5563-6055"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyi Hong","raw_affiliation_strings":["Clinical Oncology School of Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Oncology School of Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147935461","display_name":"Yi Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Li","raw_affiliation_strings":["Clinical Oncology School of Fujian Medical University","Sichuan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Oncology School of Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Sichuan University","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101208198","display_name":"Chaoying Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chaoying Lin","raw_affiliation_strings":["Clinical Oncology School of Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Oncology School of Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147957500","display_name":"Jianxian Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianxian Chen","raw_affiliation_strings":["Clinical Oncology School of Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Oncology School of Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148021215","display_name":"Haosheng Zhang","orcid":"https://orcid.org/0000-0001-9085-0153","observed_orcids":["https://orcid.org/0000-0001-9085-0153"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haosheng Zhang","raw_affiliation_strings":["Clinical Oncology School of Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Oncology School of Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147913774","display_name":"Weijian Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weijian Liu","raw_affiliation_strings":["Clinical Oncology School of Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Oncology School of Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147937261","display_name":"Lanxin Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lanxin Lin","raw_affiliation_strings":["Clinical Oncology School of Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Oncology School of Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147991109","display_name":"Zongying Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zongying Qian","raw_affiliation_strings":["Clinical Oncology School of Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Oncology School of Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006625018","display_name":"Sihan Lin","orcid":"https://orcid.org/0000-0002-4422-9275","observed_orcids":["https://orcid.org/0000-0002-4422-9275"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sihan Lin","raw_affiliation_strings":["Clinical Oncology School of Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Oncology School of Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100947114","display_name":"Yuhui Pan","orcid":"https://orcid.org/0009-0009-2625-1733","observed_orcids":["https://orcid.org/0009-0009-2625-1733"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuhui Pan","raw_affiliation_strings":["Clinical Oncology School of Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Oncology School of Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035202459","display_name":"Sufang Qiu","orcid":"https://orcid.org/0000-0001-7660-6955","observed_orcids":["https://orcid.org/0000-0001-7660-6955"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210148548","display_name":"Fujian Provincial Cancer Hospital","ror":"https://ror.org/058ms9w43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148548"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Sufang Qiu","raw_affiliation_strings":["Clinical Oncology School of Fujian Medical University","Fujian Cancer Hospital"],"raw_orcid":"https://orcid.org/0000-0001-7660-6955","affiliations":[{"raw_affiliation_string":"Clinical Oncology School of Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Fujian Cancer Hospital","institution_ids":["https://openalex.org/I4210148548"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035202459","https://openalex.org/A5100947114"],"corresponding_institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210148548"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":{"value":2800,"currency":"USD","value_usd":2800},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.61184211,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":null,"first_page":"17588359261483547","last_page":"17588359261483547"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11669","display_name":"Head and Neck Surgical Oncology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nasopharyngeal-carcinoma","display_name":"nasopharyngeal carcinoma","score":0.9259999990463257},{"id":"https://openalex.org/keywords/locoregionally-advanced-nasopharyngeal-carcinoma","display_name":"locoregionally advanced nasopharyngeal carcinoma","score":0.9399999976158142},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.7519999742507935},{"id":"https://openalex.org/keywords/clinical-stage","display_name":"clinical stage","score":0.8889999985694885},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7630000114440918},{"id":"https://openalex.org/keywords/late-toxicity","display_name":"late toxicity","score":0.5189999938011169},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6639999747276306},{"id":"https://openalex.org/keywords/individualized-treatment-planning","display_name":"personalized treatment planning","score":0.4569999873638153},{"id":"https://openalex.org/keywords/definitive-chemoradiotherapy","display_name":"definitive chemoradiotherapy","score":0.6340000033378601},{"id":"https://openalex.org/keywords/salvage-therapy","display_name":"salvage therapy","score":0.4000000059604645},{"id":"https://openalex.org/keywords/salvage-surgery","display_name":"salvage surgery","score":0.33399999141693115},{"id":"https://openalex.org/keywords/salvage-radiotherapy","display_name":"salvage radiotherapy","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8805999755859375},{"id":"https://openalex.org/C2778997737","wikidata":"https://www.wikidata.org/wiki/Q1693598","display_name":"Nasopharyngeal carcinoma","level":3,"score":0.8396999835968018},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.698199987411499},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6746000051498413},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.6733999848365784},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.6638000011444092},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5648999810218811},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.5544000267982483},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4438000023365021},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.43220001459121704},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.36660000681877136},{"id":"https://openalex.org/C155512373","wikidata":"https://www.wikidata.org/wiki/Q287450","display_name":"Residual","level":2,"score":0.3416000008583069},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.33379998803138733},{"id":"https://openalex.org/C2987315675","wikidata":"https://www.wikidata.org/wiki/Q1773974","display_name":"Disease control","level":2,"score":0.3093999922275543},{"id":"https://openalex.org/C192943249","wikidata":"https://www.wikidata.org/wiki/Q1893382","display_name":"Stratification (seeds)","level":5,"score":0.28600001335144043},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.28279998898506165},{"id":"https://openalex.org/C2993277928","wikidata":"https://www.wikidata.org/wiki/Q7248370","display_name":"Prognostic model","level":3,"score":0.26969999074935913},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26820001006126404},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.2635999917984009},{"id":"https://openalex.org/C2780091936","wikidata":"https://www.wikidata.org/wiki/Q17103890","display_name":"T-stage","level":3,"score":0.25609999895095825}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1177/17588359261483547","doi":"https://doi.org/10.1177/17588359261483547","is_oa":true,"landing_page_url":"https://doi.org/10.1177/17588359261483547","pdf_url":null,"source":{"id":"https://openalex.org/S41085503","display_name":"Therapeutic Advances in Medical Oncology","issn_l":"1758-8340","issn":["1758-8340","1758-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Advances in Medical Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13504137","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13504137/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13504137/pdf/10.1177_17588359261483547.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ther Adv Med Oncol","raw_type":"Text"},{"id":"pmid:42643794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42643794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic advances in medical oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:27a2031a1e0c420c8194e07a19fb5f1d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/27a2031a1e0c420c8194e07a19fb5f1d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Therapeutic Advances in Medical Oncology, Vol 18 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/17588359261483547","doi":"https://doi.org/10.1177/17588359261483547","is_oa":true,"landing_page_url":"https://doi.org/10.1177/17588359261483547","pdf_url":null,"source":{"id":"https://openalex.org/S41085503","display_name":"Therapeutic Advances in Medical Oncology","issn_l":"1758-8340","issn":["1758-8340","1758-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Advances in Medical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1054440487","display_name":null,"funder_award_id":"2023J011267","funder_id":"https://openalex.org/F4320321878","funder_display_name":"Natural Science Foundation of Fujian Province"},{"id":"https://openalex.org/G2467272978","display_name":null,"funder_award_id":"82473376","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3216986677","display_name":"DLX6\u5728\u9f3b\u54bd\u764c\u53d1\u751f\u53d1\u5c55\u4e2d\u7684\u4f5c\u7528\u53ca\u673a\u5236\u7814\u7a76","funder_award_id":"2024J011108","funder_id":"https://openalex.org/F4320321878","funder_display_name":"Natural Science Foundation of Fujian Province"},{"id":"https://openalex.org/G4743197883","display_name":"\u9776\u5411ITGA6\u7684\u7eb3\u7c73\u81ea\u7ec4\u88c5\u591a\u80bd\u9012\u9001\u7cfb\u7edf\u8bf1\u5bfc\u9f3b\u54bd\u764c\u7126\u4ea1\u7684\u6548\u5e94\u7814\u7a76","funder_award_id":"2025J08269","funder_id":"https://openalex.org/F4320321878","funder_display_name":"Natural Science Foundation of Fujian Province"},{"id":"https://openalex.org/G576440722","display_name":null,"funder_award_id":"2021ZQNZD010","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6429755219","display_name":null,"funder_award_id":"12374405","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G726220986","display_name":"La\u76f8\u5173\u86cb\u767d6\uff08LARP6\uff09\u901a\u8fc7\u7a33\u5b9aACYP2 mRNA\u4fc3\u8fdbCa2+\u5185\u6d41\u4ecb\u5bfc\u9f3b\u54bd\u764c\u8f6c\u79fb\u673a\u5236\u7684\u7814\u7a76","funder_award_id":"2024J011086","funder_id":"https://openalex.org/F4320321878","funder_display_name":"Natural Science Foundation of Fujian Province"},{"id":"https://openalex.org/G8435226347","display_name":null,"funder_award_id":"2021\u20132022","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8864180154","display_name":null,"funder_award_id":"2023J011267","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321878","display_name":"Natural Science Foundation of Fujian Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204103650.pdf","grobid_xml":"https://content.openalex.org/works/W7204103650.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1975538233","https://openalex.org/W1977143597","https://openalex.org/W1994321029","https://openalex.org/W1997391888","https://openalex.org/W2001924074","https://openalex.org/W2008267376","https://openalex.org/W2024847643","https://openalex.org/W2032046435","https://openalex.org/W2071433338","https://openalex.org/W2111714525","https://openalex.org/W2120423701","https://openalex.org/W2130492755","https://openalex.org/W2130599429","https://openalex.org/W2132871252","https://openalex.org/W2151175321","https://openalex.org/W2151631877","https://openalex.org/W2159887595","https://openalex.org/W2161986916","https://openalex.org/W2169305817","https://openalex.org/W2171525479","https://openalex.org/W2174306046","https://openalex.org/W2275737843","https://openalex.org/W2592043832","https://openalex.org/W2725847181","https://openalex.org/W2742681205","https://openalex.org/W2896635496","https://openalex.org/W2897902933","https://openalex.org/W2947352627","https://openalex.org/W2999142891","https://openalex.org/W3020878477","https://openalex.org/W3208045032","https://openalex.org/W4211017340","https://openalex.org/W4301399211","https://openalex.org/W4308458709","https://openalex.org/W4309151336","https://openalex.org/W4372313268","https://openalex.org/W4386570029","https://openalex.org/W4393074421","https://openalex.org/W4396827307","https://openalex.org/W4400977931","https://openalex.org/W4403299677","https://openalex.org/W4404130240","https://openalex.org/W4407251635","https://openalex.org/W4408875903","https://openalex.org/W4409244582"],"related_works":["https://openalex.org/W4293792626","https://openalex.org/W4308458709","https://openalex.org/W4384520745","https://openalex.org/W3012695695","https://openalex.org/W4407251635","https://openalex.org/W3035509921","https://openalex.org/W3119658120","https://openalex.org/W3161983846","https://openalex.org/W4308000833","https://openalex.org/W4200125680"],"abstract_inverted_index":{"Background:":[0],"Residual":[1],"locoregionally":[2],"advanced":[3],"nasopharyngeal":[4],"carcinoma":[5],"(LA-NPC)":[6],"after":[7,134],"definitive":[8,135],"chemoradiation":[9],"leads":[10],"to":[11,34,287],"poor":[12],"outcomes,":[13],"but":[14],"current":[15],"treatments":[16],"lack":[17],"standardized,":[18],"evidence-based":[19],"guidance":[20],"for":[21,38,128,185],"individualized":[22],"dose":[23,98,275,291],"escalation,":[24],"causing":[25],"varied":[26],"practices.":[27],"Objective:":[28],"To":[29],"develop":[30],"a":[31,141,191,246,273,298],"risk-stratification":[32],"model":[33,86,144,181,251],"personalize":[35],"boost":[36,73,97,193,241,274,295],"doses":[37],"these":[39,90,139],"patients.":[40],"Design:":[41],"A":[42,83],"retrospective":[43,48,306],"study.":[44],"Methods:":[45],"In":[46],"this":[47,310],"study,":[49,311],"364":[50],"LA-NPC":[51,129],"patients":[52,130,184,266,283],"with":[53,131,150,158,166,175,198],"post-radiotherapy":[54],"(post-RT)":[55],"residual":[56,132],"disease":[57,133],"were":[58,61,78,124,234],"enrolled.":[59],"Patients":[60],"stratified":[62,183],"into":[63],"high-dose":[64,192,238],"(\u2265600":[65,194],"cGy,":[66,71,278],"n=201)":[67],"and":[68,92,114,171,239,255,281],"low-dose":[69,240],"(<600":[70],"n=163)":[72],"groups.":[74,221,242],"Independent":[75],"prognostic":[76,126],"factors":[77,127],"identified":[79,215],"via":[80],"Cox":[81],"regression.":[82],"risk":[84,143,249],"stratification":[85,250],"was":[87,100,145,196,214],"constructed":[88],"using":[89],"factors,":[91],"its":[93],"utility":[94],"in":[95,201,216,229],"guiding":[96],"selection":[99],"evaluated.":[101],"Results:":[102],"Multivariate":[103],"analysis":[104],"confirmed":[105],"that":[106,263],"clinical":[107,253,319],"stage":[108,254],"(HR=2.012,":[109],"95%":[110,120,206],"CI:":[111,121,207],"1.100-3.682,":[112],"p=0.023)":[113],"detectable":[115,159,176],"post-RT":[116,152,160,168,177,256],"EBV":[117,153,161,169,178,257],"DNA":[118,162,258],"(HR=1.997,":[119],"1.129-3.535,":[122],"p=0.018)":[123],"independent":[125],"chemoradiotherapy.":[136],"Based":[137],"on":[138],"variables,":[140],"three-tiered":[142],"established:":[146],"low-risk":[147],"(Stage":[148,156,173],"III":[149,157],"undetectable":[151,167],"DNA),":[154,170],"middle-risk":[155,220,282],"or":[163,219,231],"Stage":[164],"IVA":[165,174],"high-risk":[172,203,223,265],"DNA).":[179],"This":[180,293],"effectively":[182],"overall":[186],"survival":[187,212],"(OS)":[188],"(P<0.05).":[189],"Crucially,":[190],"cGy)":[195],"associated":[197],"improved":[199],"OS":[200,270],"the":[202,217,237,305],"group":[204],"(HR=0.344,":[205],"0.122-0.967,":[208],"P=0.043),":[209],"whereas":[210,279],"no":[211,225],"advantage":[213],"low-":[218,280],"Among":[222],"patients,":[224],"statistically":[226],"significant":[227],"differences":[228],"acute":[230],"late":[232],"toxicities":[233],"observed":[235],"between":[236],"Conclusion:":[243],"We":[244],"developed":[245],"clinically":[247],"applicable":[248],"integrating":[252],"status.":[259],"Our":[260],"findings":[261],"suggest":[262],"only":[264],"may":[267],"derive":[268],"an":[269],"benefit":[271,288],"from":[272,289],"of":[276,309],"\u2265600":[277],"do":[284],"not":[285],"appear":[286],"further":[290],"escalation.":[292],"risk-adapted":[294],"strategy":[296],"provides":[297],"preliminary":[299],"framework":[300],"requiring":[301],"prospective":[302,312],"validation.":[303],"Given":[304],"single-center":[307],"design":[308],"multicenter":[313],"studies":[314],"are":[315],"warranted":[316],"before":[317],"routine":[318],"implementation.":[320]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-25T00:00:00"}
