{"id":"https://openalex.org/W7204103014","doi":"https://doi.org/10.1002/advs.77271","title":"RSF1\u2010Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites","display_name":"RSF1\u2010Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites","publication_year":2026,"publication_date":"2026-08-24","ids":{"openalex":"https://openalex.org/W7204103014","doi":"https://doi.org/10.1002/advs.77271","pmid":"https://pubmed.ncbi.nlm.nih.gov/42635688"},"language":"en","primary_location":{"id":"doi:10.1002/advs.77271","doi":"https://doi.org/10.1002/advs.77271","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.77271","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/advs.77271","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072810679","display_name":"Yungyeong Heo","orcid":"https://orcid.org/0009-0007-2836-9546","observed_orcids":["https://orcid.org/0009-0007-2836-9546"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yungyeong Heo","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology Ajou University School of Medicine  Suwon Republic of Korea","Department of Biomedical Sciences, The Graduate School Ajou University  Suwon Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0007-2836-9546","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology Ajou University School of Medicine  Suwon Republic of Korea","institution_ids":["https://openalex.org/I57664883"]},{"raw_affiliation_string":"Department of Biomedical Sciences, The Graduate School Ajou University  Suwon Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065141925","display_name":"Yonghyeon Kim","orcid":"https://orcid.org/0009-0009-7064-9706","observed_orcids":["https://orcid.org/0009-0009-7064-9706"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yonghyeon Kim","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology Ajou University School of Medicine  Suwon Republic of Korea","Department of Biomedical Sciences, The Graduate School Ajou University  Suwon Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0009-7064-9706","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology Ajou University School of Medicine  Suwon Republic of Korea","institution_ids":["https://openalex.org/I57664883"]},{"raw_affiliation_string":"Department of Biomedical Sciences, The Graduate School Ajou University  Suwon Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148030077","display_name":"Nangyeong Hwang","orcid":"https://orcid.org/0009-0000-3378-9771","observed_orcids":["https://orcid.org/0009-0000-3378-9771"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Nangyeong Hwang","raw_affiliation_strings":["Department of Biochemistry, College of Natural Sciences Chungnam National University  Daejeon Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0000-3378-9771","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Natural Sciences Chungnam National University  Daejeon Republic of Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147963492","display_name":"Gwanho Sung","orcid":"https://orcid.org/0009-0004-1889-090X","observed_orcids":["https://orcid.org/0009-0004-1889-090X"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Gwanho Sung","raw_affiliation_strings":["Department of Biochemistry, College of Natural Sciences Chungnam National University  Daejeon Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0004-1889-090X","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Natural Sciences Chungnam National University  Daejeon Republic of Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147912730","display_name":"Sujin Jo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sujin Jo","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology Ajou University School of Medicine  Suwon Republic of Korea","Department of Biomedical Sciences, The Graduate School Ajou University  Suwon Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology Ajou University School of Medicine  Suwon Republic of Korea","institution_ids":["https://openalex.org/I57664883"]},{"raw_affiliation_string":"Department of Biomedical Sciences, The Graduate School Ajou University  Suwon Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063843627","display_name":"Yeonhu Lee","orcid":"https://orcid.org/0000-0002-4939-9978","observed_orcids":["https://orcid.org/0000-0002-4939-9978"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yeonhu Lee","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology Ajou University School of Medicine  Suwon Republic of Korea","Department of Biomedical Sciences, The Graduate School Ajou University  Suwon Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-4939-9978","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology Ajou University School of Medicine  Suwon Republic of Korea","institution_ids":["https://openalex.org/I57664883"]},{"raw_affiliation_string":"Department of Biomedical Sciences, The Graduate School Ajou University  Suwon Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005259900","display_name":"Ho Chul Kang","orcid":"https://orcid.org/0000-0001-5237-095X","observed_orcids":["https://orcid.org/0000-0001-5237-095X"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ho\u2010Chul Kang","raw_affiliation_strings":["Department of Physiology Ajou University School of Medicine  Suwon Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-5237-095X","affiliations":[{"raw_affiliation_string":"Department of Physiology Ajou University School of Medicine  Suwon Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100331201","display_name":"Jae\u2010Ho Lee","orcid":"https://orcid.org/0000-0002-5562-0720","observed_orcids":["https://orcid.org/0000-0002-5562-0720"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae\u2010Ho Lee","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology Ajou University School of Medicine  Suwon Republic of Korea","Department of Biomedical Sciences, The Graduate School Ajou University  Suwon Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology Ajou University School of Medicine  Suwon Republic of Korea","institution_ids":["https://openalex.org/I57664883"]},{"raw_affiliation_string":"Department of Biomedical Sciences, The Graduate School Ajou University  Suwon Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101981946","display_name":"Yong Won Choi","orcid":"https://orcid.org/0000-0002-3659-8126","observed_orcids":["https://orcid.org/0000-0002-3659-8126"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yong Won Choi","raw_affiliation_strings":["Department of Hematology and Oncology Ajou University School of Medicine  Suwon Republic of Korea","Inflamm\u2010Aging Translational Research Center Ajou University School of Medicine  Suwon Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-3659-8126","affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology Ajou University School of Medicine  Suwon Republic of Korea","institution_ids":["https://openalex.org/I57664883"]},{"raw_affiliation_string":"Inflamm\u2010Aging Translational Research Center Ajou University School of Medicine  Suwon Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050660886","display_name":"Hyeseong Cho","orcid":"https://orcid.org/0000-0002-4672-8887","observed_orcids":["https://orcid.org/0000-0002-4672-8887"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hyeseong Cho","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology Ajou University School of Medicine  Suwon Republic of Korea","Department of Biomedical Sciences, The Graduate School Ajou University  Suwon Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-4672-8887","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology Ajou University School of Medicine  Suwon Republic of Korea","institution_ids":["https://openalex.org/I57664883"]},{"raw_affiliation_string":"Department of Biomedical Sciences, The Graduate School Ajou University  Suwon Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051102612","display_name":"Sunwoo Min","orcid":"https://orcid.org/0000-0003-3385-8962","observed_orcids":["https://orcid.org/0000-0003-3385-8962"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sunwoo Min","raw_affiliation_strings":["Department of Biochemistry, College of Natural Sciences Chungnam National University  Daejeon Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-3385-8962","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Natural Sciences Chungnam National University  Daejeon Republic of Korea","institution_ids":["https://openalex.org/I196345858"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050660886","https://openalex.org/A5051102612","https://openalex.org/A5101981946"],"corresponding_institution_ids":["https://openalex.org/I196345858","https://openalex.org/I57664883"],"apc_list":{"value":6730,"currency":"USD","value_usd":6730},"apc_paid":{"value":6730,"currency":"USD","value_usd":6730},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.60445801,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"e77271","last_page":"e77271"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rsf1","display_name":"RSF1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/53bp1","display_name":"53BP1","score":0.8830000162124634},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.6010000109672546},{"id":"https://openalex.org/keywords/liquid-liquid-phase-separation","display_name":"liquid-liquid phase separation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/intrinsically-disordered-regions","display_name":"intrinsically disordered regions","score":0.8600000143051147},{"id":"https://openalex.org/keywords/parp-1","display_name":"PARP1","score":0.7900000214576721},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.7450000047683716},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.984000027179718}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6859999895095825},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6358000040054321},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6215000152587891},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6171000003814697},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5587999820709229},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.48730000853538513},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.39250001311302185},{"id":"https://openalex.org/C2778815515","wikidata":"https://www.wikidata.org/wiki/Q3408242","display_name":"Intrinsically disordered proteins","level":2,"score":0.3328999876976013},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3149999976158142},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.31290000677108765},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.30630001425743103},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.30070000886917114},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.2865000069141388},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.27959999442100525},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.26820001006126404},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.263700008392334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.259799987077713},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.2517000138759613},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25060001015663147}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1002/advs.77271","doi":"https://doi.org/10.1002/advs.77271","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.77271","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},{"id":"pmid:42635688","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42635688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13502265","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13502265/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Adv Sci (Weinh)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/advs.77271","doi":"https://doi.org/10.1002/advs.77271","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.77271","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1406854783","display_name":null,"funder_award_id":"RS-2024-00352450","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G3460104338","display_name":null,"funder_award_id":"RS\u20102025\u201025442707","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G4245533060","display_name":null,"funder_award_id":"RS\u20102025\u201000564684","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G4898484321","display_name":null,"funder_award_id":"RS\u20102026\u201025501101","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G5291225306","display_name":null,"funder_award_id":"RS\u20102026\u201025485138","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G8534360799","display_name":null,"funder_award_id":"RS\u20102024\u201000440193","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"}],"funders":[{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1611268078","https://openalex.org/W1980017984","https://openalex.org/W1981048910","https://openalex.org/W1988259427","https://openalex.org/W1989059483","https://openalex.org/W2008185037","https://openalex.org/W2008891426","https://openalex.org/W2010730368","https://openalex.org/W2027111177","https://openalex.org/W2037951413","https://openalex.org/W2055045552","https://openalex.org/W2059365987","https://openalex.org/W2066952009","https://openalex.org/W2067427915","https://openalex.org/W2071411482","https://openalex.org/W2071457560","https://openalex.org/W2079111167","https://openalex.org/W2080951756","https://openalex.org/W2082411289","https://openalex.org/W2086362981","https://openalex.org/W2103926523","https://openalex.org/W2109465247","https://openalex.org/W2127528497","https://openalex.org/W2132396299","https://openalex.org/W2157570211","https://openalex.org/W2158389792","https://openalex.org/W2160686876","https://openalex.org/W2161489869","https://openalex.org/W2162811733","https://openalex.org/W2164326598","https://openalex.org/W2271817176","https://openalex.org/W2313094648","https://openalex.org/W2396545524","https://openalex.org/W2590568317","https://openalex.org/W2612428976","https://openalex.org/W2625452721","https://openalex.org/W2742396220","https://openalex.org/W2750569114","https://openalex.org/W2756821926","https://openalex.org/W2758396775","https://openalex.org/W2794654572","https://openalex.org/W2808113406","https://openalex.org/W2883664363","https://openalex.org/W2884164644","https://openalex.org/W2889819841","https://openalex.org/W2897633992","https://openalex.org/W2928894342","https://openalex.org/W2953749471","https://openalex.org/W2975196800","https://openalex.org/W3021719481","https://openalex.org/W3109296397","https://openalex.org/W3111563780","https://openalex.org/W3118554598","https://openalex.org/W3133793763","https://openalex.org/W3159719254","https://openalex.org/W3176893970","https://openalex.org/W3177828909","https://openalex.org/W3185197558","https://openalex.org/W3202257805","https://openalex.org/W3207162746","https://openalex.org/W3214900864","https://openalex.org/W4212769969","https://openalex.org/W4281790889","https://openalex.org/W4304957164","https://openalex.org/W4319302323","https://openalex.org/W4319591809","https://openalex.org/W4388571183","https://openalex.org/W4388694440","https://openalex.org/W4404517577"],"related_works":[],"abstract_inverted_index":{"Liquid-liquid":[0],"phase":[1],"separation":[2],"(LLPS)":[3],"is":[4,96],"essential":[5],"for":[6],"proper":[7],"DNA":[8,122,183],"damage":[9,123],"signaling.":[10],"The":[11],"sequential":[12,55],"formation":[13,69,141],"of":[14,31,46,57,91,109,116,146,176],"PAR-":[15],"and":[16,25,51,173],"53BP1-based":[17],"condensates":[18,59],"must":[19],"be":[20],"tightly":[21],"controlled":[22],"in":[23,53,94,138],"space":[24],"time,":[26],"however":[27],"the":[28,54,88,92,106,114,128,171],"molecular":[29,159],"regulators":[30],"this":[32],"process":[33],"remain":[34],"insufficiently":[35],"defined.":[36],"Here,":[37],"we":[38],"show":[39],"that":[40,87,161],"RSF1":[41,63,95,104,156],"contains":[42],"a":[43,158],"substantial":[44],"proportion":[45],"intrinsically":[47],"disordered":[48],"regions":[49],"(IDRs)":[50],"participates":[52],"assembly":[56],"liquid":[58],"at":[60,182],"DSB":[61],"sites.":[62,124],"depletion":[64],"severely":[65],"abolishes":[66],"53BP1":[67,100,134,166],"optoDroplet":[68],"without":[70],"affecting":[71],"FUS":[72],"condensates,":[73],"but":[74,118],"causes":[75],"persistent":[76],"PAR":[77,110,163],"chains":[78,111],"due":[79],"to":[80,98,121,133,165],"defective":[81],"PARG":[82],"recruitment.":[83],"Domain":[84],"mapping":[85],"reveals":[86],"C-terminal":[89],"region":[90],"IDR":[93],"sufficient":[97],"support":[99],"condensate":[101,140,167],"formation.":[102],"Mechanistically,":[103],"controls":[105],"timely":[107],"extinction":[108],"by":[112],"promoting":[113],"recruitment":[115],"PARG,":[117],"not":[119],"PARP1,":[120],"This":[125],"regulation":[126,175],"enables":[127],"transition":[129],"from":[130],"PAR-based":[131],"scaffolds":[132],"condensates.":[135],"Importantly,":[136],"defects":[137],"RSF1-mediated":[139],"correlate":[142],"with":[143,178],"impaired":[144],"transcription":[145],"p53":[147],"target":[148],"genes,":[149],"including":[150],"p21CIP1.":[151],"Together,":[152],"these":[153],"findings":[154],"establish":[155],"as":[157],"coordinator":[160],"links":[162],"turnover":[164],"assembly,":[168],"thereby":[169],"coupling":[170],"spatial":[172],"temporal":[174],"LLPS":[177],"p53-dependent":[179],"transcriptional":[180],"responses":[181],"lesions.":[184]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2026-08-25T00:00:00"}
