{"id":"https://openalex.org/W7204099290","doi":"https://doi.org/10.4103/aptj.aptj_34_26","title":"Maternal\u2013Fetal Outcomes and Management of Severe Dyslipidemia, Familial Hypercholesterolemia, and Atherosclerotic Cardiovascular Disease during Pregnancy: A Systematic Review","display_name":"Maternal\u2013Fetal Outcomes and Management of Severe Dyslipidemia, Familial Hypercholesterolemia, and Atherosclerotic Cardiovascular Disease during Pregnancy: A Systematic Review","publication_year":2026,"publication_date":"2026-04-01","ids":{"openalex":"https://openalex.org/W7204099290","doi":"https://doi.org/10.4103/aptj.aptj_34_26"},"language":"en","primary_location":{"id":"doi:10.4103/aptj.aptj_34_26","doi":"https://doi.org/10.4103/aptj.aptj_34_26","is_oa":true,"landing_page_url":"https://doi.org/10.4103/aptj.aptj_34_26","pdf_url":null,"source":{"id":"https://openalex.org/S4210193764","display_name":"Journal of Atherosclerosis Prevention and Treatment","issn_l":"2654-0843","issn":["2654-0843","3117-6666"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Atherosclerosis Prevention and Treatment","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.4103/aptj.aptj_34_26","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027149217","display_name":"Wiku Andonotopo","orcid":"https://orcid.org/0000-0001-9062-8501","observed_orcids":["https://orcid.org/0000-0001-9062-8501"]},"institutions":[{"id":"https://openalex.org/I146087005","display_name":"Maranatha Christian University","ror":"https://ror.org/05pd2ed85","country_code":"ID","type":"education","lineage":["https://openalex.org/I146087005"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Wiku Andonotopo","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Fetomaternal Division, Faculty of Medicine, Maranatha Christian University, Maranatha Hospital, Bandung, West Java, Indonesia","Department of Obstetrics and Gynecology, Fetomaternal Division, Women Health Center, Eka Hospital BSD City, Tangerang, Banten, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Fetomaternal Division, Faculty of Medicine, Maranatha Christian University, Maranatha Hospital, Bandung, West Java, Indonesia","institution_ids":["https://openalex.org/I146087005"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Fetomaternal Division, Women Health Center, Eka Hospital BSD City, Tangerang, Banten, Indonesia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080561796","display_name":"Muhammad Adrianes Bachnas","orcid":"https://orcid.org/0000-0002-1710-3909","observed_orcids":["https://orcid.org/0000-0002-1710-3909"]},"institutions":[{"id":"https://openalex.org/I119896790","display_name":"Sebelas Maret University","ror":"https://ror.org/021hq5q33","country_code":"ID","type":"education","lineage":["https://openalex.org/I119896790"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Muhammad Adrianes Bachnas","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Fetomaternal Division, Medical Faculty of Sebelas Maret University, Sebelas Maret University Hospital, Solo, Surakarta, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Fetomaternal Division, Medical Faculty of Sebelas Maret University, Sebelas Maret University Hospital, Solo, Surakarta, Indonesia","institution_ids":["https://openalex.org/I119896790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016388619","display_name":"Mochammad Besari Adi Pramono","orcid":"https://orcid.org/0000-0001-8342-2302","observed_orcids":["https://orcid.org/0000-0001-8342-2302"]},"institutions":[{"id":"https://openalex.org/I11855966","display_name":"Diponegoro University","ror":"https://ror.org/056bjta22","country_code":"ID","type":"education","lineage":["https://openalex.org/I11855966"]},{"id":"https://openalex.org/I2802302920","display_name":"Dr. Kariadi Hospital","ror":"https://ror.org/040f86t49","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I2802302920"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Mochammad Besari Adi Pramono","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Fetomaternal Division, Medical Faculty of Diponegoro University, Dr. Kariadi Hospital, Semarang, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Fetomaternal Division, Medical Faculty of Diponegoro University, Dr. Kariadi Hospital, Semarang, Indonesia","institution_ids":["https://openalex.org/I11855966","https://openalex.org/I2802302920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065132623","display_name":"Julian Dewantiningrum","orcid":"https://orcid.org/0000-0002-8937-1646","observed_orcids":["https://orcid.org/0000-0002-8937-1646"]},"institutions":[{"id":"https://openalex.org/I11855966","display_name":"Diponegoro University","ror":"https://ror.org/056bjta22","country_code":"ID","type":"education","lineage":["https://openalex.org/I11855966"]},{"id":"https://openalex.org/I2802302920","display_name":"Dr. Kariadi Hospital","ror":"https://ror.org/040f86t49","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I2802302920"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Julian Dewantiningrum","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Fetomaternal Division, Medical Faculty of Diponegoro University, Dr. Kariadi Hospital, Semarang, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Fetomaternal Division, Medical Faculty of Diponegoro University, Dr. Kariadi Hospital, Semarang, Indonesia","institution_ids":["https://openalex.org/I11855966","https://openalex.org/I2802302920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108819555","display_name":"I Nyoman Hariyasa Sanjaya","orcid":"https://orcid.org/0000-0002-6646-8867","observed_orcids":["https://orcid.org/0000-0002-6646-8867"]},"institutions":[{"id":"https://openalex.org/I126826664","display_name":"Udayana University","ror":"https://ror.org/035qsg823","country_code":"ID","type":"education","lineage":["https://openalex.org/I126826664"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"I. Nyoman Hariyasa Sanjaya","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division, Faculty of Medicine, Udayana University, Prof. Dr. I.G.N.G Ngoerah General Hospital, Bali, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Division, Faculty of Medicine, Udayana University, Prof. Dr. I.G.N.G Ngoerah General Hospital, Bali, Indonesia","institution_ids":["https://openalex.org/I126826664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079347082","display_name":"Aloysius Suryawan","orcid":"https://orcid.org/0000-0001-6311-8477","observed_orcids":["https://orcid.org/0000-0001-6311-8477"]},"institutions":[{"id":"https://openalex.org/I146087005","display_name":"Maranatha Christian University","ror":"https://ror.org/05pd2ed85","country_code":"ID","type":"education","lineage":["https://openalex.org/I146087005"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Aloysius Suryawan","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Fetomaternal Division, Faculty of Medicine, Maranatha Christian University, Maranatha Hospital, Bandung, West Java, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Fetomaternal Division, Faculty of Medicine, Maranatha Christian University, Maranatha Hospital, Bandung, West Java, Indonesia","institution_ids":["https://openalex.org/I146087005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004710265","display_name":"Ridwan Abdullah Putra","orcid":"https://orcid.org/0009-0003-0438-3029","observed_orcids":["https://orcid.org/0009-0003-0438-3029"]},"institutions":[{"id":"https://openalex.org/I146087005","display_name":"Maranatha Christian University","ror":"https://ror.org/05pd2ed85","country_code":"ID","type":"education","lineage":["https://openalex.org/I146087005"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Ridwan Abdullah Putra","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Fetomaternal Division, Faculty of Medicine, Maranatha Christian University, Maranatha Hospital, Bandung, West Java, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Fetomaternal Division, Faculty of Medicine, Maranatha Christian University, Maranatha Hospital, Bandung, West Java, Indonesia","institution_ids":["https://openalex.org/I146087005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5119963627","display_name":"Waskita Ekamaheswara Kasumba Andanaputra","orcid":"https://orcid.org/0009-0009-2181-3442","observed_orcids":["https://orcid.org/0009-0009-2181-3442"]},"institutions":[{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Waskita Ekamaheswara Kasumba Andanaputra","raw_affiliation_strings":["Department of Medicine, Undergraduate Program in Medical Science, Faculty of Medicine, Padjadjaran University, Bandung, West Java, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Undergraduate Program in Medical Science, Faculty of Medicine, Padjadjaran University, Bandung, West Java, Indonesia","institution_ids":["https://openalex.org/I91819753"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0279,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.66588266,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"17","issue":"2","first_page":"42","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.30979999899864197,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.30979999899864197,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.24289999902248383,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.2037000060081482,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/familial-hypercholesterolemia","display_name":"familial hypercholesterolemia","score":0.9330000281333923},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.8960000276565552},{"id":"https://openalex.org/keywords/atherosclerotic-cardiovascular-disease","display_name":"atherosclerotic cardiovascular disease","score":0.984000027179718},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.8939999938011169},{"id":"https://openalex.org/keywords/fetal-outcomes","display_name":"fetal outcomes","score":0.9610000252723694},{"id":"https://openalex.org/keywords/acute-pancreatitis","display_name":"acute pancreatitis","score":0.7200000286102295},{"id":"https://openalex.org/keywords/hypertensive-disorders-of-pregnancy","display_name":"hypertensive disorders of pregnancy","score":0.953000009059906},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.8629999756813049},{"id":"https://openalex.org/keywords/placental-insufficiency","display_name":"placental insufficiency","score":0.9599999785423279},{"id":"https://openalex.org/keywords/intrauterine-growth-restriction","display_name":"fetal growth restriction","score":0.9919999837875366},{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.9860000014305115},{"id":"https://openalex.org/keywords/neonatal-complications","display_name":"neonatal complications","score":0.7110000252723694},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.656000018119812},{"id":"https://openalex.org/keywords/endothelial-activation","display_name":"endothelial activation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/hypercoagulability","display_name":"hypercoagulability","score":0.9200000166893005},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.8489999771118164},{"id":"https://openalex.org/keywords/bile-acid-sequestrants","display_name":"bile acid sequestrants","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lipoprotein-apheresis","display_name":"lipoprotein apheresis","score":0.996999979019165},{"id":"https://openalex.org/keywords/therapeutic-plasma-exchange","display_name":"plasma exchange","score":0.949999988079071},{"id":"https://openalex.org/keywords/cardiovascular-risk-assessment","display_name":"cardiovascular risk assessment","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8851000070571899},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5564000010490417},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5412999987602234},{"id":"https://openalex.org/C2779434492","wikidata":"https://www.wikidata.org/wiki/Q126691","display_name":"Gestational diabetes","level":4,"score":0.5400999784469604},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5113999843597412},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.4205999970436096},{"id":"https://openalex.org/C2776919658","wikidata":"https://www.wikidata.org/wiki/Q1467339","display_name":"Hypertriglyceridemia","level":4,"score":0.41819998621940613},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.3675999939441681},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.362199991941452},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.32420000433921814},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32260000705718994},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.3122999966144562},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.3070000112056732},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.304500013589859},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2953000068664551},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2897000014781952},{"id":"https://openalex.org/C2777218350","wikidata":"https://www.wikidata.org/wiki/Q61335","display_name":"Preeclampsia","level":3,"score":0.27889999747276306},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.266400009393692},{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.26570001244544983},{"id":"https://openalex.org/C2777583542","wikidata":"https://www.wikidata.org/wiki/Q1519482","display_name":"Gestational hypertension","level":4,"score":0.257999986410141},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.25279998779296875}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4103/aptj.aptj_34_26","doi":"https://doi.org/10.4103/aptj.aptj_34_26","is_oa":true,"landing_page_url":"https://doi.org/10.4103/aptj.aptj_34_26","pdf_url":null,"source":{"id":"https://openalex.org/S4210193764","display_name":"Journal of Atherosclerosis Prevention and Treatment","issn_l":"2654-0843","issn":["2654-0843","3117-6666"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Atherosclerosis Prevention and Treatment","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4103/aptj.aptj_34_26","doi":"https://doi.org/10.4103/aptj.aptj_34_26","is_oa":true,"landing_page_url":"https://doi.org/10.4103/aptj.aptj_34_26","pdf_url":null,"source":{"id":"https://openalex.org/S4210193764","display_name":"Journal of Atherosclerosis Prevention and Treatment","issn_l":"2654-0843","issn":["2654-0843","3117-6666"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Atherosclerosis Prevention and Treatment","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1981499442","https://openalex.org/W2000386205","https://openalex.org/W2065549378","https://openalex.org/W2080545893","https://openalex.org/W2136287407","https://openalex.org/W2166614479","https://openalex.org/W2178083316","https://openalex.org/W2531400118","https://openalex.org/W2995884628","https://openalex.org/W2997233813","https://openalex.org/W3135508481","https://openalex.org/W3199740697","https://openalex.org/W3201496475","https://openalex.org/W3204885228","https://openalex.org/W3205573341","https://openalex.org/W4200182412","https://openalex.org/W4287512211","https://openalex.org/W4296966958","https://openalex.org/W4297998327","https://openalex.org/W4320717361","https://openalex.org/W4389383331","https://openalex.org/W4392199096","https://openalex.org/W4395700083","https://openalex.org/W4399215613","https://openalex.org/W4402133338","https://openalex.org/W4402432817","https://openalex.org/W4410379098","https://openalex.org/W4413110491","https://openalex.org/W4416334533","https://openalex.org/W7126021714"],"related_works":["https://openalex.org/W4402133338","https://openalex.org/W4392159136","https://openalex.org/W7115017396","https://openalex.org/W7000174893","https://openalex.org/W4416334533","https://openalex.org/W4412942133","https://openalex.org/W2923970423","https://openalex.org/W4412383240","https://openalex.org/W3154007077","https://openalex.org/W7154846424"],"abstract_inverted_index":{"Abstract":[0],"Pregnancy":[1],"has":[2],"traditionally":[3],"been":[4],"regarded":[5],"as":[6,36,232],"a":[7],"physiological":[8,131],"state;":[9],"however,":[10],"in":[11,53,88,121,134,222],"women":[12,238],"with":[13,55,167,203,239],"severe":[14,19,163],"dyslipidemia,":[15],"familial":[16],"hypercholesterolemia":[17],"(FH),":[18],"hypertriglyceridemia,":[20],"or":[21],"established":[22],"atherosclerotic":[23],"cardiovascular":[24,39,157,242,252],"disease":[25],"(ASCVD),":[26],"the":[27,73,104,122,227],"normal":[28],"metabolic":[29,147],"adaptations":[30],"of":[31,43,94,101,110,172],"gestation":[32],"may":[33,144],"also":[34],"function":[35],"an":[37,233],"atherogenic":[38],"stress":[40],"test":[41],"capable":[42],"unmasking":[44],"latent":[45],"vascular":[46,149],"vulnerability.":[47],"This":[48],"systematic":[49],"review":[50],"was":[51],"conducted":[52],"accordance":[54],"Preferred":[56],"Reporting":[57],"Items":[58],"for":[59,236],"Systematic":[60],"Reviews":[61],"and":[62,70,78,84,103,118,142,148,158,162,183,214,254],"Meta-Analyses":[63],"2020":[64],"reporting":[65],"principles":[66],"to":[67,154,248],"critically":[68],"appraise":[69],"qualitatively":[71],"synthesize":[72],"available":[74,126],"evidence":[75,127,187,229],"regarding":[76],"maternal":[77,156,251],"fetal":[79,178,255],"outcomes,":[80],"underlying":[81],"pathophysiological":[82],"mechanisms,":[83],"contemporary":[85],"management":[86,194,247],"strategies":[87],"these":[89],"high-risk":[90],"pregnancies.":[91],"Comprehensive":[92],"searches":[93],"PubMed/MEDLINE,":[95],"PubMed":[96],"Central,":[97],"Embase,":[98],"Scopus,":[99],"Web":[100],"Science,":[102],"Cochrane":[105],"Library":[106],"identified":[107],"946":[108],"records,":[109],"which":[111],"34":[112],"studies":[113],"met":[114],"predefined":[115],"eligibility":[116],"criteria":[117],"were":[119,165],"included":[120],"qualitative":[123],"synthesis.":[124],"The":[125],"consistently":[128],"indicates":[129],"that":[130],"gestational":[132],"increases":[133],"circulating":[135],"lipids,":[136],"insulin":[137],"resistance,":[138],"endothelial":[139],"activation,":[140],"inflammation,":[141],"hypercoagulability":[143],"amplify":[145],"preexisting":[146],"abnormalities,":[150],"thereby":[151],"increasing":[152],"susceptibility":[153],"adverse":[155],"obstetric":[159],"outcomes.":[160,256],"FH":[161],"hypertriglyceridemia":[164],"associated":[166],"acute":[168],"pancreatitis,":[169],"hypertensive":[170],"disorders":[171],"pregnancy,":[173],"myocardial":[174],"infarction,":[175],"placental":[176],"dysfunction,":[177],"growth":[179],"restriction,":[180],"preterm":[181],"birth,":[182],"neonatal":[184],"complications,":[185],"although":[186],"certainty":[188],"varied":[189],"across":[190],"clinical":[191],"phenotypes.":[192],"Current":[193],"favors":[195],"individualized":[196,246],"risk":[197],"assessment":[198],"supported":[199],"by":[200],"multidisciplinary":[201],"care,":[202],"lifestyle":[204],"intervention,":[205],"omega-3":[206],"fatty":[207],"acids,":[208],"bile":[209],"acid":[210],"sequestrants,":[211],"lipoprotein":[212],"apheresis,":[213],"therapeutic":[215],"plasma":[216],"exchange":[217],"representing":[218],"important":[219,234],"treatment":[220],"options":[221],"carefully":[223],"selected":[224],"patients.":[225],"Overall,":[226],"synthesized":[228],"supports":[230],"pregnancy":[231],"window":[235],"identifying":[237],"increased":[240],"lifetime":[241],"vulnerability":[243],"while":[244],"emphasizing":[245],"optimize":[249],"both":[250],"health":[253]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-08-25T00:00:00"}
