{"id":"https://openalex.org/W7204098062","doi":"https://doi.org/10.3390/ani16172645","title":"Transcriptomic Profiling Reveals Candidate lncRNA-S100-GPCR Co-Expression Networks in Lungs of Piglets Infected with Glaesserella parasuis","display_name":"Transcriptomic Profiling Reveals Candidate lncRNA-S100-GPCR Co-Expression Networks in Lungs of Piglets Infected with Glaesserella parasuis","publication_year":2026,"publication_date":"2026-08-24","ids":{"openalex":"https://openalex.org/W7204098062","doi":"https://doi.org/10.3390/ani16172645","pmid":"https://pubmed.ncbi.nlm.nih.gov/42738433","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13564324"},"language":"en","primary_location":{"id":"doi:10.3390/ani16172645","doi":"https://doi.org/10.3390/ani16172645","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ani16172645","pdf_url":null,"source":{"id":"https://openalex.org/S4210168508","display_name":"Animals","issn_l":"2076-2615","issn":["2076-2615"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animals","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ani16172645","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5140743299","display_name":"Jiayi Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14116566","display_name":"Wuhan Polytechnic University","ror":"https://ror.org/05w0e5j23","country_code":"CN","type":"education","lineage":["https://openalex.org/I14116566"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiayi Zeng","raw_affiliation_strings":["Hubei Provincial Center of Technology Innovation for Domestic Animal Breeding, Wuhan Polytechnic University, Wuhan 430023, China","Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Provincial Center of Technology Innovation for Domestic Animal Breeding, Wuhan Polytechnic University, Wuhan 430023, China","institution_ids":["https://openalex.org/I14116566"]},{"raw_affiliation_string":"Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China","institution_ids":["https://openalex.org/I14116566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101316603","display_name":"Xinqi Zeng","orcid":"https://orcid.org/0009-0003-0266-5954","observed_orcids":["https://orcid.org/0009-0003-0266-5954"]},"institutions":[{"id":"https://openalex.org/I14116566","display_name":"Wuhan Polytechnic University","ror":"https://ror.org/05w0e5j23","country_code":"CN","type":"education","lineage":["https://openalex.org/I14116566"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinqi Zeng","raw_affiliation_strings":["Hubei Provincial Center of Technology Innovation for Domestic Animal Breeding, Wuhan Polytechnic University, Wuhan 430023, China","Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Provincial Center of Technology Innovation for Domestic Animal Breeding, Wuhan Polytechnic University, Wuhan 430023, China","institution_ids":["https://openalex.org/I14116566"]},{"raw_affiliation_string":"Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China","institution_ids":["https://openalex.org/I14116566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072346835","display_name":"Xiangwei Deng","orcid":"https://orcid.org/0000-0002-2774-5323","observed_orcids":["https://orcid.org/0000-0002-2774-5323"]},"institutions":[{"id":"https://openalex.org/I14116566","display_name":"Wuhan Polytechnic University","ror":"https://ror.org/05w0e5j23","country_code":"CN","type":"education","lineage":["https://openalex.org/I14116566"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangwei Deng","raw_affiliation_strings":["Hubei Provincial Center of Technology Innovation for Domestic Animal Breeding, Wuhan Polytechnic University, Wuhan 430023, China","Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Provincial Center of Technology Innovation for Domestic Animal Breeding, Wuhan Polytechnic University, Wuhan 430023, China","institution_ids":["https://openalex.org/I14116566"]},{"raw_affiliation_string":"Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China","institution_ids":["https://openalex.org/I14116566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140697336","display_name":"Shijia Duan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14116566","display_name":"Wuhan Polytechnic University","ror":"https://ror.org/05w0e5j23","country_code":"CN","type":"education","lineage":["https://openalex.org/I14116566"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shijia Duan","raw_affiliation_strings":["Hubei Provincial Center of Technology Innovation for Domestic Animal Breeding, Wuhan Polytechnic University, Wuhan 430023, China","Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Provincial Center of Technology Innovation for Domestic Animal Breeding, Wuhan Polytechnic University, Wuhan 430023, China","institution_ids":["https://openalex.org/I14116566"]},{"raw_affiliation_string":"Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China","institution_ids":["https://openalex.org/I14116566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146746181","display_name":"Ke Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14116566","display_name":"Wuhan Polytechnic University","ror":"https://ror.org/05w0e5j23","country_code":"CN","type":"education","lineage":["https://openalex.org/I14116566"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Xu","raw_affiliation_strings":["Hubei Provincial Center of Technology Innovation for Domestic Animal Breeding, Wuhan Polytechnic University, Wuhan 430023, China","Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Provincial Center of Technology Innovation for Domestic Animal Breeding, Wuhan Polytechnic University, Wuhan 430023, China","institution_ids":["https://openalex.org/I14116566"]},{"raw_affiliation_string":"Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China","institution_ids":["https://openalex.org/I14116566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038984455","display_name":"Huanhuan Zhou","orcid":"https://orcid.org/0000-0002-3205-1449","observed_orcids":["https://orcid.org/0000-0002-3205-1449"]},"institutions":[{"id":"https://openalex.org/I14116566","display_name":"Wuhan Polytechnic University","ror":"https://ror.org/05w0e5j23","country_code":"CN","type":"education","lineage":["https://openalex.org/I14116566"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huanhuan Zhou","raw_affiliation_strings":["Hubei Provincial Center of Technology Innovation for Domestic Animal Breeding, Wuhan Polytechnic University, Wuhan 430023, China","Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China"],"raw_orcid":"https://orcid.org/0000-0002-3205-1449","affiliations":[{"raw_affiliation_string":"Hubei Provincial Center of Technology Innovation for Domestic Animal Breeding, Wuhan Polytechnic University, Wuhan 430023, China","institution_ids":["https://openalex.org/I14116566"]},{"raw_affiliation_string":"Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China","institution_ids":["https://openalex.org/I14116566"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100452327","display_name":"Hongbo Chen","orcid":"https://orcid.org/0000-0002-6051-3321","observed_orcids":["https://orcid.org/0000-0002-6051-3321"]},"institutions":[{"id":"https://openalex.org/I14116566","display_name":"Wuhan Polytechnic University","ror":"https://ror.org/05w0e5j23","country_code":"CN","type":"education","lineage":["https://openalex.org/I14116566"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongbo Chen","raw_affiliation_strings":["Hubei Provincial Center of Technology Innovation for Domestic Animal Breeding, Wuhan Polytechnic University, Wuhan 430023, China","Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Provincial Center of Technology Innovation for Domestic Animal Breeding, Wuhan Polytechnic University, Wuhan 430023, China","institution_ids":["https://openalex.org/I14116566"]},{"raw_affiliation_string":"Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China","institution_ids":["https://openalex.org/I14116566"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038984455","https://openalex.org/A5100452327"],"corresponding_institution_ids":["https://openalex.org/I14116566"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2896},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2896},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.58944753,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"17","first_page":"2645","last_page":"2645"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.8970000147819519,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.8970000147819519,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13791","display_name":"Veterinary medicine and infectious diseases","score":0.05820000171661377,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glaesserella-parasuis","display_name":"Haemophilus parasuis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/swine-respiratory-disease","display_name":"swine respiratory disease","score":0.5899999737739563},{"id":"https://openalex.org/keywords/piglets","display_name":"piglets","score":0.6549999713897705},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.7229999899864197},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/lung-transcriptome","display_name":"lung transcriptome","score":0.7730000019073486},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.6579999923706055},{"id":"https://openalex.org/keywords/lncrna-mrna-co-expression","display_name":"lncRNA-mRNA co-expression","score":0.8330000042915344},{"id":"https://openalex.org/keywords/host-resilience","display_name":"host resilience","score":0.4970000088214874},{"id":"https://openalex.org/keywords/infection-severity","display_name":"infection severity","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.816100001335144},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7894999980926514},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.6062999963760376},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5728999972343445},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4941999912261963},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.483599990606308},{"id":"https://openalex.org/C129013479","wikidata":"https://www.wikidata.org/wiki/Q21111916","display_name":"CCR1","level":5,"score":0.4733999967575073},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41440001130104065},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.37380000948905945},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.36880001425743103},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.36480000615119934},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3614000082015991},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.35690000653266907},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3537999987602234},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34619998931884766},{"id":"https://openalex.org/C2780330800","wikidata":"https://www.wikidata.org/wiki/Q7884647","display_name":"UniGene","level":5,"score":0.3431999981403351},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.3407000005245209},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.3359000086784363},{"id":"https://openalex.org/C206615009","wikidata":"https://www.wikidata.org/wiki/Q4035572","display_name":"CCR2","level":5,"score":0.32739999890327454},{"id":"https://openalex.org/C2779018089","wikidata":"https://www.wikidata.org/wiki/Q17014303","display_name":"Fold change","level":4,"score":0.32030001282691956},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2971999943256378},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29409998655319214},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.2694999873638153},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.2628999948501587},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.26159998774528503},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.25920000672340393},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.257099986076355},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.25369998812675476},{"id":"https://openalex.org/C1423137","wikidata":"https://www.wikidata.org/wiki/Q21113928","display_name":"CCR3","level":5,"score":0.2533000111579895},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.25290000438690186},{"id":"https://openalex.org/C179661763","wikidata":"https://www.wikidata.org/wiki/Q21113119","display_name":"CXCL2","level":5,"score":0.25220000743865967}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/ani16172645","doi":"https://doi.org/10.3390/ani16172645","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ani16172645","pdf_url":null,"source":{"id":"https://openalex.org/S4210168508","display_name":"Animals","issn_l":"2076-2615","issn":["2076-2615"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animals","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13564324","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13564324/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13564324/pdf/animals-16-02645.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animals (Basel)","raw_type":"Text"},{"id":"pmid:42738433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42738433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animals : an open access journal from MDPI","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b3d0030d9f2347cdbc04066be6fbee9a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b3d0030d9f2347cdbc04066be6fbee9a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Animals, Vol 16, Iss 17, p 2645 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ani16172645","doi":"https://doi.org/10.3390/ani16172645","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ani16172645","pdf_url":null,"source":{"id":"https://openalex.org/S4210168508","display_name":"Animals","issn_l":"2076-2615","issn":["2076-2615"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animals","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1353224067","display_name":null,"funder_award_id":"32302723","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4661830436","display_name":null,"funder_award_id":"2023YFD1300200","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8379517232","display_name":null,"funder_award_id":"32172712","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320325512","display_name":"Wuhan Polytechnic University","ror":"https://ror.org/05w0e5j23"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W2066355775","https://openalex.org/W2097599737","https://openalex.org/W2108244474","https://openalex.org/W2112822537","https://openalex.org/W2115244736","https://openalex.org/W2121779591","https://openalex.org/W2153247605","https://openalex.org/W2282529067","https://openalex.org/W2331503091","https://openalex.org/W2615169408","https://openalex.org/W2625411163","https://openalex.org/W2735421082","https://openalex.org/W2883604145","https://openalex.org/W2947420752","https://openalex.org/W3007518858","https://openalex.org/W3044797307","https://openalex.org/W3046402559","https://openalex.org/W3151893855","https://openalex.org/W3173627137","https://openalex.org/W3174011399","https://openalex.org/W4281751826","https://openalex.org/W4284894349","https://openalex.org/W4285006800","https://openalex.org/W4305082168","https://openalex.org/W4309603937","https://openalex.org/W4320856674","https://openalex.org/W4324309803","https://openalex.org/W4386220987","https://openalex.org/W4388197244","https://openalex.org/W4390744727","https://openalex.org/W4391375855","https://openalex.org/W4392157237","https://openalex.org/W4392747091","https://openalex.org/W4395113713","https://openalex.org/W4400108966","https://openalex.org/W4400193120","https://openalex.org/W4400827374","https://openalex.org/W4401093621","https://openalex.org/W4401856515","https://openalex.org/W4401954377","https://openalex.org/W4403177208","https://openalex.org/W4403435014","https://openalex.org/W4406015343","https://openalex.org/W4407100583","https://openalex.org/W4407157076","https://openalex.org/W4408104784","https://openalex.org/W4408298710","https://openalex.org/W4410707747","https://openalex.org/W4411900395","https://openalex.org/W4412429498","https://openalex.org/W4413624507","https://openalex.org/W4414512366","https://openalex.org/W4414704225","https://openalex.org/W4417070770","https://openalex.org/W7117474028","https://openalex.org/W7155209216","https://openalex.org/W7161596521"],"related_works":["https://openalex.org/W4281751826","https://openalex.org/W4386864230","https://openalex.org/W4401856515","https://openalex.org/W4392747091","https://openalex.org/W7205010070","https://openalex.org/W7168275275","https://openalex.org/W4398196848","https://openalex.org/W4409801826","https://openalex.org/W7140286706","https://openalex.org/W4214524798"],"abstract_inverted_index":{"Glaesserella":[0],"parasuis":[1,44,181,228],"(G.":[2],"parasuis)":[3],"is":[4],"a":[5,87,217,231],"major":[6],"respiratory":[7],"pathogen":[8],"in":[9,63,73,107,113,130,153,185,226,266],"piglets,":[10],"but":[11],"the":[12,64,74,81,126,150,210,248],"regulatory":[13],"mechanisms":[14],"underlying":[15],"its":[16,100],"induced":[17],"pulmonary":[18,224],"inflammation":[19,225],"remain":[20],"poorly":[21],"understood.":[22],"In":[23],"this":[24],"study,":[25],"whole-transcriptome":[26],"sequencing":[27],"was":[28],"carried":[29],"out":[30],"on":[31],"lung":[32],"tissues":[33],"from":[34,104],"colostrum-deprived":[35],"piglets":[36],"with":[37,99,191],"mild":[38,65,108],"and":[39,46,58,70,143,168,173,194,206,234,242,263],"severe":[40,75,114,131,154],"serotype":[41],"5":[42],"G.":[43,180,227],"infection":[45,97,109],"healthy":[47],"controls.":[48],"Differential":[49],"expression":[50],"(DE)":[51],"analysis":[52,160],"revealed":[53,195],"299":[54],"nominally":[55,60],"DE":[56,61,128],"mRNAs":[57,193],"408":[59],"lncRNAs":[62],"group,":[66],"increasing":[67],"to":[68,92,110,223],"625":[69],"1193,":[71],"respectively,":[72],"group.":[76],"Ingenuity":[77],"Pathway":[78],"Analysis":[79],"identified":[80,161],"S100":[82],"family":[83,152],"signaling":[84],"pathway":[85],"as":[86],"core":[88],"inflammatory":[89,211,220],"module":[90,221],"predicted":[91],"be":[93,260],"activated":[94],"across":[95],"both":[96],"grades,":[98],"transcriptional":[101],"involvement":[102,203],"expanding":[103],"8":[105],"genes":[106,112,129],"42":[111],"infection.":[115],"Notably,":[116],"G-protein-coupled":[117],"receptors":[118],"(GPCRs)":[119],"accounted":[120],"for":[121,176,238],"nearly":[122],"half":[123],"(19/42)":[124],"of":[125,149,209],"S100-associated":[127],"infection,":[132,182,229],"covering":[133],"multiple":[134,162],"functional":[135,240],"categories":[136],"including":[137],"chemokine":[138],"receptors,":[139,142,145],"lipid":[140],"mediator":[141],"metabotropic":[144],"suggesting":[146,199],"systemic":[147],"activation":[148],"GPCR":[151],"inflammation.":[155],"Weighted":[156],"gene":[157],"co-expression":[158,190],"network":[159],"lncRNA":[163],"candidates,":[164],"among":[165],"which":[166],"two\u2014LOC110256217":[167],"LOC110259349\u2014showed":[169],"severity-associated":[170],"connectivity":[171],"patterns":[172],"were":[174],"selected":[175],"further":[177,239],"validation.":[178],"Following":[179],"time-series":[183],"RT-qPCR":[184],"3D4/21":[186],"cells":[187],"confirmed":[188],"their":[189,200],"corresponding":[192],"distinct":[196],"temporal":[197],"patterns,":[198],"potential":[201],"differential":[202],"at":[204],"early":[205],"late":[207],"stages":[208],"response.":[212],"Collectively,":[213],"these":[214,257],"findings":[215,258],"identify":[216],"putative":[218],"lncRNA-S100-GPCR-associated":[219],"linked":[222],"providing":[230],"transcriptomic":[232],"resource":[233],"candidate":[235],"lncRNA-mRNA":[236],"pairs":[237],"studies":[241],"investigation":[243],"into":[244],"host":[245],"resilience.":[246],"Given":[247],"limited":[249],"sample":[250],"size":[251],"(n":[252],"=":[253],"3":[254],"per":[255],"group),":[256],"should":[259],"considered":[261],"exploratory":[262],"warrant":[264],"validation":[265],"larger":[267],"cohorts.":[268]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-08-25T00:00:00"}