{"id":"https://openalex.org/W7204096780","doi":"https://doi.org/10.64898/2026.08.18.745337","title":"Myeloid IRF5 is required for TLR7-driven inflammatory hemophagocyte differentiation and Macrophage Activation Syndrome","display_name":"Myeloid IRF5 is required for TLR7-driven inflammatory hemophagocyte differentiation and Macrophage Activation Syndrome","publication_year":2026,"publication_date":"2026-08-23","ids":{"openalex":"https://openalex.org/W7204096780","doi":"https://doi.org/10.64898/2026.08.18.745337"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.18.745337","doi":"https://doi.org/10.64898/2026.08.18.745337","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.18.745337","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.08.18.745337","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038369605","display_name":"Natalie K. Thulin","orcid":"https://orcid.org/0000-0002-7721-3747","observed_orcids":["https://orcid.org/0000-0002-7721-3747"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie K. Thulin","raw_affiliation_strings":["Center for Fundamental Immunology, Benaroya Research Institute, Seattle, WA","Department of Immunology, University of Washington, Seattle, WA"],"raw_orcid":"https://orcid.org/0000-0002-7721-3747","affiliations":[{"raw_affiliation_string":"Center for Fundamental Immunology, Benaroya Research Institute, Seattle, WA","institution_ids":["https://openalex.org/I4391012615"]},{"raw_affiliation_string":"Department of Immunology, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069783140","display_name":"Ailing Lu","orcid":"https://orcid.org/0000-0001-5572-7790","observed_orcids":["https://orcid.org/0000-0001-5572-7790"]},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]},{"id":"https://openalex.org/I4210106353","display_name":"Donald & Barbara Zucker School of Medicine at Hofstra/Northwell","ror":"https://ror.org/01ff5td15","country_code":"US","type":"education","lineage":["https://openalex.org/I1302444339","https://openalex.org/I139290212","https://openalex.org/I4210106353"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ailing Lu","raw_affiliation_strings":["Departments of Pediatrics and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY","Institute of Molecular Medicine, Feinstein Institutes for Medical Research, Manhasset, NY"],"raw_orcid":"https://orcid.org/0000-0001-5572-7790","affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY","institution_ids":["https://openalex.org/I4210106353"]},{"raw_affiliation_string":"Institute of Molecular Medicine, Feinstein Institutes for Medical Research, Manhasset, NY","institution_ids":["https://openalex.org/I1327576362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043264680","display_name":"Susana L. Orozco","orcid":"https://orcid.org/0000-0003-1741-6275","observed_orcids":["https://orcid.org/0000-0003-1741-6275"]},"institutions":[{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susana L. Orozco","raw_affiliation_strings":["Center for Fundamental Immunology, Benaroya Research Institute, Seattle, WA","Center for Systems Immunology, Benaroya Research Institute, Seattle, WA"],"raw_orcid":"https://orcid.org/0000-0003-1741-6275","affiliations":[{"raw_affiliation_string":"Center for Fundamental Immunology, Benaroya Research Institute, Seattle, WA","institution_ids":["https://openalex.org/I4391012615"]},{"raw_affiliation_string":"Center for Systems Immunology, Benaroya Research Institute, Seattle, WA","institution_ids":["https://openalex.org/I4391012615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137063645","display_name":"Amanda Huang","orcid":"https://orcid.org/0009-0001-9751-7422","observed_orcids":["https://orcid.org/0009-0001-9751-7422"]},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Y.Y. Huang","raw_affiliation_strings":["Institute of Molecular Medicine, Feinstein Institutes for Medical Research, Manhasset, NY"],"raw_orcid":"https://orcid.org/0009-0001-9751-7422","affiliations":[{"raw_affiliation_string":"Institute of Molecular Medicine, Feinstein Institutes for Medical Research, Manhasset, NY","institution_ids":["https://openalex.org/I1327576362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080226271","display_name":"LeAnn P. Nguyen","orcid":"https://orcid.org/0000-0002-9640-8902","observed_orcids":["https://orcid.org/0000-0002-9640-8902"]},"institutions":[{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LeAnn P. Nguyen","raw_affiliation_strings":["Center for Systems Immunology, Benaroya Research Institute, Seattle, WA"],"raw_orcid":"https://orcid.org/0000-0002-9640-8902","affiliations":[{"raw_affiliation_string":"Center for Systems Immunology, Benaroya Research Institute, Seattle, WA","institution_ids":["https://openalex.org/I4391012615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080821746","display_name":"Gargi Mishra","orcid":"https://orcid.org/0000-0003-1905-3519","observed_orcids":["https://orcid.org/0000-0003-1905-3519"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gargi Mishra","raw_affiliation_strings":["Department of Immunology, University of Washington, Seattle, WA"],"raw_orcid":"https://orcid.org/0000-0003-1905-3519","affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033518970","display_name":"Ram Savan","orcid":"https://orcid.org/0000-0002-3087-1355","observed_orcids":["https://orcid.org/0000-0002-3087-1355"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ram Savan","raw_affiliation_strings":["Department of Immunology, University of Washington, Seattle, WA"],"raw_orcid":"https://orcid.org/0000-0002-3087-1355","affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030890918","display_name":"William L. Clapp","orcid":"https://orcid.org/0000-0001-5903-7113","observed_orcids":["https://orcid.org/0000-0001-5903-7113"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William L. Clapp","raw_affiliation_strings":["Department of Pathology, University of Florida College, Gainesville, Florida"],"raw_orcid":"https://orcid.org/0000-0001-5903-7113","affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Florida College, Gainesville, Florida","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063097637","display_name":"John Ray","orcid":"https://orcid.org/0000-0001-7294-4260","observed_orcids":["https://orcid.org/0000-0001-7294-4260"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John P. Ray","raw_affiliation_strings":["Center for Systems Immunology, Benaroya Research Institute, Seattle, WA","Department of Immunology, University of Washington, Seattle, WA"],"raw_orcid":"https://orcid.org/0000-0001-7294-4260","affiliations":[{"raw_affiliation_string":"Center for Systems Immunology, Benaroya Research Institute, Seattle, WA","institution_ids":["https://openalex.org/I4391012615"]},{"raw_affiliation_string":"Department of Immunology, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021144595","display_name":"Jessica A. Hamerman","orcid":"https://orcid.org/0000-0001-5864-5299","observed_orcids":["https://orcid.org/0000-0001-5864-5299"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jessica A. Hamerman","raw_affiliation_strings":["Center for Fundamental Immunology, Benaroya Research Institute, Seattle, WA","Department of Immunology, University of Washington, Seattle, WA"],"raw_orcid":"https://orcid.org/0000-0001-5864-5299","affiliations":[{"raw_affiliation_string":"Center for Fundamental Immunology, Benaroya Research Institute, Seattle, WA","institution_ids":["https://openalex.org/I4391012615"]},{"raw_affiliation_string":"Department of Immunology, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042412815","display_name":"Betsy Jo Barnes","orcid":"https://orcid.org/0000-0001-6766-4352","observed_orcids":["https://orcid.org/0000-0001-6766-4352"]},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]},{"id":"https://openalex.org/I4210106353","display_name":"Donald & Barbara Zucker School of Medicine at Hofstra/Northwell","ror":"https://ror.org/01ff5td15","country_code":"US","type":"education","lineage":["https://openalex.org/I1302444339","https://openalex.org/I139290212","https://openalex.org/I4210106353"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Betsy J. Barnes","raw_affiliation_strings":["Departments of Pediatrics and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY","Institute of Molecular Medicine, Feinstein Institutes for Medical Research, Manhasset, NY"],"raw_orcid":"https://orcid.org/0000-0001-6766-4352","affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY","institution_ids":["https://openalex.org/I4210106353"]},{"raw_affiliation_string":"Institute of Molecular Medicine, Feinstein Institutes for Medical Research, Manhasset, NY","institution_ids":["https://openalex.org/I1327576362"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5021144595"],"corresponding_institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4391012615"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irf5","display_name":"IRF5","score":0.9879999756813049},{"id":"https://openalex.org/keywords/macrophage-activation-syndrome","display_name":"macrophage activation syndrome","score":0.9649999737739563},{"id":"https://openalex.org/keywords/tlr7","display_name":"TLR7","score":0.8299999833106995},{"id":"https://openalex.org/keywords/myeloid-cells","display_name":"myeloid cells","score":0.722000002861023},{"id":"https://openalex.org/keywords/ly6c-high-monocytes","display_name":"Ly6Chi monocytes","score":0.9150000214576721},{"id":"https://openalex.org/keywords/monocyte-differentiation","display_name":"monocyte differentiation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.6510000228881836},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9760000109672546},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9049999713897705},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.7789999842643738},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6769999861717224},{"id":"https://openalex.org/keywords/ets-transcription-factors","display_name":"ETS transcription factors","score":0.7459999918937683},{"id":"https://openalex.org/keywords/ap-1-transcription-factor","display_name":"AP-1 transcription factor","score":0.8849999904632568},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C2779984610","wikidata":"https://www.wikidata.org/wiki/Q18028000","display_name":"IRF5","level":5,"score":0.8095999956130981},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5612000226974487},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5504999756813049},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5389000177383423},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4936999976634979},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4657999873161316},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.46129998564720154},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.45820000767707825},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4442000091075897},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4325999915599823},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4138000011444092},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3968000113964081},{"id":"https://openalex.org/C2779138994","wikidata":"https://www.wikidata.org/wiki/Q15332550","display_name":"TLR9","level":5,"score":0.39410001039505005},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.3716000020503998},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3555000126361847},{"id":"https://openalex.org/C2779867487","wikidata":"https://www.wikidata.org/wiki/Q952508","display_name":"Plateletpheresis","level":4,"score":0.3522000014781952},{"id":"https://openalex.org/C13164669","wikidata":"https://www.wikidata.org/wiki/Q5009628","display_name":"CCL7","level":5,"score":0.33980000019073486},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33869999647140503},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.33379998803138733},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.319599986076355},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.3154999911785126},{"id":"https://openalex.org/C117705580","wikidata":"https://www.wikidata.org/wiki/Q18027494","display_name":"IRF8","level":4,"score":0.302700012922287},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.29670000076293945},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.28290000557899475},{"id":"https://openalex.org/C101666144","wikidata":"https://www.wikidata.org/wiki/Q2587862","display_name":"CCL2","level":4,"score":0.2768999934196472},{"id":"https://openalex.org/C83396363","wikidata":"https://www.wikidata.org/wiki/Q21116062","display_name":"Interleukin-3 receptor","level":3,"score":0.2572999894618988},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.2565000057220459}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.18.745337","doi":"https://doi.org/10.64898/2026.08.18.745337","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.18.745337","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.18.745337","doi":"https://doi.org/10.64898/2026.08.18.745337","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.18.745337","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6559025645256042,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6530278836","display_name":"IRF5 and Macrophage Activation Syndrome in systemic Juvenile Idiopathic Arthritis","funder_award_id":"R01AR076242","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G75167678","display_name":"Basic Training at the Intersection of Innate and Adaptive Immunity in Disease","funder_award_id":"T32AI106677","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7975640369","display_name":null,"funder_award_id":"F31 A1172078","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W1510337463","https://openalex.org/W1514537538","https://openalex.org/W1531821806","https://openalex.org/W1652805527","https://openalex.org/W1757893380","https://openalex.org/W1758327849","https://openalex.org/W1855966522","https://openalex.org/W1900316083","https://openalex.org/W1967369695","https://openalex.org/W1975455569","https://openalex.org/W1975598191","https://openalex.org/W1988278234","https://openalex.org/W2004662779","https://openalex.org/W2006265632","https://openalex.org/W2007390167","https://openalex.org/W2007719563","https://openalex.org/W2014677321","https://openalex.org/W2025033926","https://openalex.org/W2028368428","https://openalex.org/W2031355052","https://openalex.org/W2036679352","https://openalex.org/W2040706148","https://openalex.org/W2043948229","https://openalex.org/W2046830231","https://openalex.org/W2062885812","https://openalex.org/W2063321204","https://openalex.org/W2065391646","https://openalex.org/W2093146349","https://openalex.org/W2102619694","https://openalex.org/W2106610000","https://openalex.org/W2107018762","https://openalex.org/W2108234281","https://openalex.org/W2110137421","https://openalex.org/W2131271579","https://openalex.org/W2134526812","https://openalex.org/W2139527574","https://openalex.org/W2146512944","https://openalex.org/W2149627698","https://openalex.org/W2164690155","https://openalex.org/W2165591553","https://openalex.org/W2166436539","https://openalex.org/W2166989494","https://openalex.org/W2169456326","https://openalex.org/W2304277276","https://openalex.org/W2417049822","https://openalex.org/W2515169932","https://openalex.org/W2735394628","https://openalex.org/W2750416916","https://openalex.org/W2751121822","https://openalex.org/W2783272135","https://openalex.org/W2784026193","https://openalex.org/W2886252426","https://openalex.org/W2886575447","https://openalex.org/W2897945399","https://openalex.org/W2909114367","https://openalex.org/W2910630164","https://openalex.org/W2911494316","https://openalex.org/W2912679257","https://openalex.org/W2916407275","https://openalex.org/W2944261721","https://openalex.org/W2967647113","https://openalex.org/W2994586359","https://openalex.org/W2997370835","https://openalex.org/W3004219529","https://openalex.org/W3015523006","https://openalex.org/W3026182632","https://openalex.org/W3033310345","https://openalex.org/W3048756957","https://openalex.org/W3083875854","https://openalex.org/W3129349478","https://openalex.org/W3163153730","https://openalex.org/W3175763078","https://openalex.org/W3186420002","https://openalex.org/W3195907693","https://openalex.org/W4206582106","https://openalex.org/W4224228544","https://openalex.org/W4225095275","https://openalex.org/W4285497011","https://openalex.org/W4293661003","https://openalex.org/W4366083654","https://openalex.org/W4386817753","https://openalex.org/W4391613368","https://openalex.org/W4392359599","https://openalex.org/W4396977330","https://openalex.org/W4398256031","https://openalex.org/W4399284150","https://openalex.org/W4399629196","https://openalex.org/W4401685629","https://openalex.org/W4402975258","https://openalex.org/W4412168791","https://openalex.org/W7162450812","https://openalex.org/W7164165802"],"related_works":["https://openalex.org/W4416451002","https://openalex.org/W4404175466","https://openalex.org/W4416450915","https://openalex.org/W2909114367","https://openalex.org/W7171513712","https://openalex.org/W4416446725","https://openalex.org/W2910330811","https://openalex.org/W2308903538","https://openalex.org/W2057316023","https://openalex.org/W2912236061"],"abstract_inverted_index":{"ABSTRACT":[0],"Inflammatory":[1],"hemophagocytes":[2,159],"(iHPCs)":[3],"differentiate":[4],"from":[5],"Ly6C":[6,46,109],"HI":[7,47,110],"monocytes,":[8],"phagocytose":[9],"red":[10],"blood":[11],"cells,":[12],"and":[13,16,36,43,56,77,112,117,130,133,145,176,178],"promote":[14,160],"anemia":[15],"thrombocytopenia":[17],"in":[18,50,62,86,149],"a":[19,27,34,92,124,139,146],"model":[20],"of":[21,40,91,94,142],"TLR7-driven":[22,150,154],"macrophage":[23],"activation":[24],"syndrome":[25],"(MAS),":[26],"life-threatening":[28],"disorder.":[29],"We":[30],"identify":[31],"IRF5":[32,83,98,126,136,170,180],"as":[33,121,123],"required":[35,85,101,172],"pharmacologically":[37],"targetable":[38],"driver":[39],"iHPC":[41,103,143,174],"differentiation":[42,49,104,144,175],"MAS":[44,132],"pathogenesis.":[45],"monocyte-to-iHPC":[48],"TLR7.1":[51,108],"mice":[52],"involved":[53],"extensive":[54],"transcriptome":[55],"chromatin":[57],"remodeling.":[58],"Gene":[59],"programs":[60],"gained":[61],"iHPCs":[63,129,191],"were":[64],"enriched":[65],"for":[66,88,102,107,173],"genes":[67],"near":[68],"accessible":[69],"IRF5-binding":[70],"regions":[71],"that":[72,167,179],"also":[73],"carried":[74],"NF-\u03baB,":[75,188],"ETS,":[76],"AP-1":[78],"motifs,":[79],"suggesting":[80],"collaborative":[81],"regulation.":[82],"was":[84,100],"vitro":[87],"TLR7-induced":[89],"upregulation":[90],"subset":[93],"these":[95],"genes.":[96],"Cell-intrinsic":[97],"expression":[99],"but":[105],"dispensable":[106],"monocytes":[111],"their":[113],"transcriptional":[114],"programs.":[115,192],"Constitutive":[116],"myeloid-specific":[118],"Irf5":[119],"deletion,":[120],"well":[122],"small-molecule":[125],"inhibitor,":[127],"reduced":[128],"ameliorated":[131],"lupus":[134],"features.":[135],"is":[137,171],"therefore":[138],"broad":[140],"regulator":[141],"tractable":[147],"target":[148],"inflammation.":[151],"SUMMARY":[152],"In":[153],"MAS,":[155,177],"specialized":[156],"monocyte-derived":[157],"inflammatory":[158],"disease.":[161],"Thulin,":[162],"Lu":[163],"et":[164],"al.":[165],"show":[166],"myeloid":[168],"cell":[169],"likely":[181],"partners":[182],"with":[183],"other":[184],"transcription":[185],"factors,":[186],"including":[187],"to":[189],"shape":[190]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-25T00:00:00"}