{"id":"https://openalex.org/W7204088064","doi":"https://doi.org/10.33545/26646862.2026.v8.i8b.431","title":"Synthesis and anticancer activity of some novel quinoxaline derivatives","display_name":"Synthesis and anticancer activity of some novel quinoxaline derivatives","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7204088064","doi":"https://doi.org/10.33545/26646862.2026.v8.i8b.431"},"language":"en","primary_location":{"id":"doi:10.33545/26646862.2026.v8.i8b.431","doi":"https://doi.org/10.33545/26646862.2026.v8.i8b.431","is_oa":true,"landing_page_url":"https://doi.org/10.33545/26646862.2026.v8.i8b.431","pdf_url":"https://www.pharmaceuticaljournal.net/archives/2026/vol8issue8/PartB/8-8-17-274.pdf","source":{"id":"https://openalex.org/S4387287749","display_name":"International Journal of Pharmaceutical Research and Development","issn_l":"2664-6862","issn":["2664-6862","2664-6870"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutical Research and Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.pharmaceuticaljournal.net/archives/2026/vol8issue8/PartB/8-8-17-274.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000636741","display_name":"Medidi Srinivas","orcid":"https://orcid.org/0000-0002-6028-5744","observed_orcids":["https://orcid.org/0000-0002-6028-5744"]},"institutions":[{"id":"https://openalex.org/I3133026063","display_name":"Telangana University","ror":"https://ror.org/047qsc013","country_code":"IN","type":"education","lineage":["https://openalex.org/I3133026063"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Medidi Srinivas","raw_affiliation_strings":["Department of Pharmaceutical Chemistry , Geethanjali College of Pharmacy,","Keesara (M) , Medchal (D) , Telangana , India Racha Umadevi Department of Pharmaceutical Chemistry ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry , Geethanjali College of Pharmacy,","institution_ids":[]},{"raw_affiliation_string":"Keesara (M) , Medchal (D) , Telangana , India Racha Umadevi Department of Pharmaceutical Chemistry ,","institution_ids":["https://openalex.org/I3133026063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006680417","display_name":"Racha Umadevi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Racha Umadevi","raw_affiliation_strings":["Cheeryal (V) ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cheeryal (V) ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147987549","display_name":"K Pranathi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Pranathi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147984212","display_name":"K Sai Prasanna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Sai Prasanna","raw_affiliation_strings":["Department of Pharmaceutical Chemistry , Geethanjali College of Pharmacy,","Medchal (D) , Telangana , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry , Geethanjali College of Pharmacy,","institution_ids":[]},{"raw_affiliation_string":"Medchal (D) , Telangana , India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5148004099","display_name":"Mayank Singh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mayank Singh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"8","first_page":"138","last_page":"142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quinoxaline-derivatives","display_name":"quinoxaline derivatives","score":1.0},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8669999837875366},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9380000233650208},{"id":"https://openalex.org/keywords/methoxy-group","display_name":"methoxy substituents","score":0.574999988079071},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6840000152587891},{"id":"https://openalex.org/keywords/anticancer-drug-synthesis","display_name":"anticancer drug synthesis","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2780362310","wikidata":"https://www.wikidata.org/wiki/Q419930","display_name":"Quinoxaline","level":2,"score":0.9305999875068665},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6998999714851379},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5965999960899353},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5199000239372253},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5077000260353088},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43639999628067017},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4359999895095825},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.43299999833106995},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.412200003862381},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.38920000195503235},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3677999973297119},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.3492000102996826},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.34439998865127563},{"id":"https://openalex.org/C3018146709","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Anticancer drug","level":3,"score":0.3418999910354614},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3384000062942505},{"id":"https://openalex.org/C109541995","wikidata":"https://www.wikidata.org/wiki/Q1881253","display_name":"MCF-7","level":5,"score":0.33239999413490295},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.28369998931884766},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2750000059604645},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.25859999656677246},{"id":"https://openalex.org/C175528265","wikidata":"https://www.wikidata.org/wiki/Q500256","display_name":"Chemical structure","level":2,"score":0.2529999911785126}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.33545/26646862.2026.v8.i8b.431","doi":"https://doi.org/10.33545/26646862.2026.v8.i8b.431","is_oa":true,"landing_page_url":"https://doi.org/10.33545/26646862.2026.v8.i8b.431","pdf_url":"https://www.pharmaceuticaljournal.net/archives/2026/vol8issue8/PartB/8-8-17-274.pdf","source":{"id":"https://openalex.org/S4387287749","display_name":"International Journal of Pharmaceutical Research and Development","issn_l":"2664-6862","issn":["2664-6862","2664-6870"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutical Research and Development","raw_type":"journal-article"},{"id":"doi:10.33545/26646862.2026.v8.i8a.431","doi":"https://doi.org/10.33545/26646862.2026.v8.i8a.431","is_oa":true,"landing_page_url":"https://doi.org/10.33545/26646862.2026.v8.i8a.431","pdf_url":"https://www.pharmaceuticaljournal.net/archives/2026/vol8issue8/PartA/8-8-17-229.pdf","source":{"id":"https://openalex.org/S4387287749","display_name":"International Journal of Pharmaceutical Research and Development","issn_l":"2664-6862","issn":["2664-6862","2664-6870"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutical Research and Development","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.33545/26646862.2026.v8.i8b.431","doi":"https://doi.org/10.33545/26646862.2026.v8.i8b.431","is_oa":true,"landing_page_url":"https://doi.org/10.33545/26646862.2026.v8.i8b.431","pdf_url":"https://www.pharmaceuticaljournal.net/archives/2026/vol8issue8/PartB/8-8-17-274.pdf","source":{"id":"https://openalex.org/S4387287749","display_name":"International Journal of Pharmaceutical Research and Development","issn_l":"2664-6862","issn":["2664-6862","2664-6870"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutical Research and Development","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204088064.pdf","grobid_xml":"https://content.openalex.org/works/W7204088064.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1453410951","https://openalex.org/W2019999287","https://openalex.org/W2150031760","https://openalex.org/W2315218945","https://openalex.org/W2346499661","https://openalex.org/W2889377009","https://openalex.org/W2899338774","https://openalex.org/W2915165404","https://openalex.org/W2948399281","https://openalex.org/W2984273912","https://openalex.org/W2985479685","https://openalex.org/W2991763567","https://openalex.org/W3027678013","https://openalex.org/W3154363101","https://openalex.org/W3174095671","https://openalex.org/W3198285109","https://openalex.org/W4206282481","https://openalex.org/W4390614156","https://openalex.org/W4401280276","https://openalex.org/W6912839802","https://openalex.org/W7131788803"],"related_works":["https://openalex.org/W7204145538","https://openalex.org/W7134235947","https://openalex.org/W4412703518","https://openalex.org/W4394063431","https://openalex.org/W3169847096","https://openalex.org/W2985624648","https://openalex.org/W4411939252","https://openalex.org/W7131788803","https://openalex.org/W2883389811","https://openalex.org/W2901808402"],"abstract_inverted_index":{"Cancer":[0],"remains":[1],"a":[2,40,91,109],"leading":[3],"cause":[4],"of":[5,42,77,93],"morbidity":[6],"and":[7,17,62,70,105],"mortality":[8],"globally,":[9],"highlighting":[10],"the":[11],"significant":[12,99],"need":[13],"for":[14,48],"more":[15],"effective":[16],"less":[18],"aggressive":[19],"treatments.":[20],"Quinoxaline":[21],"derivatives,":[22],"which":[23,107],"are":[24],"compounds":[25,54],"with":[26],"flexible":[27],"chemical":[28],"structures,":[29],"have":[30],"shown":[31],"promise":[32],"as":[33],"potential":[34,50],"anticancer":[35,51,75],"drugs.":[36],"In":[37],"this":[38],"study,":[39],"series":[41],"novel":[43],"quinoxalines":[44,79],"derivatives":[45,80],"were":[46,55,65,81],"developed":[47],"their":[49,58,63],"properties.":[52],"The":[53,74],"synthesized":[56],"from":[57],"corresponding":[59],"2-chloro-3-(4-methylpiperazin-1-yl)":[60],"quinoxaline,":[61],"structures":[64],"confirmed":[66],"through":[67],"IR,":[68],"NMR,":[69],"mass":[71],"spectroscopic":[72],"analyses.":[73],"efficacy":[76],"these":[78],"assessed":[82],"in":[83],"vitro":[84],"against":[85],"MCF-7":[86],"breast":[87],"cancer":[88],"cells":[89],"at":[90],"concentration":[92],"10":[94],"\u03bcg,":[95],"revealing":[96],"moderate":[97],"to":[98],"cytotoxic":[100],"effects.":[101],"Compounds":[102],"3i,":[103],"3h,":[104],"3d,":[106],"feature":[108],"metthoxy":[110],"groups":[111],"on":[112],"phenyl":[113],"ring,":[114],"exhibited":[115],"particularly":[116],"notable":[117],"activity.":[118]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-08-25T00:00:00"}
