{"id":"https://openalex.org/W7204088048","doi":"https://doi.org/10.9734/irjgh/2026/v9i1157","title":"Fatal Fulminant Hepatitis Following Leptospirosis : A Case Report","display_name":"Fatal Fulminant Hepatitis Following Leptospirosis : A Case Report","publication_year":2026,"publication_date":"2026-08-24","ids":{"openalex":"https://openalex.org/W7204088048","doi":"https://doi.org/10.9734/irjgh/2026/v9i1157"},"language":"en","primary_location":{"id":"doi:10.9734/irjgh/2026/v9i1157","doi":"https://doi.org/10.9734/irjgh/2026/v9i1157","is_oa":false,"landing_page_url":"https://doi.org/10.9734/irjgh/2026/v9i1157","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Research Journal of Gastroenterology and Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076479615","display_name":"A. A. Bah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167424","display_name":"H\u00f4pital Militaire Avicenne","ror":"https://ror.org/02cfbec64","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210167424"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"A. A. Bah","raw_affiliation_strings":["Department of Gastroenterology, Avicenne Military Hospital, Marrakech, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Avicenne Military Hospital, Marrakech, Morocco","institution_ids":["https://openalex.org/I4210167424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137072532","display_name":"K. Gharbi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167424","display_name":"H\u00f4pital Militaire Avicenne","ror":"https://ror.org/02cfbec64","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210167424"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"K. Gharbi","raw_affiliation_strings":["Department of Gastroenterology, Avicenne Military Hospital, Marrakech, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Avicenne Military Hospital, Marrakech, Morocco","institution_ids":["https://openalex.org/I4210167424"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022175842","display_name":"R. Akka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167424","display_name":"H\u00f4pital Militaire Avicenne","ror":"https://ror.org/02cfbec64","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210167424"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"R. Akka","raw_affiliation_strings":["Department of Gastroenterology, Avicenne Military Hospital, Marrakech, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Avicenne Military Hospital, Marrakech, Morocco","institution_ids":["https://openalex.org/I4210167424"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210167424"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.59584291,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"1","first_page":"261","last_page":"266"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12223","display_name":"Leptospirosis research and findings","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12223","display_name":"Leptospirosis research and findings","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptospirosis","display_name":"leptospirosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fulminant-hepatitis","display_name":"fulminant hepatitis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/acute-liver-failure","display_name":"acute liver failure","score":0.9850000143051147},{"id":"https://openalex.org/keywords/leptospira","display_name":"Leptospira","score":0.8169999718666077},{"id":"https://openalex.org/keywords/zoonoses","display_name":"zoonoses","score":0.8240000009536743},{"id":"https://openalex.org/keywords/coagulopathy","display_name":"coagulopathy","score":0.777999997138977},{"id":"https://openalex.org/keywords/hepatic-encephalopathy","display_name":"hepatic encephalopathy","score":0.8410000205039978},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.8700000047683716},{"id":"https://openalex.org/keywords/multiple-organ-failure","display_name":"multiple organ failure","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.7979999780654907},{"id":"https://openalex.org/keywords/critical-care-management","display_name":"intensive care management","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8672000169754028},{"id":"https://openalex.org/C2778033228","wikidata":"https://www.wikidata.org/wiki/Q155098","display_name":"Leptospirosis","level":2,"score":0.6980000138282776},{"id":"https://openalex.org/C2994395758","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Fulminant hepatitis","level":3,"score":0.6108999848365784},{"id":"https://openalex.org/C2781107259","wikidata":"https://www.wikidata.org/wiki/Q5508364","display_name":"Fulminant","level":2,"score":0.6101999878883362},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4221999943256378},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.36970001459121704},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3463999927043915},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3206999897956848},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.2973000109195709},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2924000024795532},{"id":"https://openalex.org/C2775876817","wikidata":"https://www.wikidata.org/wiki/Q157661","display_name":"Hepatitis A","level":3,"score":0.27720001339912415},{"id":"https://openalex.org/C2778456037","wikidata":"https://www.wikidata.org/wiki/Q133244","display_name":"Jaundice","level":2,"score":0.26919999718666077},{"id":"https://openalex.org/C2779379848","wikidata":"https://www.wikidata.org/wiki/Q917069","display_name":"Rhabdomyolysis","level":2,"score":0.2680000066757202},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2651999890804291},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2619999945163727},{"id":"https://openalex.org/C3018886096","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Acute hepatitis","level":3,"score":0.25839999318122864},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.2500999867916107}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.9734/irjgh/2026/v9i1157","doi":"https://doi.org/10.9734/irjgh/2026/v9i1157","is_oa":false,"landing_page_url":"https://doi.org/10.9734/irjgh/2026/v9i1157","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Research Journal of Gastroenterology and Hepatology","raw_type":"journal-article"},{"id":"pmh:oai:HAL:hal-05727099v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05727099","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Research Journal of Gastroenterology and Hepatology, 2026, 9 (1), pp.261-266","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7223102847","https://openalex.org/W4385311716","https://openalex.org/W7163719443","https://openalex.org/W4391377793","https://openalex.org/W2950427695","https://openalex.org/W4404373262","https://openalex.org/W2995121446","https://openalex.org/W4409118621","https://openalex.org/W4413454193","https://openalex.org/W2898249056"],"abstract_inverted_index":{"Leptospirosis":[0],"is":[1],"a":[2,19,131],"bacterial":[3],"zoonosis":[4],"that":[5],"may":[6,192],"rarely":[7],"cause":[8],"severe":[9,79,123,189],"hepatic":[10,65,147,190],"involvement":[11,191],"and":[12,37,59,94,103,106,114,139,153,158,184,199],"fulminant":[13],"acute":[14,87,181],"liver":[15,182],"failure.":[16],"We":[17],"report":[18],"32-year-old":[20],"man":[21],"with":[22,39,52,180],"no":[23],"notable":[24],"medical":[25],"history":[26],"who":[27],"presented":[28],"after":[29],"seven":[30],"days":[31],"of":[32,141,166],"fever,":[33],"intense":[34],"myalgia,":[35],"headache,":[36],"vomiting,":[38],"recent":[40],"exposure":[41],"to":[42,122,173],"stagnant":[43],"water":[44,186],"following":[45],"heavy":[46],"rainfall.":[47],"His":[48],"condition":[49],"deteriorated":[50],"rapidly,":[51],"jaundice,":[53],"cutaneous-mucosal":[54],"bleeding,":[55],"altered":[56],"consciousness,":[57],"hypotension,":[58],"tachycardia.":[60],"Laboratory":[61],"investigations":[62],"showed":[63],"marked":[64],"cytolysis":[66],"(AST":[67],"5,000":[68],"IU/L;":[69],"ALT":[70],"4,200":[71],"IU/L),":[72],"conjugated":[73],"hyperbilirubinaemia":[74],"(total":[75],"bilirubin":[76],"280":[77],"\u00b5mol/L),":[78,92],"coagulopathy":[80],"(prothrombin":[81],"time":[82],"18%;":[83],"INR":[84],"4.5),":[85],"hypoglycaemia,":[86],"kidney":[88],"injury":[89],"(creatinine":[90],"480":[91],"thrombocytopenia,":[93],"leukocytosis.":[95],"Serological":[96],"testing":[97],"for":[98],"hepatitis":[99,120],"A,":[100],"B,":[101],"C,":[102],"E":[104],"viruses":[105],"toxicological":[107],"screening":[108],"were":[109,117],"negative,":[110],"whereas":[111],"Leptospira":[112],"PCR":[113],"IgM":[115],"serology":[116],"positive.":[118],"Fulminant":[119],"secondary":[121],"leptospirosis":[124,175],"was":[125],"diagnosed.":[126],"Intensive":[127],"care":[128],"management":[129],"included":[130],"third-generation":[132],"cephalosporin,":[133],"haemodynamic":[134],"support,":[135],"mechanical":[136],"ventilation,":[137],"haemodialysis,":[138],"correction":[140],"coagulation":[142],"disorders.":[143],"Despite":[144],"these":[145],"measures,":[146],"encephalopathy":[148],"worsened,":[149],"refractory":[150],"septic":[151],"shock":[152],"multiple":[154],"organ":[155,200],"failure":[156,183],"developed,":[157],"the":[159,163,171],"patient":[160],"died":[161],"on":[162],"third":[164],"day":[165],"hospitalisation.":[167],"This":[168],"case":[169],"highlights":[170],"need":[172],"consider":[174],"early":[176],"in":[177],"febrile":[178],"patients":[179],"compatible":[185],"exposure,":[187],"because":[188],"progress":[193],"rapidly":[194],"despite":[195],"intensive":[196],"supportive":[197],"treatment":[198],"support.":[201]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-08-25T00:00:00"}