{"id":"https://openalex.org/W7204079172","doi":"https://doi.org/10.1080/15360288.2026.2702861","title":"Impact of CYP2D6 Metabolism and CYP2D6 Inhibitor Use on Post-Procedure Pain Outcomes in Patients Prescribed Codeine or Tramadol","display_name":"Impact of CYP2D6 Metabolism and CYP2D6 Inhibitor Use on Post-Procedure Pain Outcomes in Patients Prescribed Codeine or Tramadol","publication_year":2026,"publication_date":"2026-07-03","ids":{"openalex":"https://openalex.org/W7204079172","doi":"https://doi.org/10.1080/15360288.2026.2702861"},"language":"en","primary_location":{"id":"doi:10.1080/15360288.2026.2702861","doi":"https://doi.org/10.1080/15360288.2026.2702861","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15360288.2026.2702861","pdf_url":null,"source":{"id":"https://openalex.org/S8189674","display_name":"Journal of Pain & Palliative Care Pharmacotherapy","issn_l":"1536-0288","issn":["1536-0288","1536-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pain &amp; Palliative Care Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147959248","display_name":"Temple C. Coldren","orcid":"https://orcid.org/0009-0009-5901-9500","observed_orcids":["https://orcid.org/0009-0009-5901-9500"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Temple C. Coldren","raw_affiliation_strings":["Pharmacy Department, Hospital of the University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy Department, Hospital of the University of Pennsylvania","institution_ids":["https://openalex.org/I2799810409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106319780","display_name":"Victoria A. Wittner","orcid":"https://orcid.org/0009-0002-4886-2171","observed_orcids":["https://orcid.org/0009-0002-4886-2171"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria Wittner","raw_affiliation_strings":["Perelman School of Medicine, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Perelman School of Medicine, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147949547","display_name":"Ananya Kapoor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ananya Kapoor","raw_affiliation_strings":["University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009725286","display_name":"Mari Angelica S. Cayabyab","orcid":"https://orcid.org/0000-0002-5345-6154","observed_orcids":["https://orcid.org/0000-0002-5345-6154"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mari Cayabyab","raw_affiliation_strings":["Pharmacy Department, Hospital of the University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy Department, Hospital of the University of Pennsylvania","institution_ids":["https://openalex.org/I2799810409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002344967","display_name":"Jacob A. Radcliff","orcid":"https://orcid.org/0000-0002-4455-2224","observed_orcids":["https://orcid.org/0000-0002-4455-2224"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob A. Radcliff","raw_affiliation_strings":["Pharmacy Department, Hospital of the University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy Department, Hospital of the University of Pennsylvania","institution_ids":["https://openalex.org/I2799810409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050048252","display_name":"Tanya J. Uritsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanya J. Uritsky","raw_affiliation_strings":["Pharmacy Department, Hospital of the University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy Department, Hospital of the University of Pennsylvania","institution_ids":["https://openalex.org/I2799810409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126026921","display_name":"Penn Medicine Biobank","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Penn Medicine Biobank","raw_affiliation_strings":["Penn Medicine Biobank"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Penn Medicine Biobank","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080251530","display_name":"Shefali S. Verma","orcid":"https://orcid.org/0000-0001-7625-1162","observed_orcids":["https://orcid.org/0000-0001-7625-1162"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shefali Setia Verma","raw_affiliation_strings":["Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine","Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine","Institute of Biomedical Informatics, University of Pennsylvania Perelman School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute of Biomedical Informatics, University of Pennsylvania Perelman School of Medicine","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021831441","display_name":"Sony Tuteja","orcid":"https://orcid.org/0000-0001-7007-3289","observed_orcids":["https://orcid.org/0000-0001-7007-3289"]},"institutions":[{"id":"https://openalex.org/I4210143392","display_name":"University of Pennsylvania Health System","ror":"https://ror.org/04h81rw26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sony Tuteja","raw_affiliation_strings":["Division of Translational Medicine and Human Genetics, University of Pennsylvania Perelman School of Medicine","Penn Medicine Center for Genomic Medicine, University of Pennsylvania Perelman School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Translational Medicine and Human Genetics, University of Pennsylvania Perelman School of Medicine","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Penn Medicine Center for Genomic Medicine, University of Pennsylvania Perelman School of Medicine","institution_ids":["https://openalex.org/I4210143392","https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5147959248"],"corresponding_institution_ids":["https://openalex.org/I2799810409"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.61963648,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"3","first_page":"582","last_page":"583"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.9020000100135803},{"id":"https://openalex.org/keywords/codeine","display_name":"codeine","score":0.7820000052452087},{"id":"https://openalex.org/keywords/tramadol","display_name":"tramadol","score":1.0},{"id":"https://openalex.org/keywords/cyp2d6-inhibitors","display_name":"CYP2D6 inhibitors","score":0.8920000195503235},{"id":"https://openalex.org/keywords/post-procedural-pain","display_name":"post-procedural pain","score":0.7919999957084656},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.6740000247955322},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.6330000162124634},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.4819999933242798},{"id":"https://openalex.org/keywords/pain-outcomes","display_name":"pain outcomes","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C33664856","wikidata":"https://www.wikidata.org/wiki/Q3271142","display_name":"CYP2D6","level":4,"score":0.8361999988555908},{"id":"https://openalex.org/C2779777798","wikidata":"https://www.wikidata.org/wiki/Q407592","display_name":"Tramadol","level":3,"score":0.7767000198364258},{"id":"https://openalex.org/C2777866328","wikidata":"https://www.wikidata.org/wiki/Q174723","display_name":"Codeine","level":3,"score":0.695900022983551},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.694599986076355},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.534600019454956},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4902999997138977},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3677999973297119},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.32580000162124634},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.3188000023365021},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.313400000333786},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.2840999960899353},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2662999927997589},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.25929999351501465},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.25600001215934753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/15360288.2026.2702861","doi":"https://doi.org/10.1080/15360288.2026.2702861","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15360288.2026.2702861","pdf_url":null,"source":{"id":"https://openalex.org/S8189674","display_name":"Journal of Pain & Palliative Care Pharmacotherapy","issn_l":"1536-0288","issn":["1536-0288","1536-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pain &amp; Palliative Care Pharmacotherapy","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","score":0.5766761302947998,"display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2013678639","https://openalex.org/W4401253013","https://openalex.org/W2428312939","https://openalex.org/W3006734585","https://openalex.org/W2942707451","https://openalex.org/W2913964388","https://openalex.org/W2034839664","https://openalex.org/W4404355961","https://openalex.org/W7130731852","https://openalex.org/W7133497408"],"abstract_inverted_index":{"Codeine":[0],"and":[1],"tramadol":[2],"are":[3],"opioid":[4],"prodrugs":[5],"whose":[6],"analgesic":[7],"efficacy":[8],"depends":[9],"on":[10],"hepatic":[11],"bioactivation":[12],"by":[13],"cytochrome":[14],"P450":[15],"2D6":[16],"(CYP2D6).":[17],"CYP2D6":[18],"is":[19],"highly":[20],"polymorphic":[21],"resulting":[22],"in":[23],"a":[24],"spectrum":[25],"of":[26],"metaboliz...":[27]},"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2026-08-25T00:00:00"}
