{"id":"https://openalex.org/W7204078044","doi":"https://doi.org/10.1016/j.neuropharm.2026.111252","title":"Repeated swim exposure and PKN1a knockout enhance group I mGluR-dependent excitability associated with reduced EAAT3 expression in mouse dentate granule cells","display_name":"Repeated swim exposure and PKN1a knockout enhance group I mGluR-dependent excitability associated with reduced EAAT3 expression in mouse dentate granule cells","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7204078044","doi":"https://doi.org/10.1016/j.neuropharm.2026.111252","pmid":"https://pubmed.ncbi.nlm.nih.gov/42962883"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuropharm.2026.111252","doi":"https://doi.org/10.1016/j.neuropharm.2026.111252","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuropharm.2026.111252","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0028390826004272/pdf","source":{"id":"https://openalex.org/S160566677","display_name":"Neuropharmacology","issn_l":"0028-3908","issn":["0028-3908","1873-7064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0028390826004272/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054425487","display_name":"Hiroki Yasuda","orcid":"https://orcid.org/0000-0001-5911-609X","observed_orcids":["https://orcid.org/0000-0001-5911-609X"]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]},{"id":"https://openalex.org/I177136067","display_name":"Saga University","ror":"https://ror.org/04f4wg107","country_code":"JP","type":"education","lineage":["https://openalex.org/I177136067"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroki Yasuda","raw_affiliation_strings":["Education and Research Support Center, Gunma University Graduate School of Medicine, Maebashi, 371-8511, Japan; Division of Physiology, Saga University Faculty of Medicine, Saga, 849-8501, Japan. Electronic address: yasuda@cc.saga-u.ac.jp"],"raw_orcid":"https://orcid.org/0000-0001-5911-609X","affiliations":[{"raw_affiliation_string":"Education and Research Support Center, Gunma University Graduate School of Medicine, Maebashi, 371-8511, Japan; Division of Physiology, Saga University Faculty of Medicine, Saga, 849-8501, Japan. Electronic address: yasuda@cc.saga-u.ac.jp","institution_ids":["https://openalex.org/I165735259","https://openalex.org/I177136067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021672172","display_name":"Koji Kubouchi","orcid":"https://orcid.org/0000-0003-1440-1625","observed_orcids":["https://orcid.org/0000-0003-1440-1625"]},"institutions":[{"id":"https://openalex.org/I4405286400","display_name":"Biosignal Research Center, Kobe University","ror":"https://ror.org/021pfgn64","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286400","https://openalex.org/I65837984"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Kubouchi","raw_affiliation_strings":["Biosignal Research Center, Kobe University, Kobe, 657-8501, Japan"],"raw_orcid":"https://orcid.org/0000-0003-1440-1625","affiliations":[{"raw_affiliation_string":"Biosignal Research Center, Kobe University, Kobe, 657-8501, Japan","institution_ids":["https://openalex.org/I4405286400","https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072195324","display_name":"Kenji Hanamura","orcid":"https://orcid.org/0000-0002-2244-648X","observed_orcids":["https://orcid.org/0000-0002-2244-648X"]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]},{"id":"https://openalex.org/I66005833","display_name":"Niigata University of Health and Welfare","ror":"https://ror.org/00aygzx54","country_code":"JP","type":"education","lineage":["https://openalex.org/I66005833"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Hanamura","raw_affiliation_strings":["Department of Pharmacology, Gunma University Graduate School of Medicine, Maebashi, 371-8511, Japan; Department of Radiological Technology, Faculty of Medical Technology, Niigata University of Health and Welfare, Niigata, 950-3198, Japan"],"raw_orcid":"https://orcid.org/0000-0002-2244-648X","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Gunma University Graduate School of Medicine, Maebashi, 371-8511, Japan; Department of Radiological Technology, Faculty of Medical Technology, Niigata University of Health and Welfare, Niigata, 950-3198, Japan","institution_ids":["https://openalex.org/I165735259","https://openalex.org/I66005833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001216456","display_name":"Taiga Kurihara","orcid":"https://orcid.org/0000-0002-4735-8865","observed_orcids":["https://orcid.org/0000-0002-4735-8865"]},"institutions":[{"id":"https://openalex.org/I177136067","display_name":"Saga University","ror":"https://ror.org/04f4wg107","country_code":"JP","type":"education","lineage":["https://openalex.org/I177136067"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taiga Kurihara","raw_affiliation_strings":["Division of Physiology, Saga University Faculty of Medicine, Saga, 849-8501, Japan"],"raw_orcid":"https://orcid.org/0000-0002-4735-8865","affiliations":[{"raw_affiliation_string":"Division of Physiology, Saga University Faculty of Medicine, Saga, 849-8501, Japan","institution_ids":["https://openalex.org/I177136067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147581778","display_name":"Yuka Nakasone","orcid":"https://orcid.org/0009-0009-4328-9012","observed_orcids":["https://orcid.org/0009-0009-4328-9012"]},"institutions":[{"id":"https://openalex.org/I177136067","display_name":"Saga University","ror":"https://ror.org/04f4wg107","country_code":"JP","type":"education","lineage":["https://openalex.org/I177136067"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuka Nakasone","raw_affiliation_strings":["Division of Physiology, Saga University Faculty of Medicine, Saga, 849-8501, Japan"],"raw_orcid":"https://orcid.org/0009-0009-4328-9012","affiliations":[{"raw_affiliation_string":"Division of Physiology, Saga University Faculty of Medicine, Saga, 849-8501, Japan","institution_ids":["https://openalex.org/I177136067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019968973","display_name":"Hideyuki Mukai","orcid":"https://orcid.org/0000-0002-0167-8695","observed_orcids":["https://orcid.org/0000-0002-0167-8695"]},"institutions":[{"id":"https://openalex.org/I4405286400","display_name":"Biosignal Research Center, Kobe University","ror":"https://ror.org/021pfgn64","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286400","https://openalex.org/I65837984"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideyuki Mukai","raw_affiliation_strings":["Biosignal Research Center, Kobe University, Kobe, 657-8501, Japan"],"raw_orcid":"https://orcid.org/0000-0002-0167-8695","affiliations":[{"raw_affiliation_string":"Biosignal Research Center, Kobe University, Kobe, 657-8501, Japan","institution_ids":["https://openalex.org/I4405286400","https://openalex.org/I65837984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5054425487"],"corresponding_institution_ids":["https://openalex.org/I165735259","https://openalex.org/I177136067"],"apc_list":{"value":4300,"currency":"USD","value_usd":4300},"apc_paid":{"value":4300,"currency":"USD","value_usd":4300},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.51254592,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"303","issue":null,"first_page":"111252","last_page":"111252"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/group-i-metabotropic-glutamate-receptors","display_name":"group I metabotropic glutamate receptors","score":0.9610000252723694},{"id":"https://openalex.org/keywords/mglur1","display_name":"mGluR1","score":0.9039999842643738},{"id":"https://openalex.org/keywords/mglur5","display_name":"mGluR5","score":1.0},{"id":"https://openalex.org/keywords/eaat3","display_name":"EAAT3","score":0.9190000295639038},{"id":"https://openalex.org/keywords/glutamate-transporters","display_name":"glutamate transporters","score":0.8230000138282776},{"id":"https://openalex.org/keywords/dentate-granule-cells","display_name":"dentate gyrus granule cells","score":0.9459999799728394},{"id":"https://openalex.org/keywords/neuronal-excitability","display_name":"neuronal excitability","score":0.8420000076293945},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.5659999847412109},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7850000262260437},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.6299999952316284},{"id":"https://openalex.org/keywords/elevated-plus-maze","display_name":"elevated plus maze","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.7480999827384949},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.6886000037193298},{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.6546000242233276},{"id":"https://openalex.org/C2778888523","wikidata":"https://www.wikidata.org/wiki/Q1777753","display_name":"Granule cell","level":4,"score":0.6446999907493591},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6402999758720398},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.5600000023841858},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.5271999835968018},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.5224999785423279},{"id":"https://openalex.org/C26702167","wikidata":"https://www.wikidata.org/wiki/Q901988","display_name":"Metabotropic receptor","level":4,"score":0.5177000164985657},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46779999136924744},{"id":"https://openalex.org/C115955781","wikidata":"https://www.wikidata.org/wiki/Q6063798","display_name":"Ionotropic effect","level":4,"score":0.45719999074935913},{"id":"https://openalex.org/C49760210","wikidata":"https://www.wikidata.org/wiki/Q5596727","display_name":"Granule (geology)","level":2,"score":0.45190000534057617},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3971000015735626},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3950999975204468},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.39469999074935913},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.3873000144958496},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38350000977516174},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.37689998745918274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36809998750686646},{"id":"https://openalex.org/C207951395","wikidata":"https://www.wikidata.org/wiki/Q288431","display_name":"Metabotropic glutamate receptor 1","level":5,"score":0.3662000000476837},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34130001068115234},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.34130001068115234},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.33869999647140503},{"id":"https://openalex.org/C41653306","wikidata":"https://www.wikidata.org/wiki/Q6589190","display_name":"Metabotropic glutamate receptor 5","level":5,"score":0.3312999904155731},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.3199999928474426},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.31200000643730164},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.2971000075340271},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.2816999852657318},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.28060001134872437},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.2770000100135803},{"id":"https://openalex.org/C2780358027","wikidata":"https://www.wikidata.org/wiki/Q407752","display_name":"Neurotoxin","level":2,"score":0.2745000123977661},{"id":"https://openalex.org/C56940625","wikidata":"https://www.wikidata.org/wiki/Q6589868","display_name":"Metabotropic glutamate receptor 6","level":5,"score":0.272599995136261},{"id":"https://openalex.org/C2778740566","wikidata":"https://www.wikidata.org/wiki/Q181136","display_name":"Glutamic acid","level":3,"score":0.25450000166893005},{"id":"https://openalex.org/C77957584","wikidata":"https://www.wikidata.org/wiki/Q1133550","display_name":"Gene knockout","level":3,"score":0.25119999051094055}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.neuropharm.2026.111252","doi":"https://doi.org/10.1016/j.neuropharm.2026.111252","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuropharm.2026.111252","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0028390826004272/pdf","source":{"id":"https://openalex.org/S160566677","display_name":"Neuropharmacology","issn_l":"0028-3908","issn":["0028-3908","1873-7064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"journal-article"},{"id":"doi:10.64898/2026.08.19.745661","doi":"https://doi.org/10.64898/2026.08.19.745661","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.19.745661","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/24/2026.08.19.745661.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42962883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42962883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.neuropharm.2026.111252","doi":"https://doi.org/10.1016/j.neuropharm.2026.111252","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuropharm.2026.111252","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0028390826004272/pdf","source":{"id":"https://openalex.org/S160566677","display_name":"Neuropharmacology","issn_l":"0028-3908","issn":["0028-3908","1873-7064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2098206427","display_name":null,"funder_award_id":"08093928","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2835518605","display_name":null,"funder_award_id":"18022025","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G3193490794","display_name":null,"funder_award_id":"09152356","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3221211274","display_name":"\u86cb\u767d\u8cea\u30ea\u30f3\u9178\u5316\u9175\u7d20PKN1\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u8a18\u61b6\u30fb\u5b66\u7fd2\u6a5f\u69cb\u306e\u89e3\u6790","funder_award_id":"18022025","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3568114283","display_name":null,"funder_award_id":"11005815","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3722376762","display_name":null,"funder_award_id":"11005815","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G7686016480","display_name":null,"funder_award_id":"08093928","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G86228263","display_name":null,"funder_award_id":"09152356","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320316983","display_name":"Takeda Foundation","ror":"https://ror.org/05xs52z55"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204078044.pdf","grobid_xml":"https://content.openalex.org/works/W7204078044.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1812391321","https://openalex.org/W1895913202","https://openalex.org/W1970500753","https://openalex.org/W1980805930","https://openalex.org/W1980872345","https://openalex.org/W1984608574","https://openalex.org/W1986097748","https://openalex.org/W1986760345","https://openalex.org/W2002802459","https://openalex.org/W2005594217","https://openalex.org/W2012199810","https://openalex.org/W2016413199","https://openalex.org/W2017197221","https://openalex.org/W2018882965","https://openalex.org/W2019826954","https://openalex.org/W2031598294","https://openalex.org/W2032863178","https://openalex.org/W2050066016","https://openalex.org/W2051197449","https://openalex.org/W2057017838","https://openalex.org/W2057855503","https://openalex.org/W2069281265","https://openalex.org/W2071666600","https://openalex.org/W2077557590","https://openalex.org/W2084586353","https://openalex.org/W2091395194","https://openalex.org/W2114600491","https://openalex.org/W2116447452","https://openalex.org/W2120307371","https://openalex.org/W2120741241","https://openalex.org/W2121454293","https://openalex.org/W2121960517","https://openalex.org/W2128426029","https://openalex.org/W2129860046","https://openalex.org/W2149694168","https://openalex.org/W2151713736","https://openalex.org/W2159635498","https://openalex.org/W2227521591","https://openalex.org/W2406436421","https://openalex.org/W2428350633","https://openalex.org/W2547225283","https://openalex.org/W2566791353","https://openalex.org/W2792477829","https://openalex.org/W2792863161","https://openalex.org/W2890435854","https://openalex.org/W2900410080","https://openalex.org/W2910288080","https://openalex.org/W3006603159","https://openalex.org/W3048215082","https://openalex.org/W3092086665","https://openalex.org/W3110630030","https://openalex.org/W3173876705","https://openalex.org/W3201753099","https://openalex.org/W4206393097","https://openalex.org/W4308440551","https://openalex.org/W4321097890","https://openalex.org/W4360599900","https://openalex.org/W4385255236","https://openalex.org/W4386493266","https://openalex.org/W4392167136","https://openalex.org/W4401699925","https://openalex.org/W4402383141","https://openalex.org/W4403441426","https://openalex.org/W4408519809","https://openalex.org/W7161148515","https://openalex.org/W7163545633"],"related_works":["https://openalex.org/W4281704059","https://openalex.org/W3110630030","https://openalex.org/W2345789412","https://openalex.org/W3119069336","https://openalex.org/W2086892679","https://openalex.org/W2053050620","https://openalex.org/W2162379761","https://openalex.org/W2062849330","https://openalex.org/W2977461609","https://openalex.org/W333671105"],"abstract_inverted_index":{"Stress-related":[0],"experiences":[1],"alter":[2],"glutamatergic":[3],"signaling":[4],"and":[5,36,61,91,110,124,166,172,195,227],"neuronal":[6,52],"excitability,":[7,46],"but":[8,143],"the":[9,51,178,183,203],"mechanisms":[10],"that":[11],"couple":[12],"experience":[13],"to":[14],"dentate":[15,43,79,220],"granule":[16,44,80,136,221],"cell":[17,45,137],"function":[18],"remain":[19],"incompletely":[20],"understood.":[21],"Here,":[22],"we":[23],"examined":[24],"how":[25],"protein":[26,31],"kinase":[27,32],"N1a":[28],"(PKN1a),":[29],"a":[30,48,88,234],"C-like":[33],"serine/threonine":[34],"kinase,":[35],"repeated":[37,71,92,107,196,224],"swim":[38,72,93,108,164,197,225],"exposure":[39,73,109,165,198,226],"regulate":[40],"mouse":[41],"hippocampal":[42],"with":[47,133],"focus":[49],"on":[50],"glutamate":[53,65,131,185],"transporter":[54,58,186],"excitatory":[55],"amino":[56],"acid":[57],"3":[59],"(EAAT3)":[60],"group":[62,215],"I":[63,216],"metabotropic":[64],"receptors":[66],"(mGluRs).":[67],"Five":[68],"days":[69],"of":[70,119,130,158,161,175,182,211],"increased":[74,135],"spike":[75],"firing":[76,98,104,138,148],"in":[77,99,111,139,149,177,202,219],"mature":[78],"cells":[81],"from":[82],"wild-type":[83,141,151],"mice.":[84,101],"PKN1a":[85,112,153,167,193,228],"knockout":[86,100,113,154,168,194,229],"produced":[87],"similar":[89],"increase,":[90],"did":[94,144],"not":[95,145,189],"further":[96,146],"enhance":[97],"The":[102],"enhanced":[103],"observed":[105],"after":[106],"mice":[114,142],"was":[115,188],"reduced":[116,170,199,240],"by":[117,239],"co-application":[118],"an":[120,125],"mGluR1":[121],"antagonist":[122,127],"(LY367385)":[123],"mGluR5":[126],"(MPEP).":[128],"Inhibition":[129],"transporters":[132],"DL-TBOA":[134],"control":[140],"increase":[147],"repeated-swim":[150],"or":[152],"mice,":[155],"suggesting":[156],"occlusion":[157],"transporter-dependent":[159],"regulation":[160,210],"excitability.":[162],"Repeated":[163],"also":[169],"total":[171],"surface":[173],"expression":[174,181],"EAAT3":[176,212],"hippocampus,":[179],"whereas":[180,223],"glial":[184],"EAAT2":[187],"significantly":[190],"altered.":[191],"Finally,":[192],"anxiety-related":[200,241],"behavior":[201],"elevated":[204],"plus":[205],"maze":[206],"test.":[207],"Thus,":[208],"PKN1a-dependent":[209],"may":[213],"restrain":[214],"mGluR-dependent":[217],"excitability":[218],"cells,":[222],"shift":[230],"this":[231],"system":[232],"toward":[233],"lower-EAAT3,":[235],"higher-excitability":[236],"state":[237],"accompanied":[238],"behavior.":[242]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-08-25T00:00:00"}
