{"id":"https://openalex.org/W7204073558","doi":"https://doi.org/10.64898/2026.08.20.26359523","title":"Construction of a Standardized Time-Lapse Imaging Database and a Gradient Boosting Ensemble Framework for Integrating Zygote Morphokinetic Parameters with Conventional Embryo Assessment","display_name":"Construction of a Standardized Time-Lapse Imaging Database and a Gradient Boosting Ensemble Framework for Integrating Zygote Morphokinetic Parameters with Conventional Embryo Assessment","publication_year":2026,"publication_date":"2026-08-24","ids":{"openalex":"https://openalex.org/W7204073558","doi":"https://doi.org/10.64898/2026.08.20.26359523"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.20.26359523","doi":"https://doi.org/10.64898/2026.08.20.26359523","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.20.26359523","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/24/2026.08.20.26359523.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/24/2026.08.20.26359523.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101100673","display_name":"Mingpeng Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ming-Peng Zhao","raw_affiliation_strings":["Center for Reproductive Medicine, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147962643","display_name":"Jie LIU","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Liu","raw_affiliation_strings":["Center for Reproductive Medicine, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069175973","display_name":"Dong Han","orcid":"https://orcid.org/0000-0001-7872-7371","observed_orcids":["https://orcid.org/0000-0001-7872-7371"]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Han","raw_affiliation_strings":["Center for Reproductive Medicine, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102006500","display_name":"Chaofan Zhang","orcid":"https://orcid.org/0000-0003-0504-5999","observed_orcids":["https://orcid.org/0000-0003-0504-5999"]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao-Fan Zhang","raw_affiliation_strings":["Center for Reproductive Medicine, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137245652","display_name":"Yan Zhou","orcid":"https://orcid.org/0009-0009-4564-4014","observed_orcids":["https://orcid.org/0009-0009-4564-4014"]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Zhou","raw_affiliation_strings":["Center for Reproductive Medicine, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043470959","display_name":"Shiping Chen","orcid":"https://orcid.org/0000-0002-4603-0024","observed_orcids":["https://orcid.org/0000-0002-4603-0024"]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shi-Ping Chen","raw_affiliation_strings":["Center for Reproductive Medicine, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007246703","display_name":"Kubi Appiah","orcid":"https://orcid.org/0000-0003-0412-5276","observed_orcids":["https://orcid.org/0000-0003-0412-5276"]},"institutions":[{"id":"https://openalex.org/I141568987","display_name":"Hong Kong Baptist University","ror":"https://ror.org/0145fw131","country_code":"HK","type":"education","lineage":["https://openalex.org/I141568987"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Kubi Appiah","raw_affiliation_strings":["Division of Nursing Education, School of Continuing Education, Hong Kong Baptist University, Hong Kong SAR, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nursing Education, School of Continuing Education, Hong Kong Baptist University, Hong Kong SAR, China","institution_ids":["https://openalex.org/I141568987"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084294816","display_name":"Caixia Liu","orcid":"https://orcid.org/0000-0003-4747-6826","observed_orcids":["https://orcid.org/0000-0003-4747-6826"]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cai-Xia Liu","raw_affiliation_strings":["Center for Reproductive Medicine, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101100673"],"corresponding_institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.12809999287128448,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/time-lapse-embryo-monitoring","display_name":"time-lapse embryo imaging","score":0.8309999704360962},{"id":"https://openalex.org/keywords/embryo-quality-assessment","display_name":"embryo quality assessment","score":0.6309999823570251},{"id":"https://openalex.org/keywords/in-vitro-fertilization","display_name":"in vitro fertilization","score":0.8299999833106995},{"id":"https://openalex.org/keywords/embryo-segmentation","display_name":"embryo segmentation","score":0.35100001096725464},{"id":"https://openalex.org/keywords/lightgbm","display_name":"LightGBM","score":0.5429999828338623},{"id":"https://openalex.org/keywords/heterogeneous-data-fusion","display_name":"heterogeneous data fusion","score":0.6809999942779541},{"id":"https://openalex.org/keywords/shap","display_name":"SHAP","score":0.6460000276565552},{"id":"https://openalex.org/keywords/zona-pellucida","display_name":"zona pellucida","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6836000084877014},{"id":"https://openalex.org/C28748434","wikidata":"https://www.wikidata.org/wiki/Q170145","display_name":"Zygote","level":4,"score":0.5436000227928162},{"id":"https://openalex.org/C46686674","wikidata":"https://www.wikidata.org/wiki/Q466303","display_name":"Boosting (machine learning)","level":2,"score":0.5327000021934509},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.49399998784065247},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4864000082015991},{"id":"https://openalex.org/C114466953","wikidata":"https://www.wikidata.org/wiki/Q6034165","display_name":"Initialization","level":2,"score":0.40700000524520874},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.4016999900341034},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3833000063896179},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.35190001130104065},{"id":"https://openalex.org/C52622490","wikidata":"https://www.wikidata.org/wiki/Q1026626","display_name":"Feature extraction","level":2,"score":0.3508000075817108},{"id":"https://openalex.org/C45942800","wikidata":"https://www.wikidata.org/wiki/Q245652","display_name":"Ensemble learning","level":2,"score":0.3465999960899353},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.34529998898506165},{"id":"https://openalex.org/C512716672","wikidata":"https://www.wikidata.org/wiki/Q200117","display_name":"In vitro fertilisation","level":3,"score":0.33329999446868896},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3248000144958496},{"id":"https://openalex.org/C158525013","wikidata":"https://www.wikidata.org/wiki/Q2593739","display_name":"Fusion","level":2,"score":0.3231000006198883},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.3111000061035156},{"id":"https://openalex.org/C110758877","wikidata":"https://www.wikidata.org/wiki/Q2614103","display_name":"Pronucleus","level":5,"score":0.2919999957084656},{"id":"https://openalex.org/C143587482","wikidata":"https://www.wikidata.org/wiki/Q1543216","display_name":"Iterative and incremental development","level":2,"score":0.28110000491142273},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.26420000195503235}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.20.26359523","doi":"https://doi.org/10.64898/2026.08.20.26359523","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.20.26359523","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/24/2026.08.20.26359523.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.20.26359523","doi":"https://doi.org/10.64898/2026.08.20.26359523","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.20.26359523","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/24/2026.08.20.26359523.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204073558.pdf","grobid_xml":"https://content.openalex.org/works/W7204073558.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1678356000","https://openalex.org/W2078271269","https://openalex.org/W2124381929","https://openalex.org/W2124656409","https://openalex.org/W2144657135","https://openalex.org/W2158269238","https://openalex.org/W2295598076","https://openalex.org/W2769628447","https://openalex.org/W2927960701","https://openalex.org/W3136418969","https://openalex.org/W4280561193"],"related_works":["https://openalex.org/W4412192184","https://openalex.org/W4232238631","https://openalex.org/W7214976464","https://openalex.org/W4280561193","https://openalex.org/W4283729835","https://openalex.org/W7155042818","https://openalex.org/W4414368748","https://openalex.org/W7204121265","https://openalex.org/W7167694176","https://openalex.org/W3136138984"],"abstract_inverted_index":{"In":[0],"vitro":[1],"fertilization":[2],"(IVF)":[3],"laboratories":[4],"equipped":[5],"with":[6,63,104,126,209],"time-lapse":[7,38,93],"incubators":[8],"generate":[9],"vast":[10],"quantities":[11],"of":[12,19,26],"sequential":[13],"embryo":[14,31,83,107],"images,":[15],"yet":[16],"the":[17,24,36,118,146,190],"absence":[18],"standardized,":[20],"annotated":[21],"databases":[22],"impedes":[23],"development":[25],"reproducible":[27,202],"computational":[28],"tools":[29],"for":[30,78,204],"assessment.":[32],"Here":[33],"we":[34],"describe":[35],"standardized":[37],"imaging":[39,207],"database":[40,196],"built":[41],"upon":[42],"prior":[43],"research":[44],"groundwork":[45],"comprising":[46],"631":[47],"two-pronuclear":[48],"(2PN)":[49],"zygotes":[50],"from":[51,91],"218":[52],"treatment":[53],"cycles":[54],"performed":[55],"at":[56,111],"Guangdong":[57],"Provincial":[58],"People\u2019s":[59],"Hospital":[60],"(2020\u20132023),":[61],"together":[62],"a":[64,96,201],"gradient":[65],"boosting":[66],"decision":[67],"tree":[68],"(GBDT)":[69],"ensemble":[70],"framework":[71,123,203],"designed":[72],"to":[73,117],"fuse":[74],"heterogeneous":[75],"data":[76],"types":[77],"blastocyst":[79,114],"outcome":[80],"prediction.":[81],"Each":[82],"record":[84],"integrates":[85],"84":[86],"zygote-stage":[87,165],"morphokinetic":[88],"parameters":[89],"extracted":[90],"EmbryoScope":[92],"sequences":[94],"via":[95],"previously":[97],"validated":[98],"convolutional":[99],"neural":[100],"network":[101],"segmentation":[102],"pipeline":[103],"8":[105],"conventional":[106],"assessment":[108],"features":[109,208],"recorded":[110],"cleavage":[112],"and":[113,129,138,157,185,197],"stages":[115],"according":[116],"Istanbul":[119],"consensus.":[120],"The":[121,195],"fusion":[122,198],"employs":[124],"LightGBM":[125],"equal-weight":[127],"initialization":[128],"iterative":[130],"residual-decreasing":[131],"training,":[132],"augmented":[133],"by":[134],"recursive":[135],"feature":[136],"elimination":[137],"nested":[139],"five-fold":[140],"cross-validation.":[141],"Ablation":[142],"experiments":[143],"demonstrate":[144],"that":[145,164],"full":[147],"model":[148],"(AUC":[149,154,159],"=":[150,155,160],"0.78)":[151],"outperforms":[152],"morphokinetics-only":[153],"0.71)":[156],"conventional-only":[158],"0.65)":[161],"configurations,":[162],"confirming":[163],"temporal":[166],"dynamics":[167],"carry":[168],"complementary":[169],"information":[170],"beyond":[171],"standard":[172],"morphological":[173],"grading.":[174],"SHAP":[175],"analysis":[176],"identifies":[177],"cytoplasmic":[178],"area":[179],"slope,":[180],"zona":[181],"pellucida":[182],"grayscale":[183],"trend,":[184],"pronuclear":[186],"fading":[187],"time":[188],"as":[189],"three":[191],"most":[192],"influential":[193],"predictors.":[194],"methodology":[199],"provide":[200],"integrating":[205],"time-series":[206],"categorical":[210],"clinical":[211],"assessments":[212],"in":[213],"reproductive":[214],"medicine.":[215]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-25T00:00:00"}