{"id":"https://openalex.org/W7204064132","doi":null,"title":"THE ROLE OF MITOCHONDRIAL CATIONS HOMEOSTASIS IN THE CONTROL OF THE INFLAMMATORY RESPONSE","display_name":"THE ROLE OF MITOCHONDRIAL CATIONS HOMEOSTASIS IN THE CONTROL OF THE INFLAMMATORY RESPONSE","publication_year":null,"publication_date":null,"ids":{"openalex":"https://openalex.org/W7204064132"},"language":"en","primary_location":{"id":"pmh:oai:www.research.unipd.it:11577/3608364","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11577/3608364","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5137174494","display_name":"Francesca Spinelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"SPINELLI, FRANCESCA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5137174494"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-calcium-homeostasis","display_name":"mitochondrial calcium homeostasis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mitochondrial-calcium-uniporter","display_name":"mitochondrial calcium uniporter","score":0.9539999961853027},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8500000238418579},{"id":"https://openalex.org/keywords/il-1beta-release","display_name":"IL-1\u03b2 release","score":0.8140000104904175},{"id":"https://openalex.org/keywords/mitochondrial-fragmentation","display_name":"mitochondrial fragmentation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/mitochondrial-atp-sensitive-potassium-channel","display_name":"mitochondrial ATP-sensitive potassium channel","score":0.6610000133514404},{"id":"https://openalex.org/keywords/gout","display_name":"gout","score":0.7590000033378601},{"id":"https://openalex.org/keywords/monosodium-urate-crystals","display_name":"monosodium urate crystals","score":0.9649999737739563},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.9079999923706055},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.9326000213623047},{"id":"https://openalex.org/C139174496","wikidata":"https://www.wikidata.org/wiki/Q24725912","display_name":"Pyrin domain","level":4,"score":0.8604999780654907},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7652000188827515},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6747999787330627},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6488000154495239},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.5389000177383423},{"id":"https://openalex.org/C35341161","wikidata":"https://www.wikidata.org/wiki/Q289992","display_name":"Uniporter","level":4,"score":0.4726000130176544},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.47189998626708984},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4489000141620636},{"id":"https://openalex.org/C163950672","wikidata":"https://www.wikidata.org/wiki/Q14905375","display_name":"mitochondrial fusion","level":4,"score":0.4106000065803528},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.4047999978065491},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3952000141143799},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.3905999958515167},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.3686000108718872},{"id":"https://openalex.org/C187831198","wikidata":"https://www.wikidata.org/wiki/Q18034187","display_name":"AIM2","level":4,"score":0.3474000096321106},{"id":"https://openalex.org/C139964883","wikidata":"https://www.wikidata.org/wiki/Q14901964","display_name":"Caspase 1","level":4,"score":0.33149999380111694},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.31929999589920044},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.31029999256134033},{"id":"https://openalex.org/C17619807","wikidata":"https://www.wikidata.org/wiki/Q6881852","display_name":"Mitochondrial fission","level":3,"score":0.30399999022483826},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.3003000020980835},{"id":"https://openalex.org/C2777614518","wikidata":"https://www.wikidata.org/wiki/Q935710","display_name":"Mitochondrial disease","level":4,"score":0.29249998927116394},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.2858999967575073},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.27889999747276306},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.273499995470047},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.26989999413490295},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.26980000734329224},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.26510000228881836},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.2628999948501587}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:www.research.unipd.it:11577/3608364","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11577/3608364","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7162547320","https://openalex.org/W4206954899","https://openalex.org/W4283320311","https://openalex.org/W4319432365","https://openalex.org/W4388969577","https://openalex.org/W2766382861","https://openalex.org/W1985538633","https://openalex.org/W2000117406","https://openalex.org/W2890204725","https://openalex.org/W2571892914"],"abstract_inverted_index":{"Mitochondrial":[0],"calcium":[1,59],"(Ca2+)":[2],"and":[3,22,26,34,83,107,140,195,212],"potassium":[4],"(K+)":[5],"signaling":[6,32],"have":[7],"emerged":[8],"as":[9,31,214,245],"key":[10],"regulators":[11],"of":[12,24,36,67,86,157,176,220],"innate":[13,25],"immunity.":[14],"Mitochondria":[15],"are":[16],"essential":[17],"for":[18,64,123,170,239],"both":[19,80,136],"the":[20,57,68,177,184,188,218],"initiation":[21],"maintenance":[23],"adaptive":[27],"immune":[28],"responses,":[29],"acting":[30],"hubs":[33],"modulators":[35],"several":[37],"physio-pathological":[38],"functions,":[39],"particularly":[40,210],"through":[41],"their":[42],"role":[43],"in":[44,77,99,133,154,217,242],"cation":[45],"homeostasis.":[46],"In":[47],"this":[48],"study,":[49],"we":[50,88],"demonstrated":[51],"that":[52,90,163,228],"mitochondrial":[53,58,92,114,118,164,178,192,207,230],"Ca2+":[54,93,115,211,231],"uptake":[55,116],"via":[56],"uniporter":[60],"(MCU)":[61],"is":[62,167],"crucial":[63],"full":[65],"activation":[66,197],"NLR":[69],"family":[70],"pyrin":[71],"domain":[72],"containing":[73],"3":[74],"(NLRP3)":[75],"inflammasome":[76,125,172,196,222],"macrophages.":[78],"Using":[79],"pharmacological":[81],"inhibition":[82],"genetic":[84],"ablation":[85],"MCU,":[87],"showed":[89,162],"impaired":[91],"accumulation":[94],"significantly":[95],"reduces":[96],"IL-1\u03b2":[97],"release":[98],"response":[100],"to":[101,199],"various":[102],"stimuli":[103],"(ATP,":[104],"nigericin,":[105],"Poly(dA:dT)":[106],"monosodium":[108],"urate":[109],"crystals":[110],"(MSU).":[111],"Notably,":[112],"reduced":[113],"prevented":[117],"fragmentation,":[119],"a":[120,155,235],"process":[121],"required":[122,169],"optimal":[124],"activation.":[126,173,223],"These":[127],"findings":[128,205],"were":[129],"further":[130],"supported":[131],"by":[132],"vivo":[134],"studies:":[135],"MCU":[137,142],"heterozygous":[138],"(MCU+/\u2212)":[139],"macrophage-specific":[141],"knockout":[143],"(macMCU\u2212/\u2212)":[144],"mice":[145],"exhibited":[146],"attenuated":[147],"NLRP3-driven":[148],"inflammation":[149,241],"following":[150],"intra-articular":[151],"MSU":[152],"injection":[153],"model":[156],"acute":[158],"gout.":[159,246],"We":[160],"also":[161,168],"K+":[165,180,193],"flux":[166,194],"NLRP3":[171,221],"Genetic":[174],"deletion":[175],"ATP-sensitive":[179],"(MitoKATP)":[181],"channel":[182],"dampens":[183],"inflammatory":[185],"response,":[186],"although":[187],"mechanistic":[189],"link":[190],"between":[191],"remains":[198],"be":[200],"fully":[201],"elucidated.":[202],"Together,":[203],"these":[204,225],"identify":[206],"cations":[208],"fluxes,":[209],"K+,":[213],"critical":[215],"checkpoints":[216],"regulation":[219],"Moreover,":[224],"data":[226],"suggest":[227],"modulating":[229],"handling":[232],"could":[233],"represent":[234],"promising":[236],"therapeutic":[237],"strategy":[238],"controlling":[240],"diseases":[243],"such":[244]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-08-24T00:00:00"}
