{"id":"https://openalex.org/W7204062367","doi":"https://doi.org/10.1021/acs.analchem.5c07287","title":"Mapping the TCR\u2013Peptide-HLA Interface through Hydrogen\u2013Deuterium Exchange Mass Spectrometry","display_name":"Mapping the TCR\u2013Peptide-HLA Interface through Hydrogen\u2013Deuterium Exchange Mass Spectrometry","publication_year":2026,"publication_date":"2026-08-29","ids":{"openalex":"https://openalex.org/W7204062367","doi":"https://doi.org/10.1021/acs.analchem.5c07287","pmid":"https://pubmed.ncbi.nlm.nih.gov/42915246","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13584625"},"language":"en","primary_location":{"id":"doi:10.1021/acs.analchem.5c07287","doi":"https://doi.org/10.1021/acs.analchem.5c07287","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.analchem.5c07287","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acs.analchem.5c07287","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5126529833","display_name":"T. Powell","orcid":"https://orcid.org/0000-0002-8308-6510","observed_orcids":["https://orcid.org/0000-0002-8308-6510"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Thomas Powell","raw_affiliation_strings":["Immunocore Limited , 92 Park Drive, Milton Park , ,"],"raw_orcid":"https://orcid.org/0000-0002-8308-6510","affiliations":[{"raw_affiliation_string":"Immunocore Limited , 92 Park Drive, Milton Park , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138845133","display_name":"A. Colyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alice Colyer","raw_affiliation_strings":["University of Leeds , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leeds , , ,","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073420169","display_name":"Gemma C. Wildsmith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gemma Wildsmith","raw_affiliation_strings":["University of Leeds , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leeds , , ,","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055511703","display_name":"Vijaykumar Karuppiah","orcid":"https://orcid.org/0000-0002-9645-7958","observed_orcids":["https://orcid.org/0000-0002-9645-7958"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vijaykumar Karuppiah","raw_affiliation_strings":["Immunocore Limited , 92 Park Drive, Milton Park , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunocore Limited , 92 Park Drive, Milton Park , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147895884","display_name":"S. Afshan Shaikh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saher Afshan Shaikh","raw_affiliation_strings":["Immunocore Limited , 92 Park Drive, Milton Park , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunocore Limited , 92 Park Drive, Milton Park , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022569282","display_name":"Martin Ebner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Ebner","raw_affiliation_strings":["Immunocore Limited , 92 Park Drive, Milton Park , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunocore Limited , 92 Park Drive, Milton Park , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078797993","display_name":"Andrew J. Creese","orcid":"https://orcid.org/0000-0002-4825-0311","observed_orcids":["https://orcid.org/0000-0002-4825-0311"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Creese","raw_affiliation_strings":["Immunocore Limited , 92 Park Drive, Milton Park , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunocore Limited , 92 Park Drive, Milton Park , ,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035223223","display_name":"Antonio N. Calabrese","orcid":"https://orcid.org/0000-0003-2437-7761","observed_orcids":["https://orcid.org/0000-0003-2437-7761"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Antonio N. Calabrese","raw_affiliation_strings":["University of Leeds , , ,"],"raw_orcid":"https://orcid.org/0000-0003-2437-7761","affiliations":[{"raw_affiliation_string":"University of Leeds , , ,","institution_ids":["https://openalex.org/I130828816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035223223","https://openalex.org/A5126529833"],"corresponding_institution_ids":["https://openalex.org/I130828816"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.44992558,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"98","issue":"36","first_page":"26299","last_page":"26310"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-receptor","display_name":"T cell receptor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/peptide-hla-complex","display_name":"peptide-HLA complex","score":0.8629999756813049},{"id":"https://openalex.org/keywords/hydrogen-deuterium-exchange-mass-spectrometry","display_name":"hydrogen-deuterium exchange mass spectrometry","score":0.9020000100135803},{"id":"https://openalex.org/keywords/deuterium-uptake","display_name":"deuterium absorption","score":0.722000002861023},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.6899999976158142},{"id":"https://openalex.org/keywords/structure-prediction","display_name":"structure prediction","score":0.5099999904632568},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.6906999945640564},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.6313999891281128},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5681999921798706},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5252000093460083},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5223000049591064},{"id":"https://openalex.org/C113843644","wikidata":"https://www.wikidata.org/wiki/Q901882","display_name":"Interface (matter)","level":4,"score":0.47760000824928284},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.460099995136261},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.43320000171661377},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.41819998621940613},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.414000004529953},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39100000262260437},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.3813999891281128},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.3626999855041504},{"id":"https://openalex.org/C167569220","wikidata":"https://www.wikidata.org/wiki/Q5954985","display_name":"Hydrogen\u2013deuterium exchange","level":3,"score":0.36090001463890076},{"id":"https://openalex.org/C15845906","wikidata":"https://www.wikidata.org/wiki/Q1172338","display_name":"Data exchange","level":2,"score":0.3549000024795532},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.3276999890804291},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.32359999418258667},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.32109999656677246},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.31690001487731934},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.31439998745918274},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.30630001425743103},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.2962000072002411},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.295199990272522},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2874000072479248},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.2865000069141388},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.2842000126838684},{"id":"https://openalex.org/C16345878","wikidata":"https://www.wikidata.org/wiki/Q107472979","display_name":"Orientation (vector space)","level":2,"score":0.2685000002384186},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.2676999866962433},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.2628999948501587},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.26179999113082886},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.26010000705718994},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.2565000057220459},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.25360000133514404},{"id":"https://openalex.org/C189693848","wikidata":"https://www.wikidata.org/wiki/Q6031064","display_name":"Information exchange","level":2,"score":0.2524999976158142},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.250900000333786}],"mesh":[{"descriptor_ui":"D000080307","descriptor_name":"Hydrogen Deuterium Exchange-Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041961","descriptor_name":"Deuterium Exchange Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.analchem.5c07287","doi":"https://doi.org/10.1021/acs.analchem.5c07287","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.analchem.5c07287","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13584625","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13584625/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13584625/pdf/ac5c07287.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anal Chem","raw_type":"Text"},{"id":"pmid:42915246","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42915246","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.whiterose.ac.uk:244596","doi":null,"is_oa":true,"landing_page_url":"https://eprints.whiterose.ac.uk/id/eprint/244596/19/acs.analchem.5c07287.pdf","pdf_url":"https://eprints.whiterose.ac.uk/id/eprint/244596/5/Manuscript_Rev3.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1021/acs.analchem.5c07287","doi":"https://doi.org/10.1021/acs.analchem.5c07287","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.analchem.5c07287","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4570991096","display_name":"Molecular basis of phase separation in viral replication and neurodegenerative disease","funder_award_id":"220628/Z/20/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8379921446","display_name":null,"funder_award_id":"220628/Z/20/Z","funder_id":"https://openalex.org/F4320320006","funder_display_name":"Royal Society"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320320298","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204062367.pdf","grobid_xml":"https://content.openalex.org/works/W7204062367.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1879205842","https://openalex.org/W1992580374","https://openalex.org/W2029644009","https://openalex.org/W2035503835","https://openalex.org/W2047357490","https://openalex.org/W2052701858","https://openalex.org/W2073392655","https://openalex.org/W2075799289","https://openalex.org/W2116117984","https://openalex.org/W2120518061","https://openalex.org/W2146074801","https://openalex.org/W2155740919","https://openalex.org/W2167642721","https://openalex.org/W2253581743","https://openalex.org/W2267653167","https://openalex.org/W2528445598","https://openalex.org/W2757236411","https://openalex.org/W2955168413","https://openalex.org/W3017309521","https://openalex.org/W3134903930","https://openalex.org/W3165117580","https://openalex.org/W3177828909","https://openalex.org/W3197675872","https://openalex.org/W3213271440","https://openalex.org/W4313219322","https://openalex.org/W4316466421","https://openalex.org/W4368357399","https://openalex.org/W4377103650","https://openalex.org/W4380537372","https://openalex.org/W4385685582","https://openalex.org/W4389057689","https://openalex.org/W4402364312","https://openalex.org/W4404863323","https://openalex.org/W4408932125","https://openalex.org/W4410104415","https://openalex.org/W4414166927","https://openalex.org/W7147119238"],"related_works":["https://openalex.org/W4408932125","https://openalex.org/W3134903930","https://openalex.org/W3168160486","https://openalex.org/W7117972673","https://openalex.org/W7204263964","https://openalex.org/W2088407586","https://openalex.org/W2979326653","https://openalex.org/W2021310372","https://openalex.org/W7118005912","https://openalex.org/W7137056126"],"abstract_inverted_index":{"T-cell":[0,28],"receptor":[1],"(TCR)-based":[2],"therapeutics":[3],"recognize":[4],"specific":[5],"peptides":[6],"presented":[7],"by":[8],"human":[9],"leukocyte":[10],"antigens":[11],"(HLAs)":[12],"on":[13],"antigen-presenting":[14],"cells.":[15],"The":[16],"docking":[17],"orientation":[18],"of":[19,101,123,151],"TCRs":[20,82],"to":[21],"peptide-HLA":[22],"(pHLA)":[23],"complexes":[24],"is":[25],"critical":[26],"for":[27,114,141,148],"activation":[29],"as":[30,136],"it":[31],"underpins":[32],"signaling":[33],"and":[34,126,138],"downstream":[35],"immune":[36],"responses.":[37],"Traditionally,":[38],"TCR":[39,65],"binding":[40,117],"geometries":[41],"with":[42,67,95,104,145],"pHLAs":[43],"have":[44,90],"been":[45],"resolved":[46],"through":[47],"X-ray":[48],"crystallography.":[49],"Here,":[50],"we":[51,79],"demonstrate":[52],"that":[53,81,83],"conventional":[54],"peptide-level":[55],"hydrogen-deuterium":[56],"exchange":[57],"mass":[58],"spectrometry":[59],"(HDX-MS)":[60],"workflows":[61,135],"can":[62],"identify":[63],"productive":[64],"engagement":[66],"their":[68],"cognate":[69],"pHLAs.":[70],"By":[71],"quantifying":[72],"differential":[73],"deuterium":[74],"uptake":[75,92,102],"upon":[76],"complex":[77],"formation,":[78],"show":[80],"bind":[84],"centrally":[85],"within":[86],"the":[87,111,121,149],"pHLA":[88],"groove":[89],"distinct":[91,115],"profiles":[93],"compared":[94],"those":[96],"adopting":[97],"alternative":[98],"orientations.":[99],"Comparison":[100],"data":[103,113],"information":[105],"from":[106],"structure":[107],"prediction":[108],"further":[109],"contextualized":[110],"HDX":[112],"TCR-pHLA":[116,143],"modes,":[118],"thus":[119],"highlighting":[120],"value":[122],"integrating":[124],"experimental":[125],"computational":[127],"approaches.":[128],"Collectively,":[129],"our":[130],"findings":[131],"establish":[132],"existing":[133],"HDX-MS":[134],"rapid":[137],"accessible":[139],"approaches":[140],"probing":[142],"interactions,":[144],"direct":[146],"implications":[147],"development":[150],"TCR-based":[152],"biotherapeutics.":[153]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-08-24T00:00:00"}
