{"id":"https://openalex.org/W7204057247","doi":"https://doi.org/10.3389/ftox.2026.1886801","title":"Enhancing toxicological interpretation and reporting of in vitro high-throughput screening data","display_name":"Enhancing toxicological interpretation and reporting of in vitro high-throughput screening data","publication_year":2026,"publication_date":"2026-08-24","ids":{"openalex":"https://openalex.org/W7204057247","doi":"https://doi.org/10.3389/ftox.2026.1886801","pmid":"https://pubmed.ncbi.nlm.nih.gov/42703515","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13546805"},"language":"en","primary_location":{"id":"doi:10.3389/ftox.2026.1886801","doi":"https://doi.org/10.3389/ftox.2026.1886801","is_oa":true,"landing_page_url":"https://doi.org/10.3389/ftox.2026.1886801","pdf_url":"https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2026.1886801/pdf","source":{"id":"https://openalex.org/S4210231588","display_name":"Frontiers in Toxicology","issn_l":"2673-3080","issn":["2673-3080"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2026.1886801/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002157517","display_name":"Bridgett N. Hill","orcid":"https://orcid.org/0000-0003-3836-7986","observed_orcids":["https://orcid.org/0000-0003-3836-7986"]},"institutions":[{"id":"https://openalex.org/I1343953105","display_name":"General Dynamics (United States)","ror":"https://ror.org/05pyq8e17","country_code":"US","type":"company","lineage":["https://openalex.org/I1343953105"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bridgett N. Hill","raw_affiliation_strings":["General Dynamics Information Technology","Inotiv"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Dynamics Information Technology","institution_ids":["https://openalex.org/I1343953105"]},{"raw_affiliation_string":"Inotiv","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019123020","display_name":"Agnes L. Karmaus","orcid":"https://orcid.org/0000-0003-4421-6164","observed_orcids":["https://orcid.org/0000-0003-4421-6164"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agnes L. Karmaus","raw_affiliation_strings":["Inotiv"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inotiv","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059095544","display_name":"Victoria Hull","orcid":"https://orcid.org/0000-0002-2650-4392","observed_orcids":["https://orcid.org/0000-0002-2650-4392"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victoria Hull","raw_affiliation_strings":["Inotiv"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inotiv","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010290501","display_name":"Aswani Unnikrishnan","orcid":"https://orcid.org/0000-0001-9285-8714","observed_orcids":["https://orcid.org/0000-0001-9285-8714"]},"institutions":[{"id":"https://openalex.org/I4210144946","display_name":"Applied Research Associates (United States)","ror":"https://ror.org/04vpnmr86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aswani Unnikrishnan","raw_affiliation_strings":["Applied Research Associates, Inc","Inotiv"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Research Associates, Inc","institution_ids":["https://openalex.org/I4210144946"]},{"raw_affiliation_string":"Inotiv","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084541486","display_name":"Nicole Kleinstreuer","orcid":"https://orcid.org/0000-0002-7914-3682","observed_orcids":["https://orcid.org/0000-0002-7914-3682"]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole C. Kleinstreuer","raw_affiliation_strings":["National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences","institution_ids":["https://openalex.org/I4210095140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080639118","display_name":"Helena T. H\u00f6gberg","orcid":"https://orcid.org/0000-0001-8034-6818","observed_orcids":["https://orcid.org/0000-0001-8034-6818"]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Helena T. Hogberg","raw_affiliation_strings":["National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences","institution_ids":["https://openalex.org/I4210095140"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5080639118"],"corresponding_institution_ids":["https://openalex.org/I4210095140"],"apc_list":{"value":2550,"currency":"CHF","value_usd":3077},"apc_paid":{"value":2550,"currency":"CHF","value_usd":3077},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":null,"first_page":"1886801","last_page":"1886801"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.29660001397132874,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.29660001397132874,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.2619999945163727,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.09610000252723694,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toxcast","display_name":"ToxCast","score":0.6439999938011169},{"id":"https://openalex.org/keywords/tox21","display_name":"Tox21","score":1.0},{"id":"https://openalex.org/keywords/data-curation","display_name":"data curation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/data-annotation","display_name":"data annotation","score":0.765999972820282},{"id":"https://openalex.org/keywords/regulatory-endpoints","display_name":"regulatory endpoints","score":0.7009999752044678},{"id":"https://openalex.org/keywords/computational-toxicology","display_name":"computational toxicology","score":0.7200000286102295},{"id":"https://openalex.org/keywords/data-interoperability","display_name":"data interoperability","score":0.8429999947547913},{"id":"https://openalex.org/keywords/endocrine-disruption","display_name":"endocrine disruption","score":0.5960000157356262},{"id":"https://openalex.org/keywords/carcinogenicity","display_name":"carcinogenicity","score":0.984000027179718},{"id":"https://openalex.org/keywords/developmental-toxicity","display_name":"developmental toxicity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nice","display_name":"Nice","score":0.4189999997615814},{"id":"https://openalex.org/keywords/data-quality-control","display_name":"data quality control","score":0.4869999885559082},{"id":"https://openalex.org/keywords/ontology-information-science","display_name":"ontology (information science)","score":0.41499999165534973},{"id":"https://openalex.org/keywords/weight-of-evidence-assessment","display_name":"weight-of-evidence assessment","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7013999819755554},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.6868000030517578},{"id":"https://openalex.org/C93518851","wikidata":"https://www.wikidata.org/wiki/Q180160","display_name":"Metadata","level":2,"score":0.6046000123023987},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.536899983882904},{"id":"https://openalex.org/C2777146004","wikidata":"https://www.wikidata.org/wiki/Q14949826","display_name":"CLARITY","level":2,"score":0.5009999871253967},{"id":"https://openalex.org/C91632574","wikidata":"https://www.wikidata.org/wiki/Q15088675","display_name":"Data curation","level":2,"score":0.48429998755455017},{"id":"https://openalex.org/C136197465","wikidata":"https://www.wikidata.org/wiki/Q1729295","display_name":"Variety (cybernetics)","level":2,"score":0.4560000002384186},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.4553000032901764},{"id":"https://openalex.org/C24756922","wikidata":"https://www.wikidata.org/wiki/Q1757694","display_name":"Data quality","level":3,"score":0.45489999651908875},{"id":"https://openalex.org/C20136886","wikidata":"https://www.wikidata.org/wiki/Q749647","display_name":"Interoperability","level":2,"score":0.4320000112056732},{"id":"https://openalex.org/C138958017","wikidata":"https://www.wikidata.org/wiki/Q190087","display_name":"Data type","level":2,"score":0.39489999413490295},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3709999918937683},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.3481999933719635},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.33070001006126404},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.3224000036716461},{"id":"https://openalex.org/C2780233690","wikidata":"https://www.wikidata.org/wiki/Q535347","display_name":"Transparency (behavior)","level":2,"score":0.3133000135421753},{"id":"https://openalex.org/C66782513","wikidata":"https://www.wikidata.org/wiki/Q864601","display_name":"Biomedicine","level":2,"score":0.303600013256073},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.29910001158714294},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.290800005197525},{"id":"https://openalex.org/C2778917124","wikidata":"https://www.wikidata.org/wiki/Q7309705","display_name":"Regulatory science","level":2,"score":0.28769999742507935},{"id":"https://openalex.org/C2777230681","wikidata":"https://www.wikidata.org/wiki/Q7923820","display_name":"Vetting","level":2,"score":0.27790001034736633},{"id":"https://openalex.org/C47487241","wikidata":"https://www.wikidata.org/wiki/Q5227230","display_name":"Data access","level":2,"score":0.2752000093460083},{"id":"https://openalex.org/C547195049","wikidata":"https://www.wikidata.org/wiki/Q1725664","display_name":"Terminology","level":2,"score":0.27219998836517334},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.2667999863624573},{"id":"https://openalex.org/C92446256","wikidata":"https://www.wikidata.org/wiki/Q3306762","display_name":"Data validation","level":2,"score":0.2630999982357025},{"id":"https://openalex.org/C56666940","wikidata":"https://www.wikidata.org/wiki/Q788790","display_name":"Documentation","level":2,"score":0.257099986076355},{"id":"https://openalex.org/C205711294","wikidata":"https://www.wikidata.org/wiki/Q176953","display_name":"Rendering (computer graphics)","level":2,"score":0.2563999891281128},{"id":"https://openalex.org/C203394866","wikidata":"https://www.wikidata.org/wiki/Q2881060","display_name":"Chemical database","level":2,"score":0.25040000677108765}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3389/ftox.2026.1886801","doi":"https://doi.org/10.3389/ftox.2026.1886801","is_oa":true,"landing_page_url":"https://doi.org/10.3389/ftox.2026.1886801","pdf_url":"https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2026.1886801/pdf","source":{"id":"https://openalex.org/S4210231588","display_name":"Frontiers in Toxicology","issn_l":"2673-3080","issn":["2673-3080"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Toxicology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13546805","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13546805/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13546805/pdf/ftox-08-1886801.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Toxicol","raw_type":"Text"},{"id":"pmid:42703515","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42703515","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in toxicology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3389/ftox.2026.1886801","doi":"https://doi.org/10.3389/ftox.2026.1886801","is_oa":true,"landing_page_url":"https://doi.org/10.3389/ftox.2026.1886801","pdf_url":"https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2026.1886801/pdf","source":{"id":"https://openalex.org/S4210231588","display_name":"Frontiers in Toxicology","issn_l":"2673-3080","issn":["2673-3080"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1677957440","display_name":null,"funder_award_id":"HHSN273201500010C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204057247.pdf","grobid_xml":"https://content.openalex.org/works/W7204057247.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W2067519450","https://openalex.org/W2083989357","https://openalex.org/W2122025333","https://openalex.org/W2133177242","https://openalex.org/W2143431969","https://openalex.org/W2173513074","https://openalex.org/W2239928796","https://openalex.org/W2546044736","https://openalex.org/W2571392343","https://openalex.org/W2617033517","https://openalex.org/W2773956512","https://openalex.org/W2792445736","https://openalex.org/W2794565592","https://openalex.org/W2884635124","https://openalex.org/W2967389626","https://openalex.org/W2995593899","https://openalex.org/W3009563787","https://openalex.org/W3097280976","https://openalex.org/W3117032441","https://openalex.org/W3121495924","https://openalex.org/W3170771812","https://openalex.org/W4284884229","https://openalex.org/W4292461632","https://openalex.org/W4307995196","https://openalex.org/W4323036511","https://openalex.org/W4379194171","https://openalex.org/W4386914500","https://openalex.org/W4392359895","https://openalex.org/W4407760129","https://openalex.org/W4412538684","https://openalex.org/W4417120303","https://openalex.org/W6963865373"],"related_works":["https://openalex.org/W2978554036","https://openalex.org/W2322262466","https://openalex.org/W7123424360","https://openalex.org/W2546044736","https://openalex.org/W4409727872","https://openalex.org/W2955809412","https://openalex.org/W6926263764","https://openalex.org/W4226097830","https://openalex.org/W6963912269","https://openalex.org/W6944795562"],"abstract_inverted_index":{"Introduction:":[0],"A":[1],"wide":[2],"variety":[3,252],"of":[4,27,34,48,232,253,337,349],"in":[5,38,285,296],"vitro":[6],"high-throughput":[7],"screening":[8],"(HTS)":[9],"assay":[10],"data":[11,36,79,92,110,157,193,198,220,245,257,288,311,344,352],"are":[12,290],"publicly":[13,95,228],"available":[14,96],"and":[15,41,45,69,76,125,140,167,188,195,203,214,221,259,265,293,322,339,346],"have":[16],"the":[17,22,25,32,39,46,94,107,162,227,325,347],"potential":[18,126],"to":[19,51,57,105,143,151,161,176,182,199,246,263,273],"serve":[20],"as":[21,115],"foundation":[23],"for":[24,81,164,250,277,353],"development":[26],"computational":[28],"toxicology":[29],"approaches.":[30],"However,":[31],"sources":[33],"these":[35,197,244,305],"vary":[37],"format":[40,175],"metadata":[42,113],"they":[43],"provide":[44],"clarity":[47],"their":[49,271],"relevance":[50],"toxicological":[52,82,279,298],"endpoints.":[53,155,280],"Thus,":[54],"applying":[55],"them":[56],"decisions":[58],"about":[59],"chemical":[60,116],"effects":[61],"remains":[62],"a":[63,85,100,251,297],"challenge.":[64],"To":[65,129],"overcome":[66],"this":[67,130],"challenge":[68],"help":[70],"democratize":[71],"HTS":[72,78,98,132,149,287,351],"data,":[73,119,268],"we":[74,135],"curated":[75,131,187],"annotated":[77,189],"specifically":[80],"interpretation":[83,321],"within":[84],"regulatory":[86,154,183,206,320,354],"endpoint":[87],"context.":[88],"Methods:":[89],"Focusing":[90],"on":[91],"from":[93,226,255],"ToxCast/Tox21":[97],"program,":[99],"curation":[101],"workflow":[102],"was":[103],"developed":[104],"identify":[106],"most":[108],"reliable":[109],"by":[111,205,313],"integrating":[112],"such":[114],"quality":[117],"control":[118],"concentration-response":[120],"curve-fitting":[121],"robustness,":[122],"assay-specific":[123],"limitations,":[124],"technological":[127],"interference.":[128],"(cHTS)":[133],"dataset,":[134],"then":[136],"applied":[137],"structured":[138,340],"vocabularies":[139],"expert":[141],"review":[142],"develop":[144],"molecular/cellular":[145],"process":[146],"annotations":[147,222],"mapping":[148],"assays":[150],"toxicologically":[152],"relevant":[153],"These":[156],"were":[158],"also":[159],"mapped":[160],"Organization":[163],"Economic":[165],"Co-operation":[166],"Development's":[168],"Harmonised":[169],"Template":[170],"201":[171],"(OHT":[172],"201)":[173],"reporting":[174,316,341],"standardize":[177],"reporting,":[178],"rendering":[179],"outputs":[180],"amenable":[181],"submission.":[184],"Results:":[185],"The":[186,217],"cHTS":[190,219],"dataset":[191],"supports":[192],"interoperability":[194,345],"allows":[196,243],"be":[200,224,247],"searched,":[201],"grouped,":[202],"visualized":[204],"endpoints":[207],"(e.g.,":[208],"endocrine":[209],"disruption,":[210],"carcinogenicity,":[211],"developmental":[212],"toxicity,":[213],"systemic":[215],"effects).":[216],"robust":[218],"can":[223,303,342],"retrieved":[225],"accessible":[229],"National":[230],"Institute":[231],"Health":[233],"(NIH)":[234],"Integrated":[235],"Chemical":[236],"Environment":[237],"(NICE,":[238],"https://ice.ntp.niehs.nih.gov/).":[239],"Access":[240],"through":[241],"NICE":[242],"optimally":[248],"leveraged":[249],"uses,":[254],"identifying":[256],"gaps":[258],"providing":[260],"mechanistic":[261],"insights":[262],"confidently":[264],"reproducibly":[266],"retrieving":[267],"thus":[269],"supporting":[270],"integration":[272],"build":[274],"weight-of-evidence":[275],"assessments":[276],"regulatory-relevant":[278],"Discussion:":[281],"Developing":[282],"an":[283],"environment":[284],"which":[286],"that":[289,301],"structured,":[291],"accessible,":[292],"readily":[294],"interpretable":[295],"context,":[299],"ensures":[300],"users":[302],"apply":[304],"evolving":[306],"resources.":[307],"Working":[308],"toward":[309],"consistent":[310],"summaries":[312],"leveraging":[314],"established":[315],"formats":[317],"helps":[318],"bolster":[319],"adoption.":[323],"Overall,":[324],"work":[326],"summarized":[327],"herein":[328],"demonstrates":[329],"how":[330],"fit-for-purpose":[331],"standardized":[332],"curation,":[333],"annotations,":[334],"ontologies,":[335],"ease":[336],"accessibility,":[338],"support":[343],"application":[348],"complex":[350],"application.":[355]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-08-24T00:00:00"}