{"id":"https://openalex.org/W7204024003","doi":"https://doi.org/10.17632/trwpc8xwyp","title":"Azithromycin for acute wheezing and bronchiolitis in children younger than six years: a systematic review and meta-analysis","display_name":"Azithromycin for acute wheezing and bronchiolitis in children younger than six years: a systematic review and meta-analysis","publication_year":2026,"publication_date":"2026-08-23","ids":{"openalex":"https://openalex.org/W7204024003","doi":"https://doi.org/10.17632/trwpc8xwyp"},"language":"en","primary_location":{"id":"doi:10.17632/trwpc8xwyp","doi":"https://doi.org/10.17632/trwpc8xwyp","is_oa":true,"landing_page_url":"https://doi.org/10.17632/trwpc8xwyp","pdf_url":null,"source":{"id":"https://openalex.org/S7407050775","display_name":"Mendeley Data","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"volume":null,"type":"dataset","is_traditional":false,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.17632/trwpc8xwyp","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5146394985","display_name":"Douglas Amaral da Silva Menegazzo Miotto","orcid":"https://orcid.org/0000-0003-3207-0831","observed_orcids":["https://orcid.org/0000-0003-3207-0831"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Miotto, Douglas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5146394985"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.02979999966919422,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13770","display_name":"Pediatric health and respiratory diseases","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/azithromycin","display_name":"azithromycin","score":1.0},{"id":"https://openalex.org/keywords/acute-wheezing","display_name":"acute wheezing","score":0.8700000047683716},{"id":"https://openalex.org/keywords/bronchiolitis","display_name":"bronchiolitis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/children-under-6-years","display_name":"children under 6 years","score":0.7110000252723694},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9610000252723694},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8840000033378601},{"id":"https://openalex.org/keywords/airway-epithelial-barrier-function","display_name":"airway epithelial barrier function","score":0.8320000171661377},{"id":"https://openalex.org/keywords/viral-bronchiolitis","display_name":"viral bronchiolitis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/emergency-department-care","display_name":"emergency department care","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9276999831199646},{"id":"https://openalex.org/C2778907293","wikidata":"https://www.wikidata.org/wiki/Q165399","display_name":"Azithromycin","level":3,"score":0.8532000184059143},{"id":"https://openalex.org/C2778821649","wikidata":"https://www.wikidata.org/wiki/Q424227","display_name":"Bronchiolitis","level":3,"score":0.7186999917030334},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5572999715805054},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.5400999784469604},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47909998893737793},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.41780000925064087},{"id":"https://openalex.org/C2909094123","wikidata":"https://www.wikidata.org/wiki/Q424227","display_name":"Acute Bronchiolitis","level":4,"score":0.4124999940395355},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.39500001072883606},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.37279999256134033},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.35580000281333923},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.3424000144004822},{"id":"https://openalex.org/C2984752397","wikidata":"https://www.wikidata.org/wiki/Q3259956","display_name":"Primary care","level":2,"score":0.314300000667572},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.313400000333786},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2937000095844269},{"id":"https://openalex.org/C2776012195","wikidata":"https://www.wikidata.org/wiki/Q754447","display_name":"Respiratory tract infections","level":3,"score":0.28299999237060547},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.27959999442100525},{"id":"https://openalex.org/C2910844663","wikidata":"https://www.wikidata.org/wiki/Q767485","display_name":"Acute respiratory failure","level":3,"score":0.27149999141693115},{"id":"https://openalex.org/C2777402568","wikidata":"https://www.wikidata.org/wiki/Q779038","display_name":"Respiratory sounds","level":3,"score":0.26899999380111694},{"id":"https://openalex.org/C502991105","wikidata":"https://www.wikidata.org/wiki/Q5133849","display_name":"Clinical research","level":2,"score":0.2567000091075897},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.2547999918460846},{"id":"https://openalex.org/C2776888751","wikidata":"https://www.wikidata.org/wiki/Q767485","display_name":"Respiratory failure","level":2,"score":0.25369998812675476}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.17632/trwpc8xwyp","doi":"https://doi.org/10.17632/trwpc8xwyp","is_oa":true,"landing_page_url":"https://doi.org/10.17632/trwpc8xwyp","pdf_url":null,"source":{"id":"https://openalex.org/S7407050775","display_name":"Mendeley Data","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.17632/trwpc8xwyp.1","doi":"https://doi.org/10.17632/trwpc8xwyp.1","is_oa":true,"landing_page_url":"https://doi.org/10.17632/trwpc8xwyp.1","pdf_url":null,"source":{"id":"https://openalex.org/S7407050775","display_name":"Mendeley Data","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.17632/trwpc8xwyp","doi":"https://doi.org/10.17632/trwpc8xwyp","is_oa":true,"landing_page_url":"https://doi.org/10.17632/trwpc8xwyp","pdf_url":null,"source":{"id":"https://openalex.org/S7407050775","display_name":"Mendeley Data","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389484977","https://openalex.org/W7215501600","https://openalex.org/W2018968111","https://openalex.org/W2953236960","https://openalex.org/W3154491293","https://openalex.org/W3012050839","https://openalex.org/W4301501400","https://openalex.org/W2971628281","https://openalex.org/W2375125481","https://openalex.org/W29551048"],"abstract_inverted_index":{"This":[0],"meta-analysis":[1],"tests":[2],"a":[3],"primary":[4],"hypothesis":[5],"that":[6,36,61,140],"azithromycin":[7],"offers":[8],"no":[9],"meaningful":[10],"clinical":[11,25,125],"benefit":[12,39,126],"for":[13,87],"acute":[14,85,154],"wheezing":[15],"and":[16,29,55,109,135],"bronchiolitis":[17],"in":[18,23,41,68,77,83,120,127],"young":[19],"children":[20],"when":[21],"prescribed":[22],"routine":[24],"settings":[26,71],"(emergency":[27],"departments":[28],"general":[30],"hospital":[31],"wards).":[32],"We":[33,138],"further":[34],"hypothesize":[35],"any":[37],"apparent":[38],"observed":[40],"specific":[42],"contexts":[43],"is":[44],"driven":[45],"not":[46,82],"by":[47,52],"the":[48,117],"drug":[49],"itself":[50],"but":[51,81],"care":[53,70,86],"setting":[54],"patient":[56,133],"phenotype.":[57],"Specifically,":[58],"we":[59],"postulate":[60],"azithromycin's":[62],"anti-inflammatory":[63,96,122],"properties":[64],"may":[65],"reduce":[66],"symptoms":[67],"intensive":[69],"with":[72],"high-acuity":[73],"respiratory":[74,144],"failure":[75],"or":[76],"home-managed":[78],"recurrent":[79,146],"episodes,":[80],"standard":[84],"viral":[88],"bronchiolitis.":[89],"The":[90],"mechanistic":[91],"rationale":[92],"rests":[93],"on":[94,132],"macrolide":[95],"activity:":[97],"inhibition":[98],"of":[99,103,111,119],"NF-\u03baB":[100],"signaling,":[101],"reduction":[102],"pro-inflammatory":[104],"cytokines":[105],"(IL-8,":[106],"TNF-\u03b1,":[107],"MCP-1),":[108],"enhancement":[110],"airway":[112],"epithelial":[113],"barrier":[114],"function.":[115],"However,":[116],"translation":[118],"vitro":[121],"efficacy":[123],"to":[124],"real":[128],"patients":[129],"depends":[130],"critically":[131],"phenotype":[134],"disease":[136],"severity.":[137],"predicted":[139],"high-inflammation":[141],"phenotypes":[142],"(PICU":[143],"failure,":[145],"post-viral":[147],"wheezing)":[148],"would":[149,156],"demonstrate":[150],"benefit,":[151],"while":[152],"unselected":[153],"presentations":[155],"not.":[157]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-24T00:00:00"}