{"id":"https://openalex.org/W7204017712","doi":null,"title":"The Role of Acetylcholine Producing T cells in Hypertensive Heart Disease and Viral Myocarditis","display_name":"The Role of Acetylcholine Producing T cells in Hypertensive Heart Disease and Viral Myocarditis","publication_year":2026,"publication_date":"2026-06-01","ids":{"openalex":"https://openalex.org/W7204017712"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/153858","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1807/153858","pdf_url":"https://utoronto.scholaris.ca/bitstreams/66d7aaa8-589f-405a-ab39-48acd8815251/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/66d7aaa8-589f-405a-ab39-48acd8815251/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147817735","display_name":"Julia Mei-Ting Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Lin, Julia Mei-Ting","raw_affiliation_strings":["Doctorate of Philosophy Department of Immunology University of Toronto 2026"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctorate of Philosophy Department of Immunology University of Toronto 2026","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5147817735"],"corresponding_institution_ids":["https://openalex.org/I185261750"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.41749998927116394,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.41749998927116394,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.2915000021457672,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.09839999675750732,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/choline-acetyltransferase","display_name":"choline acetyltransferase","score":0.8600000143051147},{"id":"https://openalex.org/keywords/hypertensive-heart-disease","display_name":"hypertensive heart disease","score":0.8799999952316284},{"id":"https://openalex.org/keywords/viral-myocarditis","display_name":"viral myocarditis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/encephalomyocarditis-virus","display_name":"encephalomyocarditis virus","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neuroimmune-axis","display_name":"neuroimmune axis","score":0.824999988079071},{"id":"https://openalex.org/keywords/bystander-injuries","display_name":"bystander injuries","score":0.5419999957084656},{"id":"https://openalex.org/keywords/myeloid-cell-recruitment","display_name":"myeloid cell recruitment","score":0.6759999990463257},{"id":"https://openalex.org/keywords/ccr2","display_name":"CCR2","score":0.6019999980926514},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/age-related-susceptibility","display_name":"age-related susceptibility","score":0.5370000004768372},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8529999852180481},{"id":"https://openalex.org/keywords/viral-dissemination","display_name":"viral dissemination","score":0.41200000047683716}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7139999866485596},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6445000171661377},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.626800000667572},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.583899974822998},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.5382000207901001},{"id":"https://openalex.org/C2909190889","wikidata":"https://www.wikidata.org/wiki/Q186235","display_name":"Viral Myocarditis","level":3,"score":0.5364000201225281},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5131999850273132},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4334999918937683},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.4120999872684479},{"id":"https://openalex.org/C2777899865","wikidata":"https://www.wikidata.org/wiki/Q1634879","display_name":"Encephalomyelitis","level":3,"score":0.3736000061035156},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3702999949455261},{"id":"https://openalex.org/C19106626","wikidata":"https://www.wikidata.org/wiki/Q230749","display_name":"Bystander effect","level":2,"score":0.3506999909877777},{"id":"https://openalex.org/C198399640","wikidata":"https://www.wikidata.org/wiki/Q14863671","display_name":"Choline acetyltransferase","level":3,"score":0.35010001063346863},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.34709998965263367},{"id":"https://openalex.org/C2780194698","wikidata":"https://www.wikidata.org/wiki/Q6005429","display_name":"Immune dysregulation","level":3,"score":0.334199994802475},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.328000009059906},{"id":"https://openalex.org/C2780875844","wikidata":"https://www.wikidata.org/wiki/Q186235","display_name":"Myocarditis","level":2,"score":0.3181000053882599},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3142000138759613},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2937999963760376},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2856000065803528},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.28459998965263367},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.27889999747276306},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.27559998631477356},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.266400009393692},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2612999975681305},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.2578999996185303},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/153858","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1807/153858","pdf_url":"https://utoronto.scholaris.ca/bitstreams/66d7aaa8-589f-405a-ab39-48acd8815251/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/153858","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1807/153858","pdf_url":"https://utoronto.scholaris.ca/bitstreams/66d7aaa8-589f-405a-ab39-48acd8815251/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204017712.pdf","grobid_xml":"https://content.openalex.org/works/W7204017712.grobid-xml"},"referenced_works_count":310,"referenced_works":["https://openalex.org/W167198678","https://openalex.org/W1487018400","https://openalex.org/W1495554157","https://openalex.org/W1507976770","https://openalex.org/W1513183398","https://openalex.org/W1530235393","https://openalex.org/W1533714684","https://openalex.org/W1565592289","https://openalex.org/W1577070562","https://openalex.org/W1599185640","https://openalex.org/W1607892649","https://openalex.org/W1668896487","https://openalex.org/W1719844260","https://openalex.org/W1748441885","https://openalex.org/W1763873242","https://openalex.org/W1893260165","https://openalex.org/W1900806927","https://openalex.org/W1907832415","https://openalex.org/W1929110414","https://openalex.org/W1964077677","https://openalex.org/W1964196894","https://openalex.org/W1964249139","https://openalex.org/W1966474318","https://openalex.org/W1968286569","https://openalex.org/W1975110303","https://openalex.org/W1975120250","https://openalex.org/W1975212304","https://openalex.org/W1976256751","https://openalex.org/W1976555160","https://openalex.org/W1977152294","https://openalex.org/W1978539621","https://openalex.org/W1980891271","https://openalex.org/W1981207579","https://openalex.org/W1981353210","https://openalex.org/W1981635815","https://openalex.org/W1982090891","https://openalex.org/W1984811742","https://openalex.org/W1985810679","https://openalex.org/W1986449294","https://openalex.org/W1988311061","https://openalex.org/W1988711597","https://openalex.org/W1988742135","https://openalex.org/W1991113258","https://openalex.org/W1993537924","https://openalex.org/W1993620441","https://openalex.org/W1993734178","https://openalex.org/W1994657650","https://openalex.org/W1995525413","https://openalex.org/W1996990557","https://openalex.org/W1998310721","https://openalex.org/W1999379804","https://openalex.org/W1999819607","https://openalex.org/W2000031391","https://openalex.org/W2001624197","https://openalex.org/W2002075344","https://openalex.org/W2004228512","https://openalex.org/W2005599815","https://openalex.org/W2006027051","https://openalex.org/W2006792282","https://openalex.org/W2007000106","https://openalex.org/W2007143131","https://openalex.org/W2007359345","https://openalex.org/W2008808029","https://openalex.org/W2009219530","https://openalex.org/W2010507403","https://openalex.org/W2011290533","https://openalex.org/W2012561790","https://openalex.org/W2013521729","https://openalex.org/W2013817923","https://openalex.org/W2015479125","https://openalex.org/W2016122381","https://openalex.org/W2016777949","https://openalex.org/W2017490850","https://openalex.org/W2019057590","https://openalex.org/W2019969899","https://openalex.org/W2021141031","https://openalex.org/W2023941297","https://openalex.org/W2024277710","https://openalex.org/W2024756894","https://openalex.org/W2026028987","https://openalex.org/W2026208410","https://openalex.org/W2026443089","https://openalex.org/W2027988197","https://openalex.org/W2028137895","https://openalex.org/W2028575270","https://openalex.org/W2029123674","https://openalex.org/W2035764211","https://openalex.org/W2037211353","https://openalex.org/W2037817605","https://openalex.org/W2039689821","https://openalex.org/W2040137876","https://openalex.org/W2040407112","https://openalex.org/W2046208657","https://openalex.org/W2046775696","https://openalex.org/W2046841774","https://openalex.org/W2046886831","https://openalex.org/W2047265728","https://openalex.org/W2048147848","https://openalex.org/W2048615211","https://openalex.org/W2048700200","https://openalex.org/W2050446323","https://openalex.org/W2053221827","https://openalex.org/W2053384955","https://openalex.org/W2054329126","https://openalex.org/W2054366648","https://openalex.org/W2056176542","https://openalex.org/W2056307424","https://openalex.org/W2056742043","https://openalex.org/W2060500618","https://openalex.org/W2061516091","https://openalex.org/W2061931574","https://openalex.org/W2062012360","https://openalex.org/W2065654550","https://openalex.org/W2066737143","https://openalex.org/W2069368135","https://openalex.org/W2069819211","https://openalex.org/W2069876149","https://openalex.org/W2070416023","https://openalex.org/W2071415293","https://openalex.org/W2071831134","https://openalex.org/W2072052992","https://openalex.org/W2073295417","https://openalex.org/W2074507269","https://openalex.org/W2074617527","https://openalex.org/W2075323804","https://openalex.org/W2077791460","https://openalex.org/W2077857097","https://openalex.org/W2079212325","https://openalex.org/W2080152737","https://openalex.org/W2080909361","https://openalex.org/W2083383767","https://openalex.org/W2083670745","https://openalex.org/W2084130233","https://openalex.org/W2084147684","https://openalex.org/W2084194797","https://openalex.org/W2085919832","https://openalex.org/W2086051107","https://openalex.org/W2087401044","https://openalex.org/W2089335976","https://openalex.org/W2091129202","https://openalex.org/W2091429277","https://openalex.org/W2091882370","https://openalex.org/W2092698466","https://openalex.org/W2093152656","https://openalex.org/W2093897672","https://openalex.org/W2094736478","https://openalex.org/W2095278260","https://openalex.org/W2096012039","https://openalex.org/W2097147259","https://openalex.org/W2100293227","https://openalex.org/W2101567381","https://openalex.org/W2103768578","https://openalex.org/W2104397221","https://openalex.org/W2104838343","https://openalex.org/W2105274196","https://openalex.org/W2105860922","https://openalex.org/W2106059368","https://openalex.org/W2106557745","https://openalex.org/W2106684817","https://openalex.org/W2107564764","https://openalex.org/W2107746773","https://openalex.org/W2109342780","https://openalex.org/W2110913939","https://openalex.org/W2111729216","https://openalex.org/W2111897512","https://openalex.org/W2112526496","https://openalex.org/W2113630547","https://openalex.org/W2113836432","https://openalex.org/W2120303646","https://openalex.org/W2120963937","https://openalex.org/W2122141298","https://openalex.org/W2122647962","https://openalex.org/W2129071472","https://openalex.org/W2129472676","https://openalex.org/W2130158896","https://openalex.org/W2132091762","https://openalex.org/W2133588896","https://openalex.org/W2133938655","https://openalex.org/W2134598491","https://openalex.org/W2134916334","https://openalex.org/W2135439806","https://openalex.org/W2135788465","https://openalex.org/W2137367243","https://openalex.org/W2138101248","https://openalex.org/W2139731518","https://openalex.org/W2140445474","https://openalex.org/W2140921081","https://openalex.org/W2141309802","https://openalex.org/W2141415377","https://openalex.org/W2147022432","https://openalex.org/W2148658155","https://openalex.org/W2149561244","https://openalex.org/W2151067022","https://openalex.org/W2151546806","https://openalex.org/W2151660617","https://openalex.org/W2154865730","https://openalex.org/W2156595997","https://openalex.org/W2158340998","https://openalex.org/W2158419225","https://openalex.org/W2158796327","https://openalex.org/W2159203244","https://openalex.org/W2160281104","https://openalex.org/W2161003987","https://openalex.org/W2161291046","https://openalex.org/W2161434052","https://openalex.org/W2162829843","https://openalex.org/W2168044782","https://openalex.org/W2168938667","https://openalex.org/W2169139395","https://openalex.org/W2170215368","https://openalex.org/W2176471821","https://openalex.org/W2179021824","https://openalex.org/W2190558971","https://openalex.org/W2206572452","https://openalex.org/W2225972580","https://openalex.org/W2233660390","https://openalex.org/W2275972429","https://openalex.org/W2285065014","https://openalex.org/W2295416986","https://openalex.org/W2299292241","https://openalex.org/W2301272550","https://openalex.org/W2313271309","https://openalex.org/W2313309879","https://openalex.org/W2319131210","https://openalex.org/W2320029923","https://openalex.org/W2467563104","https://openalex.org/W2520792892","https://openalex.org/W2521027544","https://openalex.org/W2525313139","https://openalex.org/W2556561046","https://openalex.org/W2573339072","https://openalex.org/W2581024054","https://openalex.org/W2596144742","https://openalex.org/W2605897822","https://openalex.org/W2728782542","https://openalex.org/W2734704016","https://openalex.org/W2753006146","https://openalex.org/W2766947086","https://openalex.org/W2768483164","https://openalex.org/W2768527926","https://openalex.org/W2771968994","https://openalex.org/W2785308950","https://openalex.org/W2793382211","https://openalex.org/W2800974699","https://openalex.org/W2801032953","https://openalex.org/W2805170482","https://openalex.org/W2808558476","https://openalex.org/W2890977746","https://openalex.org/W2914780443","https://openalex.org/W2915138723","https://openalex.org/W2937033043","https://openalex.org/W2943217114","https://openalex.org/W2948670761","https://openalex.org/W2963031972","https://openalex.org/W2968552237","https://openalex.org/W2968696613","https://openalex.org/W2987913309","https://openalex.org/W2988471964","https://openalex.org/W2996419311","https://openalex.org/W3000431818","https://openalex.org/W3008164932","https://openalex.org/W3010066757","https://openalex.org/W3015840146","https://openalex.org/W3038604852","https://openalex.org/W3087458297","https://openalex.org/W3092415006","https://openalex.org/W3093977070","https://openalex.org/W3111065404","https://openalex.org/W3112265823","https://openalex.org/W3113178943","https://openalex.org/W3115729369","https://openalex.org/W3133626942","https://openalex.org/W3190179284","https://openalex.org/W3207467583","https://openalex.org/W4200017946","https://openalex.org/W4205763248","https://openalex.org/W4210937888","https://openalex.org/W4220684044","https://openalex.org/W4223475123","https://openalex.org/W4224052226","https://openalex.org/W4283446020","https://openalex.org/W4286255765","https://openalex.org/W4292607973","https://openalex.org/W4312066765","https://openalex.org/W4321786489","https://openalex.org/W4361302786","https://openalex.org/W4376631082","https://openalex.org/W4381549239","https://openalex.org/W4383879255","https://openalex.org/W4386162351","https://openalex.org/W4386225610","https://openalex.org/W4388533127","https://openalex.org/W4388902498","https://openalex.org/W4389623666","https://openalex.org/W4391979318","https://openalex.org/W4392796853","https://openalex.org/W4393442316","https://openalex.org/W4395447822","https://openalex.org/W4400493288","https://openalex.org/W4400735360","https://openalex.org/W4402581553","https://openalex.org/W4407317715","https://openalex.org/W4408054022","https://openalex.org/W4409607453","https://openalex.org/W4409802149","https://openalex.org/W4410557221","https://openalex.org/W4410907168","https://openalex.org/W4412116172","https://openalex.org/W4412463234","https://openalex.org/W4413139742"],"related_works":["https://openalex.org/W4313383122","https://openalex.org/W2913511231","https://openalex.org/W2891260920","https://openalex.org/W7126299745","https://openalex.org/W2030228073","https://openalex.org/W3007514864","https://openalex.org/W7101128552","https://openalex.org/W1941056073","https://openalex.org/W2107226432","https://openalex.org/W1964581596"],"abstract_inverted_index":{"The":[0],"need":[1],"for":[2,289],"an":[3,84],"immune":[4,66,251],"response":[5],"to":[6,32,48,69,100,187,223,267],"clear":[7],"pathogens":[8],"is":[9,287],"balanced":[10],"by":[11],"the":[12,18,82,124,159,168,224,235],"risks":[13],"of":[14,37,51,104,123,128,161,178,195,215,274],"bystander":[15],"injury,":[16,79],"yet":[17],"mechanisms":[19],"regulating":[20],"these":[21,38],"critical":[22,288],"trade-offs":[23],"remain":[24],"unclear.":[25],"Here,":[26],"ChAT+":[27],"T":[28,43,98,116,132,162,179],"cells":[29,44,99],"were":[30],"found":[31],"be":[33],"associated":[34,142],"with":[35,86,130],"many":[36],"trade-offs.":[39],"Choline":[40],"acetyltransferase-expressing":[41],"(ChAT+)":[42],"have":[45],"been":[46],"linked":[47],"neuro-immune":[49,284],"control":[50],"vascular":[52],"flow":[53],"and":[54,75,95,149,181,205,226,277],"leukocyte":[55],"recruitment,":[56],"so":[57],"we":[58],"asked":[59],"how":[60],"T-cell":[61,247],"acetylcholine":[62],"(ACh)":[63],"production":[64],"regulates":[65],"mediated":[67],"outcomes":[68],"non-ischemic":[70],"cardiomyopathy,":[71],"particularly":[72],"hypertensive":[73,148],"(sterile)":[74],"viral":[76,125,152,196,258,293],"(infectious)":[77],"cardiac":[78,188],"focusing":[80],"on":[81],"myocardium,":[83],"organ":[85,265],"little":[87],"regenerative":[88],"ability.Encephalomyocarditis":[89],"virus":[90],"(EMCV)":[91],"infection":[92,171],"primed":[93],"differentiated":[94],"cytotoxic":[96],"CD4+":[97],"express":[101],"high":[102],"levels":[103,214],"ChAT,":[105],"indicating":[106,245],"that":[107,229,246,286],"ChAT":[108,118,134,248],"upregulation":[109],"was":[110,193,263],"activation-linked.":[111],"Hypertensive":[112],"stress":[113],"weakly":[114],"activated":[115,230],"cell":[117,163,180,221,243],"expression":[119,249],"at":[120],"a":[121,131,139,185,271,282],"fraction":[122],"model.":[126],"Use":[127],"mice":[129,211],"cell-specific":[133],"deletion":[135],"(T-ChATKO;":[136],"ChATfl/flCD4cre)":[137],"demonstrated":[138],"strong":[140],"age":[141],"bias":[143],"in":[144,155,158,173,291],"disease":[145],"outcomes.":[146],"Middle-aged":[147],"male":[150,174,209],"adolescent":[151,292],"infections":[153],"resulted":[154,172],"increased":[156,176,241,264],"mortality":[157],"absence":[160],"specific":[164,175],"ACh":[165],"production.":[166],"In":[167,190],"EMCV":[169],"model,":[170],"infiltration":[177],"monocyte":[182],"influx,":[183,244],"without":[184],"change":[186],"injury.":[189],"adolescents,":[191],"there":[192,262],"evidence":[194],"disseminationand":[197],"multi-organ":[198],"pathology,":[199],"including":[200],"hind":[201],"limb":[202],"paralysis,":[203],"encephalomyelitis":[204],"diaphragmitis.":[206],"Paradoxically,":[207],"susceptible":[208],"T-ChATKO":[210,238],"had":[212,240],"reduced":[213],"astrocyte":[216],"stress,":[217],"decreased":[218],"CCR2+":[219],"myeloid":[220,242],"influx":[222],"brain,":[225],"serum":[227],"cytokines":[228],"monocytes":[231],"(CCL2,":[232],"GM-CSF).":[233],"Within":[234],"dural":[236],"meninges":[237],"males":[239],"controlled":[250],"recruitment":[252],"through":[253],"compartment-dependent":[254],"effects.":[255],"By":[256],"increasing":[257],"pathogenicity":[259],"(with":[260],"age),":[261],"injury":[266],"maintain":[268],"survival,":[269],"suggesting":[270],"calculated":[272],"trade-off":[273],"neuroinflammatory":[275],"complications":[276],"survival.":[278],"This":[279],"work":[280],"unveils":[281],"novel":[283],"axis":[285],"survival":[290],"infection.":[294]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-08-23T00:00:00"}