{"id":"https://openalex.org/W7204013765","doi":"https://doi.org/10.1093/omcr/omag159","title":"Nivolumab after recurrent pembrolizumab-associated hepatotoxicity in PD-L1-high metastatic squamous non-small cell lung cancer: a case report","display_name":"Nivolumab after recurrent pembrolizumab-associated hepatotoxicity in PD-L1-high metastatic squamous non-small cell lung cancer: a case report","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7204013765","doi":"https://doi.org/10.1093/omcr/omag159","pmid":"https://pubmed.ncbi.nlm.nih.gov/42633086","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13499018"},"language":"en","primary_location":{"id":"doi:10.1093/omcr/omag159","doi":"https://doi.org/10.1093/omcr/omag159","is_oa":true,"landing_page_url":"https://doi.org/10.1093/omcr/omag159","pdf_url":null,"source":{"id":"https://openalex.org/S2734620550","display_name":"Oxford Medical Case Reports","issn_l":"2053-8855","issn":["2053-8855"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxford Medical Case Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/omcr/omag159","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5130768998","display_name":"Adam Bowen","orcid":"https://orcid.org/0009-0000-5677-9736","observed_orcids":["https://orcid.org/0009-0000-5677-9736"]},"institutions":[{"id":"https://openalex.org/I4210153933","display_name":"McLaren Greater Lansing","ror":"https://ror.org/045zcth28","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210153933"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adam Bowen","raw_affiliation_strings":["Department of Internal Medicine, McLaren Greater Lansing Hospital , Michigan State University, 2900 Collins Rd, Lansing, MI 48910,"],"raw_orcid":"https://orcid.org/0009-0000-5677-9736","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, McLaren Greater Lansing Hospital , Michigan State University, 2900 Collins Rd, Lansing, MI 48910,","institution_ids":["https://openalex.org/I4210153933","https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137111278","display_name":"Katlyn Wendel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153933","display_name":"McLaren Greater Lansing","ror":"https://ror.org/045zcth28","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210153933"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katlyn Wendel","raw_affiliation_strings":["Department of Internal Medicine, McLaren Greater Lansing Hospital , Michigan State University, 2900 Collins Rd, Lansing, MI 48910,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, McLaren Greater Lansing Hospital , Michigan State University, 2900 Collins Rd, Lansing, MI 48910,","institution_ids":["https://openalex.org/I4210153933","https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130763186","display_name":"Muhammad Danish Saleem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153933","display_name":"McLaren Greater Lansing","ror":"https://ror.org/045zcth28","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210153933"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muhammad-Danish Saleem","raw_affiliation_strings":["Department of Hematology/Oncology, Karmanos Cancer Institute at McLaren Greater Lansing Hospital , Michigan State University, 3520 Forest Rd, Lansing, MI 48910,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology/Oncology, Karmanos Cancer Institute at McLaren Greater Lansing Hospital , Michigan State University, 3520 Forest Rd, Lansing, MI 48910,","institution_ids":["https://openalex.org/I4210153933","https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043800652","display_name":"Zijin Lin","orcid":"https://orcid.org/0000-0002-6706-5410","observed_orcids":["https://orcid.org/0000-0002-6706-5410"]},"institutions":[{"id":"https://openalex.org/I4210153933","display_name":"McLaren Greater Lansing","ror":"https://ror.org/045zcth28","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210153933"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zijin Lin","raw_affiliation_strings":["Department of Internal Medicine, McLaren Greater Lansing Hospital, Michigan State University , 2900 Collins Rd, Lansing, MI 48910,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, McLaren Greater Lansing Hospital, Michigan State University , 2900 Collins Rd, Lansing, MI 48910,","institution_ids":["https://openalex.org/I4210153933","https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119750186","display_name":"Ramalakshmi Thulluri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153933","display_name":"McLaren Greater Lansing","ror":"https://ror.org/045zcth28","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210153933"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramalakshmi Thulluri","raw_affiliation_strings":["Department of Internal Medicine, McLaren Greater Lansing Hospital, Michigan State University , 2900 Collins Rd, Lansing, MI 48910,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, McLaren Greater Lansing Hospital, Michigan State University , 2900 Collins Rd, Lansing, MI 48910,","institution_ids":["https://openalex.org/I4210153933","https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069003336","display_name":"Borys W. Hrinczenko","orcid":"https://orcid.org/0000-0002-1042-0215","observed_orcids":["https://orcid.org/0000-0002-1042-0215"]},"institutions":[{"id":"https://openalex.org/I4210153933","display_name":"McLaren Greater Lansing","ror":"https://ror.org/045zcth28","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210153933"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Borys Hrinczenko","raw_affiliation_strings":["Department of Hematology/Oncology, Karmanos Cancer Institute at McLaren Greater Lansing Hospital , Michigan State University, 3520 Forest Rd, Lansing, MI 48910,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology/Oncology, Karmanos Cancer Institute at McLaren Greater Lansing Hospital , Michigan State University, 3520 Forest Rd, Lansing, MI 48910,","institution_ids":["https://openalex.org/I4210153933","https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5130768998"],"corresponding_institution_ids":["https://openalex.org/I4210153933","https://openalex.org/I87216513"],"apc_list":{"value":1103,"currency":"USD","value_usd":1103},"apc_paid":{"value":1103,"currency":"USD","value_usd":1103},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2026","issue":"8","first_page":"omag159","last_page":"omag159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":0.9620000123977661},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":0.9909999966621399},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.8199999928474426},{"id":"https://openalex.org/keywords/immune-related-hepatitis","display_name":"immune-related hepatitis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.9049999713897705},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.722000002861023},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.6439999938011169},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.8610000014305115},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9695000052452087},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.8891000151634216},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.8787999749183655},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5090000033378601},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4973999857902527},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.48410001397132874},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4163999855518341},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.41190001368522644},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.40529999136924744},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3249000012874603},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.3084000051021576},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.2985000014305115},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.2937000095844269},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29269999265670776},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.2912999987602234},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2831999957561493},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.2824000120162964},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.2816999852657318},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.2603999972343445},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2567000091075897},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.2526000142097473}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/omcr/omag159","doi":"https://doi.org/10.1093/omcr/omag159","is_oa":true,"landing_page_url":"https://doi.org/10.1093/omcr/omag159","pdf_url":null,"source":{"id":"https://openalex.org/S2734620550","display_name":"Oxford Medical Case Reports","issn_l":"2053-8855","issn":["2053-8855"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxford Medical Case Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13499018","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13499018/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13499018/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxf Med Case Reports","raw_type":"Text"},{"id":"pmid:42633086","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42633086","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxford medical case reports","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1093/omcr/omag159","doi":"https://doi.org/10.1093/omcr/omag159","is_oa":true,"landing_page_url":"https://doi.org/10.1093/omcr/omag159","pdf_url":null,"source":{"id":"https://openalex.org/S2734620550","display_name":"Oxford Medical Case Reports","issn_l":"2053-8855","issn":["2053-8855"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxford Medical Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320317266","display_name":"Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204013765.pdf","grobid_xml":"https://content.openalex.org/works/W7204013765.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W2789465456","https://openalex.org/W2805103957","https://openalex.org/W2805827066","https://openalex.org/W2892640821","https://openalex.org/W2939863421","https://openalex.org/W2945590213","https://openalex.org/W2957570007","https://openalex.org/W3210474759","https://openalex.org/W4224984865","https://openalex.org/W4306692674"],"related_works":["https://openalex.org/W4316080041","https://openalex.org/W2936650642","https://openalex.org/W3094046453","https://openalex.org/W2301237000","https://openalex.org/W2981068483","https://openalex.org/W4405739631","https://openalex.org/W3021669191","https://openalex.org/W2777677409","https://openalex.org/W2974630967","https://openalex.org/W4282979309"],"abstract_inverted_index":{"Immune-related":[0],"hepatitis":[1,53],"can":[2],"interrupt":[3],"effective":[4],"PD-1":[5],"therapy,":[6],"and":[7,36,61,94,113],"evidence":[8],"guiding":[9],"within-class":[10],"retreatment":[11],"after":[12,76,91],"recurrent":[13,103],"toxicity":[14],"remains":[15],"limited.":[16],"An":[17],"82-year-old":[18],"woman":[19],"with":[20,34,72],"remote":[21],"resected":[22],"lung":[23,32],"cancer":[24,33],"later":[25],"developed":[26,46],"PD-L1-high":[27],"metastatic":[28],"squamous":[29],"non-small":[30],"cell":[31],"thoracic":[35,112],"hepatic":[37,114],"disease.":[38,115],"After":[39],"4":[40],"pembrolizumab":[41,78],"doses,":[42],"mixed":[43],"liver":[44,50,57],"injury":[45],"despite":[47],"normal":[48],"baseline":[49],"chemistries.":[51],"Viral":[52],"serologies":[54],"were":[55],"negative,":[56],"ultrasound":[58],"was":[59,89,95],"unrevealing,":[60],"acetaminophen":[62],"exposure":[63],"remained":[64],"a":[65,81],"non-significant":[66],"competing":[67],"factor.":[68],"Liver":[69],"tests":[70],"improved":[71],"corticosteroids":[73],"but":[74],"recurred":[75],"2":[77],"rechallenges,":[79],"including":[80],"grade":[82],"3":[83,100],"event,":[84],"prompting":[85],"permanent":[86],"discontinuation.":[87],"Nivolumab":[88],"started":[90],"biochemical":[92],"recovery":[93],"tolerated":[96],"for":[97],"more":[98],"than":[99],"years":[101],"without":[102],"hepatotoxicity.":[104],"Follow-up":[105],"PET-CT":[106],"demonstrated":[107],"durable":[108],"metabolic":[109],"resolution":[110],"of":[111]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-08-23T00:00:00"}