{"id":"https://openalex.org/W7204004782","doi":"https://doi.org/10.1016/j.xjon.2026.102068","title":"The interaction of age and time on durable left ventricular assist device and its effect on heart transplant outcomes","display_name":"The interaction of age and time on durable left ventricular assist device and its effect on heart transplant outcomes","publication_year":2026,"publication_date":"2026-08-22","ids":{"openalex":"https://openalex.org/W7204004782","doi":"https://doi.org/10.1016/j.xjon.2026.102068","pmid":"https://pubmed.ncbi.nlm.nih.gov/42948138","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13711219"},"language":"en","primary_location":{"id":"doi:10.1016/j.xjon.2026.102068","doi":"https://doi.org/10.1016/j.xjon.2026.102068","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xjon.2026.102068","pdf_url":null,"source":{"id":"https://openalex.org/S4210197350","display_name":"JTCVS Open","issn_l":"2666-2736","issn":["2666-2736"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTCVS Open","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.xjon.2026.102068","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028068236","display_name":"Zachary Sollie","orcid":"https://orcid.org/0009-0002-6835-9434","observed_orcids":["https://orcid.org/0009-0002-6835-9434","https://orcid.org/0000-0001-6888-8876"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary W. Sollie","raw_affiliation_strings":["Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC"],"raw_orcid":"https://orcid.org/0009-0002-6835-9434","affiliations":[{"raw_affiliation_string":"Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082338811","display_name":"Jennie H. Kwon","orcid":"https://orcid.org/0000-0001-5249-6501","observed_orcids":["https://orcid.org/0000-0001-5249-6501"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennie H. Kwon","raw_affiliation_strings":["Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134470763","display_name":"Caroline C. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline C. Miller","raw_affiliation_strings":["Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134541170","display_name":"Jingwen Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingwen Zhang","raw_affiliation_strings":["Department of Medicine, Medical University of South Carolina, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Medical University of South Carolina, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015441641","display_name":"Brett A. Welch","orcid":"https://orcid.org/0009-0008-3059-466X","observed_orcids":["https://orcid.org/0009-0008-3059-466X","https://orcid.org/0009-0004-6623-6494"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brett A. Welch","raw_affiliation_strings":["Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053504850","display_name":"Chakradhari Inampudi","orcid":"https://orcid.org/0000-0003-2940-6330","observed_orcids":["https://orcid.org/0000-0003-2940-6330"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chakradhari Inampudi","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066548014","display_name":"Arman Kilic","orcid":"https://orcid.org/0000-0001-8112-8345","observed_orcids":["https://orcid.org/0000-0001-8112-8345"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arman Kilic","raw_affiliation_strings":["Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066548014"],"corresponding_institution_ids":["https://openalex.org/I153297377"],"apc_list":{"value":2431,"currency":"USD","value_usd":2431},"apc_paid":{"value":2431,"currency":"USD","value_usd":2431},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.61051341,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":null,"first_page":"102068","last_page":"102068"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.059300001710653305,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10300","display_name":"Congenital Heart Disease Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/left-ventricular-assist-device","display_name":"left ventricular assist device","score":0.972000002861023},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/old-age","display_name":"old age","score":0.7850000262260437},{"id":"https://openalex.org/keywords/post-transplant-survival","display_name":"post-transplant survival","score":0.8299999833106995},{"id":"https://openalex.org/keywords/post-transplant-mortality","display_name":"post-transplant mortality","score":0.7099999785423279},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8748999834060669},{"id":"https://openalex.org/C2778774980","wikidata":"https://www.wikidata.org/wiki/Q2897721","display_name":"Ventricular assist device","level":3,"score":0.7979999780654907},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6159999966621399},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.54830002784729},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5235000252723694},{"id":"https://openalex.org/C112758219","wikidata":"https://www.wikidata.org/wiki/Q16038819","display_name":"Duration (music)","level":2,"score":0.39800000190734863},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.35929998755455017},{"id":"https://openalex.org/C2778849806","wikidata":"https://www.wikidata.org/wiki/Q643396","display_name":"Heart transplantation","level":3,"score":0.34389999508857727},{"id":"https://openalex.org/C2986834420","wikidata":"https://www.wikidata.org/wiki/Q5932254","display_name":"Age groups","level":2,"score":0.3382999897003174},{"id":"https://openalex.org/C3018023364","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Significant difference","level":2,"score":0.3276999890804291},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.310699999332428},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.3034999966621399},{"id":"https://openalex.org/C2779326848","wikidata":"https://www.wikidata.org/wiki/Q5265191","display_name":"Destination therapy","level":4,"score":0.29809999465942383},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.2946000099182129},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.2831999957561493},{"id":"https://openalex.org/C2985264121","wikidata":"https://www.wikidata.org/wiki/Q216320","display_name":"Continuous flow","level":2,"score":0.2734000086784363},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.2513999938964844}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.xjon.2026.102068","doi":"https://doi.org/10.1016/j.xjon.2026.102068","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xjon.2026.102068","pdf_url":null,"source":{"id":"https://openalex.org/S4210197350","display_name":"JTCVS Open","issn_l":"2666-2736","issn":["2666-2736"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTCVS Open","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13711219","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13711219/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13711219/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTCVS Open","raw_type":"Text"},{"id":"pmid:42948138","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42948138","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTCVS open","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0ed447514feb45aea9ca53b49d553bdf","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0ed447514feb45aea9ca53b49d553bdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JTCVS Open, Vol 33, Iss , Pp 102068- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.xjon.2026.102068","doi":"https://doi.org/10.1016/j.xjon.2026.102068","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xjon.2026.102068","pdf_url":null,"source":{"id":"https://openalex.org/S4210197350","display_name":"JTCVS Open","issn_l":"2666-2736","issn":["2666-2736"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTCVS Open","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204004782.pdf","grobid_xml":"https://content.openalex.org/works/W7204004782.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W2127341635","https://openalex.org/W2169336583","https://openalex.org/W3048530310","https://openalex.org/W3095231582","https://openalex.org/W3143199777","https://openalex.org/W4289334548","https://openalex.org/W4391169031","https://openalex.org/W4392982635","https://openalex.org/W4403586458","https://openalex.org/W4410433304","https://openalex.org/W4417290755","https://openalex.org/W7128236561","https://openalex.org/W7135212262"],"related_works":["https://openalex.org/W7155527404","https://openalex.org/W2027054797","https://openalex.org/W3014735551","https://openalex.org/W2412669778","https://openalex.org/W152540391","https://openalex.org/W4311221185","https://openalex.org/W4365141491","https://openalex.org/W2326742480","https://openalex.org/W4362581893","https://openalex.org/W2118431762"],"abstract_inverted_index":{"Objective":[0],"This":[1],"study":[2],"aims":[3],"to":[4],"assess":[5],"interaction":[6,204,244],"between":[7,38,99],"age":[8,58,172,206],"and":[9,54,59,63,87,135,158,207,232],"left":[10],"ventricular":[11],"assist":[12],"device":[13],"(LVAD)":[14],"duration":[15,101,209],"on":[16,174,248],"heart":[17],"transplant":[18],"(HT)":[19],"outcomes":[20],"in":[21,28,96,227],"the":[22],"modern":[23],"era.":[24],"Methods":[25],"All":[26],"HT":[27],"adults":[29],"with":[30,81,129],"a":[31,168,222],"fully":[32],"magnetically":[33],"levitated":[34],"centrifugal":[35],"flow":[36],"LVAD":[37,67,84,100,132,139,184,208,235],"October":[39],"2018-":[40],"June":[41],"2025":[42],"were":[43,49,78,126],"identified":[44],"from":[45],"UNOS":[46],"database.":[47],"Groups":[48],"stratified":[50],"primarily":[51],"by":[52,61,234],"<55":[53,79],"\u226555":[55,127,173],"years":[56,65,80,86,119,128,134,141,160,231],"of":[57,66,171,205,211,245],"secondarily":[60],"<2":[62,85,133,140],"\u22652":[64,89,137,185],"support.":[68],"The":[69],"primary":[70],"outcome":[71],"was":[72,92],"post-HT":[73,97,175,225],"survival.":[74],"Results":[75],"1005":[76],"patients":[77,125,228],"608":[82],"having":[83,131],"397":[88],"years.":[90,138],"There":[91],"no":[93,189,202,242],"significant":[94,169,190,203,243],"difference":[95],"survival":[98,144,226],"groups":[102],"at":[103,145],"90":[104,146],"days":[105,147],"(95.3%":[106],"vs":[107,114,121,149,155,162],"94.4":[108],"%,":[109],"p=0.57),":[110],"1":[111,152],"year":[112,153],"(93.7%":[113],"90.2%,":[115],"p=0.07),":[116],"or":[117],"3":[118,159],"(88.0%":[120],"83.9%,":[122],"p=0.061).":[123],"1411":[124],"935":[130],"476":[136],"exhibited":[142],"improved":[143],"[92.4%":[148],"89.2%,":[150],"p=0.046],":[151],"[87.8%":[154],"81.9%,":[156],"p=0.0051],":[157],"[81.4%":[161],"72.7%,":[163],"p=0.0011].":[164],"Multivariable":[165],"adjustment":[166],"showed":[167,188],"impact":[170,191],"mortality":[176],"[HR":[177,192,210],"1.96":[178],"(95%":[179,194,213],"CI":[180,195,214],"1.34-2.86),":[181],"p":[182,197,216],"<0.001];":[183],"years,":[186,238],"however,":[187],"1.47":[193],"0.91-2.36),":[196],"0.116].":[198],"Formal":[199],"testing":[200,240],"revealed":[201],"1.1":[212],"0.63-1.91),":[215],"0.735].":[217],"Conclusions":[218],"Although":[219],"there":[220],"is":[221],"lower":[223],"observed":[224],"\u2265":[229,236],"55":[230],"supported":[233],"2":[237],"formal":[239],"reveals":[241],"these":[246],"variables":[247],"mortality.":[249]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-23T00:00:00"}