{"id":"https://openalex.org/W7203985776","doi":"https://doi.org/10.51244/ijrsi.2026.1307000394","title":"Targeting the Motor Protein Cag\u03b2 Blocks Oncoprotein CagA-induced Host Inflammation in Helicobacter pylori: An in silico Analysis","display_name":"Targeting the Motor Protein Cag\u03b2 Blocks Oncoprotein CagA-induced Host Inflammation in Helicobacter pylori: An in silico Analysis","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7203985776","doi":"https://doi.org/10.51244/ijrsi.2026.1307000394"},"language":"en","primary_location":{"id":"doi:10.51244/ijrsi.2026.1307000394","doi":"https://doi.org/10.51244/ijrsi.2026.1307000394","is_oa":true,"landing_page_url":"https://doi.org/10.51244/ijrsi.2026.1307000394","pdf_url":"https://rsisinternational.org/journals/ijrsi/uploads/vol13-iss7-pg5363-5371-202608_pdf.pdf","source":{"id":"https://openalex.org/S4210172017","display_name":"International journal of research and scientific innovation","issn_l":"2320-5520","issn":["2320-5520","2321-2705"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Research and Scientific Innovation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rsisinternational.org/journals/ijrsi/uploads/vol13-iss7-pg5363-5371-202608_pdf.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147858286","display_name":"Shubhangi Majumder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405256552","display_name":"JIS University","ror":"https://ror.org/049ndh460","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405256552"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shubhangi Majumder","raw_affiliation_strings":["Department of Bioscience, JIS University","India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioscience, JIS University","institution_ids":["https://openalex.org/I4405256552"]},{"raw_affiliation_string":"India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054456266","display_name":"Sanjib Das","orcid":"https://orcid.org/0000-0003-1988-8014","observed_orcids":["https://orcid.org/0000-0003-1988-8014"]},"institutions":[{"id":"https://openalex.org/I77501641","display_name":"University of Kalyani","ror":"https://ror.org/03v783k16","country_code":"IN","type":"education","lineage":["https://openalex.org/I77501641"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sanjib Das","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, University of Kalyani","India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, University of Kalyani","institution_ids":["https://openalex.org/I77501641"]},{"raw_affiliation_string":"India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029538126","display_name":"Amalesh Mondal","orcid":"https://orcid.org/0000-0003-1448-2517","observed_orcids":["https://orcid.org/0000-0003-1448-2517"]},"institutions":[{"id":"https://openalex.org/I77501641","display_name":"University of Kalyani","ror":"https://ror.org/03v783k16","country_code":"IN","type":"education","lineage":["https://openalex.org/I77501641"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Amalesh Mondal","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, University of Kalyani; Department of Physiology, Katwa College, Katwa, Purba Bardhaman, West Bengal, 713130","India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, University of Kalyani; Department of Physiology, Katwa College, Katwa, Purba Bardhaman, West Bengal, 713130","institution_ids":["https://openalex.org/I77501641"]},{"raw_affiliation_string":"India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025210369","display_name":"Tanima Saha","orcid":"https://orcid.org/0000-0002-9529-160X","observed_orcids":["https://orcid.org/0000-0002-9529-160X"]},"institutions":[{"id":"https://openalex.org/I77501641","display_name":"University of Kalyani","ror":"https://ror.org/03v783k16","country_code":"IN","type":"education","lineage":["https://openalex.org/I77501641"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tanima Saha","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, University of Kalyani","India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, University of Kalyani","institution_ids":["https://openalex.org/I77501641"]},{"raw_affiliation_string":"India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"7","first_page":"5363","last_page":"5371"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.7368000149726868,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.7368000149726868,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.2551000118255615,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":0.996999979019165},{"id":"https://openalex.org/keywords/cag-pathogenicity-island","display_name":"cag pathogenicity island","score":0.871999979019165},{"id":"https://openalex.org/keywords/type-iv-secretion-system","display_name":"type IV secretion system","score":0.9639999866485596},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.8379999995231628},{"id":"https://openalex.org/keywords/venetoclax","display_name":"venetoclax","score":0.9929999709129333},{"id":"https://openalex.org/keywords/host-inflammatory-response","display_name":"host inflammatory response","score":0.6579999923706055},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.6899999976158142},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.7300000190734863},{"id":"https://openalex.org/keywords/drug-binding-affinity","display_name":"drug binding affinity","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2778204961","wikidata":"https://www.wikidata.org/wiki/Q83146136","display_name":"CagA","level":4,"score":0.8557999730110168},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.7628999948501587},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5866000056266785},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5665000081062317},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5231000185012817},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4894999861717224},{"id":"https://openalex.org/C62130838","wikidata":"https://www.wikidata.org/wiki/Q5196163","display_name":"Pathogenicity island","level":4,"score":0.450300008058548},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.40560001134872437},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3873000144958496},{"id":"https://openalex.org/C2777119779","wikidata":"https://www.wikidata.org/wiki/Q963278","display_name":"Molecular mimicry","level":3,"score":0.3853999972343445},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3831000030040741},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.38040000200271606},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.353300005197525},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31850001215934753},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.311599999666214},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3057999908924103},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.299699991941452},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.29589998722076416},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.26339998841285706},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.262800008058548},{"id":"https://openalex.org/C2781443798","wikidata":"https://www.wikidata.org/wiki/Q383249","display_name":"Gastric mucosa","level":3,"score":0.2565999925136566}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.51244/ijrsi.2026.1307000394","doi":"https://doi.org/10.51244/ijrsi.2026.1307000394","is_oa":true,"landing_page_url":"https://doi.org/10.51244/ijrsi.2026.1307000394","pdf_url":"https://rsisinternational.org/journals/ijrsi/uploads/vol13-iss7-pg5363-5371-202608_pdf.pdf","source":{"id":"https://openalex.org/S4210172017","display_name":"International journal of research and scientific innovation","issn_l":"2320-5520","issn":["2320-5520","2321-2705"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Research and Scientific Innovation","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.51244/ijrsi.2026.1307000394","doi":"https://doi.org/10.51244/ijrsi.2026.1307000394","is_oa":true,"landing_page_url":"https://doi.org/10.51244/ijrsi.2026.1307000394","pdf_url":"https://rsisinternational.org/journals/ijrsi/uploads/vol13-iss7-pg5363-5371-202608_pdf.pdf","source":{"id":"https://openalex.org/S4210172017","display_name":"International journal of research and scientific innovation","issn_l":"2320-5520","issn":["2320-5520","2321-2705"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Research and Scientific Innovation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322759","display_name":"University of Kalyani","ror":"https://ror.org/03v783k16"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203985776.pdf","grobid_xml":"https://content.openalex.org/works/W7203985776.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1533711237","https://openalex.org/W1969980017","https://openalex.org/W1980337077","https://openalex.org/W1992192767","https://openalex.org/W2049902088","https://openalex.org/W2088933990","https://openalex.org/W2102993309","https://openalex.org/W2159614853","https://openalex.org/W2172242534","https://openalex.org/W2248134792","https://openalex.org/W2609752905","https://openalex.org/W2804822363","https://openalex.org/W3011645765","https://openalex.org/W3128646645","https://openalex.org/W4246356731","https://openalex.org/W4303984105","https://openalex.org/W4309506674","https://openalex.org/W4318473684"],"related_works":["https://openalex.org/W4206959240","https://openalex.org/W4391952914","https://openalex.org/W7213965988","https://openalex.org/W4375955879","https://openalex.org/W2248134792","https://openalex.org/W2332072761","https://openalex.org/W2581991380","https://openalex.org/W6950576851","https://openalex.org/W1991444764","https://openalex.org/W4229774532"],"abstract_inverted_index":{"Helicobacter":[0],"pylori":[1,27,187],"is":[2],"a":[3,32,73,90,103],"common":[4],"gut":[5],"microbiota,":[6],"responsible":[7],"for":[8],"severe":[9],"gastritis,":[10],"peptic":[11],"ulcer":[12],"disease":[13,29],"and":[14,63,78,121,159,180],"an":[15,82],"increased":[16],"risk":[17],"of":[18,70,93,117,126,138,146,185],"gastric":[19,46],"cancer.":[20],"The":[21],"Cag":[22,53],"pathogenicity":[23],"island":[24],"helps":[25],"H.":[26,186],"cause":[28],"by":[30],"forming":[31],"molecular":[33,91,131],"syringe":[34],"to":[35,60,105,112],"attack":[36],"host":[37,51,172],"cells":[38],"that":[39],"transfer":[40],"the":[41,45,50,67,94,114,139,168,182],"CagA":[42,80,107,169],"oncoprotein":[43],"into":[44,171],"cells.":[47],"Once":[48],"inside":[49],"cell,":[52],"A":[54],"modifies":[55],"multiple":[56],"signalling":[57,178],"pathways,":[58],"leading":[59],"major":[61],"alterations":[62],"even":[64],"malignancy.":[65],"Cag\u03b2,":[66],"coupling":[68],"protein":[69,100,120],"T4SS,":[71],"plays":[72],"significant":[74],"role":[75],"in":[76],"detecting":[77],"carrying":[79],"through":[81,130],"ATP-":[83],"dependent":[84],"mechanism.":[85],"As":[86],"Cag\u03b2":[87,118,163],"functions":[88],"like":[89],"motor":[92,119],"secretion":[95],"system,":[96],"targeting":[97],"this":[98],"particular":[99],"may":[101,166],"provide":[102],"way":[104],"prevent":[106],"delivery.":[108],"This":[109],"study":[110],"aims":[111],"model":[113],"3D":[115],"structure":[116],"identify":[122],"repurposed":[123],"drugs":[124],"capable":[125],"inhibiting":[127],"its":[128],"activity":[129,165],"docking":[132],"studies.":[133],"Venetoclax":[134],"was":[135],"found":[136],"one":[137],"most":[140],"promising":[141],"drug,":[142],"having":[143],"binding":[144],"affinity":[145],"-11.6":[147],"Kcal/mol":[148],"with":[149,155],"expected":[150],"structural":[151],"stability":[152],"via":[153],"interaction":[154],"SER301,":[156],"MET297,":[157],"GLY309":[158],"LEU249":[160],"residue.":[161],"Blocking":[162],"regulated":[164],"block":[167],"delivery":[170],"cells,":[173],"subsequently":[174],"reducing":[175],"downstream":[176],"inflammatory":[177],"pathways":[179],"limiting":[181],"further":[183],"pathogenesis":[184],"infection.":[188]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-23T00:00:00"}