{"id":"https://openalex.org/W7203975015","doi":"https://doi.org/10.1038/s41419-026-09203-0","title":"NEK2-AURKA axis drives ubiquitin-dependent IFT88 degradation to suppress ciliogenesis and promote basal-type bladder cancer","display_name":"NEK2-AURKA axis drives ubiquitin-dependent IFT88 degradation to suppress ciliogenesis and promote basal-type bladder cancer","publication_year":2026,"publication_date":"2026-08-22","ids":{"openalex":"https://openalex.org/W7203975015","doi":"https://doi.org/10.1038/s41419-026-09203-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/42918762","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13690740"},"language":"en","primary_location":{"id":"doi:10.1038/s41419-026-09203-0","doi":"https://doi.org/10.1038/s41419-026-09203-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-026-09203-0","pdf_url":"https://www.nature.com/articles/s41419-026-09203-0_reference.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41419-026-09203-0_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035930888","display_name":"E Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133270","display_name":"Second Hospital of Tianjin Medical University","ror":"https://ror.org/03rc99w60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133270"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"E Du","raw_affiliation_strings":["Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China","institution_ids":["https://openalex.org/I4210133270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147843957","display_name":"Wei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133270","display_name":"Second Hospital of Tianjin Medical University","ror":"https://ror.org/03rc99w60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133270"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China","institution_ids":["https://openalex.org/I4210133270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143714418","display_name":"Qiang Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133270","display_name":"Second Hospital of Tianjin Medical University","ror":"https://ror.org/03rc99w60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133270"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Su","raw_affiliation_strings":["Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China","institution_ids":["https://openalex.org/I4210133270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140566256","display_name":"Wei Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133270","display_name":"Second Hospital of Tianjin Medical University","ror":"https://ror.org/03rc99w60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133270"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Huang","raw_affiliation_strings":["Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China","institution_ids":["https://openalex.org/I4210133270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108835093","display_name":"Yuanjiong Qi","orcid":"https://orcid.org/0000-0002-2331-2205","observed_orcids":["https://orcid.org/0000-0002-2331-2205"]},"institutions":[{"id":"https://openalex.org/I4210133270","display_name":"Second Hospital of Tianjin Medical University","ror":"https://ror.org/03rc99w60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133270"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanjiong Qi","raw_affiliation_strings":["Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China","institution_ids":["https://openalex.org/I4210133270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147876723","display_name":"Weijie Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181046868","display_name":"BI Norwegian Business School","ror":"https://ror.org/03ez40v33","country_code":"NO","type":"education","lineage":["https://openalex.org/I181046868"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Weijie Tang","raw_affiliation_strings":["Department of Data Science and Analytics, BI Norwegian Business School, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Data Science and Analytics, BI Norwegian Business School, Oslo, Norway","institution_ids":["https://openalex.org/I181046868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100419467","display_name":"Zhihong Zhang","orcid":"https://orcid.org/0000-0002-5788-3479","observed_orcids":["https://orcid.org/0000-0002-5788-3479"]},"institutions":[{"id":"https://openalex.org/I4210133270","display_name":"Second Hospital of Tianjin Medical University","ror":"https://ror.org/03rc99w60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133270"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhihong Zhang","raw_affiliation_strings":["Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China. zhangzhihongtianj@163.com"],"raw_orcid":"https://orcid.org/0000-0002-5788-3479","affiliations":[{"raw_affiliation_string":"Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China. zhangzhihongtianj@163.com","institution_ids":["https://openalex.org/I4210133270","https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017752115","display_name":"Changwen Zhang","orcid":"https://orcid.org/0000-0002-0607-9480","observed_orcids":["https://orcid.org/0000-0002-0607-9480"]},"institutions":[{"id":"https://openalex.org/I4210133270","display_name":"Second Hospital of Tianjin Medical University","ror":"https://ror.org/03rc99w60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133270"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Changwen Zhang","raw_affiliation_strings":["Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China. zhangchangwen05@tmu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0002-0607-9480","affiliations":[{"raw_affiliation_string":"Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China. zhangchangwen05@tmu.edu.cn","institution_ids":["https://openalex.org/I4210133270","https://openalex.org/I5740404"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020086916","display_name":"Jingxian Li","orcid":"https://orcid.org/0000-0003-2682-9063","observed_orcids":["https://orcid.org/0000-0003-2682-9063"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I4210133270","display_name":"Second Hospital of Tianjin Medical University","ror":"https://ror.org/03rc99w60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133270"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN","NO"],"is_corresponding":true,"raw_author_name":"Jingxian Li","raw_affiliation_strings":["Norwegian Centre for Molecular Biosciences and Medicine (NCMBM), University of Oslo, Oslo, Norway. 15022458347@163.com","Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China. 15022458347@163.com"],"raw_orcid":"https://orcid.org/0000-0003-2682-9063","affiliations":[{"raw_affiliation_string":"Norwegian Centre for Molecular Biosciences and Medicine (NCMBM), University of Oslo, Oslo, Norway. 15022458347@163.com","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China. 15022458347@163.com","institution_ids":["https://openalex.org/I4210133270","https://openalex.org/I5740404"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5017752115","https://openalex.org/A5020086916","https://openalex.org/A5100419467"],"corresponding_institution_ids":["https://openalex.org/I184942183","https://openalex.org/I4210133270","https://openalex.org/I5740404"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.03920000046491623,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nek2","display_name":"NEK2","score":0.9369999766349792},{"id":"https://openalex.org/keywords/aurora-a-kinase","display_name":"AURKA","score":0.7120000123977661},{"id":"https://openalex.org/keywords/ift88","display_name":"IFT88","score":0.9990000128746033},{"id":"https://openalex.org/keywords/primary-cilia","display_name":"primary cilia","score":0.6909999847412109},{"id":"https://openalex.org/keywords/ciliogenesis","display_name":"ciliogenesis","score":0.921999990940094},{"id":"https://openalex.org/keywords/muscle-invasive-bladder-cancer","display_name":"muscle-invasive bladder cancer","score":0.9229999780654907},{"id":"https://openalex.org/keywords/ubiquitin-mediated-degradation","display_name":"ubiquitin-mediated proteolysis","score":0.6890000104904175},{"id":"https://openalex.org/keywords/tumor-cell-proliferation-and-migration","display_name":"tumor cell proliferation and migration","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C195267511","wikidata":"https://www.wikidata.org/wiki/Q5119969","display_name":"Ciliogenesis","level":3,"score":0.9053999781608582},{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.8392999768257141},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7224000096321106},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6057999730110168},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5741999745368958},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.52920001745224},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46320000290870667},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.4429999887943268},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.43549999594688416},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42989999055862427},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.42809998989105225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41819998621940613},{"id":"https://openalex.org/C2779545874","wikidata":"https://www.wikidata.org/wiki/Q2070286","display_name":"Vismodegib","level":4,"score":0.37279999256134033},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.3075999915599823},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.30660000443458557},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2973000109195709},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.28839999437332153},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2858000099658966},{"id":"https://openalex.org/C102658986","wikidata":"https://www.wikidata.org/wiki/Q5266092","display_name":"Deubiquitinating enzyme","level":4,"score":0.2793000042438507},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2766000032424927},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.27619999647140503},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.27379998564720154},{"id":"https://openalex.org/C131151476","wikidata":"https://www.wikidata.org/wiki/Q809753","display_name":"Basal body","level":4,"score":0.2718000113964081}],"mesh":[{"descriptor_ui":"D000072379","descriptor_name":"NIMA-Related Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000072379","descriptor_name":"NIMA-Related Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002923","descriptor_name":"Cilia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002923","descriptor_name":"Cilia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064096","descriptor_name":"Aurora Kinase A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064096","descriptor_name":"Aurora Kinase A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41419-026-09203-0","doi":"https://doi.org/10.1038/s41419-026-09203-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-026-09203-0","pdf_url":"https://www.nature.com/articles/s41419-026-09203-0_reference.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13690740","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13690740/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13690740/pdf/41419_2026_Article_9203.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Dis","raw_type":"Text"},{"id":"pmid:42918762","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42918762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death & disease","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:967d80034d644fcc837b80c4817bea7c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/967d80034d644fcc837b80c4817bea7c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Death and Disease, Vol 17, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41419-026-09203-0","doi":"https://doi.org/10.1038/s41419-026-09203-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-026-09203-0","pdf_url":"https://www.nature.com/articles/s41419-026-09203-0_reference.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203975015.pdf","grobid_xml":"https://content.openalex.org/works/W7203975015.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W2017952926","https://openalex.org/W2033775272","https://openalex.org/W2046199803","https://openalex.org/W2066480724","https://openalex.org/W2067964015","https://openalex.org/W2141640690","https://openalex.org/W2145278939","https://openalex.org/W2176387927","https://openalex.org/W2268404930","https://openalex.org/W2550949056","https://openalex.org/W2604535399","https://openalex.org/W2741508285","https://openalex.org/W2763670669","https://openalex.org/W2791111208","https://openalex.org/W2975497362","https://openalex.org/W3010303390","https://openalex.org/W3035746651","https://openalex.org/W3107880858","https://openalex.org/W3108775243","https://openalex.org/W3123995258","https://openalex.org/W3125070163","https://openalex.org/W3166074522","https://openalex.org/W3183514487","https://openalex.org/W4210469340","https://openalex.org/W4323310020","https://openalex.org/W4366280060","https://openalex.org/W4367052828","https://openalex.org/W4385012823","https://openalex.org/W4387966914","https://openalex.org/W4391744412","https://openalex.org/W4402745267","https://openalex.org/W4406128347","https://openalex.org/W4409903294","https://openalex.org/W4412534308"],"related_works":["https://openalex.org/W4367052828","https://openalex.org/W6958534037","https://openalex.org/W3125070163","https://openalex.org/W7164682000","https://openalex.org/W2888843540","https://openalex.org/W2066480724","https://openalex.org/W4397012895","https://openalex.org/W2574696544","https://openalex.org/W6902058987","https://openalex.org/W2033096876"],"abstract_inverted_index":{"Loss":[0],"of":[1,14,44,62,80,134,174,228],"primary":[2],"cilia":[3,45,51,115,163,215],"is":[4,19],"common":[5],"in":[6,30,47,55,58,90,96,193,217,231],"cancer,":[7],"but":[8],"its":[9,144,148],"relevance":[10],"to":[11,40],"molecular":[12],"subtypes":[13],"muscle-invasive":[15],"bladder":[16,31,106],"cancer":[17,32,107],"(MIBC)":[18],"unclear.":[20],"Here,":[21],"we":[22],"combined":[23],"transcriptomic":[24],"and":[25,38,66,70,83,93,114,117,120,146,159,166,196,214],"co-expression":[26],"analyses":[27],"with":[28,100,141,184],"experiments":[29,129],"cell":[33,68],"lines,":[34],"human":[35],"tumor":[36,194],"specimens,":[37],"xenografts":[39],"investigate":[41],"the":[42,78,125,161,172,185,190,199],"basis":[43,224],"loss":[46,216],"basal":[48,56,91,105,218,233],"MIBC.":[49,60,234],"Primary":[50],"were":[52],"less":[53],"frequent":[54],"than":[57],"luminal":[59],"Depletion":[61],"IFT88":[63,73,112,154,212],"reduced":[64,118,153],"ciliogenesis":[65],"increased":[67,111,143],"proliferation":[69,119],"migration.":[71],"Conversely,":[72],"overexpression":[74,123,158,170],"restored":[75],"cilia,":[76],"delayed":[77],"appearance":[79],"palpable":[81],"xenografts,":[82],"limited":[84],"xenograft":[85,179],"growth.":[86],"NEK2":[87,109,122,135,139,157,175,186,229],"was":[88,98],"enriched":[89],"MIBC,":[92],"higher":[94],"expression":[95],"TCGA":[97],"associated":[99,162],"shorter":[101],"disease-free":[102],"survival.":[103],"In":[104,177],"cells,":[108],"knockdown":[110,152],"abundance":[113],"formation":[116],"migration;":[121],"had":[124],"opposite":[126],"effects.":[127],"Rescue":[128],"showed":[130],"that":[131,209],"these":[132],"effects":[133,173],"depended":[136],"on":[137],"IFT88.":[138],"interacted":[140],"IFT88,":[142],"ubiquitination,":[145],"accelerated":[147],"proteasomal":[149],"turnover.":[150],"AURKA":[151,169],"ubiquitination":[155],"after":[156],"attenuated":[160],"loss,":[164],"proliferation,":[165],"migration,":[167],"whereas":[168],"reversed":[171],"knockdown.":[176],"a":[178,206,222],"experiment,":[180],"pretreating":[181],"IFT88-overexpressing":[182],"cells":[183],"inhibitor":[187],"JH295":[188],"produced":[189],"greatest":[191],"reduction":[192],"establishment":[195],"growth":[197],"among":[198],"four":[200],"conditions":[201],"tested.":[202],"These":[203],"data":[204],"identify":[205],"NEK2-AURKA-IFT88":[207],"pathway":[208],"promotes":[210],"ubiquitin-dependent":[211],"degradation":[213],"MIBC":[219],"models,":[220],"providing":[221],"preclinical":[223],"for":[225],"further":[226],"testing":[227],"targeting":[230],"cilia-deficient":[232]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-08-23T00:00:00"}