{"id":"https://openalex.org/W7203973127","doi":"https://doi.org/10.1016/j.xjon.2026.102076","title":"Pilot safety and efficacy trial of amiodarone-infused biologic acellular biatrial patches to prevent new-onset postoperative atrial fibrillation","display_name":"Pilot safety and efficacy trial of amiodarone-infused biologic acellular biatrial patches to prevent new-onset postoperative atrial fibrillation","publication_year":2026,"publication_date":"2026-08-22","ids":{"openalex":"https://openalex.org/W7203973127","doi":"https://doi.org/10.1016/j.xjon.2026.102076","pmid":"https://pubmed.ncbi.nlm.nih.gov/42948487","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13711286"},"language":"en","primary_location":{"id":"doi:10.1016/j.xjon.2026.102076","doi":"https://doi.org/10.1016/j.xjon.2026.102076","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xjon.2026.102076","pdf_url":null,"source":{"id":"https://openalex.org/S4210197350","display_name":"JTCVS Open","issn_l":"2666-2736","issn":["2666-2736"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTCVS Open","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.xjon.2026.102076","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007048499","display_name":"Mark S. Slaughter","orcid":"https://orcid.org/0000-0001-5412-762X","observed_orcids":["https://orcid.org/0000-0001-5412-762X"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark S. Slaughter","raw_affiliation_strings":["Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky"],"raw_orcid":"https://orcid.org/0000-0001-5412-762X","affiliations":[{"raw_affiliation_string":"Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039037998","display_name":"Joshua G. Crane","orcid":"https://orcid.org/0009-0007-2553-2133","observed_orcids":["https://orcid.org/0009-0007-2553-2133"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua G. Crane","raw_affiliation_strings":["Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037295798","display_name":"Toyokazu Endo","orcid":"https://orcid.org/0000-0002-0772-236X","observed_orcids":["https://orcid.org/0000-0002-0772-236X"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toyokazu Endo","raw_affiliation_strings":["Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081482232","display_name":"Michele Gallo","orcid":"https://orcid.org/0000-0002-1392-4558","observed_orcids":["https://orcid.org/0000-0002-1392-4558"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michele Gallo","raw_affiliation_strings":["Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017603381","display_name":"Yash Pradeep Vaidya","orcid":"https://orcid.org/0000-0002-2522-1104","observed_orcids":["https://orcid.org/0000-0002-2522-1104"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yash Vaidya","raw_affiliation_strings":["Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068838276","display_name":"Siddharth V. Pahwa","orcid":"https://orcid.org/0000-0001-9190-984X","observed_orcids":["https://orcid.org/0000-0001-9190-984X"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siddharth V. Pahwa","raw_affiliation_strings":["Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108651823","display_name":"Niv Ad","orcid":"https://orcid.org/0000-0001-8576-8761","observed_orcids":["https://orcid.org/0000-0001-8576-8761"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Niv Ad","raw_affiliation_strings":["Department of Cardiac Surgery, Johns Hopkins University, Baltimore, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, Johns Hopkins University, Baltimore, Md","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022303797","display_name":"Clayton Allen Kaiser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clayton A. Kaiser","raw_affiliation_strings":["Department of Cardiac Surgery, Ascension Saint Thomas, Nashville, Tenn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, Ascension Saint Thomas, Nashville, Tenn","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012694099","display_name":"Jaimin R. Trivedi","orcid":"https://orcid.org/0000-0001-7152-1338","observed_orcids":["https://orcid.org/0000-0001-7152-1338"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaimin R. Trivedi","raw_affiliation_strings":["Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007048499"],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":{"value":2431,"currency":"USD","value_usd":2431},"apc_paid":{"value":2431,"currency":"USD","value_usd":2431},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.60958282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":null,"first_page":"102076","last_page":"102076"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/postoperative-atrial-fibrillation","display_name":"postoperative atrial fibrillation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/amiodarone","display_name":"amiodarone","score":0.9340000152587891},{"id":"https://openalex.org/keywords/acellular-dermal-matrix","display_name":"acellular dermal matrix","score":0.7799999713897705},{"id":"https://openalex.org/keywords/cardiac-surgery","display_name":"cardiac surgery","score":0.6430000066757202},{"id":"https://openalex.org/keywords/atrial-fibrillation-prevention","display_name":"atrial fibrillation prevention","score":0.7250000238418579},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.7620000243186951},{"id":"https://openalex.org/keywords/30-day-readmission","display_name":"30-day readmission","score":0.9279999732971191},{"id":"https://openalex.org/keywords/amiodarone-toxicity","display_name":"amiodarone toxicity","score":0.796999990940094},{"id":"https://openalex.org/keywords/major-adverse-cardiac-and-cerebrovascular-events","display_name":"major adverse cardiac and cerebrovascular events","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9562000036239624},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.7890999913215637},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.626800000667572},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6049000024795532},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5540000200271606},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5275999903678894},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5220999717712402},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.48080000281333923},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4625999927520752},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.43630000948905945},{"id":"https://openalex.org/C2994577977","wikidata":"https://www.wikidata.org/wiki/Q1203526","display_name":"Pilot trial","level":3,"score":0.415800005197525},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3935999870300293},{"id":"https://openalex.org/C2778789114","wikidata":"https://www.wikidata.org/wiki/Q235007","display_name":"Cardiac surgery","level":2,"score":0.37709999084472656},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3422999978065491},{"id":"https://openalex.org/C2780120127","wikidata":"https://www.wikidata.org/wiki/Q743664","display_name":"Abdominal surgery","level":2,"score":0.33809998631477356},{"id":"https://openalex.org/C202953159","wikidata":"https://www.wikidata.org/wiki/Q382695","display_name":"Intention-to-treat analysis","level":3,"score":0.29840001463890076},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.2939000129699707},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.28529998660087585},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.2549000084400177}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.xjon.2026.102076","doi":"https://doi.org/10.1016/j.xjon.2026.102076","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xjon.2026.102076","pdf_url":null,"source":{"id":"https://openalex.org/S4210197350","display_name":"JTCVS Open","issn_l":"2666-2736","issn":["2666-2736"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTCVS Open","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13711286","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13711286/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13711286/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTCVS Open","raw_type":"Text"},{"id":"pmid:42948487","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42948487","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTCVS open","raw_type":"Clinical Trial"},{"id":"pmh:oai:doaj.org/article:e43905be91b24552ad7c9b2737bc9a18","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e43905be91b24552ad7c9b2737bc9a18","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JTCVS Open, Vol 33, Iss , Pp 102076- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.xjon.2026.102076","doi":"https://doi.org/10.1016/j.xjon.2026.102076","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xjon.2026.102076","pdf_url":null,"source":{"id":"https://openalex.org/S4210197350","display_name":"JTCVS Open","issn_l":"2666-2736","issn":["2666-2736"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTCVS Open","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310177","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203973127.pdf","grobid_xml":"https://content.openalex.org/works/W7203973127.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W797967506","https://openalex.org/W1963374490","https://openalex.org/W1966010228","https://openalex.org/W2025368702","https://openalex.org/W2042866702","https://openalex.org/W2050392216","https://openalex.org/W2141616636","https://openalex.org/W2148121491","https://openalex.org/W2316170887","https://openalex.org/W2322898357","https://openalex.org/W2598304221","https://openalex.org/W2606389550","https://openalex.org/W2789187909","https://openalex.org/W2790443829","https://openalex.org/W3014431602","https://openalex.org/W3096527791","https://openalex.org/W3134134745","https://openalex.org/W4212806492","https://openalex.org/W4387218540","https://openalex.org/W4392244750","https://openalex.org/W4414440232","https://openalex.org/W7133361671"],"related_works":["https://openalex.org/W7160392037","https://openalex.org/W7126059510","https://openalex.org/W7202204635","https://openalex.org/W1980471642","https://openalex.org/W7133361671","https://openalex.org/W1973910900","https://openalex.org/W2742632566","https://openalex.org/W2985748489","https://openalex.org/W2164846985","https://openalex.org/W7166803207"],"abstract_inverted_index":{"Objective":[0],"New":[1],"onset":[2],"post":[3],"operative":[4],"atrial":[5],"fibrillation":[6],"(POAF)":[7],"occurs":[8],"in":[9,57,61,139,155,200,208,229,237,248,289],"approximately":[10],"25-40%":[11],"of":[12,33,93,114,176,273,292],"patients":[13,49,236],"undergoing":[14],"heart":[15],"surgery":[16],"and":[17,24,30,53,105,120,153,186,233,242,294],"is":[18],"associated":[19,283],"with":[20,79,147,270,278,284],"increased":[21],"perioperative":[22],"morbidity":[23],"mortality.":[25],"We":[26],"evaluated":[27],"the":[28,62,66,88,140,156,171,201,209,230,238,249],"safety":[29],"exploratory":[31],"efficacy":[32],"amiodarone-infused":[34,264,279],"CardiaMend\u2122":[35,67,265,280],"biatrial":[36,266],"patches":[37,267,281],"for":[38],"POAF":[39,121,177],"prevention.":[40],"Methods":[41],"A":[42],"single-center":[43],"pilot":[44,258],"clinical":[45,260],"trial":[46,261],"enrolled":[47],"40":[48],"after":[50],"applying":[51],"inclusions":[52],"exclusion":[54],"criteria,":[55],"randomized,":[56],"1:1":[58],"fashion.":[59],"Patients":[60],"treatment":[63,157,202,210,231,250],"group":[64,90,142,158,211,232,240,251],"received":[65,91],"patch,":[68],"a":[69,285],"porous":[70],"acellular":[71],"matrix":[72],"derived":[73],"from":[74,160],"fetal":[75],"bovine":[76],"dermis,":[77],"infused":[78],"70":[80],"mg":[81],"amiodarone,":[82],"placed":[83],"on":[84],"both":[85],"atria,":[86],"while":[87],"control":[89,141,239],"standard":[92],"care.":[94],"The":[95,124,174],"primary":[96],"endpoint":[97],"was":[98,206,282],"safety,":[99],"defined":[100],"as":[101],"major":[102],"adverse":[103],"cardiovascular":[104],"cerebrovascular":[106],"events":[107],"(MACCE).":[108],"Secondary":[109],"endpoints":[110],"included":[111],"POAF,":[112,290],"length":[113,291],"hospital":[115],"stay":[116],"(LOS),":[117],"30-day":[118,222],"readmission,":[119],"duration.":[122],"Results":[123],"two":[125,134],"randomized":[126,259],"groups":[127],"had":[128,143],"similar":[129],"baseline":[130],"characteristics.":[131],"There":[132],"were":[133,198,245,268],"MACCE":[135],"events:":[136],"one":[137,154],"patient":[138],"an":[144,161],"embolic":[145],"stroke":[146],"full":[148],"recovery":[149],"prior":[150],"to":[151,170],"discharge,":[152],"died":[159],"acute":[162],"abdominal":[163],"event":[164],"following":[165],"IABP":[166],"removal,":[167],"deemed":[168],"unrelated":[169],"study":[172],"device.":[173],"incidence":[175],"(4":[178],"patients,":[179,183],"20%":[180],"vs.":[181,193,215,253],"8":[182],"40%,":[184],"p=0.30)":[185],"mean":[187],"AF":[188,228],"duration":[189],"(2.5":[190],"+/-":[191,195,213,217],"2.4":[192],"3.8":[194],"4.1":[196],"days)":[197],"lower":[199,247],"group.":[203],"Mean":[204],"LOS":[205],"shorter":[207],"(5.8":[212],"1.2":[214],"9.3":[216],"7.5":[218],"days,":[219],"p=0.07).":[220],"At":[221],"follow-up,":[223],"Holter":[224],"monitoring":[225],"revealed":[226],"no":[227,271],"3":[234],"(15%)":[235],"(p=0.23),":[241],"readmission":[243],"rates":[244],"also":[246],"(5%":[252],"15%,":[254],"p=0.6).":[255],"Conclusion":[256],"This":[257],"showed":[262],"that":[263],"safe,":[269],"evidence":[272],"systemic":[274],"amiodarone":[275],"toxicity.":[276],"Treatment":[277],"clinically":[286],"noticeable":[287],"reduction":[288],"stay,":[293],"post-discharge":[295],"AF.":[296]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-23T00:00:00"}