{"id":"https://openalex.org/W7203930847","doi":"https://doi.org/10.64898/2026.09.08.750185","title":"CIDER: detecting changes in gene regulatory networks that are associated with changes in phenotype","display_name":"CIDER: detecting changes in gene regulatory networks that are associated with changes in phenotype","publication_year":2026,"publication_date":"2026-09-11","ids":{"openalex":"https://openalex.org/W7203930847","doi":"https://doi.org/10.64898/2026.09.08.750185","pmid":"https://pubmed.ncbi.nlm.nih.gov/42818338","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13622636"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.08.750185","doi":"https://doi.org/10.64898/2026.09.08.750185","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.08.750185","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.08.750185.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.08.750185.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084806853","display_name":"Wooseok J. Jung","orcid":"https://orcid.org/0000-0001-8439-2133","observed_orcids":["https://orcid.org/0000-0001-8439-2133"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wooseok J. Jung","raw_affiliation_strings":["Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO,","Department of Computer Science and Engineering, Washington University, St. Louis, MO,"],"raw_orcid":"https://orcid.org/0000-0001-8439-2133","affiliations":[{"raw_affiliation_string":"Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO,","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, Washington University, St. Louis, MO,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128102441","display_name":"Mingyue Ding","orcid":"https://orcid.org/0009-0004-5200-9530","observed_orcids":["https://orcid.org/0009-0004-5200-9530"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingyue Ding","raw_affiliation_strings":["Department of Computer Science and Engineering, Washington University, St. Louis, MO,"],"raw_orcid":"https://orcid.org/0009-0004-5200-9530","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Washington University, St. Louis, MO,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110609462","display_name":"Shu Liao","orcid":"https://orcid.org/0000-0001-7740-8096","observed_orcids":["https://orcid.org/0000-0001-7740-8096"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shu Liao","raw_affiliation_strings":["Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO,","Department of Computer Science and Engineering, Washington University, St. Louis, MO,"],"raw_orcid":"https://orcid.org/0000-0001-7740-8096","affiliations":[{"raw_affiliation_string":"Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO,","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, Washington University, St. Louis, MO,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120022074","display_name":"Zolboo Erdenebaatar","orcid":"https://orcid.org/0009-0004-8330-2019","observed_orcids":["https://orcid.org/0009-0004-8330-2019"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zolboo Erdenebaatar","raw_affiliation_strings":["Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO,","Department of Computer Science and Engineering, Washington University, St. Louis, MO,"],"raw_orcid":"https://orcid.org/0009-0004-8330-2019","affiliations":[{"raw_affiliation_string":"Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO,","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, Washington University, St. Louis, MO,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010345611","display_name":"Michael R. Brent","orcid":"https://orcid.org/0000-0002-8689-0299","observed_orcids":["https://orcid.org/0000-0002-8689-0299"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael R. Brent","raw_affiliation_strings":["Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO,","Department of Computer Science and Engineering, Washington University, St. Louis, MO,","Department of Genetics, Washington University School of Medicine, St. Louis, MO"],"raw_orcid":"https://orcid.org/0000-0002-8689-0299","affiliations":[{"raw_affiliation_string":"Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO,","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, Washington University, St. Louis, MO,","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Genetics, Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010345611"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.04010000079870224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.9179999828338623},{"id":"https://openalex.org/keywords/continuous-traits","display_name":"continuous traits","score":0.6850000023841858},{"id":"https://openalex.org/keywords/generalized-additive-models","display_name":"generalized additive models","score":0.5809999704360962},{"id":"https://openalex.org/keywords/whole-blood-transcriptome","display_name":"whole blood transcriptome","score":0.7689999938011169},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.7870000004768372},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9810000061988831},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.9269999861717224},{"id":"https://openalex.org/keywords/csf3r","display_name":"CSF3R","score":0.8679999709129333},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.43700000643730164},{"id":"https://openalex.org/keywords/cardiovascular-health","display_name":"cardiovascular health","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5630000233650208},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5558000206947327},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5521000027656555},{"id":"https://openalex.org/C33498276","wikidata":"https://www.wikidata.org/wiki/Q2138797","display_name":"Regulator gene","level":4,"score":0.5447999835014343},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47859999537467957},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.44519999623298645},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4275999963283539},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4059999883174896},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.3781999945640564},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3537999987602234},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2849999964237213},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2786000072956085}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.64898/2026.09.08.750185","doi":"https://doi.org/10.64898/2026.09.08.750185","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.08.750185","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.08.750185.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13622636","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13622636/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13622636/pdf/nihpp-2026.09.08.750185v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42818338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42818338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"doi:10.5281/zenodo.22047900","doi":"https://doi.org/10.5281/zenodo.22047900","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22047900","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Software"},{"id":"doi:10.5281/zenodo.22047901","doi":"https://doi.org/10.5281/zenodo.22047901","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22047901","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Software"}],"best_oa_location":{"id":"doi:10.64898/2026.09.08.750185","doi":"https://doi.org/10.64898/2026.09.08.750185","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.08.750185","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.08.750185.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.46810001134872437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1490530680","display_name":null,"funder_award_id":"HC25195","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G250621538","display_name":null,"funder_award_id":"N01\u2010HC25195","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G278200998","display_name":null,"funder_award_id":"HHSN268201500001I","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3205625555","display_name":null,"funder_award_id":"N01-HC-25195","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3667269547","display_name":null,"funder_award_id":"N01-HC","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4976486911","display_name":null,"funder_award_id":"75N92019D00031","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5518071353","display_name":null,"funder_award_id":"HHSN268201500001I","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G641917991","display_name":"The Framingham Heart Study","funder_award_id":"n01hc25195-41-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7114400168","display_name":null,"funder_award_id":"75N92019D00031","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G77860733","display_name":null,"funder_award_id":"phs001237","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000863725","display_name":"The Long Life Family Study","funder_award_id":"U19AG063893","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000887882","display_name":"Health and Retirement Study: Yrs 35-40","funder_award_id":"U01AG009740","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000920058","display_name":"Mapping and modeling transcription factor networks","funder_award_id":"R35GM141012","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203930847.pdf","grobid_xml":"https://content.openalex.org/works/W7203930847.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1593442063","https://openalex.org/W1965055200","https://openalex.org/W1967247922","https://openalex.org/W1968228833","https://openalex.org/W1969298821","https://openalex.org/W1971240021","https://openalex.org/W1972796654","https://openalex.org/W1973370947","https://openalex.org/W1988985184","https://openalex.org/W1998977949","https://openalex.org/W2002286769","https://openalex.org/W2028197440","https://openalex.org/W2045362835","https://openalex.org/W2093012377","https://openalex.org/W2104548816","https://openalex.org/W2108096958","https://openalex.org/W2108156593","https://openalex.org/W2116404316","https://openalex.org/W2118625269","https://openalex.org/W2119160928","https://openalex.org/W2119725374","https://openalex.org/W2122713183","https://openalex.org/W2141215651","https://openalex.org/W2144083456","https://openalex.org/W2147566730","https://openalex.org/W2156280702","https://openalex.org/W2157829573","https://openalex.org/W2160234571","https://openalex.org/W2160272053","https://openalex.org/W2182189596","https://openalex.org/W2211287272","https://openalex.org/W2338408645","https://openalex.org/W2554705260","https://openalex.org/W2785792383","https://openalex.org/W2789734804","https://openalex.org/W2808841066","https://openalex.org/W2949475756","https://openalex.org/W3008100024","https://openalex.org/W3018150850","https://openalex.org/W3035534563","https://openalex.org/W3037641286","https://openalex.org/W3047334669","https://openalex.org/W3049766339","https://openalex.org/W3122434617","https://openalex.org/W3133859624","https://openalex.org/W3136484527","https://openalex.org/W4318817498","https://openalex.org/W4399072232","https://openalex.org/W4403180347","https://openalex.org/W4405833554","https://openalex.org/W7220834125"],"related_works":["https://openalex.org/W2072463751","https://openalex.org/W3092452148","https://openalex.org/W4246642899","https://openalex.org/W2236425561","https://openalex.org/W2161778727","https://openalex.org/W6957599710","https://openalex.org/W7098077713","https://openalex.org/W2513473844","https://openalex.org/W2987739270","https://openalex.org/W7095275900"],"abstract_inverted_index":{"Changes":[0],"in":[1,208],"gene":[2,76],"regulatory":[3,77,134],"networks":[4],"may":[5,10],"drive":[6],"quantitative":[7,200],"traits,":[8,202],"or":[9],"transmit":[11],"the":[12,29,43,80,95,105,109,115,119,129,144,147,187,218,223,227,245],"effects":[13],"of":[14,45,104,131,146,182,213,222,248],"one":[15],"trait,":[16,110,219],"such":[17,24],"as":[18,25,101,159,234],"blood":[19,52],"lipid":[20],"level,":[21,108],"on":[22],"another,":[23],"cardiovascular":[26],"health.":[27],"Yet":[28],"standard":[30],"tools,":[31],"differential":[32,35],"correlation":[33],"and":[34,51,86,111,177,237],"network":[36,78],"analysis,":[37],"compare":[38],"two":[39,163],"discrete":[40],"groups,":[41],"while":[42],"contexts":[44],"interest":[46],"-":[47,54],"circulating":[48],"lipids,":[49],"inflammation,":[50],"glucose":[53],"vary":[55],"continuously;":[56],"applying":[57],"them":[58],"forces":[59],"dichotomization,":[60],"discarding":[61],"within-trait":[62],"variation.":[63],"We":[64],"introduce":[65],"Continuous":[66],"Interaction-based":[67],"Differential":[68],"Edge":[69],"Regulation":[70],"(CIDER),":[71],"which":[72,209],"tests":[73,127],"whether":[74],"a":[75,83,92,102,132,160,210,238],"edge,":[79],"relationship":[81],"between":[82,162],"transcription":[84],"factor":[85],"its":[87,151,183,214],"target":[88,96,215],"gene,":[89],"varies":[90,216],"with":[91,114,180,217],"continuous":[93],"trait:":[94],"gene's":[97],"expression":[98,107],"is":[99],"modeled":[100],"function":[103],"TF's":[106,211],"their":[112],"interaction,":[113],"interaction":[116],"coefficient":[117],"measuring":[118],"trait":[120,188],"dependence.":[121],"To":[122],"limit":[123],"multiple":[124],"testing,":[125],"CIDER":[126,203],"only":[128,150],"edges":[130],"reference":[133],"network.":[135],"A":[136],"generalized":[137],"additive":[138],"extension":[139],"detects":[140],"interactions":[141],"that":[142,155,232],"change":[143],"shape":[145],"relationship,":[148],"not":[149],"slope,":[152],"including":[153,220],"forms":[154],"cannot":[156],"be":[157],"expressed":[158],"difference":[161],"correlations.":[164],"In":[165,190],"simulations":[166],"it":[167],"outperformed":[168],"four":[169,194],"two-group":[170],"methods":[171],"across":[172,198,244],"sample":[173],"sizes,":[174,176],"effect":[175],"noise":[178],"levels,":[179],"most":[181],"advantage":[184],"from":[185,193],"keeping":[186],"continuous.":[189],"whole-blood":[191],"transcriptomes":[192],"independent":[195],"human":[196],"cohorts":[197],"ten":[199],"health":[201],"identified":[204],"63":[205],"replicated":[206],"cases":[207],"regulation":[212,241],"coupling":[221],"glucocorticoid-receptor":[224],"(NR3C1)":[225],"to":[226],"granulocyte":[228],"colony-stimulating-factor":[229],"receptor":[230],"(CSF3R)":[231],"strengthens":[233],"triglycerides":[235],"rise,":[236],"pair":[239],"whose":[240],"reverses":[242],"direction":[243],"observed":[246],"range":[247],"C-reactive":[249],"protein.":[250]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-08-22T00:00:00"}
