{"id":"https://openalex.org/W7203928249","doi":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20262843","title":"Clinical and safety outcomes of a prospective, eight-week and monocentric study of a multi-active topical serum in facial hyperpigmentation in Indian skin","display_name":"Clinical and safety outcomes of a prospective, eight-week and monocentric study of a multi-active topical serum in facial hyperpigmentation in Indian skin","publication_year":2026,"publication_date":"2026-08-21","ids":{"openalex":"https://openalex.org/W7203928249","doi":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20262843"},"language":"en","primary_location":{"id":"doi:10.18203/issn.2455-4529.intjresdermatol20262843","doi":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20262843","is_oa":true,"landing_page_url":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20262843","pdf_url":"https://www.ijord.com/index.php/ijord/article/download/2251/1259","source":{"id":"https://openalex.org/S2764585087","display_name":"International Journal of Research in Dermatology","issn_l":"2455-4529","issn":["2455-4529"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Research in Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.ijord.com/index.php/ijord/article/download/2251/1259","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104161942","display_name":"Ketan Kulkarni","orcid":"https://orcid.org/0009-0008-9573-9356","observed_orcids":["https://orcid.org/0009-0008-9573-9356"]},"institutions":[{"id":"https://openalex.org/I4210098465","display_name":"Emcure Pharmaceuticals (India)","ror":"https://ror.org/00zkm9w64","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210098465"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ketan Kulkarni","raw_affiliation_strings":["Department of Medical Services, Emcure Pharmaceutical Limited, Pune, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Services, Emcure Pharmaceutical Limited, Pune, Maharashtra, India","institution_ids":["https://openalex.org/I4210098465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035650791","display_name":"Anil Kukreja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098465","display_name":"Emcure Pharmaceuticals (India)","ror":"https://ror.org/00zkm9w64","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210098465"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anil Kukreja","raw_affiliation_strings":["Department of Clinical Research and Medical Affairs, Emcure Pharmaceutical Limited, Mumbai, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research and Medical Affairs, Emcure Pharmaceutical Limited, Mumbai, Maharashtra, India","institution_ids":["https://openalex.org/I4210098465"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086093406","display_name":"Monika Chinda","orcid":"https://orcid.org/0000-0001-8447-7305","observed_orcids":["https://orcid.org/0000-0001-8447-7305"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Monika Chinda","raw_affiliation_strings":["Department of Medical Affairs, Emcutix Biopharmaceutical Limited, Mumbai, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Affairs, Emcutix Biopharmaceutical Limited, Mumbai, Maharashtra, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"5","first_page":"449","last_page":"456"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.6323000192642212,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.6323000192642212,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.36039999127388,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/facial-hyperpigmentation","display_name":"facial hyperpigmentation","score":1.0},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.5699999928474426},{"id":"https://openalex.org/keywords/patient-satisfaction","display_name":"patient satisfaction","score":0.8669999837875366},{"id":"https://openalex.org/keywords/skin-tone-evenness","display_name":"skin tone evenness","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9153000116348267},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.8465999960899353},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.7811999917030334},{"id":"https://openalex.org/C2776728111","wikidata":"https://www.wikidata.org/wiki/Q1641068","display_name":"Hyperpigmentation","level":2,"score":0.7279000282287598},{"id":"https://openalex.org/C2776677263","wikidata":"https://www.wikidata.org/wiki/Q305190","display_name":"Melasma","level":2,"score":0.6122000217437744},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.47029998898506165},{"id":"https://openalex.org/C2777063393","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Irritation","level":2,"score":0.46239998936653137},{"id":"https://openalex.org/C2780576536","wikidata":"https://www.wikidata.org/wiki/Q7451065","display_name":"Sensitive skin","level":2,"score":0.35679998993873596},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.35589998960494995},{"id":"https://openalex.org/C2778561401","wikidata":"https://www.wikidata.org/wiki/Q5223550","display_name":"Dark skin","level":2,"score":0.3440000116825104},{"id":"https://openalex.org/C2779121184","wikidata":"https://www.wikidata.org/wiki/Q1166142","display_name":"Erythema","level":2,"score":0.32919999957084656},{"id":"https://openalex.org/C3019129585","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Skin irritation","level":2,"score":0.3278999924659729},{"id":"https://openalex.org/C2992053201","wikidata":"https://www.wikidata.org/wiki/Q2585693","display_name":"Clinical efficacy","level":2,"score":0.310699999332428},{"id":"https://openalex.org/C2909381827","wikidata":"https://www.wikidata.org/wiki/Q1641068","display_name":"Skin hyperpigmentation","level":3,"score":0.30059999227523804},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2741999924182892},{"id":"https://openalex.org/C2987828669","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical study","level":2,"score":0.2628999948501587},{"id":"https://openalex.org/C2775876775","wikidata":"https://www.wikidata.org/wiki/Q595010","display_name":"Hypertrichosis","level":2,"score":0.2515999972820282}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18203/issn.2455-4529.intjresdermatol20262843","doi":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20262843","is_oa":true,"landing_page_url":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20262843","pdf_url":"https://www.ijord.com/index.php/ijord/article/download/2251/1259","source":{"id":"https://openalex.org/S2764585087","display_name":"International Journal of Research in Dermatology","issn_l":"2455-4529","issn":["2455-4529"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Research in Dermatology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18203/issn.2455-4529.intjresdermatol20262843","doi":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20262843","is_oa":true,"landing_page_url":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20262843","pdf_url":"https://www.ijord.com/index.php/ijord/article/download/2251/1259","source":{"id":"https://openalex.org/S2764585087","display_name":"International Journal of Research in Dermatology","issn_l":"2455-4529","issn":["2455-4529"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Research in Dermatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203928249.pdf","grobid_xml":"https://content.openalex.org/works/W7203928249.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1968055097","https://openalex.org/W2000629418","https://openalex.org/W2016165863","https://openalex.org/W2024787648","https://openalex.org/W2048025247","https://openalex.org/W2080217405","https://openalex.org/W2090020569","https://openalex.org/W2095289520","https://openalex.org/W2129045562","https://openalex.org/W2280636911","https://openalex.org/W2471321097","https://openalex.org/W2519643340","https://openalex.org/W2770310317","https://openalex.org/W2936988850","https://openalex.org/W2950739468","https://openalex.org/W2976884097","https://openalex.org/W2996679632","https://openalex.org/W3103722522","https://openalex.org/W3116139997","https://openalex.org/W3142062264","https://openalex.org/W3175549914","https://openalex.org/W4281927581","https://openalex.org/W4313646616","https://openalex.org/W4367627708","https://openalex.org/W4377097569","https://openalex.org/W4379233096","https://openalex.org/W4379508254","https://openalex.org/W4388695996","https://openalex.org/W4393316033","https://openalex.org/W4393473521","https://openalex.org/W4394573669","https://openalex.org/W4406756576","https://openalex.org/W4408917818","https://openalex.org/W4412156917"],"related_works":["https://openalex.org/W1415721447","https://openalex.org/W4392713947","https://openalex.org/W79870540","https://openalex.org/W4240313696","https://openalex.org/W4238368456","https://openalex.org/W4402994050","https://openalex.org/W4293106425","https://openalex.org/W4250791974","https://openalex.org/W2981001380","https://openalex.org/W2292443585"],"abstract_inverted_index":{"Background:":[0],"Facial":[1],"hyperpigmentation":[2,62],"is":[3],"a":[4,40],"common":[5],"dermatological":[6],"concern":[7],"in":[8,45,152,185,188,197],"individuals":[9],"with":[10,48,60,143,161,200],"Fitzpatrick":[11,201],"skin":[12,98,127,154,202],"phototypes":[13,203],"III-IV.":[14],"Current":[15],"treatment":[16],"options":[17],"are":[18],"often":[19],"limited":[20],"by":[21,124,131,139],"tolerability":[22,196],"issues":[23],"and":[24,35,87,94,101,105,113,134,159,194],"restrictions":[25],"on":[26],"long-term":[27],"hydroquinone":[28],"use.":[29],"This":[30],"study":[31],"evaluated":[32,109],"the":[33,69,162,208,216],"efficacy":[34],"safety":[36],"of":[37,65,148,178,210,218],"SOLGLO-AZ":[38,73,179],"Serum,":[39],"hydroquinone-free":[41,211],"multi-active":[42,212],"topical":[43,213],"formulation,":[44],"Indian":[46,198],"adults":[47,59,199],"facial":[49,61,189,219],"hyperpigmentation.":[50,220],"Methods:":[51],"In":[52],"this":[53],"prospective,":[54],"open-label,":[55],"monocentric":[56],"study,":[57],"34":[58],"were":[63,108,173],"enrolled,":[64],"whom":[66],"32":[67],"completed":[68],"study.":[70],"Participants":[71],"applied":[72],"serum":[74],"once":[75],"nightly":[76],"for":[77,181,215],"8":[78,182],"weeks.":[79],"Efficacy":[80],"was":[81],"assessed":[82],"at":[83],"baseline,":[84],"day":[85,88,118],"30,":[86],"60":[89],"using":[90,110],"clinical":[91,111],"blemish":[92,121],"scores":[93,122],"Antera":[95],"3D":[96],"imaging-derived":[97],"luminance":[99,128],"(L*)":[100,129],"pigmentation":[102,136],"indices.":[103],"Safety":[104],"participant":[106],"satisfaction":[107,160],"assessments":[112],"self-assessment":[114],"questionnaires.":[115],"Results:":[116],"By":[117],"60,":[119],"mean":[120,135],"decreased":[123,138],"25%":[125],"(p<0.05),":[126,133],"increased":[130],"18.8%":[132],"values":[137],"9.2%":[140],"(p<0.05)":[141],"compared":[142],"baseline.":[144],"More":[145],"than":[146],"93%":[147],"participants":[149],"reported":[150],"improvement":[151,187],"pigmentation,":[153],"tone":[155],"evenness,":[156],"overall":[157],"appearance,":[158],"product.":[163],"No":[164],"clinically":[165],"significant":[166,186],"adverse":[167],"events,":[168],"erythema,":[169],"edema,":[170],"or":[171],"irritation":[172],"observed.":[174],"Conclusions:":[175],"Once-nightly":[176],"application":[177],"Serum":[180],"weeks":[183],"resulted":[184],"hyperpigmentation,":[190],"high":[191],"patient":[192],"satisfaction,":[193],"excellent":[195],"III\u2013IV.":[204],"These":[205],"findings":[206],"support":[207],"use":[209],"formulations":[214],"management":[217]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-22T00:00:00"}