{"id":"https://openalex.org/W7203926132","doi":"https://doi.org/10.1093/genetics/iyag298","title":"Metazoan Orc6 Proteins Evolved Alternative Mechanisms for Association with the ORC Complex: Insights from Drosophila Modeling","display_name":"Metazoan Orc6 Proteins Evolved Alternative Mechanisms for Association with the ORC Complex: Insights from Drosophila Modeling","publication_year":2026,"publication_date":"2026-10-26","ids":{"openalex":"https://openalex.org/W7203926132","doi":"https://doi.org/10.1093/genetics/iyag298","pmid":"https://pubmed.ncbi.nlm.nih.gov/42933861"},"language":"en","primary_location":{"id":"doi:10.1093/genetics/iyag298","doi":"https://doi.org/10.1093/genetics/iyag298","is_oa":false,"landing_page_url":"https://doi.org/10.1093/genetics/iyag298","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GENETICS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/21/2026.08.20.745992.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009965544","display_name":"Maxim Balasov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maxim Balasov","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, School of Medicine , Birmingham, Alabama 35233 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, School of Medicine , Birmingham, Alabama 35233 ,","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080880753","display_name":"Etsuko Shibata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Etsuko Shibata","raw_affiliation_strings":["Department of Genetics, The University of Alabama at Birmingham, School of Medicine , Birmingham, Alabama 35233 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, The University of Alabama at Birmingham, School of Medicine , Birmingham, Alabama 35233 ,","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041200927","display_name":"Katarina Akhmetova","orcid":"https://orcid.org/0000-0003-2475-3288","observed_orcids":["https://orcid.org/0000-0003-2475-3288"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katarina Akhmetova","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, School of Medicine , Birmingham, Alabama 35233 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, School of Medicine , Birmingham, Alabama 35233 ,","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040218340","display_name":"Anindya Dutta","orcid":"https://orcid.org/0000-0002-4319-0073","observed_orcids":["https://orcid.org/0000-0002-4319-0073"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anindya Dutta","raw_affiliation_strings":["Department of Genetics, The University of Alabama at Birmingham, School of Medicine , Birmingham, Alabama 35233 ,"],"raw_orcid":"https://orcid.org/0000-0002-3559-2574","affiliations":[{"raw_affiliation_string":"Department of Genetics, The University of Alabama at Birmingham, School of Medicine , Birmingham, Alabama 35233 ,","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019636239","display_name":"Igor N. Chesnokov","orcid":"https://orcid.org/0000-0002-6659-2913","observed_orcids":["https://orcid.org/0000-0002-6659-2913"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Igor Chesnokov","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, School of Medicine , Birmingham, Alabama 35233 ,"],"raw_orcid":"https://orcid.org/0000-0002-6659-2913","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, School of Medicine , Birmingham, Alabama 35233 ,","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019636239"],"corresponding_institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.48928534,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.5268999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.5268999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.3686999976634979,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orc6","display_name":"ORC6","score":0.996999979019165},{"id":"https://openalex.org/keywords/origin-recognition-complex","display_name":"origin recognition complex","score":0.9879999756813049},{"id":"https://openalex.org/keywords/dna-replication-initiation","display_name":"DNA replication initiation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/nuclear-localization-signal","display_name":"nuclear localization signal","score":0.9679999947547913},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.6890000104904175},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.7549999952316284},{"id":"https://openalex.org/keywords/nuclear-localization","display_name":"nuclear localization","score":0.32499998807907104}],"concepts":[{"id":"https://openalex.org/C149187182","wikidata":"https://www.wikidata.org/wiki/Q22325217","display_name":"Replisome","level":5,"score":0.763700008392334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7336000204086304},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.6083999872207642},{"id":"https://openalex.org/C151158763","wikidata":"https://www.wikidata.org/wiki/Q1626856","display_name":"Origin recognition complex","level":5,"score":0.548799991607666},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.5315999984741211},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4902999997138977},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46320000290870667},{"id":"https://openalex.org/C186435350","wikidata":"https://www.wikidata.org/wiki/Q1050365","display_name":"NLS","level":4,"score":0.4316999912261963},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42890000343322754},{"id":"https://openalex.org/C59157529","wikidata":"https://www.wikidata.org/wiki/Q994741","display_name":"Nuclear transport","level":4,"score":0.40560001134872437},{"id":"https://openalex.org/C49805395","wikidata":"https://www.wikidata.org/wiki/Q910966","display_name":"Nuclear localization sequence","level":3,"score":0.3894999921321869},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.37229999899864197},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.3686000108718872},{"id":"https://openalex.org/C160704184","wikidata":"https://www.wikidata.org/wiki/Q18031028","display_name":"Ran","level":2,"score":0.3562000095844269},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.3488999903202057},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.3431999981403351},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.32580000162124634},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.3240000009536743},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.32109999656677246},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.3093000054359436},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.30889999866485596},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3084000051021576},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.2946000099182129},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.2809999883174896},{"id":"https://openalex.org/C58337764","wikidata":"https://www.wikidata.org/wiki/Q976651","display_name":"Origin of replication","level":4,"score":0.2775999903678894},{"id":"https://openalex.org/C54757728","wikidata":"https://www.wikidata.org/wiki/Q3511067","display_name":"Nuclear export signal","level":4,"score":0.25780001282691956},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.257099986076355},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.25679999589920044},{"id":"https://openalex.org/C3019440265","wikidata":"https://www.wikidata.org/wiki/Q238156","display_name":"Complex formation","level":2,"score":0.2508000135421753}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/genetics/iyag298","doi":"https://doi.org/10.1093/genetics/iyag298","is_oa":false,"landing_page_url":"https://doi.org/10.1093/genetics/iyag298","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GENETICS","raw_type":"journal-article"},{"id":"doi:10.64898/2026.08.20.745992","doi":"https://doi.org/10.64898/2026.08.20.745992","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.20.745992","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/21/2026.08.20.745992.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42933861","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42933861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.08.20.745992","doi":"https://doi.org/10.64898/2026.08.20.745992","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.20.745992","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/21/2026.08.20.745992.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2413311921","display_name":null,"funder_award_id":"R01CA060499","funder_id":"https://openalex.org/F4320338403","funder_display_name":"Common Fund"},{"id":"https://openalex.org/G8473187570","display_name":null,"funder_award_id":"R35GM148158","funder_id":"https://openalex.org/F4320338403","funder_display_name":"Common Fund"},{"id":"https://openalex.org/G9000887614","display_name":"DNA Replication and Cytokinesis.","funder_award_id":"R35GM148158","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320338403","display_name":"Common Fund","ror":"https://ror.org/001d55x84"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203926132.pdf","grobid_xml":"https://content.openalex.org/works/W7203926132.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2126943194","https://openalex.org/W2035313782","https://openalex.org/W3090366785","https://openalex.org/W2080271001","https://openalex.org/W2070050544","https://openalex.org/W3006084035","https://openalex.org/W2001222878","https://openalex.org/W1614067100","https://openalex.org/W1981843200","https://openalex.org/W1991843148"],"abstract_inverted_index":{"In":[0,32,83],"eukaryotes,":[1],"DNA":[2,45],"replication":[3,48],"requires":[4],"the":[5,22,38,60,63,91,104,137,147,154,159,165],"origin":[6],"recognition":[7],"complex":[8,64,106,163],"(ORC),":[9],"a":[10,117],"six-subunit":[11],"assembly":[12],"that":[13,95,123,130],"promotes":[14],"replisome":[15],"formation":[16,157],"on":[17],"chromosomal":[18],"origins.":[19],"Orc6":[20,34,56,75,102,110,151],"is":[21,42,96,124],"smallest":[23],"and":[24,41,47,53,139,152],"least":[25],"evolutionarily":[26],"conserved":[27],"among":[28],"all":[29,81],"ORC":[30,105,162],"subunits.":[31],"Drosophila,":[33],"binds":[35],"tightly":[36],"with":[37,59,103],"core":[39],"ORC(1-5)":[40],"required":[43],"for":[44,69,78,98,141],"binding":[46],"initiation,":[49],"whereas":[50],"in":[51,66,80,107,126],"Xenopus":[52],"human":[54,134],"systems":[55],"loosely":[57],"associates":[58],"rest":[61],"of":[62,101,150,158],"resulting":[65],"some":[67],"differences":[68],"replication-associated":[70],"activities.":[71],"Despite":[72],"these":[73,112],"variations,":[74],"remains":[76],"essential":[77],"viability":[79],"species.":[82],"current":[84],"study":[85],"we":[86],"analyzed":[87],"specific":[88],"residues":[89],"within":[90],"C-terminal":[92],"\u03b111":[93],"helix":[94],"critical":[97],"stable":[99],"association":[100],"Drosophila.":[108],"Human":[109],"lacks":[111],"residues,":[113],"however":[114],"it":[115],"possesses":[116],"strong":[118],"nuclear":[119,148],"localization":[120],"signal":[121],"(NLS)":[122],"absent":[125],"Drosophilidae.":[127],"We":[128],"propose":[129],"this":[131],"NLS":[132],"drives":[133],"protein":[135],"to":[136],"nucleus":[138],"compensates":[140],"weaker":[142],"Orc6-ORC(1-5)":[143],"interactions":[144],"by":[145],"increasing":[146],"concentration":[149],"shifting":[153],"equilibrium":[155],"toward":[156],"fully":[160],"assembled":[161],"at":[164],"DNA.":[166]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2026-08-22T00:00:00"}
