{"id":"https://openalex.org/W7203903455","doi":"https://doi.org/10.63330/sasciencesv6n2-135","title":"INOVA\u00c7\u00c3O BIOTECNOL\u00d3GICA E EFIC\u00c1CIA CL\u00cdNICA DA PAPA\u00cdNA NO REPARO DE FERIDAS: DA EXTRA\u00c7\u00c3O SUSTENT\u00c1VEL \u00c0 SINERGIA COM A FOTOBIOMODULA\u00c7\u00c3O","display_name":"INOVA\u00c7\u00c3O BIOTECNOL\u00d3GICA E EFIC\u00c1CIA CL\u00cdNICA DA PAPA\u00cdNA NO REPARO DE FERIDAS: DA EXTRA\u00c7\u00c3O SUSTENT\u00c1VEL \u00c0 SINERGIA COM A FOTOBIOMODULA\u00c7\u00c3O","publication_year":2026,"publication_date":"2026-08-21","ids":{"openalex":"https://openalex.org/W7203903455","doi":"https://doi.org/10.63330/sasciencesv6n2-135"},"language":"pt","primary_location":{"id":"doi:10.63330/sasciencesv6n2-135","doi":"https://doi.org/10.63330/sasciencesv6n2-135","is_oa":true,"landing_page_url":"https://doi.org/10.63330/sasciencesv6n2-135","pdf_url":"https://southamericansciences.com.br/index.php/sas/article/download/361/423","source":{"id":"https://openalex.org/S4210197492","display_name":"South American Sciences","issn_l":"2675-7222","issn":["2675-7222"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"South American Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://southamericansciences.com.br/index.php/sas/article/download/361/423","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5126623892","display_name":"Karine Valverde da Costa Gomes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karine Valverde da Costa Gomes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147801174","display_name":"Cl\u00e1udia Cristina Hastenreiter da Costa Nascimento","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cl\u00e1udia Cristina Hastenreiter da Costa Nascimento","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5126888063","display_name":"GL\u00c1UCIO DIR\u00c9 FELICIANO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gl\u00e1ucio Dir\u00e9 Feliciano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.6509000062942505,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.6509000062942505,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14478","display_name":"Papaya Research and Applications","score":0.1454000025987625,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11566","display_name":"Laser Applications in Dentistry and Medicine","score":0.11379999667406082,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/papain","display_name":"papain","score":0.9670000076293945},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9179999828338623},{"id":"https://openalex.org/keywords/enzymatic-debridement","display_name":"enzymatic debridement","score":0.8859999775886536},{"id":"https://openalex.org/keywords/low-level-laser-therapy","display_name":"low-level laser therapy","score":0.875},{"id":"https://openalex.org/keywords/tissue-regeneration","display_name":"tissue regeneration","score":0.7680000066757202},{"id":"https://openalex.org/keywords/enzyme-immobilization","display_name":"enzyme immobilization","score":0.7329999804496765},{"id":"https://openalex.org/keywords/neovascularization","display_name":"neovascularization","score":0.7179999947547913},{"id":"https://openalex.org/keywords/collagen-synthesis","display_name":"collagen synthesis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mitochondrial-bioenergetics","display_name":"mitochondrial bioenergetics","score":0.703000009059906},{"id":"https://openalex.org/keywords/carica-papaya","display_name":"Carica papaya","score":0.7289999723434448},{"id":"https://openalex.org/keywords/biotechnology-innovation","display_name":"biotechnology innovation","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3774999976158142},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3118000030517578},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.25839999318122864},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.2551000118255615},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2522999942302704},{"id":"https://openalex.org/C2984889486","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing care","level":2,"score":0.2451999932527542},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.22599999606609344},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.21449999511241913},{"id":"https://openalex.org/C2909361675","wikidata":"https://www.wikidata.org/wiki/Q2712821","display_name":"Mechanical compression","level":2,"score":0.2094999998807907},{"id":"https://openalex.org/C2779254040","wikidata":"https://www.wikidata.org/wiki/Q4914782","display_name":"Biodosimetry","level":4,"score":0.18559999763965607}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.63330/sasciencesv6n2-135","doi":"https://doi.org/10.63330/sasciencesv6n2-135","is_oa":true,"landing_page_url":"https://doi.org/10.63330/sasciencesv6n2-135","pdf_url":"https://southamericansciences.com.br/index.php/sas/article/download/361/423","source":{"id":"https://openalex.org/S4210197492","display_name":"South American Sciences","issn_l":"2675-7222","issn":["2675-7222"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"South American Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.63330/sasciencesv6n2-135","doi":"https://doi.org/10.63330/sasciencesv6n2-135","is_oa":true,"landing_page_url":"https://doi.org/10.63330/sasciencesv6n2-135","pdf_url":"https://southamericansciences.com.br/index.php/sas/article/download/361/423","source":{"id":"https://openalex.org/S4210197492","display_name":"South American Sciences","issn_l":"2675-7222","issn":["2675-7222"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"South American Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203903455.pdf","grobid_xml":"https://content.openalex.org/works/W7203903455.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1704033785","https://openalex.org/W1965817500","https://openalex.org/W2401700760","https://openalex.org/W2528578108","https://openalex.org/W2528810222","https://openalex.org/W2552053245","https://openalex.org/W2604732841","https://openalex.org/W2984087076","https://openalex.org/W3025829757","https://openalex.org/W3028064682","https://openalex.org/W3037057213","https://openalex.org/W3137946569","https://openalex.org/W3181807434","https://openalex.org/W3188202879","https://openalex.org/W4210961324","https://openalex.org/W4221126977","https://openalex.org/W4226509352","https://openalex.org/W4311971357","https://openalex.org/W4320487989","https://openalex.org/W4376609222","https://openalex.org/W4388866311","https://openalex.org/W4399460623","https://openalex.org/W4400407457","https://openalex.org/W4401483238","https://openalex.org/W4401709470","https://openalex.org/W4401967392","https://openalex.org/W4405481186","https://openalex.org/W4406151286","https://openalex.org/W4410487899","https://openalex.org/W4412513263"],"related_works":["https://openalex.org/W4297827612","https://openalex.org/W4395104588","https://openalex.org/W3197678139","https://openalex.org/W3049506880","https://openalex.org/W2948095567","https://openalex.org/W4210395346","https://openalex.org/W2169929141","https://openalex.org/W3086130697","https://openalex.org/W2164153391","https://openalex.org/W3173766082"],"abstract_inverted_index":{"O":[0],"tratamento":[1],"de":[2,37,51,116,126,133,136,140,167,194,199],"feridas":[3],"complexas":[4],"representa":[5,186],"um":[6,187,204],"importante":[7],"desafio":[8],"assistencial":[9],"e":[10,19,54,64,87,105,128,142,152,169],"econ\u00f4mico,":[11],"demandando":[12],"estrat\u00e9gias":[13],"que":[14,130,159,182],"combinem":[15],"desbridamento":[16],"enzim\u00e1tico":[17],"eficiente":[18],"est\u00edmulo":[20,89],"\u00e0":[21,71],"regenera\u00e7\u00e3o":[22],"tecidual.":[23,114],"A":[24,67],"papa\u00edna,":[25],"enzima":[26],"proteol\u00edtica":[27],"extra\u00edda":[28],"da":[29,69,100,103,120,179],"Carica":[30],"papaya":[31],"L.,":[32],"destaca-se":[33],"pela":[34],"degrada\u00e7\u00e3o":[35],"seletiva":[36],"tecidos":[38],"desvitalizados":[39],"sem":[40],"lesionar":[41],"o":[42,124,170],"par\u00eanquima":[43],"h\u00edgido.":[44],"Paralelamente,":[45],"avan\u00e7os":[46],"em":[47,57,145,206],"bioprocessos":[48],"impulsionaram":[49],"m\u00e9todos":[50],"extra\u00e7\u00e3o":[52],"sustent\u00e1vel":[53],"a":[55,110,160,163,165,176,191,197],"imobiliza\u00e7\u00e3o":[56],"matrizes":[58],"nanostruturadas,":[59],"aumentando":[60],"sua":[61],"estabilidade":[62],"f\u00edsico-qu\u00edmica":[63],"viabilidade":[65],"comercial.":[66],"associa\u00e7\u00e3o":[68],"papa\u00edna":[70,104],"fotobiomodula\u00e7\u00e3o":[72,111],"(FBM)":[73],"surge":[74],"como":[75,203],"uma":[76,117],"abordagem":[77],"sin\u00e9rgica":[78],"promissora,":[79],"atuando":[80],"simultaneamente":[81],"na":[82],"limpeza":[83],"do":[84,172],"leito":[85],"lesado":[86],"no":[88,112],"bioenerg\u00e9tico":[90],"mitocondrial.":[91],"Este":[92],"estudo":[93],"objetivou":[94],"analisar":[95],"as":[96],"evid\u00eancias":[97],"cient\u00edficas":[98],"acerca":[99],"inova\u00e7\u00e3o":[101],"biotecnol\u00f3gica":[102],"seu":[106],"potencial":[107],"sin\u00e9rgico":[108],"com":[109],"reparo":[113],"Trata-se":[115],"revis\u00e3o":[118],"integrativa":[119],"literatura":[121],"desenvolvida":[122],"segundo":[123],"referencial":[125],"Whittemore":[127],"Knafl,":[129],"mapeou":[131],"rotas":[132],"obten\u00e7\u00e3o,":[134],"sistemas":[135],"libera\u00e7\u00e3o,":[137],"aspectos":[138],"cr\u00edticos":[139],"seguran\u00e7a":[141],"desfechos":[143],"cl\u00ednicos":[144,201],"bases":[146],"internacionais":[147],"(PubMed,":[148],"ScienceDirect,":[149],"Scopus,":[150],"SciELO":[151],"Web":[153],"of":[154],"Science).":[155],"Os":[156],"achados":[157],"indicam":[158],"fototerapia":[161],"potencializa":[162],"neovasculariza\u00e7\u00e3o,":[164],"s\u00edntese":[166],"col\u00e1geno":[168],"controle":[171],"estresse":[173],"oxidativo,":[174],"complementando":[175],"a\u00e7\u00e3o":[177],"enzim\u00e1tica":[178],"papa\u00edna.":[180],"Conclui-se":[181],"essa":[183],"integra\u00e7\u00e3o":[184],"tecnol\u00f3gica":[185],"avan\u00e7o":[188],"significativo":[189],"para":[190],"terapia":[192],"avan\u00e7ada":[193],"feridas,":[195],"embora":[196],"padroniza\u00e7\u00e3o":[198],"protocolos":[200],"permane\u00e7a":[202],"campo":[205],"expans\u00e3o.":[207]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-22T00:00:00"}